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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RPL23 (ImmuneEditome ID:9349)

1. Gene summary of enriched editing regions for RPL23

check button Gene summary
Gene informationGene symbol

RPL23

Gene ID

9349

GeneSynonymsL23|rpL17|uL14
GeneCytomap

17q12

GeneTypeprotein-coding
GeneDescription60S ribosomal protein L23|60S ribosomal protein L17|large ribosomal subunit protein uL14|ribosomal protein L17
GeneModificationdate20230329
UniprotIDA0A024R1Q8;P62829;J3KTJ3;C9JD32;J3KT29;B9ZVP7;J3QQT9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:38848305-38850084:-ENST00000584912.4ENSG00000125691.11RPL23ncRNA_exonicAluSx,MER5B,AluSgchr17:38848305-38850084:-.alignment


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2. Tumor-specific enriched editing regions for RPL23


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr17:38848305-38850084:-BRCAEER5.1361e-29image
ENSG00000125691.11,RPL23BRCAEAG3.4770e-29image
chr17:38848305-38850084:-KIRCEER9.1286e-10image
ENSG00000125691.11,RPL23KIRCEAG9.5706e-10image
chr17:38848305-38850084:-LUSCEER2.1917e-11image
ENSG00000125691.11,RPL23LUSCEAG2.2396e-11image
chr17:38848305-38850084:-THCAEER2.7650e-09image
ENSG00000125691.11,RPL23THCAEAG2.7401e-08image
chr17:38848305-38850084:-UCECEER6.4067e-04image
ENSG00000125691.11,RPL23UCECEAG6.8409e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000125691.11,RPL23BRCAPathEAG5.8966e-033.3471e-020.0688image
chr17:38848305-38850084:-BRCAPathEER5.6537e-033.2439e-020.0693image
chr17:38848305-38850084:-KIRCPathEER7.3732e-041.2247e-040.1720image
ENSG00000125691.11,RPL23KIRCPathEAG8.1125e-041.4036e-040.1705image
ENSG00000125691.11,RPL23LUSCPathEAG2.7432e-023.4320e-020.1145image
chr17:38848305-38850084:-LUSCPathEER2.8129e-023.5038e-020.1140image
chr17:38848305-38850084:-TGCTCliEER5.7463e-033.1803e-02-0.2403image
ENSG00000125691.11,RPL23TGCTCliEAG8.0836e-034.7723e-02-0.2207image
ENSG00000125691.11,RPL23THCAPathEAG9.7077e-034.0532e-030.1290image
chr17:38848305-38850084:-THCAPathEER8.9027e-033.7623e-030.1300image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for RPL23


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:38848305-38850084:-KIRCEERENSG00000088812,ATRN-0.40159.8290e-121.2707e-16-0.4197imageNNATRNT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr17:38848305-38850084:-KIRCEERENSG00000177989,ODF3B0.39264.3142e-114.2241e-200.4606imageNNNAT_cells_CD8GSVA_HALLMARK_ANDROGEN_RESPONSE
chr17:38848305-38850084:-KIRCEERENSG00000110321,EIF4G2-0.38761.0919e-107.5761e-16-0.4098imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr17:38848305-38850084:-KIRCEERENSG00000009335,UBE3C-0.38661.3166e-102.8334e-15-0.4022imageNNUBE3CT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr17:38848305-38850084:-KIRCEERENSG00000130731,C16orf130.37641.7672e-101.3016e-200.4662imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr17:38848305-38850084:-KIRCEERENSG00000163156,SCNM10.37104.9155e-109.1580e-200.4569imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ANDROGEN_RESPONSE
chr17:38848305-38850084:-KIRCEERENSG00000144560,VGLL4-0.36755.2137e-103.8140e-15-0.4005imageNNNAMast_cells_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr17:38848305-38850084:-KIRCEERENSG00000102103,PQBP10.36601.0089e-095.0368e-180.4369imageNNPQBP1T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr17:38848305-38850084:-KIRCEERENSG00000229809,ZNF6880.34032.8755e-083.0772e-160.4148imageNNNANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
chr17:38848305-38850084:-KIRCEERENSG00000149806,FAU0.33654.2429e-081.7675e-160.4179imageNNNAMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for RPL23


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000125691.11,RPL23
ESCAEAGESENSG00000115207.9chr227343330:27343578:27350313:27350389:27356738:27356767-0.39334.6200e-033.5270e-07-0.4041imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAB_cells_naiveGSVA_HALLMARK_BILE_ACID_METABOLISM
chr17:38848305-38850084:-
ESCAEERIRENSG00000117650.8chr1211663402:211663628:211667105:211667231-0.34361.6768e-028.5883e-07-0.4101imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
ENSG00000125691.11,RPL23
ESCAEAGIRENSG00000117650.8chr1211663402:211663628:211667105:211667231-0.34431.9441e-028.3031e-07-0.4106imageNADAR;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;SAFB2;SBDS;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr17:38848305-38850084:-
ESCAEERESENSG00000115207.9chr227343330:27343578:27350313:27350389:27356738:27356767-0.39443.8682e-033.3614e-07-0.4047imageNNNAB_cells_naiveGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000125691.11,RPL23
GBMEAGIRENSG00000164403.10chr5132825017:132825073:132825162:132826140-0.44271.9790e-047.8359e-07-0.4158imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NANK_cells_activatedGSVA_HALLMARK_BILE_ACID_METABOLISM
chr17:38848305-38850084:-
GBMEERIRENSG00000164403.10chr5132825017:132825073:132825162:132826140-0.44072.0144e-048.3076e-07-0.4150imageNNNANK_cells_activatedGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000125691.11,RPL23
KIRCEAGMEXENSG00000099622.9chr191271980:1272051:1272426:1272439:1273650:1273715:1274306:1274363-0.30861.9982e-065.5783e-18-0.4363imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM6;RC3H1;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD8GSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000125691.11,RPL23
KIRCEAGIRENSG00000151694.8chr29488485:9492986:9493746:94938250.27804.9733e-052.3899e-160.4189imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184ADAM17NK_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
ENSG00000125691.11,RPL23
KIRCEAGMEXENSG00000104613.7chr819837080:19837160:19842847:19842927:19845703:19845797:19851648:19852083-0.32194.1001e-075.1522e-17-0.4246imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr17:38848305-38850084:-
KIRCEERMEXENSG00000147403.12chrX154399486:154399594:154399802:154399917:154400557:154400626:154400701:154400917-0.29625.5607e-061.4497e-16-0.4190imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for RPL23


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000125691.11,RPL23ACCEAGB_cells_memory9.3812e-030.4214image
chr17:38848305-38850084:-BLCAEERT_cells_CD81.3328e-050.2561image
ENSG00000125691.11,RPL23BLCAEAGT_cells_CD81.3328e-050.2561image
chr17:38848305-38850084:-BRCAEERMacrophages_M18.4644e-070.1585image
ENSG00000125691.11,RPL23BRCAEAGMacrophages_M17.6084e-070.1591image
ENSG00000125691.11,RPL23CESCEAGT_cells_CD4_memory_resting1.1592e-03-0.2270image
chr17:38848305-38850084:-DLBCEERT_cells_CD4_memory_activated2.2651e-020.3552image
ENSG00000125691.11,RPL23DLBCEAGT_cells_CD4_memory_activated2.2651e-020.3552image
chr17:38848305-38850084:-ESCAEERT_cells_CD81.3036e-030.2610image
ENSG00000125691.11,RPL23ESCAEAGT_cells_CD81.2781e-030.2615image
chr17:38848305-38850084:-GBMEERMast_cells_resting2.1952e-030.2568image
ENSG00000125691.11,RPL23GBMEAGMast_cells_resting1.7576e-030.2621image
chr17:38848305-38850084:-HNSCEERPlasma_cells7.9333e-04-0.1690image
ENSG00000125691.11,RPL23HNSCEAGPlasma_cells7.9333e-04-0.1690image
chr17:38848305-38850084:-KIRCEERT_cells_CD85.4347e-060.2384image
ENSG00000125691.11,RPL23KIRCEAGT_cells_CD85.4347e-060.2384image
chr17:38848305-38850084:-KIRPEERMacrophages_M11.2581e-030.2505image
ENSG00000125691.11,RPL23KIRPEAGMacrophages_M11.2581e-030.2505image
chr17:38848305-38850084:-LGGEERT_cells_CD4_memory_activated4.9596e-030.1324image
ENSG00000125691.11,RPL23LGGEAGT_cells_CD4_memory_activated4.9760e-030.1323image
chr17:38848305-38850084:-LIHCEERMacrophages_M11.3570e-020.1960image
ENSG00000125691.11,RPL23LIHCEAGMacrophages_M11.3570e-020.1960image
chr17:38848305-38850084:-LUADEERT_cells_CD81.4939e-030.1641image
ENSG00000125691.11,RPL23LUADEAGT_cells_CD81.4787e-030.1642image
chr17:38848305-38850084:-LUSCEERT_cells_CD4_memory_activated1.6329e-060.2551image
ENSG00000125691.11,RPL23LUSCEAGT_cells_CD4_memory_activated1.6543e-060.2550image
chr17:38848305-38850084:-MESOEERNeutrophils2.2556e-02-0.2723image
ENSG00000125691.11,RPL23MESOEAGNeutrophils2.2556e-02-0.2723image
chr17:38848305-38850084:-OVEERT_cells_CD81.0949e-030.2029image
ENSG00000125691.11,RPL23OVEAGT_cells_CD89.1726e-040.2060image
chr17:38848305-38850084:-PCPGEERT_cells_CD81.7811e-030.2627image
ENSG00000125691.11,RPL23PCPGEAGT_cells_CD81.7930e-030.2626image
chr17:38848305-38850084:-PRADEERMast_cells_activated3.6091e-02-0.1006image
ENSG00000125691.11,RPL23PRADEAGMast_cells_activated3.5961e-02-0.1007image
ENSG00000125691.11,RPL23READEAGMacrophages_M22.2666e-030.4391image
chr17:38848305-38850084:-SARCEERMacrophages_M12.8534e-030.2084image
ENSG00000125691.11,RPL23SARCEAGMacrophages_M12.7462e-030.2092image
chr17:38848305-38850084:-SKCMEERT_cells_CD81.1739e-050.2210image
ENSG00000125691.11,RPL23SKCMEAGT_cells_CD81.1739e-050.2210image
chr17:38848305-38850084:-STADEERT_cells_CD4_memory_activated1.9260e-020.1331image
ENSG00000125691.11,RPL23STADEAGT_cells_CD4_memory_activated1.9490e-020.1328image
chr17:38848305-38850084:-TGCTEERNeutrophils8.6945e-070.3990image
ENSG00000125691.11,RPL23TGCTEAGNeutrophils4.6028e-070.4068image
chr17:38848305-38850084:-THCAEERT_cells_regulatory_(Tregs)2.4027e-050.1884image
ENSG00000125691.11,RPL23THCAEAGT_cells_regulatory_(Tregs)2.4523e-050.1882image
chr17:38848305-38850084:-THYMEERT_cells_CD4_naive1.0681e-05-0.3978image
ENSG00000125691.11,RPL23THYMEAGT_cells_CD4_naive1.0681e-05-0.3978image
chr17:38848305-38850084:-UCSEERMacrophages_M01.2196e-030.4404image
ENSG00000125691.11,RPL23UCSEAGMacrophages_M01.2196e-030.4404image


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6. Enriched editing regions and immune gene sets for RPL23


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr17:38848305-38850084:-THCAEER4.3304e-02image2.2319e-020.1026image
ENSG00000125691.11,RPL23THCAEAG4.2839e-02image2.2467e-020.1025image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr17:38848305-38850084:-BRCAEER1.7128e-020.07711.4222e-020.07934.8955e-020.06372.2539e-020.0738image
ENSG00000125691.11,RPL23KIRPEAG1.0346e-02-0.20035.0571e-04-0.26945.7582e-05-0.30973.8170e-02-0.1625image
chr17:38848305-38850084:-KIRPEER1.0346e-02-0.20035.0571e-04-0.26945.7582e-05-0.30973.8170e-02-0.1625image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000125691.11,RPL23ACCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0146e-020.3569image
ENSG00000125691.11,RPL23BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.2100e-080.3219image
chr17:38848305-38850084:-BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.2100e-080.3219image
ENSG00000125691.11,RPL23BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.7859e-190.2862image
chr17:38848305-38850084:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.8341e-190.2861image
ENSG00000125691.11,RPL23CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5588e-070.3530image
chr17:38848305-38850084:-CHOLGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.9335e-03-0.5107image
ENSG00000125691.11,RPL23CHOLGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG4.0870e-03-0.5088image
ENSG00000125691.11,RPL23COADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG6.6792e-03-0.2117image
chr17:38848305-38850084:-COADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER6.6792e-03-0.2117image
ENSG00000125691.11,RPL23DLBCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.2942e-020.3850image
chr17:38848305-38850084:-DLBCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.2942e-020.3850image
chr17:38848305-38850084:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3081e-02-0.2029image
ENSG00000125691.11,RPL23ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3068e-02-0.2029image
chr17:38848305-38850084:-GBMGSVA_HALLMARK_ANGIOGENESISEER1.0986e-02-0.2144image
ENSG00000125691.11,RPL23GBMGSVA_HALLMARK_ANGIOGENESISEAG1.0583e-02-0.2154image
ENSG00000125691.11,RPL23HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2974e-050.2186image
chr17:38848305-38850084:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2974e-050.2186image
ENSG00000125691.11,RPL23KIRCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.7476e-07-0.2726image
chr17:38848305-38850084:-KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER1.7476e-07-0.2726image
chr17:38848305-38850084:-KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER8.9001e-06-0.3401image
ENSG00000125691.11,RPL23KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.9001e-06-0.3401image
ENSG00000125691.11,RPL23LGGGSVA_HALLMARK_MYOGENESISEAG6.1826e-060.2115image
chr17:38848305-38850084:-LGGGSVA_HALLMARK_MYOGENESISEER6.3743e-060.2112image
ENSG00000125691.11,RPL23LIHCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.1307e-040.2637image
chr17:38848305-38850084:-LIHCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.1307e-040.2637image
chr17:38848305-38850084:-LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEER7.1427e-04-0.1747image
ENSG00000125691.11,RPL23LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG7.2388e-04-0.1745image
ENSG00000125691.11,RPL23LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.7567e-050.2292image
chr17:38848305-38850084:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.8320e-050.2288image
chr17:38848305-38850084:-MESOGSVA_HALLMARK_TGF_BETA_SIGNALINGEER4.3599e-030.3368image
ENSG00000125691.11,RPL23MESOGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG4.3599e-030.3368image
chr17:38848305-38850084:-OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.2285e-05-0.2567image
ENSG00000125691.11,RPL23OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.8801e-05-0.2510image
ENSG00000125691.11,RPL23PAADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.8875e-030.2651image
chr17:38848305-38850084:-PAADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.8875e-030.2651image
chr17:38848305-38850084:-PCPGGSVA_HALLMARK_HYPOXIAEER5.1235e-04-0.2909image
ENSG00000125691.11,RPL23PCPGGSVA_HALLMARK_HYPOXIAEAG5.1333e-04-0.2909image
chr17:38848305-38850084:-PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.9037e-050.1961image
ENSG00000125691.11,RPL23PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.0520e-050.1957image
ENSG00000125691.11,RPL23READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8739e-020.3227image
chr17:38848305-38850084:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.4648e-030.1873image
ENSG00000125691.11,RPL23SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.2006e-030.1881image
chr17:38848305-38850084:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.2213e-040.1821image
ENSG00000125691.11,RPL23SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.2213e-040.1821image
chr17:38848305-38850084:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3038e-030.1821image
ENSG00000125691.11,RPL23STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2469e-030.1828image
chr17:38848305-38850084:-TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.9431e-05-0.3429image
ENSG00000125691.11,RPL23TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.1649e-04-0.3167image
ENSG00000125691.11,RPL23THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.0707e-040.1731image
chr17:38848305-38850084:-THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.1110e-040.1727image
ENSG00000125691.11,RPL23THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.7562e-07-0.4463image
chr17:38848305-38850084:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER5.7562e-07-0.4463image
chr17:38848305-38850084:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.7875e-040.2828image
ENSG00000125691.11,RPL23UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.9680e-040.2793image
ENSG00000125691.11,RPL23UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.7404e-040.4126image
chr17:38848305-38850084:-UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.7404e-040.4126image


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7. Enriched editing regions and drugs for RPL23


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000125691.11,RPL23ACCLFM.A13EAG3.3936e-020.3496image
chr17:38848305-38850084:-BLCACGP.60474EER2.6907e-08-0.3236image
ENSG00000125691.11,RPL23BLCACGP.60474EAG2.6907e-08-0.3236image
ENSG00000125691.11,RPL23BRCAAxitinibEAG8.1816e-070.1588image
chr17:38848305-38850084:-BRCAAxitinibEER8.7050e-070.1584image
ENSG00000125691.11,RPL23CESCFH535EAG5.2258e-050.2806image
ENSG00000125691.11,RPL23CHOLA.770041EAG2.9097e-020.3987image
chr17:38848305-38850084:-CHOLA.770041EER2.9609e-020.3975image
ENSG00000125691.11,RPL23COADAZ628EAG4.3497e-030.2223image
chr17:38848305-38850084:-COADAZ628EER4.3497e-030.2223image
ENSG00000125691.11,RPL23DLBCAMG.706EAG1.8139e-04-0.5523image
chr17:38848305-38850084:-DLBCAMG.706EER1.8139e-04-0.5523image
chr17:38848305-38850084:-ESCAABT.888EER1.9062e-04-0.3011image
ENSG00000125691.11,RPL23ESCAABT.888EAG1.8792e-04-0.3014image
chr17:38848305-38850084:-GBMGefitinibEER2.0886e-04-0.3085image
ENSG00000125691.11,RPL23GBMGefitinibEAG2.1006e-04-0.3084image
chr17:38848305-38850084:-HNSCFH535EER4.3636e-050.2052image
ENSG00000125691.11,RPL23HNSCFH535EAG4.3636e-050.2052image
ENSG00000125691.11,RPL23KIRCAZD6482EAG1.3974e-090.3152image
chr17:38848305-38850084:-KIRCAZD6482EER1.3974e-090.3152image
chr17:38848305-38850084:-KIRPAZD6482EER1.3716e-030.2486image
ENSG00000125691.11,RPL23KIRPAZD6482EAG1.3716e-030.2486image
chr17:38848305-38850084:-LGGBAY.61.3606EER8.7612e-070.2296image
ENSG00000125691.11,RPL23LGGBAY.61.3606EAG8.7437e-070.2296image
ENSG00000125691.11,RPL23LIHCBleomycinEAG3.5597e-040.2859image
chr17:38848305-38850084:-LIHCBleomycinEER3.5597e-040.2859image
chr17:38848305-38850084:-LUADGW843682XEER2.8945e-04-0.1869image
ENSG00000125691.11,RPL23LUADGW843682XEAG2.9280e-04-0.1867image
ENSG00000125691.11,RPL23LUSCDocetaxelEAG2.6677e-03-0.1615image
chr17:38848305-38850084:-LUSCDocetaxelEER2.6025e-03-0.1619image
chr17:38848305-38850084:-MESOAZD.0530EER2.2495e-02-0.2725image
ENSG00000125691.11,RPL23MESOAZD.0530EAG2.2495e-02-0.2725image
chr17:38848305-38850084:-OVBexaroteneEER1.5011e-050.2669image
ENSG00000125691.11,RPL23OVBexaroteneEAG2.2285e-050.2617image
chr17:38848305-38850084:-PAADKU.55933EER5.6953e-030.2394image
ENSG00000125691.11,RPL23PAADKU.55933EAG5.6953e-030.2394image
chr17:38848305-38850084:-PCPGMidostaurinEER7.0729e-050.3305image
ENSG00000125691.11,RPL23PCPGMidostaurinEAG8.3737e-050.3273image
chr17:38848305-38850084:-PRADATRAEER4.0052e-08-0.2601image
ENSG00000125691.11,RPL23PRADATRAEAG3.9869e-08-0.2601image
ENSG00000125691.11,RPL23READCytarabineEAG2.2411e-030.4395image
ENSG00000125691.11,RPL23SARCEmbelinEAG6.7402e-030.1896image
chr17:38848305-38850084:-SARCEmbelinEER6.7236e-030.1897image
chr17:38848305-38850084:-SKCMKU.55933EER2.3201e-06-0.2377image
ENSG00000125691.11,RPL23SKCMKU.55933EAG2.3201e-06-0.2377image
chr17:38848305-38850084:-STADAZ628EER7.2437e-03-0.1525image
ENSG00000125691.11,RPL23STADAZ628EAG6.9980e-03-0.1531image
chr17:38848305-38850084:-TGCTFTI.277EER3.5047e-040.2959image
ENSG00000125691.11,RPL23TGCTFTI.277EAG1.1705e-030.2688image
ENSG00000125691.11,RPL23THCAEmbelinEAG5.0423e-170.3644image
chr17:38848305-38850084:-THCAEmbelinEER4.6508e-170.3648image
chr17:38848305-38850084:-THYMBAY.61.3606EER5.5049e-100.5382image
ENSG00000125691.11,RPL23THYMBAY.61.3606EAG5.5049e-100.5382image
chr17:38848305-38850084:-UCECABT.888EER7.1471e-05-0.3281image
ENSG00000125691.11,RPL23UCECABT.888EAG7.2294e-05-0.3278image
chr17:38848305-38850084:-UCSLFM.A13EER4.4775e-03-0.3917image
ENSG00000125691.11,RPL23UCSLFM.A13EAG4.4775e-03-0.3917image
chr17:38848305-38850084:-UVMEmbelinEER7.1627e-060.4839image
ENSG00000125691.11,RPL23UVMEmbelinEAG7.1627e-060.4839image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType