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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: SYAP1 (ImmuneEditome ID:94056)

1. Gene summary of enriched editing regions for SYAP1

check button Gene summary
Gene informationGene symbol

SYAP1

Gene ID

94056

GeneSynonymsBSTA|PRO3113
GeneCytomap

Xp22.2

GeneTypeprotein-coding
GeneDescriptionsynapse-associated protein 1|BSD domain-containing signal transducer and Akt interactor protein|SAP47 homolog|synapse associated protein 1, SAP47 homolog
GeneModificationdate20230518
UniprotIDQ96A49
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chrX:16734251-16734789:+ENST00000495743.1ENSG00000169895.5SYAP1ncRNA_intronicAluSx1chrX:16734251-16734789:+.alignment
chrX:16736529-16737349:+ENST00000380155.3ENSG00000169895.5SYAP1intronicAluSg,AluJochrX:16736529-16737349:+.alignment
chrX:16749060-16749812:+ENST00000380155.3ENSG00000169895.5SYAP1intronicAluSz,MER103C,AluJbchrX:16749060-16749812:+.alignment
chrX:16760922-16761260:+ENST00000380155.3ENSG00000169895.5SYAP1UTR3AluSx1chrX:16760922-16761260:+.alignment
chrX:16762977-16765007:+ENST00000380155.3ENSG00000169895.5SYAP1UTR3AluSx1,AluJo,AluSx,AluJbchrX:16762977-16765007:+.alignment


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2. Tumor-specific enriched editing regions for SYAP1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chrX:16762977-16765007:+BRCAEER5.7731e-05image
ENSG00000169895.5,SYAP1BRCAEAG8.4618e-05image
chrX:16762977-16765007:+HNSCEER2.3654e-02image
ENSG00000169895.5,SYAP1HNSCEAG6.3819e-03image
ENSG00000169895.5,SYAP1UCECEAG3.0403e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chrX:16762977-16765007:+ESCAPathEER4.6886e-028.9566e-030.2202image
chrX:16762977-16765007:+KIRCPathEER1.1166e-021.5606e-03-0.1392image
ENSG00000169895.5,SYAP1KIRCPathEAG1.3889e-022.2161e-03-0.1344image
chrX:16762977-16765007:+LUSCPathEER5.5329e-036.1524e-030.1412image
ENSG00000169895.5,SYAP1LUSCPathEAG9.3543e-037.4613e-030.1365image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chrX:16762977-16765007:+COADEER1.9640e-036.1005e-032.0991e+01image

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3. Enriched editing regions and immune related genes for SYAP1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chrX:16762977-16765007:+LIHCEERENSG00000198898,CAPZA20.34002.3811e-088.8759e-240.5036imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1NAMacrophages_M0GSVA_HALLMARK_PROTEIN_SECRETION
chrX:16762977-16765007:+LIHCEERENSG00000249936,RAC1P20.26461.9728e-057.4402e-210.4736imageNNNAMacrophages_M0GSVA_HALLMARK_BILE_ACID_METABOLISM
chrX:16762977-16765007:+LIHCEERENSG00000075790,BCAP290.23272.4675e-042.9880e-150.4061imageNAUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1BCAP29Plasma_cellsGSVA_HALLMARK_PROTEIN_SECRETION
chrX:16762977-16765007:+LIHCEERENSG00000225573,RPL35P5-0.17399.1971e-036.7278e-150.4013imageNNNAGSVA_HALLMARK_HEME_METABOLISM
chrX:16762977-16765007:+KIRCEERENSG00000135387,CAPRIN10.44724.4723e-154.1969e-170.4152imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1CAPRIN1T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chrX:16762977-16765007:+KIRCEERENSG00000229833,PET100-0.42112.7963e-131.0937e-16-0.4101imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chrX:16762977-16765007:+KIRCEERENSG00000162910,MRPL55-0.39633.2883e-126.8220e-16-0.4002imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chrX:16762977-16765007:+UCECEERENSG00000143256,PFDN2-0.46831.2059e-058.1921e-08-0.4097imageNAUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chrX:16762977-16765007:+UCECEERENSG00000139343,SNRPF-0.43757.2121e-051.0403e-07-0.4067imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chrX:16762977-16765007:+UCECEERENSG00000162961,DPY30-0.41972.1576e-041.6831e-07-0.4005imageNEIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAMast_cells_restingGSVA_HALLMARK_SPERMATOGENESIS

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4. Enriched editing regions and immune related splicing for SYAP1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000169895.5,SYAP1
CESCEAGIRENSG00000198825.7chr10119791853:119792036:119792156:119792213-0.33079.2629e-074.7359e-10-0.4156imageNACIN1;ADAR;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;SLBP;SLTM;SMNDC1;SRSF1;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chrX:16762977-16765007:+
CESCEERIRENSG00000126216.8chr13112545698:112545865:112547619:112547752-0.45438.8991e-101.0929e-12-0.4175imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000169895.5,SYAP1
CESCEAGIRENSG00000126216.8chr13112545698:112545865:112547619:112547752-0.45207.7122e-101.7924e-12-0.4132imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chrX:16762977-16765007:+
CESCEERIRENSG00000198825.7chr10119791853:119792036:119792156:119792213-0.32362.8732e-061.1144e-09-0.4074imageNEIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chrX:16762977-16765007:+
COADEERMEXENSG00000104522.11chr8143613769:143613817:143614163:143614195:143614319:143614453:143614623:143614697-0.24821.2636e-023.2978e-13-0.4277imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1TSTA3EosinophilsGSVA_HALLMARK_DNA_REPAIR
chrX:16762977-16765007:+
COADEERMEXENSG00000104522.11chr8143613769:143613817:143614163:143614195:143614335:143614453:143614623:143614697-0.24821.2660e-023.3408e-13-0.4276imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1TSTA3EosinophilsGSVA_HALLMARK_DNA_REPAIR
chrX:16762977-16765007:+
COADEERMEXENSG00000165637.9chr1075220742:75220970:75222251:75222337:75222367:75222402:75229643:752297010.31003.5991e-044.4899e-120.4084imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_DNA_REPAIR
ENSG00000169895.5,SYAP1
ESCAEAGIRENSG00000182944.13chr2229288605:29288755:29292136:29292169-0.31511.3894e-021.1149e-07-0.4046imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
chrX:16762977-16765007:+
ESCAEERIRENSG00000046653.10chrX13771455:13776303:13777351:13777425-0.32564.8604e-031.1167e-05-0.4020imageNAIFM1;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;U2AF2;UPF1NAB_cells_naiveGSVA_HALLMARK_HYPOXIA
chrX:16762977-16765007:+
KIRCEERMEXENSG00000204628.7chr5181237019:181237042:181237608:181237694:181241491:181242345:181243691:181243772-0.39653.5698e-121.8971e-18-0.4311imageNAIFM1;AUH;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;LIN28;NOP58;PTBP1;RBFOX2;RNF219;U2AF2;UPF1GNB2L1T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for SYAP1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chrX:16762977-16765007:+ACCEERNK_cells_resting2.0981e-030.3498image
ENSG00000169895.5,SYAP1ACCEAGNK_cells_resting1.5635e-030.3590image
chrX:16762977-16765007:+BLCAEERT_cells_CD4_memory_resting2.9948e-020.1223image
ENSG00000169895.5,SYAP1BLCAEAGMacrophages_M22.4125e-02-0.1262image
chrX:16760922-16761260:+BRCAEERT_cells_CD4_memory_resting7.9218e-030.5393image
chrX:16762977-16765007:+BRCAEERT_cells_CD4_memory_resting2.6274e-040.1114image
ENSG00000169895.5,SYAP1BRCAEAGNK_cells_activated2.0496e-03-0.0940image
chrX:16762977-16765007:+CESCEERT_cells_regulatory_(Tregs)3.5329e-02-0.1279image
ENSG00000169895.5,SYAP1CESCEAGT_cells_regulatory_(Tregs)2.0199e-02-0.1408image
chrX:16762977-16765007:+CHOLEERT_cells_gamma_delta4.1373e-020.3517image
ENSG00000169895.5,SYAP1CHOLEAGT_cells_gamma_delta2.4153e-020.3860image
chrX:16762977-16765007:+COADEERT_cells_CD4_memory_resting5.2345e-030.1711image
chrX:16762977-16765007:+ESCAEERT_cells_CD4_memory_resting2.4026e-03-0.2398image
ENSG00000169895.5,SYAP1ESCAEAGT_cells_CD4_memory_resting1.4521e-03-0.2497image
chrX:16762977-16765007:+GBMEERT_cells_CD4_memory_activated3.6482e-02-0.1704image
ENSG00000169895.5,SYAP1GBMEAGT_cells_CD4_memory_activated4.9480e-03-0.2268image
chrX:16762977-16765007:+HNSCEERT_cells_CD83.4549e-03-0.1617image
ENSG00000169895.5,SYAP1HNSCEAGT_cells_CD85.9741e-03-0.1504image
chrX:16762977-16765007:+KICHEERMonocytes3.5694e-020.2631image
ENSG00000169895.5,SYAP1KICHEAGMonocytes1.5442e-020.3016image
chrX:16762977-16765007:+KIRCEERT_cells_regulatory_(Tregs)1.9774e-08-0.2845image
ENSG00000169895.5,SYAP1KIRCEAGT_cells_regulatory_(Tregs)2.4435e-07-0.2621image
chrX:16762977-16765007:+KIRPEERB_cells_memory1.4841e-02-0.1471image
ENSG00000169895.5,SYAP1KIRPEAGB_cells_memory1.2759e-02-0.1503image
ENSG00000169895.5,SYAP1LAMLEAGMacrophages_M02.6286e-040.3927image
chrX:16762977-16765007:+LGGEERNK_cells_resting3.6589e-020.0960image
chrX:16762977-16765007:+LUADEERT_cells_CD4_memory_resting1.9502e-040.1716image
ENSG00000169895.5,SYAP1LUADEAGT_cells_CD4_memory_resting3.1941e-030.1354image
chrX:16762977-16765007:+LUSCEERDendritic_cells_activated4.9369e-04-0.1791image
ENSG00000169895.5,SYAP1LUSCEAGDendritic_cells_activated5.2025e-04-0.1765image
chrX:16762977-16765007:+OVEERB_cells_memory2.1021e-02-0.1379image
ENSG00000169895.5,SYAP1OVEAGMast_cells_activated1.3557e-020.1461image
chrX:16762977-16765007:+PAADEERT_cells_CD4_naive3.0104e-040.2747image
ENSG00000169895.5,SYAP1PAADEAGT_cells_CD4_naive2.6072e-040.2774image
chrX:16762977-16765007:+PRADEERB_cells_naive1.4502e-030.1430image
ENSG00000169895.5,SYAP1PRADEAGB_cells_naive9.6250e-040.1482image
chrX:16762977-16765007:+SARCEERT_cells_CD81.6073e-03-0.2047image
ENSG00000169895.5,SYAP1SARCEAGT_cells_CD82.3658e-03-0.1962image
chrX:16762977-16765007:+SKCMEERT_cells_CD4_naive2.5273e-040.1928image
ENSG00000169895.5,SYAP1SKCMEAGT_cells_CD4_naive1.9739e-040.1961image
chrX:16762977-16765007:+STADEERT_cells_CD4_memory_resting1.1349e-06-0.2560image
ENSG00000169895.5,SYAP1STADEAGT_cells_CD4_memory_activated5.4920e-040.1822image
chrX:16762977-16765007:+TGCTEERB_cells_memory2.3728e-02-0.3133image
ENSG00000169895.5,SYAP1TGCTEAGMacrophages_M23.2375e-020.2864image
chrX:16762977-16765007:+THYMEERT_cells_CD81.4196e-02-0.2667image
ENSG00000169895.5,SYAP1THYMEAGT_cells_CD81.1226e-02-0.2738image
chrX:16762977-16765007:+UCECEERT_cells_CD4_memory_resting8.5305e-030.2080image
ENSG00000169895.5,SYAP1UCECEAGT_cells_CD4_memory_resting2.5326e-020.1774image
chrX:16762977-16765007:+UCSEEREosinophils4.1609e-020.2864image
ENSG00000169895.5,SYAP1UCSEAGMast_cells_activated3.6931e-020.2930image
chrX:16762977-16765007:+UVMEERMonocytes2.6818e-040.5720image
ENSG00000169895.5,SYAP1UVMEAGMonocytes2.6616e-040.5722image


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6. Enriched editing regions and immune gene sets for SYAP1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000169895.5,SYAP1ESCAEAG8.2840e-070.37801.5045e-030.24894.3277e-060.35424.4368e-020.1592image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chrX:16762977-16765007:+ACCGSVA_HALLMARK_MITOTIC_SPINDLEEER5.1389e-030.3199image
ENSG00000169895.5,SYAP1ACCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.5077e-030.3245image
ENSG00000169895.5,SYAP1BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.0786e-03-0.1822image
chrX:16762977-16765007:+BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER7.3587e-05-0.2215image
chrX:16760922-16761260:+BRCAGSVA_HALLMARK_UV_RESPONSE_UPEER4.2874e-02-0.4256image
chrX:16762977-16765007:+BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER6.7520e-180.2594image
ENSG00000169895.5,SYAP1BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.5825e-200.2734image
ENSG00000169895.5,SYAP1CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.0840e-070.3153image
chrX:16762977-16765007:+CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER9.0026e-080.3177image
chrX:16762977-16765007:+CHOLGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.1881e-030.4911image
ENSG00000169895.5,SYAP1CHOLGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.1333e-030.5085image
chrX:16762977-16765007:+COADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.2584e-04-0.2042image
ENSG00000169895.5,SYAP1COADGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.3937e-040.2234image
chrX:16762977-16765007:+DLBCGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.9707e-03-0.4942image
ENSG00000169895.5,SYAP1DLBCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.9707e-03-0.4942image
ENSG00000169895.5,SYAP1ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.4938e-040.2954image
chrX:16762977-16765007:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER9.0198e-03-0.2071image
ENSG00000169895.5,SYAP1GBMGSVA_HALLMARK_SPERMATOGENESISEAG1.7866e-020.1919image
chrX:16762977-16765007:+GBMGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5029e-020.1976image
ENSG00000169895.5,SYAP1HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.6910e-070.2818image
chrX:16762977-16765007:+HNSCGSVA_HALLMARK_UV_RESPONSE_DNEER3.0660e-080.3012image
ENSG00000169895.5,SYAP1KIRCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6289e-090.3042image
chrX:16762977-16765007:+KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER1.2119e-090.3069image
chrX:16762977-16765007:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER6.0199e-100.3628image
ENSG00000169895.5,SYAP1KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.5614e-100.3700image
ENSG00000169895.5,SYAP1LAMLGSVA_HALLMARK_COAGULATIONEAG1.5841e-03-0.3434image
chrX:16736529-16737349:+LAMLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER9.8398e-04-0.4115image
ENSG00000169895.5,SYAP1LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.6342e-080.2484image
chrX:16762977-16765007:+LGGGSVA_HALLMARK_UV_RESPONSE_DNEER3.8499e-080.2492image
ENSG00000169895.5,SYAP1LIHCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.9200e-070.2732image
chrX:16762977-16765007:+LIHCGSVA_HALLMARK_UV_RESPONSE_DNEER2.2370e-070.2733image
ENSG00000169895.5,SYAP1LUADGSVA_HALLMARK_UV_RESPONSE_DNEAG3.1574e-090.2683image
chrX:16762977-16765007:+LUADGSVA_HALLMARK_UV_RESPONSE_DNEER3.8533e-090.2683image
ENSG00000169895.5,SYAP1LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG9.1797e-030.1330image
chrX:16762977-16765007:+LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.3054e-020.1281image
ENSG00000169895.5,SYAP1MESOGSVA_HALLMARK_DNA_REPAIREAG8.0488e-03-0.2980image
chrX:16762977-16765007:+MESOGSVA_HALLMARK_DNA_REPAIREER5.3361e-03-0.3126image
ENSG00000169895.5,SYAP1OVGSVA_HALLMARK_HEME_METABOLISMEAG2.6808e-050.2460image
chrX:16762977-16765007:+OVGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.3747e-030.1746image
ENSG00000169895.5,SYAP1PAADGSVA_HALLMARK_UV_RESPONSE_DNEAG4.3933e-030.2181image
chrX:16762977-16765007:+PAADGSVA_HALLMARK_UV_RESPONSE_DNEER3.9885e-040.2693image
chrX:16762977-16765007:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2672e-040.2931image
ENSG00000169895.5,SYAP1PCPGGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6629e-040.2874image
chrX:16762977-16765007:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER5.2043e-080.2422image
ENSG00000169895.5,SYAP1PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.1795e-080.2487image
ENSG00000169895.5,SYAP1READGSVA_HALLMARK_UV_RESPONSE_DNEAG3.7274e-020.2187image
chrX:16762977-16765007:+SARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0707e-06-0.3119image
ENSG00000169895.5,SYAP1SARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.4457e-05-0.2614image
chrX:16762977-16765007:+SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER6.2048e-040.1805image
ENSG00000169895.5,SYAP1SKCMGSVA_HALLMARK_UV_RESPONSE_DNEAG9.7836e-040.1740image
ENSG00000169895.5,SYAP1STADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG9.4323e-080.2782image
chrX:16762977-16765007:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7538e-080.2947image
chrX:16762977-16765007:+TGCTGSVA_HALLMARK_DNA_REPAIREER4.7985e-03-0.3852image
ENSG00000169895.5,SYAP1TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.2480e-02-0.2721image
ENSG00000169895.5,SYAP1THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.5609e-050.1852image
chrX:16762977-16765007:+THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.2431e-060.2116image
ENSG00000169895.5,SYAP1THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.0397e-040.3694image
chrX:16762977-16765007:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER5.8663e-040.3674image
ENSG00000169895.5,SYAP1UCECGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.2727e-030.2121image
chrX:16762977-16765007:+UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER1.0234e-020.2031image
chrX:16762977-16765007:+UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.4454e-020.3406image
ENSG00000169895.5,SYAP1UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.1509e-020.3512image
chrX:16762977-16765007:+UVMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.2212e-02-0.3801image
ENSG00000169895.5,SYAP1UVMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.9771e-02-0.3868image


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7. Enriched editing regions and drugs for SYAP1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000169895.5,SYAP1ACCAxitinibEAG1.9740e-02-0.2687image
chrX:16762977-16765007:+ACCAxitinibEER1.7078e-02-0.2747image
ENSG00000169895.5,SYAP1BLCABMS.536924EAG5.5317e-050.2238image
chrX:16762977-16765007:+BLCAJW.7.52.1EER3.0399e-060.2595image
chrX:16762977-16765007:+BRCABryostatin.1EER8.0894e-090.1753image
chrX:16760922-16761260:+BRCABMS.708163EER3.9500e-03-0.5769image
ENSG00000169895.5,SYAP1BRCABryostatin.1EAG6.5471e-080.1641image
ENSG00000169895.5,SYAP1CESCBMS.536924EAG1.3423e-050.2610image
chrX:16762977-16765007:+CESCBMS.536924EER1.0167e-050.2650image
ENSG00000169895.5,SYAP1CHOLMidostaurinEAG2.9969e-03-0.4938image
chrX:16762977-16765007:+CHOLMidostaurinEER3.1891e-03-0.4910image
chrX:16762977-16765007:+COADCCT007093EER1.6452e-03-0.1925image
ENSG00000169895.5,SYAP1COADLapatinibEAG1.9390e-03-0.1896image
chrX:16762977-16765007:+DLBCGDC.0449EER1.9628e-040.5966image
ENSG00000169895.5,SYAP1DLBCGDC.0449EAG1.9628e-040.5966image
chrX:16762977-16765007:+ESCACMKEER2.7542e-04-0.2856image
ENSG00000169895.5,SYAP1ESCAErlotinibEAG1.2252e-03-0.2534image
ENSG00000169895.5,SYAP1GBMAICAREAG2.1987e-03-0.2466image
chrX:16762977-16765007:+GBMErlotinibEER7.3475e-040.2718image
ENSG00000169895.5,SYAP1HNSCCGP.60474EAG1.0049e-070.2868image
chrX:16762977-16765007:+HNSCDocetaxelEER1.1735e-080.3098image
chrX:16762977-16765007:+KICHGefitinibEER1.1686e-02-0.3134image
ENSG00000169895.5,SYAP1KICHGefitinibEAG1.9148e-02-0.2922image
ENSG00000169895.5,SYAP1KIRCEmbelinEAG2.8611e-09-0.2998image
chrX:16762977-16765007:+KIRCEmbelinEER3.5815e-09-0.2984image
chrX:16762977-16765007:+KIRPBMS.536924EER5.4840e-100.3648image
ENSG00000169895.5,SYAP1KIRPBMS.536924EAG4.4237e-090.3463image
ENSG00000169895.5,SYAP1LAMLBicalutamideEAG4.6406e-020.2206image
chrX:16736529-16737349:+LAMLA.770041EER5.5982e-030.3506image
chrX:16762977-16765007:+LGGKU.55933EER2.2425e-060.2155image
ENSG00000169895.5,SYAP1LGGKU.55933EAG7.0185e-060.2039image
chrX:16762977-16765007:+LIHCA.770041EER1.5001e-080.3122image
ENSG00000169895.5,SYAP1LIHCA.770041EAG5.7269e-080.2990image
ENSG00000169895.5,SYAP1LUADABT.263EAG9.6515e-05-0.1789image
chrX:16762977-16765007:+LUADABT.263EER3.6450e-06-0.2128image
chrX:16762977-16765007:+LUSCGW843682XEER1.3437e-020.1276image
ENSG00000169895.5,SYAP1LUSCGW843682XEAG3.7155e-030.1479image
chrX:16762977-16765007:+MESOGW843682XEER4.3424e-040.3888image
ENSG00000169895.5,SYAP1MESOErlotinibEAG5.9455e-040.3803image
ENSG00000169895.5,SYAP1OVDMOGEAG9.3954e-05-0.2293image
chrX:16762977-16765007:+OVAG.014699EER5.7457e-030.1647image
chrX:16762977-16765007:+PAADATRAEER5.7657e-04-0.2668image
ENSG00000169895.5,SYAP1PAADATRAEAG3.8052e-04-0.2750image
chrX:16762977-16765007:+PCPGEmbelinEER1.0820e-04-0.2960image
ENSG00000169895.5,SYAP1PCPGEmbelinEAG2.4341e-05-0.3204image
ENSG00000169895.5,SYAP1PRADBryostatin.1EAG2.7389e-090.2637image
chrX:16762977-16765007:+PRADBryostatin.1EER1.1845e-080.2532image
ENSG00000169895.5,SYAP1READABT.263EAG2.1524e-02-0.2421image
chrX:16762977-16765007:+READABT.263EER2.9849e-02-0.2304image
chrX:16762977-16765007:+SARCAG.014699EER1.4052e-08-0.3595image
ENSG00000169895.5,SYAP1SARCBortezomibEAG5.2748e-070.3183image
ENSG00000169895.5,SYAP1SKCMEmbelinEAG1.2084e-03-0.1709image
chrX:16762977-16765007:+SKCMEmbelinEER1.2448e-03-0.1704image
ENSG00000169895.5,SYAP1STADGemcitabineEAG5.0980e-03-0.1481image
chrX:16762977-16765007:+STADCisplatinEER8.3301e-07-0.2591image
chrX:16762977-16765007:+TGCTA.443654EER1.3659e-020.3400image
chrX:16762977-16765007:+THCAEmbelinEER6.2097e-11-0.2895image
ENSG00000169895.5,SYAP1THCABMS.536924EAG1.3885e-070.2352image
ENSG00000169895.5,SYAP1THYMAZD6482EAG2.0164e-04-0.3927image
chrX:16762977-16765007:+THYMAZD6482EER2.0054e-04-0.3950image
chrX:16762977-16765007:+UCECEmbelinEER3.3829e-05-0.3225image
ENSG00000169895.5,SYAP1UCECEmbelinEAG8.7915e-05-0.3059image
chrX:16762977-16765007:+UCSCEP.701EER1.2401e-030.4398image
ENSG00000169895.5,SYAP1UCSCEP.701EAG4.0440e-030.3958image
ENSG00000169895.5,SYAP1UVMFH535EAG8.6680e-06-0.6676image
chrX:16762977-16765007:+UVMFH535EER1.2477e-05-0.6589image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType