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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PTER (ImmuneEditome ID:9317)

1. Gene summary of enriched editing regions for PTER

check button Gene summary
Gene informationGene symbol

PTER

Gene ID

9317

GeneSynonymsHPHRP|RPR-1
GeneCytomap

10p13

GeneTypeprotein-coding
GeneDescriptionphosphotriesterase-related protein|parathion hydrolase-related protein|resiniferatoxin-binding, phosphotriesterase-related
GeneModificationdate20230329
UniprotIDQ96BW5;A0A0A0MSI3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:16437364-16438925:+ENST00000378000.4ENSG00000165983.13PTERsplicingAluSx4,AluJb,AluJo,AluSz6chr10:16437364-16438925:+.alignment
chr10:16462997-16463154:+ENST00000378000.4ENSG00000165983.13PTERintronicAluSc8chr10:16462997-16463154:+.alignment
chr10:16462997-16463154:+ENST00000423462.5ENSG00000165983.13PTERintronicAluSc8chr10:16462997-16463154:+.alignment
chr10:16462997-16463154:+ENST00000535784.5ENSG00000165983.13PTERintronicAluSc8chr10:16462997-16463154:+.alignment
chr10:16467603-16469753:+ENST00000378000.4ENSG00000165983.13PTERintronicAluJr,AluJo,AluSq2,L4_B_Mam,L2b,AluSx1chr10:16467603-16469753:+.alignment
chr10:16467603-16469753:+ENST00000423462.5ENSG00000165983.13PTERintronicAluJr,AluJo,AluSq2,L4_B_Mam,L2b,AluSx1chr10:16467603-16469753:+.alignment
chr10:16467603-16469753:+ENST00000535784.5ENSG00000165983.13PTERintronicAluJr,AluJo,AluSq2,L4_B_Mam,L2b,AluSx1chr10:16467603-16469753:+.alignment


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2. Tumor-specific enriched editing regions for PTER


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000165983.13,PTERBRCAEAG3.4210e-02image
ENSG00000165983.13,PTERKICHEAG3.3646e-02image
chr10:16437364-16438925:+KIRCEER1.8412e-03image
ENSG00000165983.13,PTERKIRCEAG1.7272e-03image
ENSG00000165983.13,PTERPRADEAG2.9801e-02image
ENSG00000165983.13,PTERTHCAEAG1.9813e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000165983.13,PTERTHCAPathEAG1.4810e-021.7712e-030.1948image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for PTER


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:16437364-16438925:+STADEERENSG00000220793,RPL21P1190.22062.0070e-034.0414e-140.4013imageNNNAT_cells_CD8GSVA_HALLMARK_HEME_METABOLISM

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4. Enriched editing regions and immune related splicing for PTER


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for PTER


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000165983.13,PTERBLCAEAGB_cells_memory1.6615e-02-0.2098image
ENSG00000165983.13,PTERHNSCEAGMacrophages_M21.9902e-020.2303image
ENSG00000165983.13,PTERKIRPEAGMast_cells_resting1.8023e-020.1631image
ENSG00000165983.13,PTERLAMLEAGPlasma_cells9.4051e-030.3569image
ENSG00000165983.13,PTERLIHCEAGMacrophages_M02.3522e-030.3334image
ENSG00000165983.13,PTERLUADEAGNeutrophils4.8602e-03-0.1867image
ENSG00000165983.13,PTERLUSCEAGDendritic_cells_activated1.5294e-020.1971image
ENSG00000165983.13,PTEROVEAGMacrophages_M13.1226e-03-0.1888image
ENSG00000165983.13,PTERPAADEAGT_cells_CD4_memory_resting4.7099e-03-0.3251image
ENSG00000165983.13,PTERPRADEAGT_cells_regulatory_(Tregs)1.1248e-020.1896image
ENSG00000165983.13,PTERREADEAGMacrophages_M26.9318e-030.3928image
ENSG00000165983.13,PTERSKCMEAGNK_cells_activated4.0959e-02-0.1869image
chr10:16437364-16438925:+STADEERT_cells_regulatory_(Tregs)6.9070e-030.1489image
ENSG00000165983.13,PTERSTADEAGT_cells_regulatory_(Tregs)7.1145e-030.1484image
ENSG00000165983.13,PTERTHCAEAGT_cells_regulatory_(Tregs)1.7745e-020.1478image
ENSG00000165983.13,PTERUCECEAGMonocytes7.4226e-030.4714image


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6. Enriched editing regions and immune gene sets for PTER


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000165983.13,PTERBLCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.6658e-020.2097image
ENSG00000165983.13,PTERBRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4778e-03-0.1297image
ENSG00000165983.13,PTERCHOLGSVA_HALLMARK_COMPLEMENTEAG3.9040e-02-0.4646image
ENSG00000165983.13,PTERESCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.5047e-020.1703image
chr10:16437364-16438925:+ESCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.5210e-02-0.1708image
ENSG00000165983.13,PTERHNSCGSVA_HALLMARK_HYPOXIAEAG4.1319e-020.2024image
ENSG00000165983.13,PTERKIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.0168e-020.1182image
ENSG00000165983.13,PTERKIRPGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.4756e-02-0.1681image
ENSG00000165983.13,PTERLAMLGSVA_HALLMARK_COMPLEMENTEAG1.8946e-03-0.4208image
ENSG00000165983.13,PTERLIHCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.5060e-03-0.3470image
ENSG00000165983.13,PTERLUADGSVA_HALLMARK_GLYCOLYSISEAG4.4415e-03-0.1886image
ENSG00000165983.13,PTERLUSCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG3.3694e-02-0.1730image
ENSG00000165983.13,PTERMESOGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.4275e-020.5015image
ENSG00000165983.13,PTEROVGSVA_HALLMARK_HEME_METABOLISMEAG1.0935e-03-0.2082image
ENSG00000165983.13,PTERPAADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.0431e-030.3736image
ENSG00000165983.13,PTERPRADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.0474e-03-0.2093image
ENSG00000165983.13,PTERREADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.4177e-02-0.2981image
ENSG00000165983.13,PTERSTADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.6946e-04-0.1921image
chr10:16437364-16438925:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5739e-03-0.1738image
ENSG00000165983.13,PTERUCECGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.0005e-020.3708image


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7. Enriched editing regions and drugs for PTER


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000165983.13,PTERBLCAFH535EAG4.0186e-020.1802image
ENSG00000165983.13,PTERBRCACEP.701EAG1.4561e-03-0.1299image
ENSG00000165983.13,PTERCESCDasatinibEAG2.8556e-030.2998image
ENSG00000165983.13,PTERCHOLBIBW2992EAG1.0853e-02-0.5563image
ENSG00000165983.13,PTERCOADAS601245EAG3.1813e-020.1816image
ENSG00000165983.13,PTERESCALenalidomideEAG5.3349e-03-0.2351image
chr10:16437364-16438925:+ESCALenalidomideEER3.8403e-03-0.2446image
ENSG00000165983.13,PTERHNSCDocetaxelEAG2.0487e-02-0.2292image
ENSG00000165983.13,PTERKIRCAZ628EAG8.6608e-05-0.2243image
chr10:16437364-16438925:+KIRCAZ628EER1.9871e-04-0.2129image
ENSG00000165983.13,PTERKIRPBMS.708163EAG1.7425e-020.1639image
ENSG00000165983.13,PTERLAMLCGP.082996EAG1.1819e-020.3466image
ENSG00000165983.13,PTERLIHCBMS.708163EAG2.8462e-030.3274image
ENSG00000165983.13,PTERLUADGW843682XEAG4.0025e-040.2335image
ENSG00000165983.13,PTERLUSCGW.441756EAG3.1244e-02-0.1754image
ENSG00000165983.13,PTERMESOAKT.inhibitor.VIIIEAG4.4126e-02-0.4544image
ENSG00000165983.13,PTEROVABT.263EAG7.6680e-03-0.1707image
ENSG00000165983.13,PTERPAADDocetaxelEAG5.2902e-05-0.4548image
ENSG00000165983.13,PTERPRADBicalutamideEAG1.7267e-020.1783image
ENSG00000165983.13,PTERREADCyclopamineEAG1.9341e-020.3437image
ENSG00000165983.13,PTERSKCMElesclomolEAG3.0261e-02-0.1979image
ENSG00000165983.13,PTERSTADBleomycinEAG8.8962e-03-0.1442image
chr10:16437364-16438925:+STADBleomycinEER9.3957e-03-0.1432image
ENSG00000165983.13,PTERTHCAABT.263EAG1.5553e-020.1508image
ENSG00000165983.13,PTERUCECJNK.9LEAG1.0637e-020.4523image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType