CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: LYRM7 (ImmuneEditome ID:90624)

1. Gene summary of enriched editing regions for LYRM7

check button Gene summary
Gene informationGene symbol

LYRM7

Gene ID

90624

GeneSynonymsC5orf31|MC3DN8|MZM1L
GeneCytomap

5q23.3-q31.1

GeneTypeprotein-coding
GeneDescriptioncomplex III assembly factor LYRM7|LYR motif-containing protein 7|Lyrm7 homolog
GeneModificationdate20230518
UniprotIDQ5U5X0;D6R994;D6RBV5
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:131201088-131204246:+ENST00000521227.1ENSG00000186687.14LYRM7ncRNA_exonicAluSp,L1ME4a,FLAM_A,AluSx4,FAM,AluJbchr5:131201088-131204246:+.alignment


Top

2. Tumor-specific enriched editing regions for LYRM7


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr5:131201088-131204246:+BRCAEER4.0662e-12image
ENSG00000186687.14,LYRM7BRCAEAG4.0794e-12image
chr5:131201088-131204246:+COADEER1.6608e-09image
ENSG00000186687.14,LYRM7COADEAG1.4977e-09image
chr5:131201088-131204246:+HNSCEER1.1625e-03image
ENSG00000186687.14,LYRM7HNSCEAG1.1625e-03image
chr5:131201088-131204246:+KIRCEER3.2873e-09image
ENSG00000186687.14,LYRM7KIRCEAG4.6321e-09image
chr5:131201088-131204246:+KIRPEER6.8871e-06image
ENSG00000186687.14,LYRM7KIRPEAG6.9634e-06image
chr5:131201088-131204246:+LIHCEER4.6973e-02image
ENSG00000186687.14,LYRM7LIHCEAG4.7730e-02image
chr5:131201088-131204246:+LUADEER3.6017e-02image
ENSG00000186687.14,LYRM7LUADEAG3.6199e-02image
chr5:131201088-131204246:+THCAEER4.0876e-14image
ENSG00000186687.14,LYRM7THCAEAG6.4848e-14image
chr5:131201088-131204246:+UCECEER7.0821e-08image
ENSG00000186687.14,LYRM7UCECEAG4.8885e-08image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr5:131201088-131204246:+KIRCPathEER5.4118e-046.0455e-030.1206image
ENSG00000186687.14,LYRM7KIRCPathEAG4.3707e-044.8855e-030.1235image
chr5:131201088-131204246:+SKCMPathEER2.0664e-023.6076e-020.1154image
ENSG00000186687.14,LYRM7SKCMPathEAG2.0636e-023.6067e-020.1154image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for LYRM7


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:131201088-131204246:+STADEERENSG00000230191,RP4-725G10.30.19785.0770e-032.0966e-150.4050imageNNNAT_cells_CD8GSVA_HALLMARK_BILE_ACID_METABOLISM
chr5:131201088-131204246:+STADEERENSG00000173432,SAA10.17171.8339e-021.3970e-190.4560imageNNSAA1T_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr5:131201088-131204246:+STADEERENSG00000134339,SAA20.15982.9878e-022.5774e-190.4530imageNNSAA2GSVA_HALLMARK_UV_RESPONSE_DN
chr5:131201088-131204246:+STADEERENSG00000213275,IFITM9P0.15034.4397e-027.3638e-160.4110imageNNIFITM9PMacrophages_M1GSVA_HALLMARK_BILE_ACID_METABOLISM
chr5:131201088-131204246:+THCAEERENSG00000186687,LYRM7-0.36374.7532e-146.2682e-20-0.4065imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_COAGULATION
chr5:131201088-131204246:+THCAEERENSG00000163191,S100A110.31461.2753e-106.2291e-210.4165imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_COAGULATION
chr5:131201088-131204246:+KIRPEERENSG00000061337,LZTS10.26841.7495e-038.1924e-160.5256imageNNNAMacrophages_M1GSVA_HALLMARK_NOTCH_SIGNALING
chr5:131201088-131204246:+KIRPEERENSG00000086544,ITPKC0.23081.1865e-021.7293e-090.4067imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr5:131201088-131204246:+KIRPEERENSG00000268903,RP11-34P13.150.21252.3114e-021.5908e-100.4296imageNNNANeutrophilsGSVA_HALLMARK_PROTEIN_SECRETION
chr5:131201088-131204246:+KIRPEERENSG00000222057,RNU4-62P0.19482.5378e-022.9406e-160.5324imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION

More results



Top

4. Enriched editing regions and immune related splicing for LYRM7


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000186687.14,LYRM7
KIRPEAGIRENSG00000141367.7chr1759663841:59663994:59664786:596649090.22173.9817e-028.9084e-110.4440imageNACIN1;ADAR;AUH;BUD13;CBX7;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184CLTCNK_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr5:131201088-131204246:+
KIRPEERIRENSG00000141367.7chr1759663841:59663994:59664786:596649090.22173.7522e-028.9084e-110.4440imageNNCLTCNK_cells_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr5:131201088-131204246:+
PCPGEERIRENSG00000136003.11chr12108567189:108567268:108567657:108567743-0.30803.4762e-034.4605e-07-0.4256imageNNNAGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000186687.14,LYRM7
PCPGEAGIRENSG00000136003.11chr12108567189:108567268:108567657:108567743-0.30773.1771e-034.5726e-07-0.4253imageNACIN1;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RBM5;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184NAGSVA_HALLMARK_UV_RESPONSE_UP
chr5:131201088-131204246:+
TGCTEERA5ENSG00000187514.10chr2231711347:231711380:231708713:231709041:231708713:231709615-0.33639.3813e-043.6231e-06-0.4485imageNNPTMAMacrophages_M2GSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
ENSG00000186687.14,LYRM7
TGCTEAGIRENSG00000196405.8chr14100137739:100137802:100138847:100138897-0.16052.5971e-023.6148e-06-0.4424imageNACIN1;ADAR;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM27;RBM5;RNF219;SAFB2;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184NAGSVA_HALLMARK_HEDGEHOG_SIGNALING
chr5:131201088-131204246:+
TGCTEERIRENSG00000196405.8chr14100137739:100137802:100138847:100138897-0.16052.7694e-023.6148e-06-0.4424imageNNNAGSVA_HALLMARK_HEDGEHOG_SIGNALING
ENSG00000186687.14,LYRM7
TGCTEAGA5ENSG00000187514.10chr2231711347:231711380:231708713:231709041:231708713:231709615-0.33637.2091e-043.6231e-06-0.4485imageNACIN1;ADAR;AUH;BUD13;CBX7;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM22;RBM27;RBM47;RNF219;SAFB2;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184PTMAMacrophages_M2GSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
ENSG00000186687.14,LYRM7
TGCTEAGESENSG00000160097.11chr132862267:32863776:32864438:32864483:32864663:328647170.22144.0225e-028.9056e-050.4098imageNCNBP;DDX54;DGCR8;DKC1;FBL;FUS;HNRNPA2B1;LIN28A;MOV10;NOP58;PRPF8;TAF15;TARDBP;ZNF184NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr5:131201088-131204246:+
TGCTEERESENSG00000160097.11chr132862267:32863776:32864438:32864483:32864663:328647170.22144.2500e-028.9056e-050.4098imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN

More results



Top

5. Enriched editing regions and immune infiltration for LYRM7


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr5:131201088-131204246:+ACCEERT_cells_CD4_memory_resting2.9160e-03-0.3635image
ENSG00000186687.14,LYRM7ACCEAGT_cells_CD4_memory_resting2.9160e-03-0.3635image
chr5:131201088-131204246:+BLCAEERT_cells_CD4_memory_activated8.3111e-040.2092image
ENSG00000186687.14,LYRM7BLCAEAGT_cells_CD4_memory_activated8.2207e-040.2094image
chr5:131201088-131204246:+BRCAEERT_cells_CD4_memory_activated4.2794e-040.1121image
ENSG00000186687.14,LYRM7BRCAEAGT_cells_CD4_memory_activated4.2694e-040.1122image
ENSG00000186687.14,LYRM7CHOLEAGMacrophages_M21.3448e-03-0.6053image
chr5:131201088-131204246:+COADEERB_cells_memory9.7232e-040.2116image
ENSG00000186687.14,LYRM7COADEAGB_cells_memory9.7232e-040.2116image
ENSG00000186687.14,LYRM7DLBCEAGEosinophils1.3713e-020.4072image
chr5:131201088-131204246:+ESCAEERMacrophages_M23.3795e-040.2799image
ENSG00000186687.14,LYRM7ESCAEAGMacrophages_M23.3741e-040.2799image
chr5:131201088-131204246:+GBMEERMacrophages_M02.2084e-03-0.2367image
ENSG00000186687.14,LYRM7GBMEAGMacrophages_M02.2028e-03-0.2367image
chr5:131201088-131204246:+HNSCEERMacrophages_M11.3038e-030.1679image
ENSG00000186687.14,LYRM7HNSCEAGMacrophages_M11.3038e-030.1679image
chr5:131201088-131204246:+KICHEERT_cells_CD4_memory_activated1.5831e-030.3870image
ENSG00000186687.14,LYRM7KICHEAGT_cells_CD4_memory_activated1.6028e-030.3866image
chr5:131201088-131204246:+KIRCEERMast_cells_resting5.0850e-04-0.1791image
ENSG00000186687.14,LYRM7KIRCEAGMast_cells_resting5.7087e-04-0.1773image
chr5:131201088-131204246:+KIRPEERT_cells_CD83.8631e-020.1453image
ENSG00000186687.14,LYRM7KIRPEAGT_cells_CD83.8631e-020.1453image
chr5:131201088-131204246:+LAMLEERB_cells_memory1.1423e-02-0.2140image
ENSG00000186687.14,LYRM7LAMLEAGB_cells_memory1.0738e-02-0.2158image
chr5:131201088-131204246:+LGGEERMacrophages_M12.0254e-050.1848image
ENSG00000186687.14,LYRM7LGGEAGMacrophages_M12.1887e-050.1841image
chr5:131201088-131204246:+LIHCEERB_cells_naive1.4805e-020.1487image
ENSG00000186687.14,LYRM7LIHCEAGB_cells_naive1.4120e-020.1498image
chr5:131201088-131204246:+LUADEERT_cells_regulatory_(Tregs)4.7656e-020.1010image
ENSG00000186687.14,LYRM7LUADEAGT_cells_regulatory_(Tregs)4.7379e-020.1011image
chr5:131201088-131204246:+MESOEERT_cells_follicular_helper3.8085e-020.2641image
ENSG00000186687.14,LYRM7MESOEAGT_cells_follicular_helper3.8085e-020.2641image
chr5:131201088-131204246:+OVEERT_cells_CD89.3308e-040.1978image
ENSG00000186687.14,LYRM7OVEAGT_cells_CD89.3448e-040.1978image
chr5:131201088-131204246:+PCPGEERMacrophages_M13.8214e-030.2227image
ENSG00000186687.14,LYRM7PCPGEAGMacrophages_M13.8117e-030.2228image
chr5:131201088-131204246:+PRADEERT_cells_gamma_delta4.9355e-030.1325image
ENSG00000186687.14,LYRM7PRADEAGT_cells_gamma_delta4.8823e-030.1326image
chr5:131201088-131204246:+SARCEERT_cells_CD4_memory_activated2.1108e-040.2436image
ENSG00000186687.14,LYRM7SARCEAGT_cells_CD4_memory_activated1.7739e-040.2464image
chr5:131201088-131204246:+SKCMEERT_cells_CD82.0060e-030.1574image
ENSG00000186687.14,LYRM7SKCMEAGT_cells_CD82.0095e-030.1574image
chr5:131201088-131204246:+STADEERT_cells_CD84.8029e-030.1496image
ENSG00000186687.14,LYRM7STADEAGT_cells_CD81.0104e-020.1366image
chr5:131201088-131204246:+TGCTEERT_cells_gamma_delta8.7262e-030.2425image
ENSG00000186687.14,LYRM7TGCTEAGT_cells_gamma_delta8.7262e-030.2425image
chr5:131201088-131204246:+THCAEERT_cells_CD4_memory_activated1.7347e-040.1733image
ENSG00000186687.14,LYRM7THCAEAGT_cells_CD4_memory_activated1.4133e-040.1754image
chr5:131201088-131204246:+THYMEERT_cells_regulatory_(Tregs)8.5861e-05-0.3704image
ENSG00000186687.14,LYRM7THYMEAGT_cells_regulatory_(Tregs)8.5861e-05-0.3704image
chr5:131201088-131204246:+UCECEERDendritic_cells_activated8.0686e-050.3622image
ENSG00000186687.14,LYRM7UCECEAGDendritic_cells_activated9.5193e-050.3588image
chr5:131201088-131204246:+UVMEERDendritic_cells_resting3.8612e-040.5530image
ENSG00000186687.14,LYRM7UVMEAGDendritic_cells_resting3.8612e-040.5530image


Top

6. Enriched editing regions and immune gene sets for LYRM7


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000186687.14,LYRM7BLCAEAG1.8729e-020.14808.3947e-030.16571.5700e-020.15204.8302e-020.1245image
chr5:131201088-131204246:+BLCAEER1.8591e-020.14828.2792e-030.16601.5371e-020.15254.8061e-020.1247image
ENSG00000186687.14,LYRM7BRCAEAG7.5906e-070.15702.5180e-030.09634.2124e-040.11238.7276e-050.1248image
chr5:131201088-131204246:+BRCAEER7.6063e-070.15702.5236e-030.09624.2359e-040.11228.8020e-050.1247image
ENSG00000186687.14,LYRM7HNSCEAG2.2763e-020.11941.5727e-02-0.12655.4150e-030.14556.8370e-050.2072image
chr5:131201088-131204246:+HNSCEER2.2763e-020.11941.5727e-02-0.12655.4150e-030.14556.8370e-050.2072image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr5:131201088-131204246:+ACCGSVA_HALLMARK_UV_RESPONSE_UPEER3.7343e-020.2588image
ENSG00000186687.14,LYRM7ACCGSVA_HALLMARK_UV_RESPONSE_UPEAG3.7343e-020.2588image
chr5:131201088-131204246:+BLCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER6.6934e-050.2484image
ENSG00000186687.14,LYRM7BLCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.5046e-050.2488image
ENSG00000186687.14,LYRM7BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.6898e-120.2182image
chr5:131201088-131204246:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.8785e-120.2180image
ENSG00000186687.14,LYRM7CHOLGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8656e-03-0.5910image
ENSG00000186687.14,LYRM7COADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG7.0800e-030.1734image
chr5:131201088-131204246:+COADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER7.0800e-030.1734image
ENSG00000186687.14,LYRM7DLBCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.4321e-030.4897image
chr5:131201088-131204246:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.5142e-030.2234image
ENSG00000186687.14,LYRM7ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.1746e-030.2319image
chr5:131201088-131204246:+GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER6.2111e-060.3436image
ENSG00000186687.14,LYRM7GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG6.3522e-060.3433image
ENSG00000186687.14,LYRM7HNSCGSVA_HALLMARK_P53_PATHWAYEAG2.3469e-060.2445image
chr5:131201088-131204246:+HNSCGSVA_HALLMARK_P53_PATHWAYEER2.3469e-060.2445image
ENSG00000186687.14,LYRM7KICHGSVA_HALLMARK_ANDROGEN_RESPONSEEAG9.9094e-04-0.4020image
chr5:131201088-131204246:+KICHGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.1482e-03-0.3974image
ENSG00000186687.14,LYRM7KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.0055e-060.2388image
chr5:131201088-131204246:+KIRCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.5490e-060.2374image
chr5:131201088-131204246:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER4.1873e-03-0.2002image
ENSG00000186687.14,LYRM7KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.1873e-03-0.2002image
chr5:131201088-131204246:+LAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.8430e-040.2921image
ENSG00000186687.14,LYRM7LAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.5506e-040.2934image
chr5:131201088-131204246:+LGGGSVA_HALLMARK_MYOGENESISEER3.1399e-150.3350image
ENSG00000186687.14,LYRM7LGGGSVA_HALLMARK_MYOGENESISEAG3.3362e-150.3346image
ENSG00000186687.14,LYRM7LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.9769e-020.1423image
chr5:131201088-131204246:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.9648e-020.1424image
chr5:131201088-131204246:+LUADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER7.0342e-030.1372image
ENSG00000186687.14,LYRM7LUADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG7.0074e-030.1372image
chr5:131201088-131204246:+LUSCGSVA_HALLMARK_UV_RESPONSE_UPEER2.6114e-020.1104image
ENSG00000186687.14,LYRM7LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.6153e-020.1104image
chr5:131201088-131204246:+MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER3.9905e-030.3606image
ENSG00000186687.14,LYRM7MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG3.9905e-030.3606image
ENSG00000186687.14,LYRM7OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.5264e-040.2132image
chr5:131201088-131204246:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.6303e-040.2127image
ENSG00000186687.14,LYRM7PAADGSVA_HALLMARK_P53_PATHWAYEAG8.7429e-040.3075image
chr5:131201088-131204246:+PAADGSVA_HALLMARK_P53_PATHWAYEER8.7429e-040.3075image
ENSG00000186687.14,LYRM7PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6759e-060.3607image
chr5:131201088-131204246:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6554e-060.3609image
chr5:131201088-131204246:+PRADGSVA_HALLMARK_UV_RESPONSE_UPEER5.4368e-030.1310image
ENSG00000186687.14,LYRM7PRADGSVA_HALLMARK_UV_RESPONSE_UPEAG5.3875e-030.1311image
chr5:131201088-131204246:+SARCGSVA_HALLMARK_APOPTOSISEER2.4363e-050.2762image
ENSG00000186687.14,LYRM7SARCGSVA_HALLMARK_APOPTOSISEAG2.1200e-050.2782image
ENSG00000186687.14,LYRM7SKCMGSVA_HALLMARK_UV_RESPONSE_UPEAG6.5903e-080.2717image
chr5:131201088-131204246:+SKCMGSVA_HALLMARK_UV_RESPONSE_UPEER6.5825e-080.2717image
chr5:131201088-131204246:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.1772e-040.1771image
ENSG00000186687.14,LYRM7STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.0996e-040.1791image
ENSG00000186687.14,LYRM7THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG4.4571e-130.3270image
chr5:131201088-131204246:+THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER3.9731e-130.3280image
ENSG00000186687.14,LYRM7THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.2639e-050.3739image
chr5:131201088-131204246:+THYMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.2639e-050.3739image
ENSG00000186687.14,LYRM7UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.2938e-040.3132image
chr5:131201088-131204246:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.5598e-040.3066image
ENSG00000186687.14,LYRM7UCSGSVA_HALLMARK_P53_PATHWAYEAG4.9226e-040.5144image
chr5:131201088-131204246:+UCSGSVA_HALLMARK_P53_PATHWAYEER4.9056e-040.5145image


Top

7. Enriched editing regions and drugs for LYRM7


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr5:131201088-131204246:+ACCBIBW2992EER3.2420e-02-0.2657image
ENSG00000186687.14,LYRM7ACCBIBW2992EAG3.2420e-02-0.2657image
chr5:131201088-131204246:+BLCAKIN001.135EER8.4921e-04-0.2089image
ENSG00000186687.14,LYRM7BLCAKIN001.135EAG8.7709e-04-0.2083image
ENSG00000186687.14,LYRM7BRCACGP.082996EAG5.6207e-06-0.1442image
chr5:131201088-131204246:+BRCACGP.082996EER5.6265e-06-0.1442image
ENSG00000186687.14,LYRM7CESCBI.2536EAG9.1848e-030.1729image
chr5:131201088-131204246:+CESCBI.2536EER9.1096e-030.1731image
ENSG00000186687.14,LYRM7CHOLCamptothecinEAG2.3939e-03-0.5796image
ENSG00000186687.14,LYRM7COADJNK.9LEAG2.3578e-040.2352image
chr5:131201088-131204246:+COADJNK.9LEER2.3578e-040.2352image
ENSG00000186687.14,LYRM7DLBCBexaroteneEAG6.7601e-03-0.4434image
ENSG00000186687.14,LYRM7ESCACGP.60474EAG2.7995e-04-0.2835image
chr5:131201088-131204246:+ESCACGP.60474EER3.3851e-04-0.2798image
ENSG00000186687.14,LYRM7GBMCGP.082996EAG1.2296e-09-0.4508image
chr5:131201088-131204246:+GBMCGP.082996EER1.2310e-09-0.4508image
chr5:131201088-131204246:+HNSCEHT.1864EER4.3349e-060.2382image
ENSG00000186687.14,LYRM7HNSCEHT.1864EAG4.3349e-060.2382image
chr5:131201088-131204246:+KICHAZD.2281EER4.3740e-08-0.6210image
ENSG00000186687.14,LYRM7KICHAZD.2281EAG4.2274e-08-0.6216image
chr5:131201088-131204246:+KIRCBMS.509744EER2.2309e-07-0.2643image
ENSG00000186687.14,LYRM7KIRCBMS.536924EAG1.4061e-06-0.2474image
chr5:131201088-131204246:+KIRPBMS.708163EER2.9408e-040.2516image
ENSG00000186687.14,LYRM7KIRPBMS.708163EAG2.9408e-040.2516image
ENSG00000186687.14,LYRM7LAMLDasatinibEAG3.5541e-06-0.3817image
chr5:131201088-131204246:+LAMLDasatinibEER4.2724e-06-0.3788image
ENSG00000186687.14,LYRM7LGGBexaroteneEAG1.7273e-15-0.3379image
chr5:131201088-131204246:+LGGBexaroteneEER1.8164e-15-0.3377image
chr5:131201088-131204246:+LIHCBexaroteneEER3.8175e-040.2154image
ENSG00000186687.14,LYRM7LIHCBexaroteneEAG3.5433e-040.2166image
chr5:131201088-131204246:+LUADAxitinibEER2.4570e-020.1146image
ENSG00000186687.14,LYRM7LUADAxitinibEAG2.4879e-020.1143image
ENSG00000186687.14,LYRM7LUSCGNF.2EAG1.2462e-02-0.1239image
chr5:131201088-131204246:+LUSCGNF.2EER1.2428e-02-0.1240image
chr5:131201088-131204246:+MESOCHIR.99021EER1.5333e-03-0.3940image
ENSG00000186687.14,LYRM7MESOCHIR.99021EAG1.5333e-03-0.3940image
chr5:131201088-131204246:+OVEmbelinEER3.8880e-060.2734image
ENSG00000186687.14,LYRM7OVEmbelinEAG7.1330e-060.2661image
chr5:131201088-131204246:+PAADATRAEER3.5491e-030.2733image
ENSG00000186687.14,LYRM7PAADATRAEAG3.5491e-030.2733image
ENSG00000186687.14,LYRM7PCPGAxitinibEAG5.5764e-040.2643image
chr5:131201088-131204246:+PCPGAxitinibEER5.4771e-040.2647image
ENSG00000186687.14,LYRM7PRADMethotrexateEAG8.5593e-04-0.1572image
chr5:131201088-131204246:+PRADMethotrexateEER8.6305e-04-0.1571image
chr5:131201088-131204246:+READAZD8055EER3.3176e-030.3064image
ENSG00000186687.14,LYRM7READAZD8055EAG3.3176e-030.3064image
ENSG00000186687.14,LYRM7SARCErlotinibEAG1.9509e-030.2046image
chr5:131201088-131204246:+SARCErlotinibEER1.9955e-030.2041image
chr5:131201088-131204246:+SKCMGNF.2EER1.3282e-06-0.2441image
ENSG00000186687.14,LYRM7SKCMGNF.2EAG1.3285e-06-0.2441image
chr5:131201088-131204246:+STADAZD6244EER4.1982e-03-0.1518image
ENSG00000186687.14,LYRM7STADAZD6244EAG4.4005e-03-0.1510image
ENSG00000186687.14,LYRM7TGCTGefitinibEAG1.2329e-02-0.2317image
chr5:131201088-131204246:+TGCTGefitinibEER1.2329e-02-0.2317image
ENSG00000186687.14,LYRM7THCAKU.55933EAG3.6422e-13-0.3285image
chr5:131201088-131204246:+THCAKU.55933EER1.5571e-13-0.3337image
chr5:131201088-131204246:+THYMBleomycinEER6.0618e-050.3777image
ENSG00000186687.14,LYRM7THYMBleomycinEAG6.0618e-050.3777image
chr5:131201088-131204246:+UCECAMG.706EER1.4969e-030.2953image
ENSG00000186687.14,LYRM7UCECAxitinibEAG1.2079e-030.3008image
chr5:131201088-131204246:+UCSATRAEER4.5120e-040.5173image
ENSG00000186687.14,LYRM7UCSATRAEAG4.4759e-040.5176image
ENSG00000186687.14,LYRM7UVMBexaroteneEAG2.5494e-02-0.3669image
chr5:131201088-131204246:+UVMBexaroteneEER2.5494e-02-0.3669image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType