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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ATP2C2 (ImmuneEditome ID:9914)

1. Gene summary of enriched editing regions for ATP2C2

check button Gene summary
Gene informationGene symbol

ATP2C2

Gene ID

9914

GeneSynonymsSPCA2
GeneCytomap

16q24.1

GeneTypeprotein-coding
GeneDescriptioncalcium-transporting ATPase type 2C member 2|ATPase 2C2|ATPase, Ca++ transporting, type 2C, member 2|Ca(2+)/Mn(2+)-ATPase 2C2|secretory pathway Ca(2+)-ATPase 2|secretory pathway Ca(2+)-transporting ATPase type 2|secretory pathway calcium ATPase 2
GeneModificationdate20230329
UniprotIDO75185
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:84427453-84427635:+ENST00000420010.5ENSG00000064270.11ATP2C2ncRNA_intronicAluSx1chr16:84427453-84427635:+.alignment
chr16:84427453-84427635:+ENST00000565631.4ENSG00000064270.11ATP2C2ncRNA_intronicAluSx1chr16:84427453-84427635:+.alignment
chr16:84429133-84431502:+ENST00000420010.5ENSG00000064270.11ATP2C2ncRNA_intronicMLT1C,L2c,L2b,MIRb,L2,AluSz,AluSq2chr16:84429133-84431502:+.alignment
chr16:84429133-84431502:+ENST00000565631.4ENSG00000064270.11ATP2C2ncRNA_intronicMLT1C,L2c,L2b,MIRb,L2,AluSz,AluSq2chr16:84429133-84431502:+.alignment
chr16:84432601-84433646:+ENST00000420010.5ENSG00000064270.11ATP2C2ncRNA_intronicMER5A1,AluSx1,AluSg,AluJbchr16:84432601-84433646:+.alignment
chr16:84432601-84433646:+ENST00000565631.4ENSG00000064270.11ATP2C2ncRNA_intronicMER5A1,AluSx1,AluSg,AluJbchr16:84432601-84433646:+.alignment
chr16:84434730-84437826:+ENST00000420010.5ENSG00000064270.11ATP2C2ncRNA_intronicAluSp,MER104,L1MB7,MER102a,AluSz,AluSx,AluJbchr16:84434730-84437826:+.alignment
chr16:84434730-84437826:+ENST00000565631.4ENSG00000064270.11ATP2C2ncRNA_intronicAluSp,MER104,L1MB7,MER102a,AluSz,AluSx,AluJbchr16:84434730-84437826:+.alignment
chr16:84449606-84450798:+ENST00000420010.5ENSG00000064270.11ATP2C2ncRNA_intronicNoRepeatchr16:84449606-84450798:+.alignment
chr16:84449606-84450798:+ENST00000565631.4ENSG00000064270.11ATP2C2ncRNA_intronicNoRepeatchr16:84449606-84450798:+.alignment


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2. Tumor-specific enriched editing regions for ATP2C2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ATP2C2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ATP2C2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for ATP2C2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr16:84429133-84431502:+BRCAEERT_cells_CD4_memory_activated8.3848e-030.3653image
ENSG00000064270.11,ATP2C2BRCAEAGNeutrophils4.8111e-020.2541image
ENSG00000064270.11,ATP2C2CESCEAGDendritic_cells_activated3.8323e-020.4166image
chr16:84432601-84433646:+COADEERB_cells_memory2.0749e-020.5129image
ENSG00000064270.11,ATP2C2COADEAGB_cells_memory3.7051e-020.2110image
chr16:84429133-84431502:+ESCAEERT_cells_CD4_naive4.4788e-030.4252image
chr16:84432601-84433646:+ESCAEERMast_cells_activated8.0233e-04-0.5968image
chr16:84434730-84437826:+ESCAEERNeutrophils5.9121e-030.4985image
chr16:84429133-84431502:+LUADEERNK_cells_activated2.8843e-02-0.2872image
ENSG00000064270.11,ATP2C2LUADEAGT_cells_CD4_memory_resting4.9096e-02-0.2361image
chr16:84429133-84431502:+PRADEERT_cells_CD84.9599e-020.4050image
ENSG00000064270.11,ATP2C2READEAGMacrophages_M14.6876e-020.3084image
chr16:84429133-84431502:+STADEERNeutrophils9.5916e-030.2795image
chr16:84432601-84433646:+STADEERNeutrophils1.3531e-020.2982image
chr16:84434730-84437826:+STADEERT_cells_follicular_helper3.5572e-020.2719image
chr16:84449606-84450798:+STADEERB_cells_naive1.6308e-020.3562image


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6. Enriched editing regions and immune gene sets for ATP2C2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000064270.11,ATP2C2BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0354e-030.4099image
chr16:84429133-84431502:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.8105e-030.4100image
chr16:84429133-84431502:+CESCGSVA_HALLMARK_MYC_TARGETS_V2EER1.7973e-030.6268image
ENSG00000064270.11,ATP2C2CESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8917e-02-0.4659image
chr16:84432601-84433646:+COADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.8752e-020.4652image
chr16:84429133-84431502:+COADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.5969e-030.3280image
chr16:84449606-84450798:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.3278e-020.4131image
chr16:84432601-84433646:+ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER4.8357e-020.3764image
chr16:84434730-84437826:+ESCAGSVA_HALLMARK_P53_PATHWAYEER3.5340e-030.5239image
ENSG00000064270.11,ATP2C2LUADGSVA_HALLMARK_DNA_REPAIREAG4.8304e-020.2369image
ENSG00000064270.11,ATP2C2PRADGSVA_HALLMARK_PEROXISOMEEAG8.1802e-040.5960image
chr16:84429133-84431502:+PRADGSVA_HALLMARK_PEROXISOMEEER4.5199e-030.5590image
ENSG00000064270.11,ATP2C2READGSVA_HALLMARK_UV_RESPONSE_UPEAG2.7003e-020.3412image
chr16:84429133-84431502:+STADGSVA_HALLMARK_GLYCOLYSISEER6.0561e-040.3644image


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7. Enriched editing regions and drugs for ATP2C2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000064270.11,ATP2C2BRCADocetaxelEAG3.7377e-02-0.2672image
chr16:84429133-84431502:+BRCACCT007093EER1.5481e-020.3374image
chr16:84429133-84431502:+CESCCytarabineEER3.3946e-03-0.5964image
ENSG00000064270.11,ATP2C2CESCAZD6482EAG1.5485e-050.7506image
chr16:84432601-84433646:+COADGDC.0449EER2.9332e-02-0.4872image
ENSG00000064270.11,ATP2C2COADJNK.Inhibitor.VIIIEAG3.7388e-030.2903image
chr16:84429133-84431502:+COADJNK.Inhibitor.VIIIEER3.4124e-040.3693image
chr16:84429133-84431502:+ESCAABT.888EER1.8217e-020.3586image
chr16:84449606-84450798:+ESCAAZD6482EER2.8938e-020.3990image
chr16:84432601-84433646:+ESCACMKEER2.6761e-030.5456image
chr16:84434730-84437826:+ESCAGefitinibEER3.6398e-07-0.7891image
ENSG00000064270.11,ATP2C2ESCACGP.60474EAG7.5845e-03-0.3443image
ENSG00000064270.11,ATP2C2LUADJNK.Inhibitor.VIIIEAG4.9463e-02-0.2357image
ENSG00000064270.11,ATP2C2PRADCHIR.99021EAG3.2292e-030.5368image
chr16:84429133-84431502:+PRADEpothilone.BEER1.2775e-02-0.5003image
chr16:84434730-84437826:+STADBMS.708163EER4.6878e-02-0.2576image
ENSG00000064270.11,ATP2C2STADMetforminEAG2.7717e-020.2027image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType