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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZSWIM1 (ImmuneEditome ID:90204)

1. Gene summary of enriched editing regions for ZSWIM1

check button Gene summary
Gene informationGene symbol

ZSWIM1

Gene ID

90204

GeneSynonymsC20orf162
GeneCytomap

20q13.12

GeneTypeprotein-coding
GeneDescriptionzinc finger SWIM domain-containing protein 1|zinc finger, SWIM domain containing 1
GeneModificationdate20230517
UniprotIDQ9BR11
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:45884443-45885010:+ENST00000372520.1ENSG00000168612.4ZSWIM1UTR3AluSx1,AluYchr20:45884443-45885010:+.alignment
chr20:45884443-45885010:+ENST00000372523.1ENSG00000168612.4ZSWIM1UTR3AluSx1,AluYchr20:45884443-45885010:+.alignment


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2. Tumor-specific enriched editing regions for ZSWIM1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr20:45884443-45885010:+COADEER9.4061e-03image
ENSG00000168612.4,ZSWIM1COADEAG9.4061e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000168612.4,ZSWIM1KIRCPathEAG4.9155e-025.5928e-03-0.1371image
chr20:45884443-45885010:+KIRCPathEER4.9155e-025.5928e-03-0.1371image
chr20:45884443-45885010:+UCECCliEER4.8037e-024.8968e-03-0.1296image
ENSG00000168612.4,ZSWIM1UCECCliEAG4.9025e-025.0227e-03-0.1292image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr20:45884443-45885010:+CESCEER3.7563e-024.6977e-021.0148e-01image
ENSG00000168612.4,ZSWIM1CESCEAG3.7563e-024.6977e-021.0148e-01image

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3. Enriched editing regions and immune related genes for ZSWIM1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr20:45884443-45885010:+GBMEERENSG00000168612,ZSWIM1-0.50267.0631e-074.3559e-09-0.4510imageNDDX54;IGF2BP2;NOP56NAMonocytesGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr20:45884443-45885010:+KICHEERENSG00000161955,TNFSF130.56333.0189e-028.6092e-050.4813imageNIGF2BP2TNFSF13MonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr20:45884443-45885010:+UCECEERENSG00000120690,ELF10.39352.5337e-042.1768e-090.4330imageNDDX54;IGF2BP2;NOP56ELF1T_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr20:45884443-45885010:+UCECEERENSG00000198833,UBE2J10.39202.5896e-043.0204e-080.4037imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000012660,ELOVL50.37705.5148e-042.5649e-080.4056imageNDDX54;IGF2BP2;NOP56NAMacrophages_M2GSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000139517,LNX20.35661.4772e-033.7389e-090.4272imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr20:45884443-45885010:+UCECEERENSG00000133103,COG60.34122.5469e-032.0971e-080.4080imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr20:45884443-45885010:+UCECEERENSG00000112379,KIAA12440.33442.8140e-031.0883e-080.4154imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000123983,ACSL30.33143.6824e-032.5185e-090.4314imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000150961,SEC24D0.31755.8176e-031.0767e-080.4155imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr20:45884443-45885010:+GBMEERENSG00000168612,ZSWIM1-0.50267.0631e-074.3559e-09-0.4510imageNDDX54;IGF2BP2;NOP56NAMonocytesGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr20:45884443-45885010:+KICHEERENSG00000161955,TNFSF130.56333.0189e-028.6092e-050.4813imageNIGF2BP2TNFSF13MonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr20:45884443-45885010:+UCECEERENSG00000120690,ELF10.39352.5337e-042.1768e-090.4330imageNDDX54;IGF2BP2;NOP56ELF1T_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
chr20:45884443-45885010:+UCECEERENSG00000198833,UBE2J10.39202.5896e-043.0204e-080.4037imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000012660,ELOVL50.37705.5148e-042.5649e-080.4056imageNDDX54;IGF2BP2;NOP56NAMacrophages_M2GSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000139517,LNX20.35661.4772e-033.7389e-090.4272imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr20:45884443-45885010:+UCECEERENSG00000133103,COG60.34122.5469e-032.0971e-080.4080imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr20:45884443-45885010:+UCECEERENSG00000112379,KIAA12440.33442.8140e-031.0883e-080.4154imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000123983,ACSL30.33143.6824e-032.5185e-090.4314imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr20:45884443-45885010:+UCECEERENSG00000150961,SEC24D0.31755.8176e-031.0767e-080.4155imageNDDX54;IGF2BP2;NOP56NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

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4. Enriched editing regions and immune related splicing for ZSWIM1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000168612.4,ZSWIM1
DLBCEAGA3ENSG00000137161.12chr642935419:42935473:42935573:42935670:42935536:42935670-0.60584.6301e-026.5471e-04-0.4840imageNADAR;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBM10;RBM27;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YWHAGCNPY3
chr20:45884443-45885010:+
ESCAEERIRENSG00000132530.12chr176758088:6758263:6758553:6758577-0.22791.3118e-021.1682e-06-0.4318imageNIGF2BP2XAF1Macrophages_M1GSVA_HALLMARK_APICAL_SURFACE
ENSG00000168612.4,ZSWIM1
ESCAEAGIRENSG00000078369.13chr11852480:1852680:1853151:1853297-0.29633.1746e-021.6504e-05-0.4069imageNADAR;AUH;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBM10;RBM27;RNF219;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YWHAG;ZNF184NANK_cells_restingGSVA_HALLMARK_HEME_METABOLISM
chr20:45884443-45885010:+
ESCAEERIRENSG00000164896.15chr7151076623:151077027:151077100:151077155-0.36681.3769e-025.2330e-07-0.4011imageNDDX54;IGF2BP2;NOP56FASTKB_cells_naiveGSVA_HALLMARK_HYPOXIA
ENSG00000168612.4,ZSWIM1
ESCAEAGIRENSG00000132530.12chr176758088:6758263:6758553:6758577-0.22801.5540e-021.1711e-06-0.4318imageNADAR;CSTF2T;EIF4A3;ELAVL1;EWSR1;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP2;MSI2;PRPF8;PTBP1;SRSF1;TAF15;TIA1;TROVE2;U2AF1;U2AF2XAF1Macrophages_M1GSVA_HALLMARK_APICAL_SURFACE
chr20:45884443-45885010:+
ESCAEERIRENSG00000078369.13chr11852480:1852680:1853151:1853297-0.29592.6893e-021.6695e-05-0.4067imageNDDX54;IGF2BP2;NOP56NANK_cells_restingGSVA_HALLMARK_HEME_METABOLISM
ENSG00000168612.4,ZSWIM1
ESCAEAGIRENSG00000164896.15chr7151076623:151077027:151077100:151077155-0.36661.6562e-025.3224e-07-0.4009imageNAUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBM10;RBM27;RNF219;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;YWHAG;ZNF184FASTKB_cells_naiveGSVA_HALLMARK_HYPOXIA
chr20:45884443-45885010:+
GBMEERIRENSG00000109083.9chr1728328886:28329276:28330110:28330228-0.35689.8351e-042.5794e-06-0.4033imageNDDX54;IGF2BP2;NOP56IFT20NK_cells_restingGSVA_HALLMARK_ADIPOGENESIS
ENSG00000168612.4,ZSWIM1
GBMEAGIRENSG00000109083.9chr1728328886:28329276:28330110:28330228-0.35681.1206e-032.5794e-06-0.4033imageNADAR;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBM10;RBM27;RNF219;SAFB2;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184IFT20NK_cells_restingGSVA_HALLMARK_ADIPOGENESIS
chr20:45884443-45885010:+
THYMEERIRENSG00000064601.12chr2045890143:45892323:45892397:45892454-0.61072.1170e-086.8140e-12-0.5999imageNDDX54;IGF2BP2;NOP56CTSAMacrophages_M1GSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for ZSWIM1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr20:45884443-45885010:+ACCEERT_cells_CD4_memory_resting5.3273e-03-0.3126image
ENSG00000168612.4,ZSWIM1ACCEAGT_cells_CD4_memory_resting5.3273e-03-0.3126image
chr20:45884443-45885010:+BLCAEERDendritic_cells_resting3.3111e-02-0.1082image
ENSG00000168612.4,ZSWIM1BLCAEAGDendritic_cells_resting3.4122e-02-0.1076image
chr20:45884443-45885010:+BRCAEERT_cells_follicular_helper8.4227e-03-0.0834image
ENSG00000168612.4,ZSWIM1BRCAEAGT_cells_follicular_helper8.4129e-03-0.0834image
chr20:45884443-45885010:+COADEERMacrophages_M23.0266e-020.1393image
ENSG00000168612.4,ZSWIM1COADEAGMacrophages_M23.0266e-020.1393image
chr20:45884443-45885010:+DLBCEERT_cells_follicular_helper2.6867e-02-0.3263image
ENSG00000168612.4,ZSWIM1DLBCEAGT_cells_follicular_helper2.6867e-02-0.3263image
chr20:45884443-45885010:+HNSCEERMacrophages_M02.6956e-020.1074image
ENSG00000168612.4,ZSWIM1HNSCEAGMacrophages_M02.6956e-020.1074image
chr20:45884443-45885010:+KICHEERMonocytes2.4421e-030.3811image
ENSG00000168612.4,ZSWIM1KICHEAGMonocytes2.4421e-030.3811image
chr20:45884443-45885010:+KIRCEERT_cells_regulatory_(Tregs)1.4985e-03-0.1837image
ENSG00000168612.4,ZSWIM1KIRCEAGT_cells_regulatory_(Tregs)1.4985e-03-0.1837image
chr20:45884443-45885010:+KIRPEERMacrophages_M23.0819e-020.1324image
ENSG00000168612.4,ZSWIM1KIRPEAGMacrophages_M22.9911e-020.1332image
chr20:45884443-45885010:+LGGEERNeutrophils3.9646e-02-0.0923image
ENSG00000168612.4,ZSWIM1LGGEAGNeutrophils4.0121e-02-0.0921image
chr20:45884443-45885010:+LIHCEERT_cells_gamma_delta4.4624e-020.1266image
ENSG00000168612.4,ZSWIM1LIHCEAGT_cells_gamma_delta4.4411e-020.1268image
chr20:45884443-45885010:+LUADEERNK_cells_activated1.4984e-02-0.1205image
ENSG00000168612.4,ZSWIM1LUADEAGNK_cells_activated1.5016e-02-0.1205image
chr20:45884443-45885010:+MESOEERT_cells_CD4_naive9.1589e-040.3727image
ENSG00000168612.4,ZSWIM1MESOEAGT_cells_CD4_naive9.1589e-040.3727image
chr20:45884443-45885010:+OVEERNeutrophils8.1691e-040.1979image
ENSG00000168612.4,ZSWIM1OVEAGNeutrophils7.0281e-040.1999image
chr20:45884443-45885010:+PCPGEERNeutrophils1.1733e-020.1946image
ENSG00000168612.4,ZSWIM1PCPGEAGNeutrophils1.1733e-020.1946image
chr20:45884443-45885010:+PRADEERT_cells_CD4_memory_activated1.2639e-02-0.1140image
ENSG00000168612.4,ZSWIM1PRADEAGT_cells_CD4_memory_activated1.2680e-02-0.1139image
chr20:45884443-45885010:+READEERNK_cells_activated2.1116e-02-0.2470image
ENSG00000168612.4,ZSWIM1READEAGNK_cells_activated2.1116e-02-0.2470image
chr20:45884443-45885010:+SARCEERT_cells_CD4_naive3.8428e-020.1335image
ENSG00000168612.4,ZSWIM1SARCEAGT_cells_CD4_naive3.6814e-020.1346image
chr20:45884443-45885010:+STADEERT_cells_CD4_memory_activated1.9090e-020.1405image
ENSG00000168612.4,ZSWIM1STADEAGT_cells_CD4_memory_activated1.9025e-020.1406image
chr20:45884443-45885010:+TGCTEERMacrophages_M22.6755e-02-0.1791image
ENSG00000168612.4,ZSWIM1TGCTEAGMacrophages_M22.8074e-02-0.1776image
chr20:45884443-45885010:+THYMEERNK_cells_activated1.2862e-040.3481image
ENSG00000168612.4,ZSWIM1THYMEAGNK_cells_activated1.2862e-040.3481image
chr20:45884443-45885010:+UCECEERT_cells_follicular_helper3.3226e-020.1611image
ENSG00000168612.4,ZSWIM1UCECEAGT_cells_follicular_helper3.3036e-020.1612image
chr20:45884443-45885010:+UCSEERMast_cells_resting1.4073e-020.3264image
ENSG00000168612.4,ZSWIM1UCSEAGMast_cells_resting1.4073e-020.3264image


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6. Enriched editing regions and immune gene sets for ZSWIM1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr20:45884443-45885010:+OVEER1.6531e-040.22214.0945e-020.12161.6003e-020.14316.7783e-040.2008image
ENSG00000168612.4,ZSWIM1OVEAG2.6848e-040.21462.8604e-020.12991.3434e-020.14654.4218e-040.2071image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr20:45884443-45885010:+ACCGSVA_HALLMARK_NOTCH_SIGNALINGEER3.0498e-02-0.2452image
ENSG00000168612.4,ZSWIM1ACCGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.0498e-02-0.2452image
ENSG00000168612.4,ZSWIM1BLCAGSVA_HALLMARK_UV_RESPONSE_DNEAG1.2659e-030.1631image
chr20:45884443-45885010:+BLCAGSVA_HALLMARK_UV_RESPONSE_DNEER1.2274e-030.1635image
ENSG00000168612.4,ZSWIM1BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.6260e-020.0761image
chr20:45884443-45885010:+BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.6250e-020.0761image
ENSG00000168612.4,ZSWIM1CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.7236e-050.2409image
chr20:45884443-45885010:+CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.7236e-050.2409image
ENSG00000168612.4,ZSWIM1CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.6744e-030.4562image
chr20:45884443-45885010:+CHOLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.6744e-030.4562image
ENSG00000168612.4,ZSWIM1COADGSVA_HALLMARK_P53_PATHWAYEAG1.5088e-020.1561image
chr20:45884443-45885010:+COADGSVA_HALLMARK_P53_PATHWAYEER1.5088e-020.1561image
ENSG00000168612.4,ZSWIM1ESCAGSVA_HALLMARK_HYPOXIAEAG8.3086e-050.3198image
chr20:45884443-45885010:+ESCAGSVA_HALLMARK_HYPOXIAEER8.4280e-050.3196image
ENSG00000168612.4,ZSWIM1GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.7351e-030.2504image
chr20:45884443-45885010:+GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER1.7351e-030.2504image
ENSG00000168612.4,ZSWIM1KICHGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.2823e-020.2737image
chr20:45884443-45885010:+KICHGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.2823e-020.2737image
ENSG00000168612.4,ZSWIM1KIRCGSVA_HALLMARK_HEME_METABOLISMEAG1.6773e-040.2170image
chr20:45884443-45885010:+KIRCGSVA_HALLMARK_HEME_METABOLISMEER1.6773e-040.2170image
chr20:45884443-45885010:+KIRPGSVA_HALLMARK_ANDROGEN_RESPONSEEER7.5958e-070.2977image
ENSG00000168612.4,ZSWIM1KIRPGSVA_HALLMARK_ANDROGEN_RESPONSEEAG7.8241e-070.2974image
chr20:45884443-45885010:+LGGGSVA_HALLMARK_MYC_TARGETS_V2EER5.1487e-03-0.1253image
ENSG00000168612.4,ZSWIM1LGGGSVA_HALLMARK_MYC_TARGETS_V2EAG4.9901e-03-0.1258image
chr20:45884443-45885010:+LIHCGSVA_HALLMARK_MYC_TARGETS_V2EER1.4934e-02-0.1532image
ENSG00000168612.4,ZSWIM1LIHCGSVA_HALLMARK_MYC_TARGETS_V2EAG1.4784e-02-0.1534image
ENSG00000168612.4,ZSWIM1LUADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.5879e-030.1561image
chr20:45884443-45885010:+LUADGSVA_HALLMARK_UV_RESPONSE_DNEER1.5554e-030.1564image
ENSG00000168612.4,ZSWIM1LUSCGSVA_HALLMARK_MYC_TARGETS_V2EAG3.3278e-02-0.1056image
chr20:45884443-45885010:+LUSCGSVA_HALLMARK_MYC_TARGETS_V2EER3.3257e-02-0.1056image
ENSG00000168612.4,ZSWIM1MESOGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.9325e-020.2678image
chr20:45884443-45885010:+MESOGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.9325e-020.2678image
ENSG00000168612.4,ZSWIM1OVGSVA_HALLMARK_MTORC1_SIGNALINGEAG3.2283e-050.2440image
chr20:45884443-45885010:+OVGSVA_HALLMARK_MTORC1_SIGNALINGEER3.1233e-050.2448image
ENSG00000168612.4,ZSWIM1PAADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.4267e-040.2738image
chr20:45884443-45885010:+PAADGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.4267e-040.2738image
ENSG00000168612.4,ZSWIM1PCPGGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.3306e-030.2464image
chr20:45884443-45885010:+PCPGGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.3306e-030.2464image
chr20:45884443-45885010:+PRADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.6000e-020.0959image
ENSG00000168612.4,ZSWIM1PRADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.5785e-020.0960image
ENSG00000168612.4,ZSWIM1READGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.4194e-020.2416image
chr20:45884443-45885010:+READGSVA_HALLMARK_MITOTIC_SPINDLEEER2.4194e-020.2416image
chr20:45884443-45885010:+SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.1997e-020.1475image
ENSG00000168612.4,ZSWIM1SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.2406e-020.1470image
chr20:45884443-45885010:+SKCMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.0178e-02-0.1234image
ENSG00000168612.4,ZSWIM1SKCMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.0178e-02-0.1234image
chr20:45884443-45885010:+STADGSVA_HALLMARK_P53_PATHWAYEER6.0543e-110.3793image
ENSG00000168612.4,ZSWIM1STADGSVA_HALLMARK_P53_PATHWAYEAG6.1211e-110.3792image
chr20:45884443-45885010:+TGCTGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.9565e-02-0.1886image
ENSG00000168612.4,ZSWIM1TGCTGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.9548e-02-0.1886image
ENSG00000168612.4,ZSWIM1THCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.2418e-050.2018image
chr20:45884443-45885010:+THCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.2418e-050.2018image
ENSG00000168612.4,ZSWIM1THYMGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG6.4424e-040.3122image
chr20:45884443-45885010:+THYMGSVA_HALLMARK_TGF_BETA_SIGNALINGEER6.4424e-040.3122image
chr20:45884443-45885010:+UCECGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.3181e-080.4132image
ENSG00000168612.4,ZSWIM1UCECGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.2448e-080.4139image
chr20:45884443-45885010:+UCSGSVA_HALLMARK_MYOGENESISEER2.5400e-02-0.2986image
ENSG00000168612.4,ZSWIM1UCSGSVA_HALLMARK_MYOGENESISEAG2.5400e-02-0.2986image
ENSG00000168612.4,ZSWIM1UVMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG7.7693e-030.3051image
chr20:45884443-45885010:+UVMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER7.7693e-030.3051image


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7. Enriched editing regions and drugs for ZSWIM1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000168612.4,ZSWIM1ACCBAY.61.3606EAG4.6038e-030.3176image
chr20:45884443-45885010:+ACCBAY.61.3606EER4.6038e-030.3176image
ENSG00000168612.4,ZSWIM1BLCABX.795EAG3.2495e-03-0.1491image
chr20:45884443-45885010:+BLCABX.795EER3.1559e-03-0.1495image
chr20:45884443-45885010:+BRCAErlotinibEER1.8985e-030.0983image
ENSG00000168612.4,ZSWIM1BRCAErlotinibEAG1.8979e-030.0983image
chr20:45884443-45885010:+CESCFTI.277EER1.2635e-02-0.1446image
ENSG00000168612.4,ZSWIM1CESCFTI.277EAG1.2635e-02-0.1446image
ENSG00000168612.4,ZSWIM1CHOLABT.263EAG1.8595e-020.4137image
chr20:45884443-45885010:+CHOLABT.263EER1.8595e-020.4137image
chr20:45884443-45885010:+COADBX.795EER2.4535e-03-0.1939image
ENSG00000168612.4,ZSWIM1COADBX.795EAG2.4535e-03-0.1939image
ENSG00000168612.4,ZSWIM1DLBCElesclomolEAG9.9673e-030.3762image
chr20:45884443-45885010:+DLBCElesclomolEER9.9673e-030.3762image
chr20:45884443-45885010:+ESCAEHT.1864EER3.0363e-040.2948image
ENSG00000168612.4,ZSWIM1ESCAEHT.1864EAG3.0544e-040.2947image
ENSG00000168612.4,ZSWIM1GBMABT.888EAG2.5287e-050.3324image
chr20:45884443-45885010:+GBMABT.888EER2.5287e-050.3324image
chr20:45884443-45885010:+HNSCEHT.1864EER1.1058e-020.1233image
ENSG00000168612.4,ZSWIM1HNSCEHT.1864EAG1.1058e-020.1233image
ENSG00000168612.4,ZSWIM1KICHKIN001.135EAG2.1274e-03-0.3859image
chr20:45884443-45885010:+KICHKIN001.135EER2.1274e-03-0.3859image
chr20:45884443-45885010:+KIRCEHT.1864EER1.3537e-02-0.1434image
ENSG00000168612.4,ZSWIM1KIRCEHT.1864EAG1.3537e-02-0.1434image
chr20:45884443-45885010:+KIRPAICAREER1.5337e-05-0.2617image
ENSG00000168612.4,ZSWIM1KIRPAICAREAG1.5943e-05-0.2612image
ENSG00000168612.4,ZSWIM1LGGAZD.0530EAG2.7251e-04-0.1626image
chr20:45884443-45885010:+LGGAZD.0530EER2.6923e-04-0.1627image
chr20:45884443-45885010:+LIHCBMS.708163EER3.6217e-02-0.1320image
ENSG00000168612.4,ZSWIM1LIHCBMS.708163EAG3.5378e-02-0.1326image
chr20:45884443-45885010:+LUADBMS.708163EER6.4648e-03-0.1348image
ENSG00000168612.4,ZSWIM1LUADBMS.708163EAG6.4110e-03-0.1349image
chr20:45884443-45885010:+LUSCDMOGEER5.8383e-03-0.1364image
ENSG00000168612.4,ZSWIM1LUSCDMOGEAG5.8295e-03-0.1364image
chr20:45884443-45885010:+MESODMOGEER3.3097e-02-0.2448image
ENSG00000168612.4,ZSWIM1MESODMOGEAG3.3097e-02-0.2448image
ENSG00000168612.4,ZSWIM1OVAUY922EAG4.4177e-07-0.2943image
chr20:45884443-45885010:+OVAUY922EER8.8438e-07-0.2873image
chr20:45884443-45885010:+PAADAKT.inhibitor.VIIIEER4.9138e-04-0.2708image
ENSG00000168612.4,ZSWIM1PAADAKT.inhibitor.VIIIEAG4.9138e-04-0.2708image
ENSG00000168612.4,ZSWIM1PCPGDMOGEAG1.1342e-02-0.1955image
chr20:45884443-45885010:+PCPGDMOGEER1.1342e-02-0.1955image
ENSG00000168612.4,ZSWIM1PRADCCT007093EAG3.5329e-04-0.1627image
chr20:45884443-45885010:+PRADCCT007093EER3.5979e-04-0.1625image
chr20:45884443-45885010:+SARCKU.55933EER1.3812e-020.1584image
ENSG00000168612.4,ZSWIM1SARCKU.55933EAG1.3960e-020.1582image
chr20:45884443-45885010:+SKCMGW843682XEER2.1357e-030.1472image
ENSG00000168612.4,ZSWIM1SKCMGW843682XEAG2.1357e-030.1472image
chr20:45884443-45885010:+STADCI.1040EER3.5696e-05-0.2452image
ENSG00000168612.4,ZSWIM1STADCI.1040EAG3.5724e-05-0.2452image
chr20:45884443-45885010:+TGCTBMS.509744EER4.3447e-040.2810image
ENSG00000168612.4,ZSWIM1TGCTBMS.509744EAG4.6752e-040.2795image
ENSG00000168612.4,ZSWIM1THCABMS.708163EAG1.8778e-04-0.1729image
chr20:45884443-45885010:+THCABMS.708163EER1.8778e-04-0.1729image
chr20:45884443-45885010:+THYMBexaroteneEER3.6367e-08-0.4843image
ENSG00000168612.4,ZSWIM1THYMBexaroteneEAG3.6367e-08-0.4843image
ENSG00000168612.4,ZSWIM1UCECGW843682XEAG9.6433e-060.3276image
chr20:45884443-45885010:+UCECGW843682XEER9.7088e-060.3275image
chr20:45884443-45885010:+UCSA.443654EER4.2209e-03-0.3766image
ENSG00000168612.4,ZSWIM1UCSA.443654EAG4.2209e-03-0.3766image
chr20:45884443-45885010:+UVMCMKEER2.1776e-020.2646image
ENSG00000168612.4,ZSWIM1UVMCMKEAG2.1776e-020.2646image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType