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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: KIAA0586 (ImmuneEditome ID:9786)

1. Gene summary of enriched editing regions for KIAA0586

check button Gene summary
Gene informationGene symbol

KIAA0586

Gene ID

9786

GeneSynonymsJBTS23|SRTD14|Talpid3
GeneCytomap

14q23.1

GeneTypeprotein-coding
GeneDescriptionprotein TALPID3
GeneModificationdate20230329
UniprotIDQ9BVV6;A0A494C0M8;A0A494C0Z1;A0A494C075;A0A494C058;A0A494C1C3;H0YJF0;A0A087WYM5;G3V4J0;A0A494C171;G3V2T5;A0A494C110
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:58548607-58549200:+ENST00000556134.4ENSG00000100578.13KIAA0586UTR3MIRb,L1ME4bchr14:58548607-58549200:+.alignment
chr14:58548607-58549200:+ENST00000619416.3ENSG00000100578.13KIAA0586UTR3MIRb,L1ME4bchr14:58548607-58549200:+.alignment
chr14:58548607-58549200:+ENST00000619722.3ENSG00000100578.13KIAA0586UTR3MIRb,L1ME4bchr14:58548607-58549200:+.alignment
chr14:58550014-58551149:+ENST00000619416.3ENSG00000100578.13KIAA0586UTR3AluSp,AluSx,AluJbchr14:58550014-58551149:+.alignment


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2. Tumor-specific enriched editing regions for KIAA0586


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000100578.13,KIAA0586OVEAG1.4076e-022.3855e-028.7917e-05image

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3. Enriched editing regions and immune related genes for KIAA0586


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:58550014-58551149:+THYMEERENSG00000146535,GNA120.43871.5184e-031.3620e-050.4503imageNNGNA12T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr14:58550014-58551149:+THYMEERENSG00000188158,NHS0.42521.5340e-035.1380e-060.4694imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr14:58550014-58551149:+THYMEERENSG00000092108,SCFD10.43131.8072e-031.5895e-050.4471imageNNSCFD1T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr14:58550014-58551149:+THYMEERENSG00000147642,SYBU0.42182.0335e-038.7473e-050.4102imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_BILE_ACID_METABOLISM
chr14:58550014-58551149:+THYMEERENSG00000170542,SERPINB90.41822.6946e-031.5067e-050.4482imageNNSERPINB9T_cells_CD4_memory_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr14:58550014-58551149:+THYMEERENSG00000197442,MAP3K50.41682.7104e-033.3882e-060.4772imageNNMAP3K5T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr14:58550014-58551149:+THYMEERENSG00000183576,SETD30.41742.7572e-031.1101e-050.4544imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr14:58550014-58551149:+THYMEERENSG00000196663,TECPR20.40823.3076e-033.7833e-050.4289imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr14:58550014-58551149:+THYMEERENSG00000075790,BCAP290.40953.5235e-034.9233e-050.4232imageNNBCAP29T_cells_CD4_memory_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr14:58550014-58551149:+THYMEERENSG00000197535,MYO5A0.39563.9944e-035.5731e-050.4204imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for KIAA0586


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr14:58550014-58551149:+
THYMEERA3ENSG00000112511.13chr633414735:33414829:33414954:33415081:33414965:334150810.40012.7839e-021.4668e-040.4004imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr14:58550014-58551149:+
THYMEERMEXENSG00000131238.12chr140091328:40091399:40092044:40092057:40092397:40092507:40097114:40097247-0.37143.7539e-023.6421e-04-0.4009imageNNPPT1GSVA_HALLMARK_PROTEIN_SECRETION
chr14:58550014-58551149:+
THYMEERIRENSG00000196323.7chr11130226676:130231715:130233307:1302333820.35663.0959e-021.0346e-040.4415imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for KIAA0586


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr14:58550014-58551149:+BLCAEERNK_cells_activated5.8042e-030.4916image
chr14:58548607-58549200:+BRCAEERNK_cells_activated2.9485e-02-0.1552image
chr14:58550014-58551149:+BRCAEERT_cells_regulatory_(Tregs)4.9383e-02-0.1701image
ENSG00000100578.13,KIAA0586BRCAEAGT_cells_gamma_delta3.9153e-020.1216image
ENSG00000100578.13,KIAA0586ESCAEAGT_cells_regulatory_(Tregs)2.2051e-020.2881image
ENSG00000100578.13,KIAA0586GBMEAGMast_cells_resting1.2859e-020.2879image
ENSG00000100578.13,KIAA0586HNSCEAGB_cells_memory9.0529e-030.5548image
ENSG00000100578.13,KIAA0586KIRCEAGB_cells_memory5.9760e-040.5024image
chr14:58550014-58551149:+LGGEERMonocytes1.8092e-030.2209image
ENSG00000100578.13,KIAA0586LGGEAGT_cells_follicular_helper4.4415e-02-0.1236image
ENSG00000100578.13,KIAA0586LUSCEAGT_cells_CD4_naive1.2220e-020.5362image
chr14:58550014-58551149:+PCPGEERT_cells_CD4_memory_resting3.5739e-020.1927image
ENSG00000100578.13,KIAA0586PCPGEAGT_cells_CD4_memory_resting4.3857e-020.1700image
ENSG00000100578.13,KIAA0586PRADEAGT_cells_CD81.9969e-030.3737image
ENSG00000100578.13,KIAA0586SARCEAGNeutrophils7.5301e-030.3566image
ENSG00000100578.13,KIAA0586STADEAGNK_cells_activated1.9402e-050.3823image
chr14:58550014-58551149:+THCAEERMacrophages_M25.9720e-030.2506image
ENSG00000100578.13,KIAA0586THCAEAGMacrophages_M26.8392e-030.2150image
chr14:58550014-58551149:+THYMEERT_cells_CD4_memory_resting2.0315e-030.3283image


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6. Enriched editing regions and immune gene sets for KIAA0586


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000100578.13,KIAA0586BLCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.3685e-03-0.4702image
ENSG00000100578.13,KIAA0586BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.6622e-03-0.1764image
chr14:58548607-58549200:+BRCAGSVA_HALLMARK_HEME_METABOLISMEER3.5395e-030.2069image
ENSG00000100578.13,KIAA0586CESCGSVA_HALLMARK_MYOGENESISEAG5.1630e-03-0.3720image
ENSG00000100578.13,KIAA0586ESCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.8191e-02-0.2967image
ENSG00000100578.13,KIAA0586GBMGSVA_HALLMARK_ADIPOGENESISEAG1.9519e-02-0.2710image
ENSG00000100578.13,KIAA0586HNSCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6292e-02-0.5174image
ENSG00000100578.13,KIAA0586KIRCGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.0448e-04-0.5246image
chr14:58550014-58551149:+LGGGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.8237e-050.2853image
ENSG00000100578.13,KIAA0586LGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.9275e-030.1821image
ENSG00000100578.13,KIAA0586LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3679e-020.4382image
ENSG00000100578.13,KIAA0586LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.3586e-02-0.4917image
ENSG00000100578.13,KIAA0586PCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.5356e-02-0.1774image
chr14:58550014-58551149:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER2.8452e-020.2009image
ENSG00000100578.13,KIAA0586PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.0370e-04-0.4112image
ENSG00000100578.13,KIAA0586SARCGSVA_HALLMARK_GLYCOLYSISEAG1.1754e-050.5534image
ENSG00000100578.13,KIAA0586SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.1040e-020.2720image
ENSG00000100578.13,KIAA0586STADGSVA_HALLMARK_SPERMATOGENESISEAG5.5429e-06-0.4045image
ENSG00000100578.13,KIAA0586THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.4672e-04-0.2886image
chr14:58550014-58551149:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4893e-030.3374image
ENSG00000100578.13,KIAA0586THYMGSVA_HALLMARK_COMPLEMENTEAG1.3699e-020.2562image


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7. Enriched editing regions and drugs for KIAA0586


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr14:58550014-58551149:+BLCAIPA.3EER4.2125e-020.3734image
ENSG00000100578.13,KIAA0586BRCACisplatinEAG1.6663e-050.2507image
chr14:58548607-58549200:+BRCAAZD6482EER5.4724e-03-0.1977image
chr14:58550014-58551149:+BRCAGDC.0449EER2.6887e-040.3099image
ENSG00000100578.13,KIAA0586CESCCGP.60474EAG2.4844e-020.3024image
ENSG00000100578.13,KIAA0586ESCAAZD.2281EAG4.2784e-02-0.2582image
ENSG00000100578.13,KIAA0586HNSCCHIR.99021EAG2.1032e-030.6323image
ENSG00000100578.13,KIAA0586KIRCDMOGEAG3.5454e-070.6874image
chr14:58550014-58551149:+LGGAZD.2281EER3.4245e-050.2906image
ENSG00000100578.13,KIAA0586LGGLapatinibEAG4.5925e-02-0.1227image
ENSG00000100578.13,KIAA0586LUADBAY.61.3606EAG3.8549e-030.5038image
ENSG00000100578.13,KIAA0586PCPGGSK269962AEAG3.9628e-03-0.2412image
chr14:58550014-58551149:+PCPGImatinibEER2.0089e-02-0.2129image
ENSG00000100578.13,KIAA0586PRADBMS.536924EAG5.2543e-04-0.4183image
ENSG00000100578.13,KIAA0586SARCAG.014699EAG8.9879e-070.6070image
ENSG00000100578.13,KIAA0586SKCMGNF.2EAG5.9116e-04-0.4210image
ENSG00000100578.13,KIAA0586STADEpothilone.BEAG8.4849e-040.3031image
ENSG00000100578.13,KIAA0586THCABicalutamideEAG1.4905e-020.1940image
chr14:58550014-58551149:+THCABMS.509744EER1.5217e-020.2221image
chr14:58550014-58551149:+THYMBI.2536EER6.4626e-050.4171image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType