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3. Enriched editing regions and immune related genes for CHTOP


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check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark gene sets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:153638972-153640769:+ESCAEERENSG00000128340,RAC20.29353.9877e-021.4049e-070.4420imageNCSTF2T;DDX3X;DGCR8;EIF4A3;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPK;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LIN28B;MSI2;NOP58;PRPF8;PTBP1;SBDS;SMNDC1;SND1;SRSF10;TAF15;TARDBP;TNRC6A;U2AF2;YWHAGRAC2T_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr1:153638972-153640769:+ESCAEERENSG00000196656,AC004057.10.29813.8154e-023.6257e-070.4286imageNNNANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000160679.11,CHTOPESCAEAGENSG00000128340,RAC20.29983.9956e-029.6949e-080.4455imageNADAR;AUH;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DKC1;EIF4A3;EIF4G1;EIF4G2;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28B;LSM11;MSI1;MSI2;NONO;NOP58;NPM1;PRPF8;PTBP1;RBFOX2;RBM22;RBM27;RBM47;SAFB2;SBDS;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;TAF15;TARDBP;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;YWHAGRAC2T_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE