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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZBTB24 (ImmuneEditome ID:9841)

1. Gene summary of enriched editing regions for ZBTB24

check button Gene summary
Gene informationGene symbol

ZBTB24

Gene ID

9841

GeneSynonymsBIF1|ICF2|PATZ2|ZNF450
GeneCytomap

6q21

GeneTypeprotein-coding
GeneDescriptionzinc finger and BTB domain-containing protein 24|POZ (BTB) and AT hook containing zinc finger 2|zinc finger protein 450
GeneModificationdate20230329
UniprotIDO43167
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr6:109463035-109463301:-ENST00000230122.3ENSG00000112365.4ZBTB24UTR3AluSgchr6:109463035-109463301:-.alignment


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2. Tumor-specific enriched editing regions for ZBTB24


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr6:109463035-109463301:-BRCAEER1.3839e-06image
ENSG00000112365.4,ZBTB24BRCAEAG1.4793e-05image
ENSG00000112365.4,ZBTB24KIRCEAG3.5981e-02image
ENSG00000112365.4,ZBTB24PRADEAG1.8485e-02image
ENSG00000112365.4,ZBTB24THCAEAG9.9127e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000112365.4,ZBTB24LUSCPathEAG1.8829e-021.3546e-020.1157image
chr6:109463035-109463301:-LUSCPathEER3.1516e-023.4029e-020.1006image
ENSG00000112365.4,ZBTB24THCAPathEAG4.3403e-021.9886e-020.1058image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ZBTB24


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr6:109463035-109463301:-UCECEERENSG00000115875,SRSF7-0.37908.1699e-042.0434e-08-0.4160imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr6:109463035-109463301:-DLBCEERENSG00000134375,TIMM17A0.55892.7110e-028.5386e-060.5941imageNNNAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr6:109463035-109463301:-DLBCEERENSG00000214300,SPDYE3-0.54763.3496e-022.5177e-04-0.5050imageNNNAMacrophages_M1GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr6:109463035-109463301:-DLBCEERENSG00000158793,NIT10.52284.3534e-028.8423e-040.4644imageNNNAMonocytes
chr6:109463035-109463301:-DLBCEERENSG00000160688,FLAD10.53764.3647e-021.5827e-040.5188imageNNNAMonocytesGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr6:109463035-109463301:-MESOEERENSG00000044446,PHKA2-0.47283.6333e-021.6313e-04-0.4167imageNNNAT_cells_CD8GSVA_HALLMARK_P53_PATHWAY
chr6:109463035-109463301:-TGCTEERENSG00000116237,ICMT-0.43864.1711e-062.1157e-08-0.4418imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr6:109463035-109463301:-TGCTEERENSG00000116688,MFN2-0.44065.6804e-062.7668e-08-0.4385imageNNMFN2Macrophages_M2GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr6:109463035-109463301:-TGCTEERENSG00000160963,COL26A1-0.42928.4944e-061.5436e-08-0.4457imageNNNAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS
chr6:109463035-109463301:-TGCTEERENSG00000108666,C17orf75-0.43071.1537e-055.4073e-08-0.4301imageNNNAMacrophages_M2GSVA_HALLMARK_GLYCOLYSIS

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4. Enriched editing regions and immune related splicing for ZBTB24


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000112365.4,ZBTB24
GBMEAGIRENSG00000129968.11chr191877507:1878904:1879920:1880017-0.33721.6948e-024.8367e-07-0.4088imageNADAR;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZNF184NAMacrophages_M2GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77216114:77216244:77216283:77216309:77216322-0.21394.6659e-054.7909e-12-0.4037imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77215922:77216218:77216283:77216309:77216322-0.21025.2398e-053.2467e-12-0.4109imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77215997:77216218:77216283:77216309:77216802-0.20995.3129e-053.4110e-12-0.4105imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77216166:77216257:77216283:77216309:77216322-0.20985.6782e-056.0585e-12-0.4061imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77215922:77216244:77216283:77216309:77216322-0.20965.8812e-053.0794e-12-0.4112imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77215870:77216244:77216283:77216309:77216802-0.20925.9749e-053.2348e-12-0.4109imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77216166:77216244:77216283:77216309:77216322-0.20896.5382e-055.8419e-12-0.4064imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777215753:77215766:77215831:77216257:77216257:77216283:77216309:77216387-0.20777.4668e-052.9956e-12-0.4100imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000112365.4,ZBTB24
KIRCEAGMEXENSG00000129657.10chr1777213917:77215766:77215831:77215870:77215958:77216283:77216309:77216802-0.21167.7766e-054.9493e-12-0.4062imageNADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAB_cells_memoryGSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for ZBTB24


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000112365.4,ZBTB24ACCEAGB_cells_memory4.2472e-030.3640image
ENSG00000112365.4,ZBTB24BLCAEAGMacrophages_M11.8750e-060.2523image
chr6:109463035-109463301:-BRCAEERB_cells_naive7.3824e-04-0.1038image
ENSG00000112365.4,ZBTB24BRCAEAGT_cells_CD4_memory_resting3.0188e-05-0.1273image
ENSG00000112365.4,ZBTB24CESCEAGDendritic_cells_activated7.0232e-030.1594image
ENSG00000112365.4,ZBTB24CHOLEAGT_cells_follicular_helper3.1973e-020.4136image
ENSG00000112365.4,ZBTB24COADEAGMacrophages_M11.7673e-030.2038image
chr6:109463035-109463301:-DLBCEERMacrophages_M15.2340e-030.3968image
ENSG00000112365.4,ZBTB24DLBCEAGMacrophages_M18.1977e-030.3773image
chr6:109463035-109463301:-ESCAEERMacrophages_M24.4425e-040.2762image
ENSG00000112365.4,ZBTB24ESCAEAGMacrophages_M27.7974e-030.2103image
chr6:109463035-109463301:-GBMEERDendritic_cells_activated1.3463e-020.2070image
ENSG00000112365.4,ZBTB24GBMEAGDendritic_cells_activated7.5331e-030.2196image
chr6:109463035-109463301:-HNSCEERMacrophages_M22.3395e-030.1456image
ENSG00000112365.4,ZBTB24HNSCEAGMacrophages_M11.2278e-030.1529image
ENSG00000112365.4,ZBTB24KICHEAGT_cells_CD83.7240e-02-0.3587image
chr6:109463035-109463301:-KIRCEERNeutrophils2.1378e-020.1255image
ENSG00000112365.4,ZBTB24KIRCEAGMast_cells_resting4.2111e-03-0.1535image
ENSG00000112365.4,ZBTB24KIRPEAGT_cells_CD88.8760e-030.1761image
chr6:109463035-109463301:-LGGEERMacrophages_M11.5614e-040.1692image
ENSG00000112365.4,ZBTB24LGGEAGMacrophages_M12.8447e-040.1607image
chr6:109463035-109463301:-LUADEERMast_cells_activated1.0822e-020.1273image
ENSG00000112365.4,ZBTB24LUADEAGT_cells_gamma_delta2.3278e-020.1102image
chr6:109463035-109463301:-LUSCEERT_cells_CD4_memory_activated5.5957e-040.1631image
ENSG00000112365.4,ZBTB24LUSCEAGT_cells_CD4_memory_activated3.6157e-050.1922image
chr6:109463035-109463301:-MESOEERDendritic_cells_activated2.2633e-030.3429image
ENSG00000112365.4,ZBTB24MESOEAGDendritic_cells_activated2.1947e-030.3439image
chr6:109463035-109463301:-OVEEREosinophils2.2202e-050.2537image
ENSG00000112365.4,ZBTB24OVEAGEosinophils9.2660e-070.2903image
ENSG00000112365.4,ZBTB24PAADEAGT_cells_CD83.9756e-03-0.2323image
ENSG00000112365.4,ZBTB24PRADEAGT_cells_regulatory_(Tregs)2.4451e-020.1040image
chr6:109463035-109463301:-READEERT_cells_CD4_memory_activated8.5566e-04-0.3677image
ENSG00000112365.4,ZBTB24READEAGT_cells_CD4_memory_activated1.7836e-03-0.3359image
chr6:109463035-109463301:-SARCEERMacrophages_M13.9652e-040.2316image
ENSG00000112365.4,ZBTB24SARCEAGMacrophages_M11.2835e-040.2493image
chr6:109463035-109463301:-SKCMEERT_cells_CD88.1380e-040.1653image
ENSG00000112365.4,ZBTB24SKCMEAGT_cells_CD83.8866e-030.1414image
ENSG00000112365.4,ZBTB24STADEAGT_cells_CD4_memory_activated5.1976e-030.1491image
chr6:109463035-109463301:-TGCTEERMacrophages_M21.0103e-02-0.2116image
ENSG00000112365.4,ZBTB24TGCTEAGB_cells_memory1.8076e-030.2519image
ENSG00000112365.4,ZBTB24THCAEAGDendritic_cells_resting8.6074e-040.1507image
chr6:109463035-109463301:-THYMEERMacrophages_M12.1500e-070.4575image
ENSG00000112365.4,ZBTB24THYMEAGMacrophages_M13.4002e-070.4508image
chr6:109463035-109463301:-UCECEERDendritic_cells_resting7.2510e-03-0.2065image
ENSG00000112365.4,ZBTB24UCECEAGMacrophages_M01.8604e-020.1803image
chr6:109463035-109463301:-UCSEERMonocytes3.0659e-020.2972image
ENSG00000112365.4,ZBTB24UCSEAGMonocytes2.4468e-020.3088image


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6. Enriched editing regions and immune gene sets for ZBTB24


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr6:109463035-109463301:-HNSCEER4.6124e-02image1.7255e-030.1498image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000112365.4,ZBTB24BRCAEAG6.3558e-050.12214.1756e-040.10781.7220e-040.11472.0664e-020.0708image
chr6:109463035-109463301:-SKCMEER4.3463e-02-0.10011.5951e-02-0.11941.4600e-02-0.12103.2883e-030.1454image
ENSG00000112365.4,ZBTB24TGCTEAG6.5531e-05-0.31901.1593e-02-0.20499.7188e-06-0.35136.5000e-03-0.2206image
chr6:109463035-109463301:-THYMEER3.0556e-02-0.20011.6257e-05-0.38703.2405e-020.19797.6183e-060.4006image
ENSG00000112365.4,ZBTB24THYMEAG3.3450e-02-0.19681.2471e-05-0.39193.6776e-020.19331.0898e-060.4329image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000112365.4,ZBTB24ACCGSVA_HALLMARK_HEME_METABOLISMEAG4.9709e-020.2545image
ENSG00000112365.4,ZBTB24BLCAGSVA_HALLMARK_COMPLEMENTEAG8.2881e-080.2825image
chr6:109463035-109463301:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.9097e-100.1892image
ENSG00000112365.4,ZBTB24BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.8354e-140.2265image
ENSG00000112365.4,ZBTB24CESCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.1730e-070.3012image
ENSG00000112365.4,ZBTB24CHOLGSVA_HALLMARK_HYPOXIAEAG3.3308e-020.4108image
ENSG00000112365.4,ZBTB24COADGSVA_HALLMARK_SPERMATOGENESISEAG1.5529e-03-0.2062image
chr6:109463035-109463301:-ESCAGSVA_HALLMARK_G2M_CHECKPOINTEER4.6648e-03-0.2240image
ENSG00000112365.4,ZBTB24ESCAGSVA_HALLMARK_G2M_CHECKPOINTEAG2.4934e-03-0.2382image
chr6:109463035-109463301:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER8.8166e-040.2761image
ENSG00000112365.4,ZBTB24GBMGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.1217e-040.3132image
chr6:109463035-109463301:-HNSCGSVA_HALLMARK_HYPOXIAEER6.7101e-070.2356image
ENSG00000112365.4,ZBTB24HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0337e-060.2294image
ENSG00000112365.4,ZBTB24KICHGSVA_HALLMARK_UV_RESPONSE_UPEAG2.5876e-02-0.3818image
chr6:109463035-109463301:-KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.9032e-020.1279image
ENSG00000112365.4,ZBTB24KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2367e-040.2049image
ENSG00000112365.4,ZBTB24KIRPGSVA_HALLMARK_SPERMATOGENESISEAG1.7095e-03-0.2103image
chr6:109463035-109463301:-LGGGSVA_HALLMARK_MYC_TARGETS_V2EER1.9738e-10-0.2809image
ENSG00000112365.4,ZBTB24LGGGSVA_HALLMARK_MYC_TARGETS_V1EAG2.3503e-10-0.2769image
ENSG00000112365.4,ZBTB24LIHCGSVA_HALLMARK_PEROXISOMEEAG2.6104e-060.3100image
ENSG00000112365.4,ZBTB24LUADGSVA_HALLMARK_GLYCOLYSISEAG5.7254e-050.1941image
chr6:109463035-109463301:-LUADGSVA_HALLMARK_GLYCOLYSISEER1.6014e-060.2372image
chr6:109463035-109463301:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.4875e-050.1924image
ENSG00000112365.4,ZBTB24LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9681e-050.1984image
ENSG00000112365.4,ZBTB24MESOGSVA_HALLMARK_P53_PATHWAYEAG1.8654e-020.2676image
chr6:109463035-109463301:-MESOGSVA_HALLMARK_P53_PATHWAYEER2.1116e-020.2624image
ENSG00000112365.4,ZBTB24OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.8729e-050.2419image
chr6:109463035-109463301:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.2347e-040.2086image
ENSG00000112365.4,ZBTB24PAADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.3728e-030.2448image
ENSG00000112365.4,ZBTB24PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.1923e-03-0.2494image
chr6:109463035-109463301:-PCPGGSVA_HALLMARK_DNA_REPAIREER2.5311e-03-0.2343image
ENSG00000112365.4,ZBTB24PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7789e-040.1637image
ENSG00000112365.4,ZBTB24READGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.0560e-03-0.3195image
chr6:109463035-109463301:-READGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.0774e-030.3611image
chr6:109463035-109463301:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.6945e-040.2380image
ENSG00000112365.4,ZBTB24SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2610e-030.2109image
ENSG00000112365.4,ZBTB24SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.8306e-05-0.2007image
chr6:109463035-109463301:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.6900e-050.2065image
ENSG00000112365.4,ZBTB24STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.1634e-040.1965image
chr6:109463035-109463301:-TGCTGSVA_HALLMARK_GLYCOLYSISEER9.1247e-05-0.3171image
ENSG00000112365.4,ZBTB24TGCTGSVA_HALLMARK_GLYCOLYSISEAG1.2938e-05-0.3467image
ENSG00000112365.4,ZBTB24THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.9318e-120.3079image
ENSG00000112365.4,ZBTB24THYMGSVA_HALLMARK_G2M_CHECKPOINTEAG3.8299e-07-0.4490image
chr6:109463035-109463301:-THYMGSVA_HALLMARK_G2M_CHECKPOINTEER8.2243e-07-0.4373image
ENSG00000112365.4,ZBTB24UCECGSVA_HALLMARK_MYC_TARGETS_V1EAG1.2672e-03-0.2452image
chr6:109463035-109463301:-UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.6297e-030.2232image
ENSG00000112365.4,ZBTB24UVMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.2485e-020.3234image


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7. Enriched editing regions and drugs for ZBTB24


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000112365.4,ZBTB24ACCCCT007093EAG1.0367e-02-0.3286image
ENSG00000112365.4,ZBTB24BLCAEHT.1864EAG2.4542e-090.3128image
chr6:109463035-109463301:-BRCAJNK.Inhibitor.VIIIEER5.5815e-05-0.1238image
ENSG00000112365.4,ZBTB24BRCAABT.263EAG1.6802e-070.1596image
ENSG00000112365.4,ZBTB24CESCAxitinibEAG5.9952e-070.2905image
ENSG00000112365.4,ZBTB24COADLapatinibEAG9.3252e-03-0.1704image
ENSG00000112365.4,ZBTB24DLBCJNJ.26854165EAG8.4824e-04-0.4658image
chr6:109463035-109463301:-DLBCJNJ.26854165EER5.0829e-04-0.4829image
ENSG00000112365.4,ZBTB24ESCAGNF.2EAG1.9987e-03-0.2433image
chr6:109463035-109463301:-ESCABexaroteneEER3.0063e-03-0.2346image
chr6:109463035-109463301:-GBMBIRB.0796EER3.3959e-040.2965image
ENSG00000112365.4,ZBTB24GBMBIRB.0796EAG1.4293e-040.3086image
chr6:109463035-109463301:-HNSCBexaroteneEER1.0385e-06-0.2316image
ENSG00000112365.4,ZBTB24HNSCBexaroteneEAG8.3694e-07-0.2313image
chr6:109463035-109463301:-KIRCAZD6244EER1.6298e-03-0.1712image
ENSG00000112365.4,ZBTB24KIRCEmbelinEAG4.2047e-060.2445image
ENSG00000112365.4,ZBTB24KIRPCI.1040EAG2.7127e-04-0.2432image
ENSG00000112365.4,ZBTB24LAMLCisplatinEAG8.7601e-04-0.5842image
chr6:109463035-109463301:-LGGAZD8055EER1.9440e-100.2810image
ENSG00000112365.4,ZBTB24LGGAZD8055EAG4.4591e-090.2570image
ENSG00000112365.4,ZBTB24LIHCGSK.650394EAG1.6161e-050.2856image
ENSG00000112365.4,ZBTB24LUADBicalutamideEAG2.6966e-04-0.1761image
chr6:109463035-109463301:-LUADFTI.277EER1.0698e-05-0.2181image
ENSG00000112365.4,ZBTB24LUSCBMS.509744EAG4.6454e-07-0.2334image
chr6:109463035-109463301:-LUSCCI.1040EER2.3328e-05-0.1993image
chr6:109463035-109463301:-MESOMethotrexateEER3.1162e-030.3327image
ENSG00000112365.4,ZBTB24MESOMethotrexateEAG3.4973e-030.3289image
ENSG00000112365.4,ZBTB24OVATRAEAG2.3999e-060.2795image
chr6:109463035-109463301:-OVATRAEER1.9645e-040.2235image
ENSG00000112365.4,ZBTB24PAADBX.795EAG1.8858e-030.2501image
ENSG00000112365.4,ZBTB24PCPGGSK.650394EAG3.8439e-050.3138image
chr6:109463035-109463301:-PCPGGW843682XEER8.2246e-050.3026image
ENSG00000112365.4,ZBTB24PRADBortezomibEAG5.7820e-05-0.1848image
ENSG00000112365.4,ZBTB24READBMS.536924EAG1.9163e-03-0.3338image
chr6:109463035-109463301:-READAS601245EER1.1518e-02-0.2829image
chr6:109463035-109463301:-SARCBexaroteneEER1.2797e-04-0.2499image
ENSG00000112365.4,ZBTB24SARCBortezomibEAG8.2913e-04-0.2185image
ENSG00000112365.4,ZBTB24SKCMLFM.A13EAG5.9859e-09-0.2806image
chr6:109463035-109463301:-SKCMLFM.A13EER2.0962e-07-0.2538image
ENSG00000112365.4,ZBTB24STADABT.263EAG3.4089e-040.1909image
chr6:109463035-109463301:-TGCTDocetaxelEER6.1451e-060.3632image
ENSG00000112365.4,ZBTB24TGCTDocetaxelEAG2.0797e-060.3751image
ENSG00000112365.4,ZBTB24THCAAZD8055EAG3.7556e-110.2941image
ENSG00000112365.4,ZBTB24THYMDoxorubicinEAG1.1756e-110.5752image
chr6:109463035-109463301:-THYMIPA.3EER1.1964e-110.5750image
ENSG00000112365.4,ZBTB24UCECBAY.61.3606EAG2.5457e-060.3518image
chr6:109463035-109463301:-UCECBAY.61.3606EER4.2509e-050.3103image
ENSG00000112365.4,ZBTB24UCSCisplatinEAG9.2971e-03-0.3540image
chr6:109463035-109463301:-UCSCisplatinEER1.0128e-02-0.3503image
ENSG00000112365.4,ZBTB24UVMGNF.2EAG3.9211e-04-0.4466image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType