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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: PCED1B (ImmuneEditome ID:91523)

1. Gene summary of enriched editing regions for PCED1B

check button Gene summary
Gene informationGene symbol

PCED1B

Gene ID

91523

GeneSynonymsFAM113B
GeneCytomap

12q13.11

GeneTypeprotein-coding
GeneDescriptionPC-esterase domain-containing protein 1B|family with sequence similarity 113, member B
GeneModificationdate20230517
UniprotIDQ96HM7;F8VUD2;F8VYL8;F8VRF7
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:47118364-47121168:+ENST00000432328.2ENSG00000179715.11PCED1BintronicL1PA5,FLAM_C,L1MB8,(ATA)n,AluSx1chr12:47118364-47121168:+.alignment
chr12:47118364-47121168:+ENST00000546455.4ENSG00000179715.11PCED1BintronicL1PA5,FLAM_C,L1MB8,(ATA)n,AluSx1chr12:47118364-47121168:+.alignment
chr12:47173269-47174051:+ENST00000432328.2ENSG00000179715.11PCED1BintronicAluSc,AluJochr12:47173269-47174051:+.alignment
chr12:47173269-47174051:+ENST00000546455.4ENSG00000179715.11PCED1BintronicAluSc,AluJochr12:47173269-47174051:+.alignment
chr12:47195097-47195257:+ENST00000432328.2ENSG00000179715.11PCED1BintronicAluSgchr12:47195097-47195257:+.alignment
chr12:47195097-47195257:+ENST00000546455.4ENSG00000179715.11PCED1BintronicAluSgchr12:47195097-47195257:+.alignment
chr12:47198687-47198894:+ENST00000432328.2ENSG00000179715.11PCED1BintronicAluSq2chr12:47198687-47198894:+.alignment
chr12:47198687-47198894:+ENST00000546455.4ENSG00000179715.11PCED1BintronicAluSq2chr12:47198687-47198894:+.alignment
chr12:47201649-47201846:+ENST00000432328.2ENSG00000179715.11PCED1BintronicAluJbchr12:47201649-47201846:+.alignment
chr12:47201649-47201846:+ENST00000546455.4ENSG00000179715.11PCED1BintronicAluJbchr12:47201649-47201846:+.alignment
chr12:47217099-47220320:+ENST00000432328.2ENSG00000179715.11PCED1BintronicAluJr,AluJb,AluSx,MIRc,(AAT)n,MIR,AluSx1,(AAGA)nchr12:47217099-47220320:+.alignment
chr12:47217099-47220320:+ENST00000546455.4ENSG00000179715.11PCED1BintronicAluJr,AluJb,AluSx,MIRc,(AAT)n,MIR,AluSx1,(AAGA)nchr12:47217099-47220320:+.alignment
chr12:47217099-47220320:+ENST00000548348.1ENSG00000179715.11PCED1BintronicAluJr,AluJb,AluSx,MIRc,(AAT)n,MIR,AluSx1,(AAGA)nchr12:47217099-47220320:+.alignment
chr12:47217099-47220320:+ENST00000549500.1ENSG00000179715.11PCED1BintronicAluJr,AluJb,AluSx,MIRc,(AAT)n,MIR,AluSx1,(AAGA)nchr12:47217099-47220320:+.alignment
chr12:47226454-47229389:+ENST00000432328.2ENSG00000179715.11PCED1BintronicMIR,AluSx1,AluSq,Tigger4,AluSx,AluSz6,AluSz,MIRc,(GTTT)nchr12:47226454-47229389:+.alignment
chr12:47226454-47229389:+ENST00000546455.4ENSG00000179715.11PCED1BintronicMIR,AluSx1,AluSq,Tigger4,AluSx,AluSz6,AluSz,MIRc,(GTTT)nchr12:47226454-47229389:+.alignment
chr12:47226454-47229389:+ENST00000548348.1ENSG00000179715.11PCED1BintronicMIR,AluSx1,AluSq,Tigger4,AluSx,AluSz6,AluSz,MIRc,(GTTT)nchr12:47226454-47229389:+.alignment
chr12:47226454-47229389:+ENST00000549500.1ENSG00000179715.11PCED1BintronicMIR,AluSx1,AluSq,Tigger4,AluSx,AluSz6,AluSz,MIRc,(GTTT)nchr12:47226454-47229389:+.alignment
chr12:47226454-47229389:+ENST00000549630.1ENSG00000179715.11PCED1BintronicMIR,AluSx1,AluSq,Tigger4,AluSx,AluSz6,AluSz,MIRc,(GTTT)nchr12:47226454-47229389:+.alignment
chr12:47226454-47229389:+ENST00000551777.1ENSG00000179715.11PCED1BintronicMIR,AluSx1,AluSq,Tigger4,AluSx,AluSz6,AluSz,MIRc,(GTTT)nchr12:47226454-47229389:+.alignment


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2. Tumor-specific enriched editing regions for PCED1B


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000179715.11,PCED1BKIRPCliEAG1.7743e-021.7862e-020.4523image
chr12:47217099-47220320:+KIRPCliEER1.7743e-021.7862e-020.4523image
chr12:47217099-47220320:+UCECCliEER5.6281e-031.1785e-020.2548image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:47217099-47220320:+BRCAEER2.4522e-032.6976e-039.0156e+02image

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3. Enriched editing regions and immune related genes for PCED1B


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:47217099-47220320:+DLBCEERENSG00000168246,UBTD20.70785.2565e-033.5573e-080.7385imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000089682,RBM410.72905.5244e-033.5358e-040.5311imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000196678,ERI20.70075.6453e-036.2881e-140.8761imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000069329,VPS350.70168.5627e-031.5844e-040.5564imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000205302,SNX20.67319.4359e-033.0997e-040.5354imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56SNX2T_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000197713,RPE0.69399.6563e-033.3727e-040.5326imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT
chr12:47217099-47220320:+DLBCEERENSG00000149806,FAU-0.67729.7080e-034.1441e-03-0.4384imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr12:47217099-47220320:+DLBCEERENSG00000104442,ARMC10.68701.0303e-023.8932e-060.6519imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000177119,ANO60.66661.0394e-028.6028e-050.5744imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56ANO6T_cells_follicular_helperGSVA_HALLMARK_UV_RESPONSE_DN
chr12:47217099-47220320:+DLBCEERENSG00000068784,SRBD10.65461.0754e-021.8086e-070.7118imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000168246,UBTD20.70785.2565e-033.5573e-080.7385imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000089682,RBM410.72905.5244e-033.5358e-040.5311imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000196678,ERI20.70075.6453e-036.2881e-140.8761imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000069329,VPS350.70168.5627e-031.5844e-040.5564imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000205302,SNX20.67319.4359e-033.0997e-040.5354imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56SNX2T_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000197713,RPE0.69399.6563e-033.3727e-040.5326imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT
chr12:47217099-47220320:+DLBCEERENSG00000149806,FAU-0.67729.7080e-034.1441e-03-0.4384imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr12:47217099-47220320:+DLBCEERENSG00000104442,ARMC10.68701.0303e-023.8932e-060.6519imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000177119,ANO60.66661.0394e-028.6028e-050.5744imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56ANO6T_cells_follicular_helperGSVA_HALLMARK_UV_RESPONSE_DN
chr12:47217099-47220320:+DLBCEERENSG00000068784,SRBD10.65461.0754e-021.8086e-070.7118imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000168246,UBTD20.70785.2565e-033.5573e-080.7385imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000089682,RBM410.72905.5244e-033.5358e-040.5311imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000196678,ERI20.70075.6453e-036.2881e-140.8761imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000069329,VPS350.70168.5627e-031.5844e-040.5564imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000205302,SNX20.67319.4359e-033.0997e-040.5354imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56SNX2T_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000197713,RPE0.69399.6563e-033.3727e-040.5326imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT
chr12:47217099-47220320:+DLBCEERENSG00000149806,FAU-0.67729.7080e-034.1441e-03-0.4384imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr12:47217099-47220320:+DLBCEERENSG00000104442,ARMC10.68701.0303e-023.8932e-060.6519imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000177119,ANO60.66661.0394e-028.6028e-050.5744imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56ANO6T_cells_follicular_helperGSVA_HALLMARK_UV_RESPONSE_DN
chr12:47217099-47220320:+DLBCEERENSG00000068784,SRBD10.65461.0754e-021.8086e-070.7118imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000168246,UBTD20.70785.2565e-033.5573e-080.7385imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000089682,RBM410.72905.5244e-033.5358e-040.5311imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000196678,ERI20.70075.6453e-036.2881e-140.8761imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAB_cells_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000069329,VPS350.70168.5627e-031.5844e-040.5564imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000205302,SNX20.67319.4359e-033.0997e-040.5354imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56SNX2T_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000197713,RPE0.69399.6563e-033.3727e-040.5326imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT
chr12:47217099-47220320:+DLBCEERENSG00000149806,FAU-0.67729.7080e-034.1441e-03-0.4384imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr12:47217099-47220320:+DLBCEERENSG00000104442,ARMC10.68701.0303e-023.8932e-060.6519imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;DKC1;RBFOX2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr12:47217099-47220320:+DLBCEERENSG00000177119,ANO60.66661.0394e-028.6028e-050.5744imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF10;SRSF3;DKC1;RBFOX2;NOP56ANO6T_cells_follicular_helperGSVA_HALLMARK_UV_RESPONSE_DN
chr12:47217099-47220320:+DLBCEERENSG00000068784,SRBD10.65461.0754e-021.8086e-070.7118imageNDGCR8;TAF15;EIF4A3;ELAVL1;FUS;SRSF3;DKC1;RBFOX2;NOP56NAMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE

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4. Enriched editing regions and immune related splicing for PCED1B


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for PCED1B


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:47217099-47220320:+BLCAEERT_cells_gamma_delta2.5369e-030.2506image
ENSG00000179715.11,PCED1BBLCAEAGT_cells_gamma_delta2.6803e-030.2476image
chr12:47217099-47220320:+BRCAEERT_cells_CD4_memory_resting1.6034e-030.2538image
chr12:47217099-47220320:+CESCEERB_cells_naive6.2328e-030.2802image
ENSG00000179715.11,PCED1BCESCEAGB_cells_naive6.2328e-030.2802image
chr12:47217099-47220320:+DLBCEERT_cells_CD4_memory_resting1.1866e-030.4887image
ENSG00000179715.11,PCED1BDLBCEAGT_cells_CD4_memory_resting2.4237e-030.4609image
chr12:47217099-47220320:+ESCAEERDendritic_cells_activated1.1163e-020.2228image
ENSG00000179715.11,PCED1BESCAEAGDendritic_cells_activated1.4679e-020.2144image
chr12:47217099-47220320:+KIRCEERT_cells_CD4_memory_resting4.3060e-02-0.3030image
ENSG00000179715.11,PCED1BKIRCEAGMacrophages_M23.1456e-02-0.3143image
ENSG00000179715.11,PCED1BLAMLEAGMacrophages_M22.8424e-020.3875image
chr12:47217099-47220320:+LIHCEERT_cells_CD4_memory_activated4.0748e-020.4205image
ENSG00000179715.11,PCED1BLIHCEAGT_cells_CD4_memory_activated4.0748e-020.4205image
ENSG00000179715.11,PCED1BLUADEAGT_cells_CD4_memory_activated1.8397e-030.2566image
chr12:47217099-47220320:+LUSCEERT_cells_follicular_helper3.6405e-02-0.2938image
ENSG00000179715.11,PCED1BLUSCEAGT_cells_follicular_helper3.4199e-02-0.2943image
ENSG00000179715.11,PCED1BOVEAGT_cells_follicular_helper2.7699e-020.3482image
chr12:47217099-47220320:+PAADEERMonocytes2.0064e-020.3186image
ENSG00000179715.11,PCED1BPAADEAGMonocytes2.0064e-020.3186image
chr12:47217099-47220320:+PRADEERNK_cells_activated4.0322e-020.4507image
ENSG00000179715.11,PCED1BPRADEAGNK_cells_activated4.3545e-020.4341image
chr12:47217099-47220320:+SKCMEERNeutrophils4.9725e-020.2389image
ENSG00000179715.11,PCED1BSKCMEAGNeutrophils4.9482e-020.2392image
chr12:47217099-47220320:+STADEERB_cells_memory2.0020e-03-0.1989image
ENSG00000179715.11,PCED1BSTADEAGB_cells_memory1.9952e-03-0.1990image
chr12:47217099-47220320:+THCAEERMacrophages_M11.3035e-020.3088image
ENSG00000179715.11,PCED1BTHCAEAGMacrophages_M11.3035e-020.3088image
chr12:47217099-47220320:+THYMEERT_cells_gamma_delta4.0847e-030.4733image
ENSG00000179715.11,PCED1BTHYMEAGT_cells_gamma_delta4.0826e-030.4733image
chr12:47217099-47220320:+UCECEERMacrophages_M11.6263e-020.3925image
ENSG00000179715.11,PCED1BUCECEAGMacrophages_M14.7291e-020.3197image


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6. Enriched editing regions and immune gene sets for PCED1B


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000179715.11,PCED1BSTADEAG5.3529e-040.22231.1964e-020.16232.1682e-020.14858.6707e-040.2140image
chr12:47217099-47220320:+STADEER4.3919e-040.22561.0068e-020.16621.7495e-020.15361.4844e-030.2044image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000179715.11,PCED1BBLCAGSVA_HALLMARK_PEROXISOMEEAG6.1453e-030.2265image
chr12:47217099-47220320:+BLCAGSVA_HALLMARK_PEROXISOMEEER1.5759e-020.2016image
ENSG00000179715.11,PCED1BBRCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.6566e-040.2531image
chr12:47217099-47220320:+BRCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.1301e-020.1657image
ENSG00000179715.11,PCED1BCESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.5344e-020.2306image
chr12:47217099-47220320:+CESCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.5344e-020.2306image
chr12:47217099-47220320:+DLBCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.6583e-030.4438image
ENSG00000179715.11,PCED1BDLBCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.9066e-030.4410image
chr12:47217099-47220320:+ESCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.2292e-030.2669image
ENSG00000179715.11,PCED1BESCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.8155e-030.2720image
chr12:47217099-47220320:+KIRCGSVA_HALLMARK_MYC_TARGETS_V2EER4.7625e-020.2969image
ENSG00000179715.11,PCED1BKIRCGSVA_HALLMARK_MYC_TARGETS_V2EAG2.4380e-020.3280image
ENSG00000179715.11,PCED1BKIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEAG9.1185e-030.4469image
chr12:47217099-47220320:+KIRPGSVA_HALLMARK_KRAS_SIGNALING_DNEER9.1185e-030.4469image
chr12:47217099-47220320:+LAMLGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.7650e-020.4020image
ENSG00000179715.11,PCED1BLAMLGSVA_HALLMARK_DNA_REPAIREAG2.9874e-020.3843image
ENSG00000179715.11,PCED1BLIHCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.5305e-020.4890image
chr12:47217099-47220320:+LIHCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.5305e-020.4890image
chr12:47217099-47220320:+LUADGSVA_HALLMARK_E2F_TARGETSEER1.3403e-040.3228image
ENSG00000179715.11,PCED1BLUADGSVA_HALLMARK_E2F_TARGETSEAG5.7223e-060.3667image
ENSG00000179715.11,PCED1BOVGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2961e-030.4420image
chr12:47217099-47220320:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.0486e-030.4318image
ENSG00000179715.11,PCED1BPRADGSVA_HALLMARK_MYC_TARGETS_V1EAG1.1059e-020.5307image
chr12:47217099-47220320:+PRADGSVA_HALLMARK_MYC_TARGETS_V1EER3.0557e-020.4725image
ENSG00000179715.11,PCED1BSKCMGSVA_HALLMARK_GLYCOLYSISEAG1.1288e-020.3055image
chr12:47217099-47220320:+SKCMGSVA_HALLMARK_GLYCOLYSISEER1.1653e-020.3042image
chr12:47217099-47220320:+STADGSVA_HALLMARK_GLYCOLYSISEER5.9592e-070.3163image
ENSG00000179715.11,PCED1BSTADGSVA_HALLMARK_GLYCOLYSISEAG4.8320e-070.3187image
chr12:47226454-47229389:+STADGSVA_HALLMARK_ADIPOGENESISEER5.9040e-030.5795image
ENSG00000179715.11,PCED1BTGCTGSVA_HALLMARK_UV_RESPONSE_DNEAG1.0515e-020.5022image
chr12:47217099-47220320:+TGCTGSVA_HALLMARK_UV_RESPONSE_DNEER1.1863e-020.5263image
ENSG00000179715.11,PCED1BTHCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3126e-020.3085image
chr12:47217099-47220320:+THCAGSVA_HALLMARK_PROTEIN_SECRETIONEER1.3126e-020.3085image
chr12:47217099-47220320:+THYMGSVA_HALLMARK_PEROXISOMEEER2.0288e-030.5039image
ENSG00000179715.11,PCED1BTHYMGSVA_HALLMARK_PEROXISOMEEAG2.0352e-030.5037image
chr12:47217099-47220320:+UCECGSVA_HALLMARK_UV_RESPONSE_UPEER1.3416e-020.4029image
ENSG00000179715.11,PCED1BUCECGSVA_HALLMARK_UV_RESPONSE_UPEAG2.6471e-030.4682image


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7. Enriched editing regions and drugs for PCED1B


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000179715.11,PCED1BBLCAKIN001.135EAG2.5823e-02-0.1851image
chr12:47217099-47220320:+BLCAAMG.706EER2.8571e-020.1831image
ENSG00000179715.11,PCED1BBRCAIPA.3EAG7.5350e-040.2582image
chr12:47217099-47220320:+BRCACGP.60474EER6.3166e-040.2741image
ENSG00000179715.11,PCED1BCESCDocetaxelEAG2.8283e-050.4175image
chr12:47217099-47220320:+CESCDocetaxelEER2.8283e-050.4175image
chr12:47217099-47220320:+DLBCCEP.701EER3.5473e-040.5310image
ENSG00000179715.11,PCED1BDLBCCEP.701EAG3.5646e-040.5308image
chr12:47217099-47220320:+ESCADocetaxelEER1.7117e-02-0.2096image
ENSG00000179715.11,PCED1BESCADocetaxelEAG1.8107e-02-0.2078image
chr12:47217099-47220320:+HNSCGefitinibEER4.7399e-02-0.2297image
ENSG00000179715.11,PCED1BHNSCGefitinibEAG4.7399e-02-0.2297image
chr12:47217099-47220320:+KIRCBI.D1870EER1.9639e-02-0.3467image
ENSG00000179715.11,PCED1BKIRCBI.D1870EAG1.5822e-02-0.3502image
ENSG00000179715.11,PCED1BKIRPAZ628EAG3.5530e-02-0.3789image
chr12:47217099-47220320:+KIRPAZ628EER3.5530e-02-0.3789image
chr12:47217099-47220320:+LAMLBMS.509744EER9.7783e-03-0.4641image
ENSG00000179715.11,PCED1BLAMLImatinibEAG6.0709e-030.4745image
chr12:47217099-47220320:+LIHCMethotrexateEER2.8667e-02-0.4562image
ENSG00000179715.11,PCED1BLIHCMethotrexateEAG2.8667e-02-0.4562image
chr12:47217099-47220320:+LUADCI.1040EER1.0191e-030.2797image
ENSG00000179715.11,PCED1BLUADCCT007093EAG2.1896e-030.2524image
ENSG00000179715.11,PCED1BLUSCEmbelinEAG8.0009e-030.3639image
chr12:47217099-47220320:+LUSCEmbelinEER8.4703e-030.3649image
ENSG00000179715.11,PCED1BOVBI.2536EAG7.4543e-03-0.4169image
chr12:47217099-47220320:+OVEtoposideEER2.0162e-03-0.4794image
chr12:47217099-47220320:+PRADAZ628EER7.8068e-04-0.6889image
ENSG00000179715.11,PCED1BPRADAZ628EAG1.7820e-04-0.7289image
ENSG00000179715.11,PCED1BSKCMATRAEAG1.6562e-030.3744image
chr12:47217099-47220320:+SKCMATRAEER1.7029e-030.3736image
ENSG00000179715.11,PCED1BSTADAICAREAG3.7646e-030.1867image
chr12:47217099-47220320:+STADAICAREER2.5619e-030.1942image
chr12:47118364-47121168:+STADGefitinibEER4.8955e-02-0.4456image
chr12:47226454-47229389:+STADAZD7762EER3.1673e-02-0.4697image
chr12:47217099-47220320:+THCAMetforminEER8.4535e-040.4070image
ENSG00000179715.11,PCED1BTHCAMetforminEAG8.4535e-040.4070image
chr12:47217099-47220320:+THYMBryostatin.1EER7.5145e-040.5430image
ENSG00000179715.11,PCED1BTHYMBryostatin.1EAG7.5626e-040.5427image
ENSG00000179715.11,PCED1BUCECAKT.inhibitor.VIIIEAG2.0328e-020.3703image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType