CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZFAND2A (ImmuneEditome ID:90637)

1. Gene summary of enriched editing regions for ZFAND2A

check button Gene summary
Gene informationGene symbol

ZFAND2A

Gene ID

90637

GeneSynonymsAIRAP
GeneCytomap

7p22.3

GeneTypeprotein-coding
GeneDescriptionAN1-type zinc finger protein 2A|arsenite inducible RNA associated protein|zinc finger, AN1-type domain 2A
GeneModificationdate20230329
UniprotIDQ8N6M9;A8MYA3;J3KQ25
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:1153296-1155058:-ENST00000471448.1ENSG00000178381.10ZFAND2AncRNA_intronicAluSx1,AluSg,(T)n,(AGGC)n,AluSz6chr7:1153296-1155058:-.alignment


Top

2. Tumor-specific enriched editing regions for ZFAND2A


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000178381.10,ZFAND2ABLCAPathEAG6.9207e-034.0834e-03-0.4496image
ENSG00000178381.10,ZFAND2AHNSCCliEAG1.1066e-022.8791e-02-0.4209image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for ZFAND2A


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

4. Enriched editing regions and immune related splicing for ZFAND2A


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



Top

5. Enriched editing regions and immune infiltration for ZFAND2A


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000178381.10,ZFAND2ABLCAEAGMacrophages_M24.2179e-02-0.3270image
ENSG00000178381.10,ZFAND2ABRCAEAGDendritic_cells_activated3.2250e-02-0.3793image
ENSG00000178381.10,ZFAND2ACESCEAGT_cells_regulatory_(Tregs)3.1888e-020.3743image
ENSG00000178381.10,ZFAND2ACOADEAGT_cells_regulatory_(Tregs)2.7068e-02-0.4034image
ENSG00000178381.10,ZFAND2AGBMEAGT_cells_gamma_delta8.1502e-050.5759image
ENSG00000178381.10,ZFAND2AHNSCEAGDendritic_cells_activated2.9357e-02-0.4196image
ENSG00000178381.10,ZFAND2ALAMLEAGDendritic_cells_resting1.6256e-020.4424image
ENSG00000178381.10,ZFAND2ALGGEAGDendritic_cells_resting1.3958e-02-0.4370image
chr7:1153296-1155058:-LIHCEERMast_cells_activated1.1770e-020.4045image
ENSG00000178381.10,ZFAND2ALIHCEAGMast_cells_activated1.1887e-020.4040image
chr7:1153296-1155058:-LUADEERMacrophages_M23.4003e-020.3004image
ENSG00000178381.10,ZFAND2ALUADEAGMacrophages_M23.3997e-020.3005image
ENSG00000178381.10,ZFAND2ALUSCEAGT_cells_follicular_helper4.1389e-02-0.2925image
ENSG00000178381.10,ZFAND2APAADEAGMacrophages_M08.0101e-03-0.4908image
ENSG00000178381.10,ZFAND2APRADEAGMacrophages_M11.9072e-02-0.4326image
chr7:1153296-1155058:-STADEERT_cells_CD81.9172e-020.3405image
ENSG00000178381.10,ZFAND2ASTADEAGT_cells_CD88.4796e-030.3684image
ENSG00000178381.10,ZFAND2ATGCTEAGB_cells_naive4.4357e-020.4054image


Top

6. Enriched editing regions and immune gene sets for ZFAND2A


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000178381.10,ZFAND2APAADEAG3.5660e-02-0.39861.2384e-02-0.46635.8794e-03-0.50721.9892e-02-0.4375image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000178381.10,ZFAND2ABLCAGSVA_HALLMARK_DNA_REPAIREAG6.2232e-030.4305image
ENSG00000178381.10,ZFAND2ACESCGSVA_HALLMARK_SPERMATOGENESISEAG2.0958e-02-0.4004image
ENSG00000178381.10,ZFAND2ACOADGSVA_HALLMARK_SPERMATOGENESISEAG4.1501e-020.3744image
ENSG00000178381.10,ZFAND2AESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG6.0745e-03-0.3475image
chr7:1153296-1155058:-ESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER2.1640e-03-0.3916image
ENSG00000178381.10,ZFAND2AGBMGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG7.9939e-030.4086image
ENSG00000178381.10,ZFAND2AHNSCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG8.6628e-030.4950image
ENSG00000178381.10,ZFAND2AKIRCGSVA_HALLMARK_GLYCOLYSISEAG4.6609e-02-0.4285image
ENSG00000178381.10,ZFAND2ALIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG4.4628e-020.3277image
chr7:1153296-1155058:-LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER4.4298e-020.3281image
ENSG00000178381.10,ZFAND2ALUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.4518e-03-0.4384image
chr7:1153296-1155058:-LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.4624e-03-0.4381image
ENSG00000178381.10,ZFAND2ALUSCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.4072e-030.4238image
chr7:1153296-1155058:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER8.4026e-030.5592image
ENSG00000178381.10,ZFAND2AOVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.0156e-030.5904image
ENSG00000178381.10,ZFAND2APAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.9671e-03-0.5408image


Top

7. Enriched editing regions and drugs for ZFAND2A


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000178381.10,ZFAND2ABLCABI.2536EAG8.8800e-04-0.5109image
ENSG00000178381.10,ZFAND2ACESCLFM.A13EAG2.5510e-02-0.3884image
ENSG00000178381.10,ZFAND2ACOADDoxorubicinEAG8.4867e-030.4718image
ENSG00000178381.10,ZFAND2AESCAMidostaurinEAG6.7061e-03-0.3436image
chr7:1153296-1155058:-ESCAMidostaurinEER6.2528e-03-0.3520image
ENSG00000178381.10,ZFAND2AGBMAICAREAG1.7917e-030.4730image
ENSG00000178381.10,ZFAND2AHNSCCGP.60474EAG6.0868e-03-0.5141image
ENSG00000178381.10,ZFAND2AKIRCGDC0941EAG3.4841e-03-0.5951image
ENSG00000178381.10,ZFAND2ALAMLKU.55933EAG2.7876e-03-0.5350image
ENSG00000178381.10,ZFAND2ALIHCCGP.60474EAG6.1599e-03-0.4364image
chr7:1153296-1155058:-LIHCCGP.60474EER6.3105e-03-0.4353image
ENSG00000178381.10,ZFAND2ALUADDocetaxelEAG5.9503e-030.3837image
chr7:1153296-1155058:-LUADDocetaxelEER5.9557e-030.3836image
ENSG00000178381.10,ZFAND2ALUSCCCT007093EAG2.4763e-04-0.5008image
chr7:1153296-1155058:-OVImatinibEER2.5006e-030.6240image
ENSG00000178381.10,ZFAND2AOVImatinibEAG7.8503e-040.6501image
ENSG00000178381.10,ZFAND2APAADFTI.277EAG1.1720e-030.5815image
ENSG00000178381.10,ZFAND2APRADGW843682XEAG5.5157e-03-0.5021image
chr7:1153296-1155058:-SKCMAZD.2281EER8.0369e-030.5384image
ENSG00000178381.10,ZFAND2ASKCMAZD.2281EAG8.0589e-030.5383image
chr7:1153296-1155058:-STADCyclopamineEER5.0674e-03-0.4022image
ENSG00000178381.10,ZFAND2ASTADCyclopamineEAG7.9098e-03-0.3714image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType