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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: EXOG (ImmuneEditome ID:9941)

1. Gene summary of enriched editing regions for EXOG

check button Gene summary
Gene informationGene symbol

EXOG

Gene ID

9941

GeneSynonymsENDOGL1|ENDOGL2|ENGL|ENGL-a|ENGL-b|ENGLA|ENGLB
GeneCytomap

3p22.2

GeneTypeprotein-coding
GeneDescriptionnuclease EXOG, mitochondrial|endo G-like 1|endo/exonuclease (5'-3'), endonuclease G-like|endonuclease G-like 1|endonuclease G-like 2
GeneModificationdate20230329
UniprotIDF2Z2D3;Q9Y2C4;F8WEP0;H7C451;F8WE28;F8WE38;F8WC11
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:38525639-38525882:+ENST00000474071.4ENSG00000157036.11EXOGncRNA_intronicAluJbchr3:38525639-38525882:+.alignment
chr3:38540033-38540809:+ENST00000474071.4ENSG00000157036.11EXOGncRNA_intronicL1ME1,AluJb,AluJr4chr3:38540033-38540809:+.alignment


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2. Tumor-specific enriched editing regions for EXOG


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000157036.11,EXOGESCACliEAG2.9715e-034.6783e-04-0.5600image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for EXOG


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for EXOG


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000157036.11,EXOG
GBMEAGESENSG00000142534.2chr1949496453:49496471:49497193:49497299:49497519:494975620.20272.2833e-022.8360e-060.4407imageNACIN1;ADAR;AIFM1;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAGSVA_HALLMARK_BILE_ACID_METABOLISM

More results



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5. Enriched editing regions and immune infiltration for EXOG


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000157036.11,EXOGACCEAGEosinophils1.3746e-030.5749image
ENSG00000157036.11,EXOGBRCAEAGMast_cells_resting1.4791e-020.1374image
ENSG00000157036.11,EXOGCOADEAGMast_cells_activated4.1393e-030.4792image
ENSG00000157036.11,EXOGDLBCEAGB_cells_memory6.3019e-030.5214image
ENSG00000157036.11,EXOGESCAEAGT_cells_gamma_delta6.3555e-040.3100image
chr3:38540033-38540809:+GBMEERMonocytes1.5083e-020.2312image
ENSG00000157036.11,EXOGGBMEAGT_cells_CD4_memory_activated2.1524e-020.1928image
ENSG00000157036.11,EXOGHNSCEAGMacrophages_M01.3403e-020.3510image
ENSG00000157036.11,EXOGKIRCEAGMacrophages_M11.5114e-020.2065image
ENSG00000157036.11,EXOGKIRPEAGMacrophages_M02.0672e-02-0.2371image
ENSG00000157036.11,EXOGLGGEAGDendritic_cells_resting1.7143e-020.1088image
ENSG00000157036.11,EXOGLUADEAGDendritic_cells_resting1.3522e-020.2475image
ENSG00000157036.11,EXOGLUSCEAGNeutrophils2.1090e-020.2376image
chr3:38525639-38525882:+OVEERDendritic_cells_resting1.5332e-020.2908image
chr3:38540033-38540809:+OVEERB_cells_naive2.0539e-02-0.3606image
ENSG00000157036.11,EXOGPAADEAGMonocytes2.0038e-02-0.3217image
ENSG00000157036.11,EXOGPRADEAGNK_cells_activated2.9635e-020.1554image
ENSG00000157036.11,EXOGSKCMEAGNK_cells_activated2.5228e-020.1687image
chr3:38540033-38540809:+STADEERT_cells_CD4_memory_activated2.7302e-020.2639image
ENSG00000157036.11,EXOGTGCTEAGT_cells_gamma_delta2.6462e-020.3237image
ENSG00000157036.11,EXOGTHCAEAGNeutrophils1.9181e-030.2100image


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6. Enriched editing regions and immune gene sets for EXOG


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000157036.11,EXOGACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.3406e-02-0.4616image
ENSG00000157036.11,EXOGBLCAGSVA_HALLMARK_PEROXISOMEEAG3.4213e-03-0.2806image
ENSG00000157036.11,EXOGBRCAGSVA_HALLMARK_HYPOXIAEAG1.6651e-020.1350image
chr3:38525639-38525882:+BRCAGSVA_HALLMARK_HYPOXIAEER2.9747e-020.1724image
ENSG00000157036.11,EXOGCESCGSVA_HALLMARK_SPERMATOGENESISEAG3.6662e-03-0.3101image
ENSG00000157036.11,EXOGCOADGSVA_HALLMARK_E2F_TARGETSEAG2.4461e-03-0.5027image
ENSG00000157036.11,EXOGESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG4.3134e-03-0.2610image
chr3:38540033-38540809:+GBMGSVA_HALLMARK_ADIPOGENESISEER2.4170e-040.3432image
ENSG00000157036.11,EXOGGBMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.2313e-030.2686image
ENSG00000157036.11,EXOGHNSCGSVA_HALLMARK_E2F_TARGETSEAG2.1377e-03-0.4283image
ENSG00000157036.11,EXOGKIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.9332e-040.2888image
ENSG00000157036.11,EXOGLAMLGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.6885e-04-0.4378image
chr3:38540033-38540809:+LGGGSVA_HALLMARK_COAGULATIONEER7.3263e-050.1860image
ENSG00000157036.11,EXOGLGGGSVA_HALLMARK_MYC_TARGETS_V1EAG1.9520e-02-0.1066image
ENSG00000157036.11,EXOGLUADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.9342e-02-0.2075image
ENSG00000157036.11,EXOGLUSCGSVA_HALLMARK_GLYCOLYSISEAG2.2067e-030.3120image
chr3:38540033-38540809:+OVGSVA_HALLMARK_NOTCH_SIGNALINGEER3.6541e-030.4438image
chr3:38525639-38525882:+OVGSVA_HALLMARK_KRAS_SIGNALING_UPEER8.2335e-030.3157image
ENSG00000157036.11,EXOGPAADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.1175e-020.3492image
ENSG00000157036.11,EXOGPCPGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.4772e-02-0.2185image
ENSG00000157036.11,EXOGPRADGSVA_HALLMARK_COMPLEMENTEAG4.6860e-03-0.2012image
ENSG00000157036.11,EXOGSARCGSVA_HALLMARK_G2M_CHECKPOINTEAG4.7519e-04-0.2885image
ENSG00000157036.11,EXOGSKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.9777e-03-0.2226image
chr3:38540033-38540809:+STADGSVA_HALLMARK_P53_PATHWAYEER8.0253e-030.3144image
ENSG00000157036.11,EXOGTGCTGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.4419e-02-0.3547image
ENSG00000157036.11,EXOGTHYMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.4967e-030.3080image
ENSG00000157036.11,EXOGUCECGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.6536e-02-0.3127image


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7. Enriched editing regions and drugs for EXOG


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000157036.11,EXOGBLCAAZD.0530EAG1.9784e-05-0.3999image
ENSG00000157036.11,EXOGBRCAABT.263EAG1.1547e-020.1426image
chr3:38525639-38525882:+BRCAABT.263EER3.1702e-020.1710image
ENSG00000157036.11,EXOGCESCBexaroteneEAG4.2263e-020.2195image
ENSG00000157036.11,EXOGCOADLFM.A13EAG6.3771e-03-0.4586image
ENSG00000157036.11,EXOGDLBCA.443654EAG3.0013e-060.7772image
ENSG00000157036.11,EXOGESCAFTI.277EAG2.9949e-02-0.1999image
chr3:38540033-38540809:+GBMJNK.Inhibitor.VIIIEER1.7030e-030.2958image
ENSG00000157036.11,EXOGGBMBI.2536EAG2.0810e-02-0.1938image
ENSG00000157036.11,EXOGHNSCElesclomolEAG1.6915e-030.4370image
ENSG00000157036.11,EXOGKIRCGemcitabineEAG4.0696e-03-0.2431image
ENSG00000157036.11,EXOGKIRPCytarabineEAG5.8792e-030.2806image
ENSG00000157036.11,EXOGLAMLKIN001.135EAG1.3137e-030.3792image
chr3:38540033-38540809:+LGGGW.441756EER1.0928e-030.1536image
ENSG00000157036.11,EXOGLGGDoxorubicinEAG3.5988e-020.0958image
ENSG00000157036.11,EXOGLUADFTI.277EAG1.4835e-02-0.2442image
ENSG00000157036.11,EXOGLUSCBIRB.0796EAG2.0632e-020.2385image
chr3:38540033-38540809:+OVFH535EER7.7687e-04-0.5042image
chr3:38525639-38525882:+OVAMG.706EER1.7530e-020.2852image
ENSG00000157036.11,EXOGOVCI.1040EAG3.5150e-02-0.1808image
ENSG00000157036.11,EXOGPAADA.443654EAG1.7033e-02-0.3296image
chr3:38540033-38540809:+PCPGElesclomolEER7.6928e-030.2748image
ENSG00000157036.11,EXOGPCPGJNK.Inhibitor.VIIIEAG8.2098e-03-0.2364image
ENSG00000157036.11,EXOGPRADAZD7762EAG2.3176e-020.1621image
ENSG00000157036.11,EXOGSARCDasatinibEAG3.5517e-03-0.2440image
ENSG00000157036.11,EXOGSKCMBAY.61.3606EAG2.0217e-030.2312image
chr3:38540033-38540809:+STADGefitinibEER2.2290e-03-0.3597image
ENSG00000157036.11,EXOGTGCTDocetaxelEAG9.0698e-040.4681image
ENSG00000157036.11,EXOGTHCALFM.A13EAG7.6897e-03-0.1809image
ENSG00000157036.11,EXOGUCECCMKEAG4.6732e-03-0.4331image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType