Navigation

1. Detection of editing enriched region

2. Understanding annotation of ImmuneEditome
      Search page, example: APOL1
      Gene search result page
      Gene annotation result page
     1) Gene summary category
     2) Tumor-specific category
     3) Immune-related genes category
     4) Immune-related splicing category
     5) Immune infiltration category
     6) Immune gene set category
     7) Drug category
3. Download data and contact us

1. Detection of editing enriched region
RNA edited gene search

2. Understanding ImmuneEditome's annotation categories
Search page, example: APOL1
- Input query: Official HUGO gene symbol or Entrez gene ID.
RNA edited gene search

Gene search result page
Select your gene from the gene list.

Gene annotation result page
These are ImmuneEditome's annotation categories for your query with links to their corresponding annotation parts.
annotation catogries

1) Gene summary category
This category shows the information of the editing enriched genes. Firstly, it shows each partner gene's overall information from basic information such as symbol, alias, and locations and types. This table also shows the manually curated PubMed article information. The second table shows the basic information of enriched editing region, including its gene, region, repeat, and dsRNA structure formed with surrounding fragments. It also provides the UCSC links to present the enriched editing region in each cancer type.
Gene summary category

2) Tumor-specific category
This category shows the comparisons of enriched editing regions between tumor and normal samples, the correlations between enriched editing regions with pathological or clinical stages, and the survival risk of enriched editing regions for each cancer type.
RNA A-to-I editing events category 1

3) Immune-related genes category
This category shows the correlation between enriched editing regions and immune genes by QTL and Pearson method. The immune gene was defined according to the immune database, gene expression correlations with immune infiltration, and expression associations with immune gene sets.
RNA A-to-I editing positional annotations category

RNA A-to-I editing positional annotations category

4) Immune-related splicing category
This category shows the correlation between enriched editing regions and immune splicing events by QTL and Pearson method. The immune splicing event was defined according to its locations in immune genes from immune database, splicing correlations with immune infiltration, and splicing associations with immune gene sets.
RNA A-to-I editing events in the alternative splicing sites category

RNA A-to-I editing events in the alternative splicing sites category

5) Immune infiltration category
This category shows the correlation between enriched editing regions and different kind of immune cells.
RNA A-to-I editing events in the alternative splicing sites category

6) Immune gene set category
This category shows the correlation between enriched editing regions and different kind of immune gene sets. For epithelial-mesenchymal transition, two methods were selected to describe the epithelial and mesenchymal status. For hypoxia, four methods were adopted to depict the oxygen microenvironment.
Protein coding region RNA A-to-I editings category

Protein coding region RNA A-to-I editings category

7) Drug category
This category shows the correlation between enriched editing regions and drug. The first table shows their associations with drug sensitivity. The second table presents the genes with enriched editing regions targeted by drugs.
The effects of the RNA editing to the miRNA binding sites category 1

The effects of the RNA editing to the miRNA binding sites category 1

3. Download data and contact us
Please go to download page and contact page.