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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: LRIG2 (ImmuneEditome ID:9860)

1. Gene summary of enriched editing regions for LRIG2

check button Gene summary
Gene informationGene symbol

LRIG2

Gene ID

9860

GeneSynonymsLIG-2|LIG2|UFS2
GeneCytomap

1p13.2

GeneTypeprotein-coding
GeneDescriptionleucine-rich repeats and immunoglobulin-like domains protein 2
GeneModificationdate20230329
UniprotIDO94898
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:113124857-113125051:+ENST00000466161.1ENSG00000198799.10LRIG2ncRNA_exonicAluJrchr1:113124857-113125051:+.alignment
chr1:113124857-113125051:+ENST00000492207.4ENSG00000198799.10LRIG2ncRNA_exonicAluJrchr1:113124857-113125051:+.alignment
chr1:113127274-113127753:+ENST00000361127.5ENSG00000198799.10LRIG2UTR3AluSxchr1:113127274-113127753:+.alignment
chr1:113129025-113131258:+ENST00000361127.5ENSG00000198799.10LRIG2UTR3AluSx1,L3b,(AC)n,L3,AluSc,AluJbchr1:113129025-113131258:+.alignment


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2. Tumor-specific enriched editing regions for LRIG2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:113129025-113131258:+BRCAEER4.3594e-04image
ENSG00000198799.10,LRIG2BRCAEAG1.4664e-03image
chr1:113129025-113131258:+KIRCEER4.0113e-02image
ENSG00000198799.10,LRIG2KIRCEAG3.3152e-02image
chr1:113129025-113131258:+THCAEER2.0158e-03image
ENSG00000198799.10,LRIG2THCAEAG7.6000e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr1:113129025-113131258:+KIRCPathEER1.9858e-022.3648e-030.1568image
ENSG00000198799.10,LRIG2KIRCPathEAG2.8582e-023.9403e-030.1466image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000198799.10,LRIG2STADEAG1.4391e-023.0950e-021.9970e+01image

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3. Enriched editing regions and immune related genes for LRIG2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:113129025-113131258:+ESCAEERENSG00000265205,AC010761.13-0.53946.9724e-086.7430e-10-0.4648imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+ESCAEERENSG00000213793,ZNF888-0.52188.3427e-083.4411e-09-0.4472imageNDDX54;ELAVL1;HNRNPC;IGF2BP2;NOP56;NOP58NAB_cells_naiveGSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+ESCAEERENSG00000198799,LRIG2-0.54138.9020e-083.6260e-10-0.4712imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184LRIG2T_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr1:113129025-113131258:+ESCAEERENSG00000178935,ZNF552-0.52011.1414e-072.4644e-09-0.4509imageNDDX54;ELAVL1;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+ESCAEERENSG00000198466,ZNF587-0.51851.4459e-079.3910e-10-0.4613imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr1:113129025-113131258:+ESCAEERENSG00000196418,ZNF124-0.52591.8414e-074.8081e-10-0.4683imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+ESCAEERENSG00000119737,GPR75-0.52682.7419e-071.5403e-07-0.4017imageNDDX54;ELAVL1;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;NOP56;NOP58;SAFB2;TAF15;ZNF184NANK_cells_restingGSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+ESCAEERENSG00000204604,ZNF468-0.51143.1847e-071.3369e-09-0.4575imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+ESCAEERENSG00000213801,ZNF816-ZNF321P-0.50544.4522e-071.1667e-09-0.4590imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+ESCAEERENSG00000168906,MAT2A-0.51205.1630e-071.1657e-09-0.4590imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184NAB_cells_naiveGSVA_HALLMARK_HYPOXIA

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4. Enriched editing regions and immune related splicing for LRIG2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr1:113129025-113131258:+
ESCAEERIRENSG00000196510.8chr12110377392:110377617:110377704:110378014-0.37883.8702e-033.5513e-08-0.4200imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+
ESCAEERIRENSG00000046653.10chrX13771455:13776303:13777351:13777425-0.36613.9054e-046.3113e-07-0.4467imageNELAVL1;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;NOP56;NOP58;TAF15NAB_cells_naiveGSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+
ESCAEERESENSG00000135540.7chr6138433507:138433680:138441982:138442114:138447000:138447193-0.40983.9498e-041.1516e-09-0.4727imageNDDX54;ELAVL1;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;TAF15;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+
ESCAEERIRENSG00000109046.10chr1727306781:27306882:27307743:27307870-0.45281.9172e-043.2683e-10-0.4736imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+
ESCAEERA3ENSG00000014914.15chr1149936153:149936229:149935298:149935620:149935298:149935705-0.34303.8836e-031.2029e-06-0.4037imageNDDX54;ELAVL1;HNRNPA1;HNRNPC;IGF2BP2;NOP58;TAF15;ZNF184NAB_cells_naiveGSVA_HALLMARK_BILE_ACID_METABOLISM
chr1:113129025-113131258:+
ESCAEERIRENSG00000187954.8chr8144453221:144453460:144462282:144462415-0.50171.2866e-051.0430e-09-0.4602imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+
ESCAEERIRENSG00000003509.11chr237241577:37241791:37242634:37242693-0.44201.9531e-045.1642e-09-0.4465imageNDDX54;ELAVL1;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;TAF15;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
ENSG00000198799.10,LRIG2
ESCAEAGIRENSG00000109046.10chr1727306781:27306882:27307743:27307870-0.42411.0481e-033.0203e-08-0.4208imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr1:113129025-113131258:+
ESCAEERIRENSG00000140264.15chr1543792838:43793083:43793686:43793826-0.40941.4962e-031.6081e-07-0.4011imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
chr1:113129025-113131258:+
ESCAEERIRENSG00000089280.14chr1631184938:31185179:31188324:31188357-0.49811.5206e-055.3350e-10-0.4673imageNDDX54;ELAVL1;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;IGF2BP2;LARP7;NOP56;NOP58;SAFB2;TAF15;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for LRIG2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000198799.10,LRIG2ACCEAGDendritic_cells_resting2.7454e-02-0.4696image
chr1:113129025-113131258:+BLCAEERMacrophages_M14.5431e-020.1830image
ENSG00000198799.10,LRIG2BLCAEAGMacrophages_M04.8181e-020.1691image
chr1:113129025-113131258:+BRCAEERDendritic_cells_activated2.2328e-020.0780image
ENSG00000198799.10,LRIG2BRCAEAGMonocytes3.1306e-02-0.0729image
chr1:113129025-113131258:+CESCEERPlasma_cells4.3731e-02-0.1707image
ENSG00000198799.10,LRIG2CESCEAGPlasma_cells3.2142e-02-0.1756image
ENSG00000198799.10,LRIG2COADEAGMast_cells_activated2.4891e-020.2325image
chr1:113129025-113131258:+ESCAEERT_cells_regulatory_(Tregs)1.4565e-04-0.2968image
ENSG00000198799.10,LRIG2ESCAEAGT_cells_CD4_memory_resting1.4608e-03-0.2488image
chr1:113129025-113131258:+GBMEERMacrophages_M04.5177e-03-0.2412image
ENSG00000198799.10,LRIG2GBMEAGMacrophages_M08.8334e-03-0.2221image
chr1:113129025-113131258:+HNSCEERMacrophages_M22.2020e-040.2847image
ENSG00000198799.10,LRIG2HNSCEAGB_cells_memory2.8805e-020.1658image
chr1:113129025-113131258:+KICHEERT_cells_regulatory_(Tregs)1.7668e-020.5242image
ENSG00000198799.10,LRIG2KICHEAGT_cells_regulatory_(Tregs)1.7668e-020.5242image
chr1:113129025-113131258:+KIRCEERMast_cells_resting1.4994e-03-0.1923image
ENSG00000198799.10,LRIG2KIRCEAGMast_cells_resting6.5176e-04-0.2047image
chr1:113129025-113131258:+LGGEERT_cells_CD4_naive8.8573e-030.1190image
ENSG00000198799.10,LRIG2LGGEAGT_cells_CD4_naive7.1029e-030.1222image
ENSG00000198799.10,LRIG2LIHCEAGDendritic_cells_resting4.2246e-020.3149image
chr1:113129025-113131258:+LUADEERT_cells_CD4_memory_activated9.0475e-050.3027image
ENSG00000198799.10,LRIG2LUADEAGT_cells_CD4_memory_activated2.8903e-030.2265image
chr1:113129025-113131258:+LUSCEERNK_cells_activated3.9341e-02-0.1397image
ENSG00000198799.10,LRIG2LUSCEAGNK_cells_activated2.9882e-02-0.1442image
chr1:113129025-113131258:+MESOEERNK_cells_activated1.1069e-020.4077image
ENSG00000198799.10,LRIG2MESOEAGNK_cells_activated9.6784e-030.4093image
chr1:113129025-113131258:+OVEERT_cells_CD86.5757e-040.2024image
ENSG00000198799.10,LRIG2OVEAGT_cells_CD88.9185e-040.1971image
chr1:113129025-113131258:+PAADEERMast_cells_activated2.9230e-020.2312image
ENSG00000198799.10,LRIG2PAADEAGMast_cells_activated2.2741e-020.2386image
chr1:113129025-113131258:+PCPGEERNeutrophils9.9784e-040.3274image
ENSG00000198799.10,LRIG2PCPGEAGNeutrophils2.1992e-030.3013image
chr1:113129025-113131258:+PRADEERT_cells_CD83.2970e-020.1204image
ENSG00000198799.10,LRIG2READEAGMast_cells_resting2.8364e-020.3707image
chr1:113129025-113131258:+SKCMEERMacrophages_M03.4750e-020.1265image
ENSG00000198799.10,LRIG2SKCMEAGMacrophages_M01.2454e-020.1481image
chr1:113129025-113131258:+STADEEREosinophils1.6399e-050.2287image
ENSG00000198799.10,LRIG2STADEAGEosinophils6.0742e-060.2382image
chr1:113129025-113131258:+THCAEERDendritic_cells_activated1.8419e-030.1463image
ENSG00000198799.10,LRIG2THCAEAGDendritic_cells_activated3.9414e-030.1350image
chr1:113129025-113131258:+THYMEERT_cells_gamma_delta2.5127e-030.3633image
ENSG00000198799.10,LRIG2THYMEAGT_cells_gamma_delta6.3151e-030.3280image
chr1:113129025-113131258:+UCECEERMacrophages_M27.0823e-030.3335image
ENSG00000198799.10,LRIG2UCECEAGMacrophages_M24.4668e-020.2341image
chr1:113129025-113131258:+UCSEERMast_cells_activated5.0170e-030.4516image
ENSG00000198799.10,LRIG2UCSEAGMacrophages_M25.4469e-03-0.4421image
ENSG00000198799.10,LRIG2UVMEAGT_cells_CD4_naive4.5683e-02-0.3676image


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6. Enriched editing regions and immune gene sets for LRIG2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr1:113129025-113131258:+BLCAEER1.9986e-020.21222.2977e-020.20751.2204e-020.22811.0476e-020.2329image
chr1:113129025-113131258:+BRCAEER2.6594e-040.12412.3148e-020.07751.5994e-040.12859.0438e-060.1508image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000198799.10,LRIG2ACCGSVA_HALLMARK_COMPLEMENTEAG3.6139e-02-0.4488image
ENSG00000198799.10,LRIG2BLCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.6537e-020.2045image
chr1:113129025-113131258:+BLCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.0661e-050.3654image
chr1:113124857-113125051:+BRCAGSVA_HALLMARK_GLYCOLYSISEER2.7330e-020.1618image
ENSG00000198799.10,LRIG2BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.6238e-090.1998image
chr1:113129025-113131258:+BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.1707e-100.2125image
ENSG00000198799.10,LRIG2CESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG2.9551e-020.1783image
chr1:113129025-113131258:+CESCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.7593e-020.2004image
ENSG00000198799.10,LRIG2COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG5.0038e-03-0.2887image
chr1:113129025-113131258:+ESCAGSVA_HALLMARK_HYPOXIAEER2.2590e-080.4255image
ENSG00000198799.10,LRIG2ESCAGSVA_HALLMARK_HYPOXIAEAG3.3645e-060.3569image
ENSG00000198799.10,LRIG2GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.9032e-040.3039image
chr1:113129025-113131258:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1365e-040.3238image
chr1:113129025-113131258:+HNSCGSVA_HALLMARK_HYPOXIAEER2.2699e-030.2368image
chr1:113129025-113131258:+KICHGSVA_HALLMARK_MYOGENESISEER2.0575e-030.6468image
ENSG00000198799.10,LRIG2KICHGSVA_HALLMARK_MYOGENESISEAG2.0575e-030.6468image
chr1:113129025-113131258:+KIRCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER2.8810e-050.2516image
ENSG00000198799.10,LRIG2KIRCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.5248e-050.2580image
chr1:113129025-113131258:+KIRPGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.2046e-020.2030image
ENSG00000198799.10,LRIG2KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.3851e-020.2171image
chr1:113129025-113131258:+LAMLGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.9241e-02-0.2597image
ENSG00000198799.10,LRIG2LGGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.8206e-060.2083image
chr1:113129025-113131258:+LGGGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.6080e-050.1949image
ENSG00000198799.10,LRIG2LIHCGSVA_HALLMARK_DNA_REPAIREAG1.0196e-02-0.3922image
chr1:113129025-113131258:+LUADGSVA_HALLMARK_MITOTIC_SPINDLEEER2.4808e-040.2841image
ENSG00000198799.10,LRIG2LUADGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.2651e-050.2944image
ENSG00000198799.10,LRIG2LUSCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG5.3580e-050.2648image
chr1:113129025-113131258:+LUSCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER6.5812e-060.2999image
chr1:113129025-113131258:+MESOGSVA_HALLMARK_ADIPOGENESISEER4.7038e-020.3242image
ENSG00000198799.10,LRIG2MESOGSVA_HALLMARK_ADIPOGENESISEAG4.9889e-020.3162image
ENSG00000198799.10,LRIG2OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.6314e-080.3289image
chr1:113129025-113131258:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.3619e-090.3521image
ENSG00000198799.10,LRIG2PAADGSVA_HALLMARK_SPERMATOGENESISEAG1.3525e-02-0.2581image
chr1:113129025-113131258:+PAADGSVA_HALLMARK_SPERMATOGENESISEER7.2087e-03-0.2830image
ENSG00000198799.10,LRIG2PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.3071e-030.2818image
chr1:113129025-113131258:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER7.0993e-030.2703image
chr1:113129025-113131258:+PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.9369e-030.1673image
ENSG00000198799.10,LRIG2PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.4392e-030.1536image
ENSG00000198799.10,LRIG2READGSVA_HALLMARK_MYC_TARGETS_V2EAG3.5537e-02-0.3565image
ENSG00000198799.10,LRIG2SARCGSVA_HALLMARK_HYPOXIAEAG2.1493e-020.1794image
chr1:113129025-113131258:+SARCGSVA_HALLMARK_HYPOXIAEER2.9891e-020.1702image
chr1:113129025-113131258:+SKCMGSVA_HALLMARK_HYPOXIAEER5.8949e-060.2675image
ENSG00000198799.10,LRIG2SKCMGSVA_HALLMARK_HYPOXIAEAG5.6182e-050.2367image
ENSG00000198799.10,LRIG2STADGSVA_HALLMARK_UV_RESPONSE_UPEAG5.3307e-090.3043image
chr1:113129025-113131258:+STADGSVA_HALLMARK_P53_PATHWAYEER4.5130e-090.3078image
ENSG00000198799.10,LRIG2TGCTGSVA_HALLMARK_APICAL_SURFACEEAG3.2165e-02-0.2340image
ENSG00000198799.10,LRIG2THCAGSVA_HALLMARK_GLYCOLYSISEAG5.5899e-090.2692image
chr1:113129025-113131258:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.9471e-100.2939image
ENSG00000198799.10,LRIG2THYMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.7128e-04-0.4126image
chr1:113129025-113131258:+THYMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.3025e-02-0.3019image
ENSG00000198799.10,LRIG2UCSGSVA_HALLMARK_HYPOXIAEAG4.1418e-020.3325image
chr1:113129025-113131258:+UCSGSVA_HALLMARK_HYPOXIAEER4.7735e-020.3277image


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7. Enriched editing regions and drugs for LRIG2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000198799.10,LRIG2ACCFTI.277EAG1.5622e-02-0.5087image
ENSG00000198799.10,LRIG2BLCACMKEAG8.1880e-03-0.2251image
chr1:113129025-113131258:+BLCACMKEER9.0116e-04-0.2992image
ENSG00000198799.10,LRIG2BRCAAZD8055EAG1.0412e-040.1310image
chr1:113129025-113131258:+BRCAAZD8055EER1.1937e-030.1104image
chr1:113124857-113125051:+BRCAKIN001.135EER5.9005e-03-0.2012image
ENSG00000198799.10,LRIG2CESCMetforminEAG2.3648e-03-0.2473image
chr1:113129025-113131258:+CESCMetforminEER1.9238e-03-0.2600image
ENSG00000198799.10,LRIG2COADAG.014699EAG3.1303e-04-0.3657image
ENSG00000198799.10,LRIG2ESCACGP.60474EAG5.1959e-06-0.3504image
chr1:113129025-113131258:+ESCACGP.60474EER5.4718e-08-0.4147image
chr1:113129025-113131258:+GBMGNF.2EER2.0077e-04-0.3125image
ENSG00000198799.10,LRIG2GBMGNF.2EAG1.2840e-04-0.3203image
ENSG00000198799.10,LRIG2HNSCJNK.9LEAG1.5313e-03-0.2385image
chr1:113129025-113131258:+HNSCJNK.9LEER4.1892e-04-0.2723image
ENSG00000198799.10,LRIG2KIRCCCT007093EAG8.3547e-080.3168image
chr1:113129025-113131258:+KIRCCCT007093EER1.0453e-070.3168image
chr1:113129025-113131258:+KIRPBicalutamideEER1.2970e-03-0.2824image
ENSG00000198799.10,LRIG2KIRPBicalutamideEAG2.7704e-03-0.2624image
ENSG00000198799.10,LRIG2LAMLBI.2536EAG4.2679e-030.2937image
chr1:113129025-113131258:+LAMLGSK269962AEER1.5063e-020.2693image
ENSG00000198799.10,LRIG2LGGAP.24534EAG9.5194e-070.2206image
chr1:113129025-113131258:+LGGAP.24534EER2.7328e-060.2115image
ENSG00000198799.10,LRIG2LIHCCGP.082996EAG6.6003e-030.4278image
chr1:113129025-113131258:+LUADBI.D1870EER4.0046e-04-0.2749image
ENSG00000198799.10,LRIG2LUADBI.D1870EAG1.7682e-03-0.2374image
ENSG00000198799.10,LRIG2LUSCDasatinibEAG1.6448e-03-0.2083image
chr1:113129025-113131258:+LUSCBMS.509744EER1.5356e-03-0.2133image
ENSG00000198799.10,LRIG2MESOBMS.536924EAG1.0146e-02-0.4069image
chr1:113129025-113131258:+MESOJW.7.52.1EER1.1008e-02-0.4080image
chr1:113129025-113131258:+OVMG.132EER1.4371e-11-0.3900image
ENSG00000198799.10,LRIG2OVMG.132EAG5.0561e-11-0.3795image
chr1:113129025-113131258:+PAADAICAREER6.3558e-050.4108image
ENSG00000198799.10,LRIG2PAADAICAREAG7.9356e-050.4017image
ENSG00000198799.10,LRIG2PCPGBI.D1870EAG2.4778e-040.3570image
chr1:113129025-113131258:+PCPGBI.D1870EER2.2432e-040.3645image
ENSG00000198799.10,LRIG2PRADDMOGEAG1.0173e-030.1812image
chr1:113129025-113131258:+PRADDMOGEER2.9344e-050.2335image
ENSG00000198799.10,LRIG2READLFM.A13EAG2.3924e-02-0.3810image
ENSG00000198799.10,LRIG2SARCAxitinibEAG2.4452e-020.1757image
chr1:113129025-113131258:+SARCAxitinibEER2.1421e-020.1801image
chr1:113129025-113131258:+SKCMCamptothecinEER1.6275e-030.1878image
ENSG00000198799.10,LRIG2SKCMCamptothecinEAG1.2336e-030.1908image
chr1:113129025-113131258:+STADAUY922EER3.5701e-07-0.2688image
ENSG00000198799.10,LRIG2STADAUY922EAG9.2665e-06-0.2335image
ENSG00000198799.10,LRIG2TGCTCMKEAG1.5724e-02-0.2628image
chr1:113129025-113131258:+TGCTBosutinibEER4.0058e-02-0.2330image
ENSG00000198799.10,LRIG2THCAIPA.3EAG1.8119e-100.2935image
chr1:113129025-113131258:+THCACCT007093EER1.9065e-100.2940image
chr1:113129025-113131258:+THYMAUY922EER6.4488e-030.3296image
ENSG00000198799.10,LRIG2THYMAZD6244EAG1.8332e-04-0.4386image
chr1:113129025-113131258:+UCECABT.263EER5.3485e-03-0.3442image
ENSG00000198799.10,LRIG2UCECAUY922EAG3.2062e-020.2495image
ENSG00000198799.10,LRIG2UCSFTI.277EAG1.4814e-02-0.3924image
chr1:113129025-113131258:+UCSFTI.277EER2.2330e-02-0.3747image
ENSG00000198799.10,LRIG2UVMAZD.0530EAG3.4929e-020.3864image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType