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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TMEM241 (ImmuneEditome ID:85019)

1. Gene summary of enriched editing regions for TMEM241

check button Gene summary
Gene informationGene symbol

TMEM241

Gene ID

85019

GeneSynonymsC18orf45|SLC35D4|hVVT
GeneCytomap

18q11.2

GeneTypeprotein-coding
GeneDescriptiontransmembrane protein 241|putative vertebrate vrg4-like nucleotide-sugar transporter truncated variant2|putative vertebrate vrg4-like nucleotide-sugar transporter variant1|solute carrier family 35 member D4|transmembrane protein C18orf45
GeneModificationdate20230329
UniprotIDQ24JQ0;H0YDH1;F5GXY7;E9PJC2;J3QRE6;J3QR22;E9PLG4;J3QL29
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr18:23293809-23294794:-ENST00000578790.4ENSG00000134490.12TMEM241ncRNA_intronicAluJbchr18:23293809-23294794:-.alignment
chr18:23296309-23297560:-ENST00000475185.4ENSG00000134490.12TMEM241ncRNA_exonicL1MA8,AluJo,AluSxchr18:23296309-23297560:-.alignment
chr18:23344717-23344921:-ENST00000583048.4ENSG00000134490.12TMEM241ncRNA_intronicAluY,L1M5chr18:23344717-23344921:-.alignment


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2. Tumor-specific enriched editing regions for TMEM241


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr18:23296309-23297560:-BRCAEER1.0238e-02image
chr18:23296309-23297560:-LUSCEER2.9162e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for TMEM241


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr18:23296309-23297560:-GBMEERENSG00000128791,TWSG10.37154.4400e-041.2807e-090.4646imageNNNAT_cells_follicular_helperGSVA_HALLMARK_BILE_ACID_METABOLISM
chr18:23296309-23297560:-UCECEERENSG00000251369,ZNF5500.40501.8991e-036.5254e-070.4171imageNNNAEosinophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr18:23296309-23297560:-UCECEERENSG00000134186,PRPF38B0.37345.2642e-031.1296e-070.4419imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr18:23296309-23297560:-UCECEERENSG00000134250,NOTCH20.32891.4715e-023.9973e-080.4557imageNNNOTCH2T_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr18:23296309-23297560:-UCECEERENSG00000166326,TRIM440.32042.1271e-021.2166e-060.4078imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_XENOBIOTIC_METABOLISM

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4. Enriched editing regions and immune related splicing for TMEM241


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000134490.12,TMEM241
GBMEAGESENSG00000167515.6chr1688858641:88858789:88859344:88859750:88859892:888599720.40043.6807e-044.9698e-070.4071imageNADAR;AUH;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;METTL3;MOV10;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NAMast_cells_restingGSVA_HALLMARK_HEME_METABOLISM
chr18:23296309-23297560:-
GBMEERESENSG00000167515.6chr1688858641:88858789:88859344:88859750:88859892:888599720.39983.4762e-045.0678e-070.4068imageNNNAMast_cells_restingGSVA_HALLMARK_HEME_METABOLISM
ENSG00000134490.12,TMEM241
PCPGEAGMEXENSG00000129657.10chr1777215896:77215909:77215984:77216088:77216192:77216387:77216413:772168020.18141.6707e-026.5283e-070.4672imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;MBNL2;METTL3;MOV10;MSI1;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;PUM2;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;YTHDC1;YTHDF1NAMacrophages_M1
ENSG00000134490.12,TMEM241
PCPGEAGMEXENSG00000129657.10chr1777215896:77215909:77215984:77216088:77216088:77216387:77216413:772168020.18041.8006e-027.1883e-070.4656imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;MBNL2;METTL3;MOV10;MSI1;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;PUM2;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;YTHDC1;YTHDF1NAMacrophages_M1
ENSG00000134490.12,TMEM241
PCPGEAGMEXENSG00000129657.10chr1777215896:77215909:77215984:77216088:77216127:77216387:77216413:772168020.18041.8006e-027.3206e-070.4653imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;MBNL2;METTL3;MOV10;MSI1;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;PUM2;RBFOX2;RBM10;RBM22;RBM27;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;WTAP;YTHDC1;YTHDF1NAMacrophages_M1
chr18:23296309-23297560:-
PCPGEERMEXENSG00000129657.10chr1777215896:77215909:77215984:77216088:77216192:77216387:77216413:772168020.18161.7711e-026.6435e-070.4669imageNNNAMacrophages_M1
chr18:23296309-23297560:-
PCPGEERMEXENSG00000129657.10chr1777215896:77215909:77215984:77216088:77216088:77216387:77216413:772168020.18061.9111e-027.3130e-070.4654imageNNNAMacrophages_M1
chr18:23296309-23297560:-
PCPGEERMEXENSG00000129657.10chr1777215896:77215909:77215984:77216088:77216127:77216387:77216413:772168020.18061.9111e-027.4471e-070.4651imageNNNAMacrophages_M1
chr18:23296309-23297560:-
PCPGEERMEXENSG00000129657.10chr1777215896:77215909:77215984:77216049:77216088:77216387:77216413:772168020.16384.8111e-021.3171e-060.4557imageNNNAMacrophages_M1
chr18:23296309-23297560:-
PCPGEERMEXENSG00000129657.10chr1777215896:77215909:77215984:77216049:77216114:77216387:77216413:772168020.16384.8111e-021.3397e-060.4554imageNNNAMacrophages_M1

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5. Enriched editing regions and immune infiltration for TMEM241


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr18:23296309-23297560:-BLCAEERNK_cells_resting3.3569e-020.1334image
ENSG00000134490.12,TMEM241BLCAEAGNK_cells_resting2.5439e-020.1402image
chr18:23293809-23294794:-BRCAEERT_cells_CD4_memory_activated5.6072e-040.1357image
chr18:23296309-23297560:-BRCAEERT_cells_CD4_memory_activated2.4516e-060.1436image
ENSG00000134490.12,TMEM241BRCAEAGT_cells_regulatory_(Tregs)2.9783e-04-0.1102image
chr18:23293809-23294794:-CESCEERT_cells_CD4_memory_resting5.1806e-030.5744image
chr18:23296309-23297560:-CESCEERT_cells_CD4_naive7.2086e-060.2763image
ENSG00000134490.12,TMEM241CESCEAGT_cells_CD4_naive2.2507e-040.2282image
chr18:23296309-23297560:-CHOLEERMonocytes1.2620e-020.5011image
ENSG00000134490.12,TMEM241CHOLEAGMonocytes1.2620e-020.5011image
ENSG00000134490.12,TMEM241COADEAGMast_cells_activated2.3405e-030.2333image
ENSG00000134490.12,TMEM241DLBCEAGT_cells_follicular_helper1.2212e-020.5031image
chr18:23293809-23294794:-ESCAEERMonocytes3.6489e-030.4721image
chr18:23296309-23297560:-ESCAEERMacrophages_M18.0465e-030.2095image
ENSG00000134490.12,TMEM241ESCAEAGMacrophages_M12.2523e-020.1809image
chr18:23296309-23297560:-GBMEERMacrophages_M03.0820e-02-0.1741image
ENSG00000134490.12,TMEM241GBMEAGMacrophages_M03.0689e-02-0.1742image
chr18:23296309-23297560:-HNSCEERB_cells_memory1.6016e-02-0.1178image
ENSG00000134490.12,TMEM241HNSCEAGB_cells_memory1.5227e-02-0.1186image
chr18:23296309-23297560:-KIRCEERB_cells_naive1.2068e-020.1555image
ENSG00000134490.12,TMEM241KIRCEAGB_cells_naive1.4919e-020.1503image
chr18:23296309-23297560:-KIRPEERMacrophages_M23.8792e-030.2744image
ENSG00000134490.12,TMEM241KIRPEAGMacrophages_M23.7656e-030.2740image
ENSG00000134490.12,TMEM241LAMLEAGMast_cells_activated3.3512e-030.5741image
chr18:23296309-23297560:-LGGEERMacrophages_M22.4870e-02-0.1248image
ENSG00000134490.12,TMEM241LGGEAGMacrophages_M22.0086e-02-0.1293image
chr18:23296309-23297560:-LIHCEERNK_cells_activated2.0555e-020.1871image
ENSG00000134490.12,TMEM241LIHCEAGNK_cells_activated2.0563e-020.1871image
chr18:23293809-23294794:-LUADEERMast_cells_activated3.3306e-020.2413image
chr18:23296309-23297560:-LUADEERT_cells_CD4_memory_activated4.0087e-030.1299image
ENSG00000134490.12,TMEM241LUADEAGT_cells_regulatory_(Tregs)2.7613e-03-0.1351image
chr18:23293809-23294794:-LUSCEERT_cells_CD4_memory_activated4.0034e-030.6004image
ENSG00000134490.12,TMEM241MESOEAGT_cells_CD4_memory_resting2.5723e-020.3481image
chr18:23293809-23294794:-OVEERMacrophages_M23.6920e-030.5921image
chr18:23296309-23297560:-OVEERMacrophages_M11.5053e-030.1878image
ENSG00000134490.12,TMEM241OVEAGMacrophages_M11.4997e-030.1879image
chr18:23296309-23297560:-PAADEERT_cells_follicular_helper1.8818e-020.2133image
ENSG00000134490.12,TMEM241PAADEAGT_cells_follicular_helper3.0772e-020.1965image
ENSG00000134490.12,TMEM241PRADEAGT_cells_CD4_memory_resting3.8560e-020.1059image
ENSG00000134490.12,TMEM241READEAGMast_cells_activated3.6981e-030.4240image
chr18:23296309-23297560:-SARCEERMacrophages_M26.8478e-03-0.1998image
ENSG00000134490.12,TMEM241SARCEAGMacrophages_M25.6471e-03-0.2044image
chr18:23296309-23297560:-SKCMEERMonocytes1.0677e-02-0.1312image
ENSG00000134490.12,TMEM241SKCMEAGMonocytes8.8428e-03-0.1345image
chr18:23293809-23294794:-STADEERT_cells_CD4_naive1.5435e-020.3853image
chr18:23296309-23297560:-STADEERMonocytes1.2766e-020.1332image
ENSG00000134490.12,TMEM241STADEAGMonocytes1.0127e-020.1371image
ENSG00000134490.12,TMEM241TGCTEAGB_cells_naive1.3639e-020.3652image
chr18:23296309-23297560:-THCAEERNK_cells_activated9.0502e-05-0.2450image
ENSG00000134490.12,TMEM241THCAEAGNK_cells_activated3.9823e-04-0.2205image
chr18:23296309-23297560:-UCECEERT_cells_CD4_memory_resting2.1779e-020.1996image
chr18:23296309-23297560:-UCSEERDendritic_cells_activated1.3015e-020.3597image
ENSG00000134490.12,TMEM241UCSEAGDendritic_cells_activated1.4554e-020.3543image


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6. Enriched editing regions and immune gene sets for TMEM241


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr18:23296309-23297560:-STADEER1.9455e-02image3.7085e-020.1116image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr18:23296309-23297560:-BLCAGSVA_HALLMARK_PEROXISOMEEER1.9210e-03-0.1938image
ENSG00000134490.12,TMEM241BLCAGSVA_HALLMARK_PEROXISOMEEAG1.8067e-03-0.1949image
chr18:23293809-23294794:-BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.8887e-090.2340image
chr18:23296309-23297560:-BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER3.1183e-120.2112image
ENSG00000134490.12,TMEM241BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.5027e-090.1831image
chr18:23293809-23294794:-CESCGSVA_HALLMARK_UV_RESPONSE_DNEER4.9152e-020.4241image
ENSG00000134490.12,TMEM241CESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.3156e-020.1329image
ENSG00000134490.12,TMEM241COADGSVA_HALLMARK_PEROXISOMEEAG3.3107e-04-0.2737image
chr18:23296309-23297560:-ESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.1791e-030.2550image
ENSG00000134490.12,TMEM241ESCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG2.8079e-030.2355image
ENSG00000134490.12,TMEM241GBMGSVA_HALLMARK_HEME_METABOLISMEAG2.7724e-030.2395image
chr18:23296309-23297560:-GBMGSVA_HALLMARK_HEME_METABOLISMEER2.7517e-030.2397image
ENSG00000134490.12,TMEM241HNSCGSVA_HALLMARK_NOTCH_SIGNALINGEAG2.3446e-030.1484image
chr18:23296309-23297560:-HNSCGSVA_HALLMARK_NOTCH_SIGNALINGEER2.2365e-030.1491image
chr18:23296309-23297560:-KIRCGSVA_HALLMARK_HEME_METABOLISMEER2.8771e-020.1356image
ENSG00000134490.12,TMEM241KIRCGSVA_HALLMARK_HEME_METABOLISMEAG1.9124e-020.1447image
chr18:23296309-23297560:-KIRPGSVA_HALLMARK_NOTCH_SIGNALINGEER4.3660e-020.1936image
ENSG00000134490.12,TMEM241KIRPGSVA_HALLMARK_NOTCH_SIGNALINGEAG4.1608e-020.1946image
ENSG00000134490.12,TMEM241LAMLGSVA_HALLMARK_MYC_TARGETS_V2EAG1.5632e-02-0.4877image
ENSG00000134490.12,TMEM241LGGGSVA_HALLMARK_UV_RESPONSE_DNEAG6.7747e-040.1881image
chr18:23296309-23297560:-LGGGSVA_HALLMARK_UV_RESPONSE_DNEER1.5398e-040.2091image
chr18:23296309-23297560:-LIHCGSVA_HALLMARK_SPERMATOGENESISEER3.7904e-02-0.1680image
ENSG00000134490.12,TMEM241LIHCGSVA_HALLMARK_SPERMATOGENESISEAG3.7933e-02-0.1680image
chr18:23296309-23297560:-LUADGSVA_HALLMARK_UV_RESPONSE_DNEER2.7415e-050.1884image
ENSG00000134490.12,TMEM241LUADGSVA_HALLMARK_UV_RESPONSE_DNEAG3.1943e-050.1869image
ENSG00000134490.12,TMEM241LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6018e-020.1124image
chr18:23296309-23297560:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7952e-020.1104image
ENSG00000134490.12,TMEM241MESOGSVA_HALLMARK_MYC_TARGETS_V2EAG1.3108e-02-0.3843image
ENSG00000134490.12,TMEM241OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.1000e-050.2500image
chr18:23293809-23294794:-OVGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.6824e-020.4474image
chr18:23296309-23297560:-OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER6.5728e-060.2643image
chr18:23296309-23297560:-PAADGSVA_HALLMARK_MYC_TARGETS_V2EER1.3777e-02-0.2234image
ENSG00000134490.12,TMEM241PAADGSVA_HALLMARK_MYC_TARGETS_V2EAG9.9093e-03-0.2336image
ENSG00000134490.12,TMEM241PRADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.4425e-03-0.1453image
ENSG00000134490.12,TMEM241READGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.8480e-020.2958image
ENSG00000134490.12,TMEM241SARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.8938e-030.2077image
chr18:23296309-23297560:-SARCGSVA_HALLMARK_MITOTIC_SPINDLEEER4.4203e-030.2101image
ENSG00000134490.12,TMEM241SKCMGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.0124e-02-0.1056image
chr18:23293809-23294794:-STADGSVA_HALLMARK_MYC_TARGETS_V2EER1.1669e-020.3998image
chr18:23296309-23297560:-STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.4963e-040.2016image
ENSG00000134490.12,TMEM241STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG8.3174e-040.1776image
ENSG00000134490.12,TMEM241TGCTGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3576e-020.3654image
ENSG00000134490.12,TMEM241THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.4455e-030.1988image
chr18:23296309-23297560:-THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER7.4330e-040.2120image
chr18:23296309-23297560:-UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.6466e-04-0.2962image
ENSG00000134490.12,TMEM241UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.8200e-02-0.2015image
ENSG00000134490.12,TMEM241UCSGSVA_HALLMARK_P53_PATHWAYEAG2.0218e-020.3378image
chr18:23296309-23297560:-UCSGSVA_HALLMARK_P53_PATHWAYEER3.4970e-020.3084image


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7. Enriched editing regions and drugs for TMEM241


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr18:23296309-23297560:-BLCAJNK.9LEER1.1247e-04-0.2400image
ENSG00000134490.12,TMEM241BLCAJNK.9LEAG1.4551e-04-0.2361image
ENSG00000134490.12,TMEM241BRCABMS.536924EAG4.5072e-090.1781image
chr18:23296309-23297560:-BRCABMS.536924EER9.2797e-060.1355image
chr18:23293809-23294794:-BRCAEHT.1864EER4.9207e-060.1790image
chr18:23293809-23294794:-CESCCCT007093EER1.1597e-02-0.5277image
chr18:23296309-23297560:-CESCAZ628EER3.0825e-020.1353image
ENSG00000134490.12,TMEM241CESCAZ628EAG2.3260e-020.1418image
chr18:23296309-23297560:-CHOLGW.441756EER1.1330e-02-0.5076image
ENSG00000134490.12,TMEM241CHOLGW.441756EAG1.1330e-02-0.5076image
ENSG00000134490.12,TMEM241COADCCT007093EAG9.9192e-05-0.2958image
ENSG00000134490.12,TMEM241ESCAAZD6482EAG1.4287e-02-0.1940image
chr18:23296309-23297560:-ESCAAZD6482EER8.4353e-03-0.2083image
chr18:23293809-23294794:-ESCACyclopamineEER3.9288e-02-0.3451image
ENSG00000134490.12,TMEM241GBMJNJ.26854165EAG9.6152e-040.2635image
chr18:23296309-23297560:-GBMJNJ.26854165EER9.5516e-040.2636image
ENSG00000134490.12,TMEM241HNSCAZD6482EAG4.7093e-04-0.1703image
chr18:23296309-23297560:-HNSCAZD6482EER4.2027e-04-0.1717image
ENSG00000134490.12,TMEM241KIRCGW843682XEAG7.8872e-040.2061image
chr18:23296309-23297560:-KIRCGW843682XEER2.0830e-030.1901image
ENSG00000134490.12,TMEM241KIRPBI.D1870EAG9.2266e-030.2472image
chr18:23296309-23297560:-KIRPATRAEER9.0341e-03-0.2490image
ENSG00000134490.12,TMEM241LAMLJNJ.26854165EAG1.3140e-020.4986image
ENSG00000134490.12,TMEM241LGGCEP.701EAG1.2745e-040.2116image
chr18:23296309-23297560:-LGGCEP.701EER2.2382e-050.2335image
ENSG00000134490.12,TMEM241LIHCAZD.2281EAG9.4576e-030.2106image
chr18:23296309-23297560:-LIHCAZD.2281EER9.4521e-030.2106image
ENSG00000134490.12,TMEM241LUADAICAREAG3.2700e-06-0.2086image
chr18:23293809-23294794:-LUADLFM.A13EER2.0783e-02-0.2614image
chr18:23296309-23297560:-LUADAICAREER1.4121e-06-0.2161image
ENSG00000134490.12,TMEM241LUSCFTI.277EAG1.6647e-02-0.1117image
chr18:23296309-23297560:-LUSCFTI.277EER1.8189e-02-0.1102image
chr18:23293809-23294794:-LUSCBMS.708163EER7.7348e-03-0.5641image
ENSG00000134490.12,TMEM241MESOAZD6482EAG9.2193e-03-0.4018image
ENSG00000134490.12,TMEM241OVCI.1040EAG1.3385e-02-0.1469image
chr18:23293809-23294794:-OVGSK269962AEER3.9472e-02-0.4419image
chr18:23296309-23297560:-OVCI.1040EER1.0881e-02-0.1512image
chr18:23296309-23297560:-PAADCCT007093EER8.8715e-04-0.2984image
ENSG00000134490.12,TMEM241PAADCCT007093EAG5.7523e-04-0.3085image
chr18:23296309-23297560:-PCPGCHIR.99021EER2.0619e-020.1934image
ENSG00000134490.12,TMEM241PCPGCHIR.99021EAG2.0430e-020.1937image
ENSG00000134490.12,TMEM241PRADBMS.536924EAG1.8688e-040.1905image
ENSG00000134490.12,TMEM241READFH535EAG4.3548e-02-0.3023image
ENSG00000134490.12,TMEM241SARCBMS.509744EAG1.8234e-040.2740image
chr18:23296309-23297560:-SARCBMS.509744EER1.4197e-040.2784image
chr18:23296309-23297560:-SKCMCGP.082996EER1.2563e-030.1653image
ENSG00000134490.12,TMEM241SKCMCGP.082996EAG1.0102e-030.1684image
ENSG00000134490.12,TMEM241STADKU.55933EAG4.6270e-04-0.1859image
chr18:23293809-23294794:-STADAICAREER1.4556e-020.3884image
chr18:23296309-23297560:-STADGDC0941EER2.3976e-04-0.1954image
ENSG00000134490.12,TMEM241TGCTCamptothecinEAG9.3333e-030.3834image
ENSG00000134490.12,TMEM241THCAAMG.706EAG1.4240e-050.2686image
chr18:23296309-23297560:-THCAAMG.706EER5.8245e-060.2822image
ENSG00000134490.12,TMEM241UCECGDC0941EAG1.0030e-02-0.2193image
chr18:23296309-23297560:-UCECLenalidomideEER2.0686e-04-0.3176image
chr18:23296309-23297560:-UCSGDC.0449EER3.7104e-020.3050image
ENSG00000134490.12,TMEM241UCSGDC.0449EAG3.7605e-020.3042image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType