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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HOMER2 (ImmuneEditome ID:9455)

1. Gene summary of enriched editing regions for HOMER2

check button Gene summary
Gene informationGene symbol

HOMER2

Gene ID

9455

GeneSynonymsACPD|CPD|DFNA68|HOMER-2|VESL-2
GeneCytomap

15q25.2

GeneTypeprotein-coding
GeneDescriptionhomer protein homolog 2|cupidin|homer homolog 2|homer homolog 3|homer scaffolding protein 2|homer, neuronal immediate early gene, 2
GeneModificationdate20230517
UniprotIDQ9NSB8;H0YNR9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:82842328-82843441:-ENST00000558090.2ENSG00000103942.11HOMER2UTR3AluSx,AluJr,AluSx1chr15:82842328-82843441:-.alignment
chr15:82856537-82858611:-ENST00000561345.4ENSG00000103942.11HOMER2ncRNA_intronicMIRc,AluSz,MLT1A,L1MC,AluJb,AluJrchr15:82856537-82858611:-.alignment


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2. Tumor-specific enriched editing regions for HOMER2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr15:82842328-82843441:-BRCAEER1.5406e-05image
ENSG00000103942.11,HOMER2BRCAEAG1.8719e-05image
chr15:82842328-82843441:-PRADEER1.7271e-02image
ENSG00000103942.11,HOMER2PRADEAG2.4043e-02image
chr15:82842328-82843441:-STADEER4.7463e-02image
ENSG00000103942.11,HOMER2STADEAG4.7127e-02image
chr15:82842328-82843441:-THCAEER1.6109e-05image
ENSG00000103942.11,HOMER2THCAEAG1.9461e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr15:82842328-82843441:-HNSCEER2.0664e-024.9117e-021.7328e-01image
ENSG00000103942.11,HOMER2HNSCEAG2.0664e-024.9117e-021.7328e-01image

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3. Enriched editing regions and immune related genes for HOMER2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for HOMER2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for HOMER2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:82842328-82843441:-ACCEERDendritic_cells_resting2.3825e-02-0.4910image
ENSG00000103942.11,HOMER2ACCEAGDendritic_cells_resting2.3825e-02-0.4910image
chr15:82842328-82843441:-BLCAEERT_cells_follicular_helper4.7726e-02-0.3584image
ENSG00000103942.11,HOMER2BLCAEAGT_cells_follicular_helper4.7726e-02-0.3584image
chr15:82842328-82843441:-BRCAEERPlasma_cells1.0680e-02-0.1005image
ENSG00000103942.11,HOMER2BRCAEAGPlasma_cells1.3389e-02-0.0973image
chr15:82842328-82843441:-CESCEERPlasma_cells4.9357e-02-0.1695image
ENSG00000103942.11,HOMER2CESCEAGPlasma_cells4.9357e-02-0.1695image
chr15:82842328-82843441:-ESCAEERT_cells_gamma_delta1.9714e-020.2329image
ENSG00000103942.11,HOMER2ESCAEAGT_cells_gamma_delta1.8549e-020.2351image
chr15:82842328-82843441:-GBMEERT_cells_CD4_memory_activated3.5053e-040.4269image
ENSG00000103942.11,HOMER2GBMEAGT_cells_CD4_memory_activated3.5053e-040.4269image
chr15:82842328-82843441:-HNSCEERDendritic_cells_activated8.6275e-030.1947image
ENSG00000103942.11,HOMER2HNSCEAGDendritic_cells_activated8.6275e-030.1947image
chr15:82842328-82843441:-KICHEERMacrophages_M12.0308e-03-0.5770image
ENSG00000103942.11,HOMER2KICHEAGMacrophages_M12.0308e-03-0.5770image
chr15:82842328-82843441:-KIRCEERMacrophages_M11.1642e-02-0.5060image
ENSG00000103942.11,HOMER2KIRCEAGMacrophages_M11.1642e-02-0.5060image
chr15:82842328-82843441:-LGGEERNK_cells_resting4.7238e-020.1176image
ENSG00000103942.11,HOMER2LGGEAGNK_cells_resting4.7238e-020.1176image
chr15:82842328-82843441:-LIHCEERT_cells_gamma_delta1.9545e-020.1874image
ENSG00000103942.11,HOMER2LIHCEAGMacrophages_M01.4459e-020.1955image
chr15:82842328-82843441:-LUADEERDendritic_cells_activated4.2106e-020.1667image
ENSG00000103942.11,HOMER2LUADEAGDendritic_cells_activated4.2106e-020.1667image
chr15:82842328-82843441:-LUSCEEREosinophils2.5865e-020.1647image
ENSG00000103942.11,HOMER2LUSCEAGEosinophils2.5865e-020.1647image
chr15:82842328-82843441:-OVEERT_cells_CD81.5907e-020.1425image
ENSG00000103942.11,HOMER2OVEAGT_cells_CD82.1255e-020.1362image
chr15:82842328-82843441:-PAADEEREosinophils1.8678e-030.3235image
ENSG00000103942.11,HOMER2PAADEAGEosinophils1.8678e-030.3235image
chr15:82842328-82843441:-PCPGEERMast_cells_activated3.8495e-020.2127image
ENSG00000103942.11,HOMER2PCPGEAGMast_cells_activated3.8495e-020.2127image
chr15:82842328-82843441:-PRADEERMast_cells_resting2.0047e-020.1050image
ENSG00000103942.11,HOMER2PRADEAGMast_cells_resting2.0924e-020.1043image
chr15:82842328-82843441:-SARCEERB_cells_memory2.5818e-03-0.5302image
ENSG00000103942.11,HOMER2SARCEAGB_cells_memory2.5818e-03-0.5302image
chr15:82842328-82843441:-SKCMEERPlasma_cells2.6124e-030.3119image
ENSG00000103942.11,HOMER2SKCMEAGPlasma_cells2.6124e-030.3119image
chr15:82842328-82843441:-STADEERB_cells_memory7.3864e-030.2201image
ENSG00000103942.11,HOMER2STADEAGB_cells_memory7.1611e-030.2209image
chr15:82842328-82843441:-TGCTEERMacrophages_M23.3160e-020.2959image
ENSG00000103942.11,HOMER2TGCTEAGMacrophages_M23.3160e-020.2959image
chr15:82842328-82843441:-THCAEERMacrophages_M02.1286e-02-0.1044image
ENSG00000103942.11,HOMER2THCAEAGMacrophages_M02.0651e-02-0.1050image
chr15:82842328-82843441:-THYMEERPlasma_cells4.2332e-020.3502image
ENSG00000103942.11,HOMER2THYMEAGPlasma_cells4.2332e-020.3502image


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6. Enriched editing regions and immune gene sets for HOMER2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000103942.11,HOMER2BLCAGSVA_HALLMARK_SPERMATOGENESISEAG4.1048e-02-0.3690image
chr15:82842328-82843441:-BLCAGSVA_HALLMARK_SPERMATOGENESISEER4.1048e-02-0.3690image
chr15:82842328-82843441:-BRCAGSVA_HALLMARK_P53_PATHWAYEER1.6587e-040.1478image
ENSG00000103942.11,HOMER2BRCAGSVA_HALLMARK_P53_PATHWAYEAG1.7825e-040.1471image
ENSG00000103942.11,HOMER2CESCGSVA_HALLMARK_PEROXISOMEEAG5.3282e-040.2942image
chr15:82842328-82843441:-CESCGSVA_HALLMARK_PEROXISOMEEER5.3282e-040.2942image
chr15:82842328-82843441:-ESCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.1318e-020.2523image
ENSG00000103942.11,HOMER2ESCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.5895e-020.2406image
ENSG00000103942.11,HOMER2GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.1398e-040.4406image
chr15:82842328-82843441:-GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.1398e-040.4406image
chr15:82842328-82843441:-KIRPGSVA_HALLMARK_MYOGENESISEER1.3034e-020.3137image
ENSG00000103942.11,HOMER2KIRPGSVA_HALLMARK_MYOGENESISEAG1.3034e-020.3137image
ENSG00000103942.11,HOMER2LGGGSVA_HALLMARK_HYPOXIAEAG1.0040e-040.2284image
chr15:82842328-82843441:-LGGGSVA_HALLMARK_HYPOXIAEER1.0040e-040.2284image
ENSG00000103942.11,HOMER2LIHCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.6013e-02-0.1782image
ENSG00000103942.11,HOMER2LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.9873e-020.1780image
chr15:82842328-82843441:-LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.9873e-020.1780image
ENSG00000103942.11,HOMER2LUSCGSVA_HALLMARK_GLYCOLYSISEAG8.2313e-030.1948image
chr15:82842328-82843441:-LUSCGSVA_HALLMARK_GLYCOLYSISEER8.2313e-030.1948image
ENSG00000103942.11,HOMER2OVGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.6822e-03-0.1668image
chr15:82842328-82843441:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER5.2800e-03-0.1645image
ENSG00000103942.11,HOMER2PAADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.9947e-030.3095image
chr15:82842328-82843441:-PAADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.9947e-030.3095image
ENSG00000103942.11,HOMER2PCPGGSVA_HALLMARK_G2M_CHECKPOINTEAG6.2801e-04-0.3446image
chr15:82842328-82843441:-PCPGGSVA_HALLMARK_G2M_CHECKPOINTEER6.2801e-04-0.3446image
ENSG00000103942.11,HOMER2PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7734e-07-0.2332image
chr15:82842328-82843441:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER7.7448e-08-0.2398image
chr15:82842328-82843441:-SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.7929e-030.5462image
ENSG00000103942.11,HOMER2SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.7929e-030.5462image
ENSG00000103942.11,HOMER2STADGSVA_HALLMARK_MYC_TARGETS_V1EAG3.8990e-020.1705image
chr15:82842328-82843441:-STADGSVA_HALLMARK_MYC_TARGETS_V1EER3.8077e-020.1713image
ENSG00000103942.11,HOMER2TGCTGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG7.7727e-040.4516image
chr15:82842328-82843441:-TGCTGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.7727e-040.4516image
chr15:82842328-82843441:-THCAGSVA_HALLMARK_COAGULATIONEER3.0837e-030.1340image
ENSG00000103942.11,HOMER2THCAGSVA_HALLMARK_COAGULATIONEAG3.7411e-030.1313image
ENSG00000103942.11,HOMER2UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0573e-040.3566image
chr15:82842328-82843441:-UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2789e-040.3526image
ENSG00000103942.11,HOMER2UCSGSVA_HALLMARK_MYOGENESISEAG3.0928e-02-0.3602image
chr15:82842328-82843441:-UCSGSVA_HALLMARK_MYOGENESISEER3.0928e-02-0.3602image


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7. Enriched editing regions and drugs for HOMER2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr15:82842328-82843441:-BLCAMethotrexateEER6.9751e-030.4747image
ENSG00000103942.11,HOMER2BLCAMethotrexateEAG6.9751e-030.4747image
chr15:82842328-82843441:-BRCAAZD.0530EER1.8030e-04-0.1470image
ENSG00000103942.11,HOMER2BRCAAZD.0530EAG1.6726e-04-0.1477image
ENSG00000103942.11,HOMER2CESCAxitinibEAG2.3754e-020.1946image
chr15:82842328-82843441:-CESCAxitinibEER2.3754e-020.1946image
ENSG00000103942.11,HOMER2CHOLGefitinibEAG1.4262e-02-0.4661image
chr15:82842328-82843441:-CHOLGefitinibEER1.4262e-02-0.4661image
chr15:82842328-82843441:-ESCAGW.441756EER2.0453e-020.2315image
ENSG00000103942.11,HOMER2ESCAGW.441756EAG1.2421e-020.2492image
ENSG00000103942.11,HOMER2GBMGNF.2EAG2.5884e-03-0.3649image
chr15:82842328-82843441:-GBMGNF.2EER2.5884e-03-0.3649image
chr15:82842328-82843441:-HNSCMidostaurinEER3.9856e-020.1529image
ENSG00000103942.11,HOMER2HNSCMidostaurinEAG3.9856e-020.1529image
ENSG00000103942.11,HOMER2KICHGW843682XEAG2.1736e-020.4480image
chr15:82842328-82843441:-KICHGW843682XEER2.1736e-020.4480image
ENSG00000103942.11,HOMER2LGGGNF.2EAG1.0248e-04-0.2281image
chr15:82842328-82843441:-LGGGNF.2EER1.0248e-04-0.2281image
ENSG00000103942.11,HOMER2LIHCCI.1040EAG4.1439e-03-0.2283image
chr15:82842328-82843441:-LIHCGW843682XEER1.1705e-030.2584image
ENSG00000103942.11,HOMER2LUADAMG.706EAG1.9805e-020.1907image
chr15:82842328-82843441:-LUADAMG.706EER1.9805e-020.1907image
ENSG00000103942.11,HOMER2LUSCATRAEAG1.1204e-030.2390image
chr15:82842328-82843441:-LUSCATRAEER1.1204e-030.2390image
ENSG00000103942.11,HOMER2OVATRAEAG1.7547e-040.2201image
chr15:82842328-82843441:-OVATRAEER1.4520e-040.2228image
chr15:82842328-82843441:-PCPGGDC.0449EER4.4884e-03-0.2891image
ENSG00000103942.11,HOMER2PCPGGDC.0449EAG4.4884e-03-0.2891image
chr15:82842328-82843441:-PRADBMS.536924EER4.2418e-09-0.2622image
ENSG00000103942.11,HOMER2PRADBMS.536924EAG1.3904e-08-0.2536image
chr15:82842328-82843441:-SARCAUY922EER1.0107e-03-0.5699image
ENSG00000103942.11,HOMER2SARCAUY922EAG1.0107e-03-0.5699image
ENSG00000103942.11,HOMER2SKCMDoxorubicinEAG2.2769e-020.2386image
chr15:82842328-82843441:-SKCMDoxorubicinEER2.2769e-020.2386image
chr15:82842328-82843441:-STADBIBW2992EER1.0004e-02-0.2148image
ENSG00000103942.11,HOMER2STADBIBW2992EAG1.0196e-02-0.2142image
ENSG00000103942.11,HOMER2TGCTCCT018159EAG7.3852e-040.4533image
chr15:82842328-82843441:-TGCTCCT018159EER7.3852e-040.4533image
ENSG00000103942.11,HOMER2THCABMS.509744EAG9.6832e-10-0.2728image
chr15:82842328-82843441:-THCABMS.509744EER7.9424e-10-0.2741image
chr15:82842328-82843441:-UCECCCT007093EER2.9396e-060.4236image
ENSG00000103942.11,HOMER2UCECCCT007093EAG4.5853e-060.4160image
chr15:82842328-82843441:-UCSCEP.701EER8.4647e-04-0.5317image
ENSG00000103942.11,HOMER2UCSCEP.701EAG8.4647e-04-0.5317image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType