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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GMPS (ImmuneEditome ID:8833)

1. Gene summary of enriched editing regions for GMPS

check button Gene summary
Gene informationGene symbol

GMPS

Gene ID

8833

GeneSynonymsGATD7
GeneCytomap

3q25.31

GeneTypeprotein-coding
GeneDescriptionGMP synthase [glutamine-hydrolyzing]|GMP synthase|GMP synthetase|MLL/GMPS fusion protein|glutamine amidotransferase|guanine monophosphate synthetase|guanosine 5'-monophosphate synthase|testicular tissue protein Li 82
GeneModificationdate20230329
UniprotIDP49915
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr3:155941109-155943221:+ENST00000496455.5ENSG00000163655.14GMPSUTR3AluYk3,AluY,MER5B,AluSzchr3:155941109-155943221:+.alignment


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2. Tumor-specific enriched editing regions for GMPS


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr3:155941109-155943221:+THCAEER2.9595e-03image
ENSG00000163655.14,GMPSTHCAEAG2.9595e-03image
chr3:155941109-155943221:+UCECEER2.6145e-03image
ENSG00000163655.14,GMPSUCECEAG2.8530e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr3:155941109-155943221:+BRCAPathEER1.6198e-021.2516e-020.0763image
ENSG00000163655.14,GMPSBRCAPathEAG1.9861e-021.1957e-020.0768image
chr3:155941109-155943221:+ESCACliEER1.5249e-021.4488e-02-0.3341image
ENSG00000163655.14,GMPSESCACliEAG1.5394e-021.8047e-02-0.3237image
ENSG00000163655.14,GMPSKICHPathEAG3.4564e-027.6706e-03-0.3304image
chr3:155941109-155943221:+KICHPathEER3.4564e-027.6706e-03-0.3304image
chr3:155941109-155943221:+STADPathEER2.4858e-022.4711e-02-0.1251image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr3:155941109-155943221:+CESCEER4.3223e-023.1661e-031.5703e+02image
ENSG00000163655.14,GMPSCESCEAG4.3223e-023.1661e-031.5703e+02image

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3. Enriched editing regions and immune related genes for GMPS


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr3:155941109-155943221:+CESCEERENSG00000177700,POLR2L0.26923.5209e-047.2922e-130.4004imageNNNAMacrophages_M2GSVA_HALLMARK_MITOTIC_SPINDLE
chr3:155941109-155943221:+UCECEERENSG00000167644,C19orf330.28561.9221e-022.2084e-090.4421imageNNNAPlasma_cellsGSVA_HALLMARK_ANDROGEN_RESPONSE
chr3:155941109-155943221:+UCECEERENSG00000166289,PLEKHF10.26223.7756e-021.0398e-090.4501imageNNPLEKHF1T_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
chr3:155941109-155943221:+DLBCEERENSG00000166848,TERF2IP0.59102.9560e-022.2890e-050.6164imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr3:155941109-155943221:+DLBCEERENSG00000213672,NCKIPSD0.56324.0731e-027.6810e-040.5103imageNNNAGSVA_HALLMARK_DNA_REPAIR
chr3:155941109-155943221:+TGCTEERENSG00000137693,YAP1-0.42809.9970e-051.6800e-06-0.4227imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr3:155941109-155943221:+TGCTEERENSG00000103855,CD276-0.40882.3334e-048.3459e-07-0.4337imageNNCD276Macrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr3:155941109-155943221:+TGCTEERENSG00000168246,UBTD2-0.41892.6967e-043.4284e-06-0.4110imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr3:155941109-155943221:+TGCTEERENSG00000257093,KIAA1147-0.41862.8512e-043.1425e-06-0.4125imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr3:155941109-155943221:+TGCTEERENSG00000137872,SEMA6D-0.41543.3240e-043.9558e-06-0.4086imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for GMPS


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000163655.14,GMPS
ESCAEAGIRENSG00000158286.8chr16215666:6218369:6219235:6219343-0.31399.0195e-039.3375e-07-0.4388imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184NAEosinophilsGSVA_HALLMARK_HEME_METABOLISM
chr3:155941109-155943221:+
ESCAEERESENSG00000080345.13chr2151420224:151420379:151422949:151423042:151428783:151428922-0.27064.6747e-023.7540e-07-0.4151imageNNNAB_cells_naive
ENSG00000163655.14,GMPS
TGCTEAGMEXENSG00000175063.12chr2045813436:45813464:45815389:45815540:45815540:45815557:45815853:458159130.34246.0846e-031.2723e-060.4604imageNACIN1;AIFM1;ALYREF;AUH;BUD13;CAPRIN1;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP4B;LIN28;LIN28B;LSM11;METTL3;MOV10;NCBP3;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RTCB;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr3:155941109-155943221:+
TGCTEERIRENSG00000139718.6chr12121822489:121823749:121825199:1218253660.38083.3078e-034.0670e-060.4306imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr3:155941109-155943221:+
TGCTEERA5ENSG00000085999.7chr146248511:46248598:46247731:46247746:46247731:462484080.34415.2615e-031.5970e-060.4505imageNNNAMacrophages_M2GSVA_HALLMARK_ANGIOGENESIS
ENSG00000163655.14,GMPS
TGCTEAGESENSG00000145216.11chr453391008:53391139:53391429:53391498:53399729:533998390.39523.2959e-031.4939e-060.4246imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAMacrophages_M2GSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000163655.14,GMPS
TGCTEAGA3ENSG00000149636.11chr2036773661:36773720:36770872:36771193:36770872:36771473-0.41011.0642e-041.7690e-05-0.4092imageNACIN1;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000163655.14,GMPS
TGCTEAGIRENSG00000139718.6chr12121822489:121823749:121825199:1218253660.38082.7928e-034.0670e-060.4306imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RC3H1;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000163655.14,GMPS
TGCTEAGIRENSG00000177084.12chr12132660968:132661164:132661526:1326616800.40661.0341e-032.7906e-060.4353imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000163655.14,GMPS
TGCTEAGIRENSG00000084774.9chr227226130:27226173:27226524:27226649-0.25872.5760e-025.1601e-06-0.4507imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NCBP3;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAMacrophages_M2GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

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5. Enriched editing regions and immune infiltration for GMPS


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr3:155941109-155943221:+BLCAEERMacrophages_M13.7300e-020.1073image
ENSG00000163655.14,GMPSBLCAEAGMacrophages_M13.7387e-020.1072image
chr3:155941109-155943221:+BRCAEERT_cells_regulatory_(Tregs)1.2303e-030.0985image
ENSG00000163655.14,GMPSBRCAEAGT_cells_regulatory_(Tregs)1.5079e-030.0967image
chr3:155941109-155943221:+CESCEERB_cells_memory9.2687e-030.1508image
ENSG00000163655.14,GMPSCESCEAGB_cells_memory9.2588e-030.1508image
chr3:155941109-155943221:+CHOLEERT_cells_CD4_memory_resting1.3543e-020.4388image
ENSG00000163655.14,GMPSCHOLEAGT_cells_CD4_memory_resting1.3543e-020.4388image
ENSG00000163655.14,GMPSCOADEAGT_cells_regulatory_(Tregs)2.1711e-02-0.1448image
chr3:155941109-155943221:+DLBCEERNK_cells_activated3.8502e-020.3285image
ENSG00000163655.14,GMPSDLBCEAGNK_cells_activated3.8502e-020.3285image
chr3:155941109-155943221:+ESCAEERMonocytes5.1602e-03-0.2215image
ENSG00000163655.14,GMPSESCAEAGMonocytes4.2849e-03-0.2261image
chr3:155941109-155943221:+GBMEERNeutrophils1.0659e-02-0.2027image
ENSG00000163655.14,GMPSGBMEAGNeutrophils1.0931e-02-0.2020image
chr3:155941109-155943221:+HNSCEERT_cells_regulatory_(Tregs)2.6068e-04-0.1744image
ENSG00000163655.14,GMPSHNSCEAGT_cells_regulatory_(Tregs)2.8903e-04-0.1732image
chr3:155941109-155943221:+KICHEEREosinophils4.6065e-030.3498image
ENSG00000163655.14,GMPSKICHEAGEosinophils4.6065e-030.3498image
chr3:155941109-155943221:+KIRCEERT_cells_regulatory_(Tregs)3.4848e-020.1119image
ENSG00000163655.14,GMPSKIRCEAGMacrophages_M13.2256e-020.1135image
chr3:155941109-155943221:+KIRPEERB_cells_naive8.1462e-030.1596image
ENSG00000163655.14,GMPSKIRPEAGB_cells_naive8.1462e-030.1596image
chr3:155941109-155943221:+LGGEERT_cells_CD4_naive5.6259e-04-0.1498image
ENSG00000163655.14,GMPSLGGEAGT_cells_CD4_naive5.7761e-04-0.1494image
chr3:155941109-155943221:+LUADEERT_cells_CD4_naive3.8490e-02-0.1025image
ENSG00000163655.14,GMPSLUADEAGT_cells_CD4_naive3.8490e-02-0.1025image
chr3:155941109-155943221:+LUSCEERPlasma_cells2.8083e-020.1008image
ENSG00000163655.14,GMPSLUSCEAGPlasma_cells2.8591e-020.1004image
chr3:155941109-155943221:+MESOEERNeutrophils3.4200e-020.2342image
ENSG00000163655.14,GMPSMESOEAGNeutrophils3.4200e-020.2342image
chr3:155941109-155943221:+OVEERT_cells_CD87.4896e-040.1982image
ENSG00000163655.14,GMPSOVEAGT_cells_CD81.1751e-030.1909image
chr3:155941109-155943221:+PAADEERT_cells_gamma_delta4.9998e-02-0.1557image
ENSG00000163655.14,GMPSPAADEAGT_cells_gamma_delta4.9998e-02-0.1557image
chr3:155941109-155943221:+PCPGEERPlasma_cells1.5183e-020.1812image
ENSG00000163655.14,GMPSPCPGEAGPlasma_cells1.5183e-020.1812image
chr3:155941109-155943221:+PRADEERT_cells_regulatory_(Tregs)4.3914e-030.1276image
ENSG00000163655.14,GMPSPRADEAGT_cells_regulatory_(Tregs)4.3804e-030.1276image
chr3:155941109-155943221:+READEERNK_cells_activated1.6092e-020.2574image
ENSG00000163655.14,GMPSREADEAGNK_cells_activated1.6092e-020.2574image
chr3:155941109-155943221:+SARCEERPlasma_cells1.5067e-02-0.1548image
ENSG00000163655.14,GMPSSARCEAGPlasma_cells1.5067e-02-0.1548image
chr3:155941109-155943221:+SKCMEERT_cells_CD82.0788e-020.1121image
ENSG00000163655.14,GMPSSKCMEAGDendritic_cells_resting2.8229e-02-0.1063image
chr3:155941109-155943221:+STADEEREosinophils6.7372e-03-0.1469image
ENSG00000163655.14,GMPSSTADEAGEosinophils9.9090e-03-0.1389image
chr3:155941109-155943221:+TGCTEERMacrophages_M23.2590e-04-0.3239image
ENSG00000163655.14,GMPSTGCTEAGMacrophages_M23.2590e-04-0.3239image
chr3:155941109-155943221:+THCAEERT_cells_regulatory_(Tregs)4.2739e-030.1281image
ENSG00000163655.14,GMPSTHCAEAGT_cells_regulatory_(Tregs)4.2739e-030.1281image
chr3:155941109-155943221:+THYMEERT_cells_CD4_memory_activated3.0901e-030.2772image
ENSG00000163655.14,GMPSTHYMEAGT_cells_CD4_memory_activated3.0901e-030.2772image
chr3:155941109-155943221:+UCECEEREosinophils1.2939e-02-0.1920image
ENSG00000163655.14,GMPSUCECEAGEosinophils1.5144e-02-0.1871image
chr3:155941109-155943221:+UCSEERB_cells_naive1.9019e-02-0.3154image
ENSG00000163655.14,GMPSUCSEAGB_cells_naive1.9019e-02-0.3154image
chr3:155941109-155943221:+UVMEERT_cells_gamma_delta3.7470e-030.4590image
ENSG00000163655.14,GMPSUVMEAGT_cells_gamma_delta3.7470e-030.4590image


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6. Enriched editing regions and immune gene sets for GMPS


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr3:155941109-155943221:+HNSCEER8.2204e-04image5.9687e-040.1642image
ENSG00000163655.14,GMPSHNSCEAG7.0340e-04image4.5127e-040.1677image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr3:155941109-155943221:+LUADEER7.0934e-030.13318.4000e-030.13036.9880e-030.13341.7490e-030.1545image
ENSG00000163655.14,GMPSLUADEAG7.0934e-030.13318.4000e-030.13036.9880e-030.13341.7490e-030.1545image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000163655.14,GMPSACCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG8.5678e-03-0.2996image
chr3:155941109-155943221:+ACCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER8.5678e-03-0.2996image
ENSG00000163655.14,GMPSBLCAGSVA_HALLMARK_ANGIOGENESISEAG4.3624e-040.1802image
chr3:155941109-155943221:+BLCAGSVA_HALLMARK_ANGIOGENESISEER4.3060e-040.1804image
ENSG00000163655.14,GMPSBRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6771e-080.1687image
chr3:155941109-155943221:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0999e-080.1679image
ENSG00000163655.14,GMPSCESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.1094e-040.2224image
chr3:155941109-155943221:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1104e-040.2224image
ENSG00000163655.14,GMPSCOADGSVA_HALLMARK_SPERMATOGENESISEAG1.0329e-02-0.1616image
chr3:155941109-155943221:+COADGSVA_HALLMARK_SPERMATOGENESISEER3.7017e-02-0.1322image
chr3:155941109-155943221:+DLBCGSVA_HALLMARK_HEME_METABOLISMEER3.6467e-02-0.3318image
ENSG00000163655.14,GMPSDLBCGSVA_HALLMARK_HEME_METABOLISMEAG3.6467e-02-0.3318image
chr3:155941109-155943221:+ESCAGSVA_HALLMARK_G2M_CHECKPOINTEER1.9209e-02-0.1861image
chr3:155941109-155943221:+GBMGSVA_HALLMARK_MITOTIC_SPINDLEEER3.5740e-04-0.2805image
ENSG00000163655.14,GMPSGBMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.8278e-04-0.2791image
chr3:155941109-155943221:+HNSCGSVA_HALLMARK_MYOGENESISEER3.6060e-050.1969image
ENSG00000163655.14,GMPSHNSCGSVA_HALLMARK_MYOGENESISEAG2.8893e-050.1993image
chr3:155941109-155943221:+KICHGSVA_HALLMARK_DNA_REPAIREER8.3597e-04-0.4073image
ENSG00000163655.14,GMPSKICHGSVA_HALLMARK_DNA_REPAIREAG8.3597e-04-0.4073image
chr3:155941109-155943221:+KIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEER4.7562e-020.1051image
ENSG00000163655.14,GMPSKIRCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.7379e-020.1052image
chr3:155941109-155943221:+KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.3419e-03-0.1767image
ENSG00000163655.14,GMPSKIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.3419e-03-0.1767image
chr3:155941109-155943221:+LAMLGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER2.1914e-030.3206image
ENSG00000163655.14,GMPSLAMLGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG2.1479e-030.3177image
chr3:155941109-155943221:+LGGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.7206e-140.3167image
ENSG00000163655.14,GMPSLGGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.1733e-130.3157image
ENSG00000163655.14,GMPSLIHCGSVA_HALLMARK_ADIPOGENESISEAG1.3177e-030.2213image
chr3:155941109-155943221:+LIHCGSVA_HALLMARK_ADIPOGENESISEER1.3567e-030.2207image
ENSG00000163655.14,GMPSLUADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG6.9962e-060.2204image
chr3:155941109-155943221:+LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEER6.9962e-060.2204image
chr3:155941109-155943221:+LUSCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.9515e-060.2163image
ENSG00000163655.14,GMPSLUSCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.0781e-060.2158image
chr3:155941109-155943221:+OVGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.3305e-060.2750image
ENSG00000163655.14,GMPSOVGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.5654e-060.2795image
ENSG00000163655.14,GMPSPCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.1833e-030.2405image
chr3:155941109-155943221:+PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.1833e-030.2405image
chr3:155941109-155943221:+PRADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.2333e-040.1648image
ENSG00000163655.14,GMPSPRADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.2319e-040.1648image
ENSG00000163655.14,GMPSREADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.1899e-02-0.2303image
chr3:155941109-155943221:+READGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.1899e-02-0.2303image
chr3:155941109-155943221:+SARCGSVA_HALLMARK_COAGULATIONEER4.2426e-060.2884image
ENSG00000163655.14,GMPSSARCGSVA_HALLMARK_COAGULATIONEAG4.2426e-060.2884image
chr3:155941109-155943221:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.5333e-030.1412image
ENSG00000163655.14,GMPSSKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5908e-030.1371image
ENSG00000163655.14,GMPSSTADGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.4369e-040.1884image
chr3:155941109-155943221:+STADGSVA_HALLMARK_HYPOXIAEER2.2601e-020.1238image
chr3:155941109-155943221:+TGCTGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.6836e-04-0.3212image
ENSG00000163655.14,GMPSTGCTGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.6836e-04-0.3212image
ENSG00000163655.14,GMPSTHCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG4.3593e-070.2245image
chr3:155941109-155943221:+THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER4.3593e-070.2245image
ENSG00000163655.14,GMPSTHYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.7646e-04-0.3373image
chr3:155941109-155943221:+THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.7646e-04-0.3373image
ENSG00000163655.14,GMPSUCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5721e-040.2785image
chr3:155941109-155943221:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.4079e-040.2739image
ENSG00000163655.14,GMPSUCSGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.9786e-020.3135image
chr3:155941109-155943221:+UCSGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.9786e-020.3135image
chr3:155941109-155943221:+UVMGSVA_HALLMARK_UV_RESPONSE_DNEER4.0516e-02-0.3338image
ENSG00000163655.14,GMPSUVMGSVA_HALLMARK_UV_RESPONSE_DNEAG4.0516e-02-0.3338image


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7. Enriched editing regions and drugs for GMPS


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000163655.14,GMPSACCAS601245EAG4.7975e-030.3202image
chr3:155941109-155943221:+ACCAS601245EER4.7975e-030.3202image
ENSG00000163655.14,GMPSBLCACGP.60474EAG2.4222e-03-0.1558image
chr3:155941109-155943221:+BLCACGP.60474EER2.4173e-03-0.1558image
ENSG00000163655.14,GMPSBRCAAZD6244EAG5.8532e-05-0.1223image
chr3:155941109-155943221:+BRCAAZD6244EER3.1779e-05-0.1266image
chr3:155941109-155943221:+CESCDasatinibEER2.4941e-07-0.2944image
ENSG00000163655.14,GMPSCESCDasatinibEAG2.5132e-07-0.2943image
ENSG00000163655.14,GMPSCOADGefitinibEAG9.2412e-04-0.2078image
chr3:155941109-155943221:+COADGefitinibEER2.0329e-02-0.1470image
chr3:155941109-155943221:+ESCAAZD.2281EER1.4667e-03-0.2518image
ENSG00000163655.14,GMPSESCAAZD.2281EAG3.7393e-03-0.2301image
chr3:155941109-155943221:+GBMErlotinibEER9.2146e-04-0.2611image
ENSG00000163655.14,GMPSGBMErlotinibEAG8.6488e-04-0.2624image
ENSG00000163655.14,GMPSHNSCBexaroteneEAG1.9883e-06-0.2259image
chr3:155941109-155943221:+HNSCBexaroteneEER1.2796e-06-0.2300image
chr3:155941109-155943221:+KICHGefitinibEER6.5518e-04-0.4148image
ENSG00000163655.14,GMPSKICHGefitinibEAG6.5518e-04-0.4148image
ENSG00000163655.14,GMPSKIRCEpothilone.BEAG3.9624e-030.1523image
chr3:155941109-155943221:+KIRCEpothilone.BEER4.7788e-030.1492image
chr3:155941109-155943221:+KIRPBIBW2992EER3.0184e-040.2167image
ENSG00000163655.14,GMPSKIRPBIBW2992EAG3.0184e-040.2167image
ENSG00000163655.14,GMPSLAMLLenalidomideEAG5.8634e-030.2867image
chr3:155941109-155943221:+LAMLLenalidomideEER2.9250e-030.3119image
chr3:155941109-155943221:+LGGDasatinibEER1.6545e-12-0.3017image
ENSG00000163655.14,GMPSLGGDasatinibEAG1.7592e-12-0.3013image
ENSG00000163655.14,GMPSLIHCIPA.3EAG1.6490e-050.2945image
chr3:155941109-155943221:+LIHCIPA.3EER1.1070e-050.3002image
chr3:155941109-155943221:+LUADBMS.509744EER4.3310e-05-0.2010image
ENSG00000163655.14,GMPSLUADBMS.509744EAG4.3310e-05-0.2010image
ENSG00000163655.14,GMPSLUSCBMS.509744EAG3.3326e-06-0.2115image
chr3:155941109-155943221:+LUSCBMS.509744EER4.2083e-06-0.2093image
chr3:155941109-155943221:+MESOAZD.0530EER9.8816e-05-0.4166image
ENSG00000163655.14,GMPSMESOAZD.0530EAG9.8816e-05-0.4166image
ENSG00000163655.14,GMPSOVDasatinibEAG1.6711e-05-0.2520image
chr3:155941109-155943221:+OVDasatinibEER1.0892e-05-0.2573image
ENSG00000163655.14,GMPSPAADBortezomibEAG1.8266e-03-0.2469image
chr3:155941109-155943221:+PAADBortezomibEER1.8266e-03-0.2469image
chr3:155941109-155943221:+PCPGAG.014699EER1.3914e-030.2372image
ENSG00000163655.14,GMPSPCPGAG.014699EAG1.3914e-030.2372image
ENSG00000163655.14,GMPSPRADGNF.2EAG7.4805e-07-0.2202image
chr3:155941109-155943221:+PRADGNF.2EER7.5599e-07-0.2201image
chr3:155941109-155943221:+SARCDasatinibEER1.9101e-03-0.1974image
ENSG00000163655.14,GMPSSARCDasatinibEAG1.9101e-03-0.1974image
ENSG00000163655.14,GMPSSKCMCI.1040EAG4.5326e-05-0.1963image
chr3:155941109-155943221:+SKCMCI.1040EER4.2481e-05-0.1972image
ENSG00000163655.14,GMPSSTADBexaroteneEAG1.7131e-04-0.2013image
chr3:155941109-155943221:+STADFTI.277EER8.8357e-05-0.2113image
chr3:155941109-155943221:+TGCTGefitinibEER1.3362e-10-0.5460image
ENSG00000163655.14,GMPSTGCTGefitinibEAG1.3362e-10-0.5460image
chr3:155941109-155943221:+THCACI.1040EER2.4565e-07-0.2292image
ENSG00000163655.14,GMPSTHCACI.1040EAG2.4565e-07-0.2292image
ENSG00000163655.14,GMPSTHYMEmbelinEAG9.1317e-060.4056image
chr3:155941109-155943221:+THYMEmbelinEER9.1317e-060.4056image
ENSG00000163655.14,GMPSUCECDasatinibEAG3.2655e-06-0.3512image
chr3:155941109-155943221:+UCECDasatinibEER2.6194e-07-0.3869image
chr3:155941109-155943221:+UCSGDC.0449EER3.0488e-03-0.3924image
ENSG00000163655.14,GMPSUCSGDC.0449EAG3.0488e-03-0.3924image
ENSG00000163655.14,GMPSUVMMetforminEAG5.1392e-03-0.4448image
chr3:155941109-155943221:+UVMMetforminEER5.1392e-03-0.4448image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr3:155941109-155943221:+ENST00000496455.5P49915DB00142Glutamic acidSmallMoleculeDrug