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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FBXL20 (ImmuneEditome ID:84961)

1. Gene summary of enriched editing regions for FBXL20

check button Gene summary
Gene informationGene symbol

FBXL20

Gene ID

84961

GeneSynonymsFbl2|Fbl20
GeneCytomap

17q12

GeneTypeprotein-coding
GeneDescriptionF-box/LRR-repeat protein 20|F-box protein FBL2
GeneModificationdate20230329
UniprotIDQ96IG2;J3KTA1;J3QKL3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:39254067-39257260:-ENST00000264658.9ENSG00000108306.10FBXL20UTR3AluY,AluSp,AluSx1,AluSg7,AluSgchr17:39254067-39257260:-.alignment
chr17:39259690-39259950:-ENST00000264658.9ENSG00000108306.10FBXL20UTR3AluSzchr17:39259690-39259950:-.alignment
chr17:39266128-39266655:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluSx,AluSz6chr17:39266128-39266655:-.alignment
chr17:39266128-39266655:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluSx,AluSz6chr17:39266128-39266655:-.alignment
chr17:39266128-39266655:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluSx,AluSz6chr17:39266128-39266655:-.alignment
chr17:39266128-39266655:-ENST00000581781.1ENSG00000108306.10FBXL20intronicAluSx,AluSz6chr17:39266128-39266655:-.alignment
chr17:39266128-39266655:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluSx,AluSz6chr17:39266128-39266655:-.alignment
chr17:39273106-39274169:-ENST00000264658.9ENSG00000108306.10FBXL20intronicMIR,AluSx4,AluSx,AluJochr17:39273106-39274169:-.alignment
chr17:39273106-39274169:-ENST00000394294.6ENSG00000108306.10FBXL20intronicMIR,AluSx4,AluSx,AluJochr17:39273106-39274169:-.alignment
chr17:39273106-39274169:-ENST00000577399.4ENSG00000108306.10FBXL20intronicMIR,AluSx4,AluSx,AluJochr17:39273106-39274169:-.alignment
chr17:39273106-39274169:-ENST00000583610.4ENSG00000108306.10FBXL20intronicMIR,AluSx4,AluSx,AluJochr17:39273106-39274169:-.alignment
chr17:39286332-39288109:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluJr4,AluSz6,AluSg,AluSq2,AluSz,L1MC5a,L1M5chr17:39286332-39288109:-.alignment
chr17:39286332-39288109:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluJr4,AluSz6,AluSg,AluSq2,AluSz,L1MC5a,L1M5chr17:39286332-39288109:-.alignment
chr17:39286332-39288109:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluJr4,AluSz6,AluSg,AluSq2,AluSz,L1MC5a,L1M5chr17:39286332-39288109:-.alignment
chr17:39286332-39288109:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluJr4,AluSz6,AluSg,AluSq2,AluSz,L1MC5a,L1M5chr17:39286332-39288109:-.alignment
chr17:39290687-39291663:-ENST00000264658.9ENSG00000108306.10FBXL20intronicL1M5,AluSz,AluJo,AluYj4chr17:39290687-39291663:-.alignment
chr17:39290687-39291663:-ENST00000394294.6ENSG00000108306.10FBXL20intronicL1M5,AluSz,AluJo,AluYj4chr17:39290687-39291663:-.alignment
chr17:39290687-39291663:-ENST00000577399.4ENSG00000108306.10FBXL20intronicL1M5,AluSz,AluJo,AluYj4chr17:39290687-39291663:-.alignment
chr17:39290687-39291663:-ENST00000583610.4ENSG00000108306.10FBXL20intronicL1M5,AluSz,AluJo,AluYj4chr17:39290687-39291663:-.alignment
chr17:39293311-39295509:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluSz,L1MC5,L1MC5a,L1MEc,AluJb,FLAM_C,AluSxchr17:39293311-39295509:-.alignment
chr17:39293311-39295509:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluSz,L1MC5,L1MC5a,L1MEc,AluJb,FLAM_C,AluSxchr17:39293311-39295509:-.alignment
chr17:39293311-39295509:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluSz,L1MC5,L1MC5a,L1MEc,AluJb,FLAM_C,AluSxchr17:39293311-39295509:-.alignment
chr17:39293311-39295509:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluSz,L1MC5,L1MC5a,L1MEc,AluJb,FLAM_C,AluSxchr17:39293311-39295509:-.alignment
chr17:39305413-39306328:-ENST00000264658.9ENSG00000108306.10FBXL20intronicFLAM_C,AluJr,AluSq2,AluSx1,L1M3chr17:39305413-39306328:-.alignment
chr17:39305413-39306328:-ENST00000394294.6ENSG00000108306.10FBXL20intronicFLAM_C,AluJr,AluSq2,AluSx1,L1M3chr17:39305413-39306328:-.alignment
chr17:39305413-39306328:-ENST00000577399.4ENSG00000108306.10FBXL20intronicFLAM_C,AluJr,AluSq2,AluSx1,L1M3chr17:39305413-39306328:-.alignment
chr17:39305413-39306328:-ENST00000583610.4ENSG00000108306.10FBXL20intronicFLAM_C,AluJr,AluSq2,AluSx1,L1M3chr17:39305413-39306328:-.alignment
chr17:39308364-39309048:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluY,A-rich,LTR49-int,AluSx,AluJochr17:39308364-39309048:-.alignment
chr17:39308364-39309048:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluY,A-rich,LTR49-int,AluSx,AluJochr17:39308364-39309048:-.alignment
chr17:39308364-39309048:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluY,A-rich,LTR49-int,AluSx,AluJochr17:39308364-39309048:-.alignment
chr17:39308364-39309048:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluY,A-rich,LTR49-int,AluSx,AluJochr17:39308364-39309048:-.alignment
chr17:39312244-39314530:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluSz,AluSg,L4_B_Mam,L1MB7,AluY,AluSp,AluSx1chr17:39312244-39314530:-.alignment
chr17:39312244-39314530:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluSz,AluSg,L4_B_Mam,L1MB7,AluY,AluSp,AluSx1chr17:39312244-39314530:-.alignment
chr17:39312244-39314530:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluSz,AluSg,L4_B_Mam,L1MB7,AluY,AluSp,AluSx1chr17:39312244-39314530:-.alignment
chr17:39312244-39314530:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluSz,AluSg,L4_B_Mam,L1MB7,AluY,AluSp,AluSx1chr17:39312244-39314530:-.alignment
chr17:39316035-39317931:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluSg,L1M5,L1MC4,AluJr4,AluSx1,AluYj4chr17:39316035-39317931:-.alignment
chr17:39316035-39317931:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluSg,L1M5,L1MC4,AluJr4,AluSx1,AluYj4chr17:39316035-39317931:-.alignment
chr17:39316035-39317931:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluSg,L1M5,L1MC4,AluJr4,AluSx1,AluYj4chr17:39316035-39317931:-.alignment
chr17:39316035-39317931:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluSg,L1M5,L1MC4,AluJr4,AluSx1,AluYj4chr17:39316035-39317931:-.alignment
chr17:39326709-39327062:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluSz,AluJrchr17:39326709-39327062:-.alignment
chr17:39326709-39327062:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluSz,AluJrchr17:39326709-39327062:-.alignment
chr17:39326709-39327062:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluSz,AluJrchr17:39326709-39327062:-.alignment
chr17:39326709-39327062:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluSz,AluJrchr17:39326709-39327062:-.alignment
chr17:39363726-39364575:-ENST00000264658.9ENSG00000108306.10FBXL20intronicMLT1H,AluJr,AluJb,AluSz6chr17:39363726-39364575:-.alignment
chr17:39363726-39364575:-ENST00000394294.6ENSG00000108306.10FBXL20intronicMLT1H,AluJr,AluJb,AluSz6chr17:39363726-39364575:-.alignment
chr17:39363726-39364575:-ENST00000577399.4ENSG00000108306.10FBXL20intronicMLT1H,AluJr,AluJb,AluSz6chr17:39363726-39364575:-.alignment
chr17:39363726-39364575:-ENST00000583610.4ENSG00000108306.10FBXL20intronicMLT1H,AluJr,AluJb,AluSz6chr17:39363726-39364575:-.alignment
chr17:39367853-39368354:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluJr,AluSx3chr17:39367853-39368354:-.alignment
chr17:39367853-39368354:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluJr,AluSx3chr17:39367853-39368354:-.alignment
chr17:39367853-39368354:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluJr,AluSx3chr17:39367853-39368354:-.alignment
chr17:39367853-39368354:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluJr,AluSx3chr17:39367853-39368354:-.alignment
chr17:39371728-39372843:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluSq2,AluSc,AluSx,HAL1chr17:39371728-39372843:-.alignment
chr17:39371728-39372843:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluSq2,AluSc,AluSx,HAL1chr17:39371728-39372843:-.alignment
chr17:39371728-39372843:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluSq2,AluSc,AluSx,HAL1chr17:39371728-39372843:-.alignment
chr17:39371728-39372843:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluSq2,AluSc,AluSx,HAL1chr17:39371728-39372843:-.alignment
chr17:39374410-39375000:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluSc,AluSx1chr17:39374410-39375000:-.alignment
chr17:39374410-39375000:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluSc,AluSx1chr17:39374410-39375000:-.alignment
chr17:39374410-39375000:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluSc,AluSx1chr17:39374410-39375000:-.alignment
chr17:39374410-39375000:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluSc,AluSx1chr17:39374410-39375000:-.alignment
chr17:39394352-39394738:-ENST00000264658.9ENSG00000108306.10FBXL20intronicAluYk3,AluSzchr17:39394352-39394738:-.alignment
chr17:39394352-39394738:-ENST00000394294.6ENSG00000108306.10FBXL20intronicAluYk3,AluSzchr17:39394352-39394738:-.alignment
chr17:39394352-39394738:-ENST00000577399.4ENSG00000108306.10FBXL20intronicAluYk3,AluSzchr17:39394352-39394738:-.alignment
chr17:39394352-39394738:-ENST00000583610.4ENSG00000108306.10FBXL20intronicAluYk3,AluSzchr17:39394352-39394738:-.alignment


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2. Tumor-specific enriched editing regions for FBXL20


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr17:39254067-39257260:-BRCAEER4.9431e-10image
ENSG00000108306.10,FBXL20BRCAEAG1.0421e-11image
chr17:39254067-39257260:-LUSCEER6.9860e-03image
ENSG00000108306.10,FBXL20LUSCEAG2.3350e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr17:39254067-39257260:-KIRPPathEER1.5361e-024.7460e-030.2229image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for FBXL20


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:39293311-39295509:-LAMLEERENSG00000142089,IFITM30.41761.8636e-021.4012e-070.4787imageNNIFITM3T_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000233674,RP11-184I16.3-0.42382.0281e-028.9762e-06-0.4111imageNNNAMonocytesGSVA_HALLMARK_NOTCH_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000146802,TMEM168-0.42642.0785e-022.0532e-07-0.4731imageNNNAT_cells_CD8GSVA_HALLMARK_KRAS_SIGNALING_DN
chr17:39293311-39295509:-LAMLEERENSG00000196757,ZNF700-0.41032.8929e-023.4343e-06-0.4280imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000207344,SNORA22-0.40572.9820e-029.2823e-07-0.4498imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr17:39293311-39295509:-LAMLEERENSG00000175395,ZNF25-0.40513.3606e-028.7412e-06-0.4116imageNNNAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr17:39293311-39295509:-LAMLEERENSG00000278206,RP1-20N2.8-0.40233.5120e-029.7252e-06-0.4096imageNNNAMast_cells_restingGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000105778,AVL9-0.39903.6719e-023.0215e-06-0.4302imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr17:39293311-39295509:-LAMLEERENSG00000267274,CTD-2006C1.12-0.37894.2937e-021.4183e-05-0.4027imageNNNAMonocytesGSVA_HALLMARK_UV_RESPONSE_UP
chr17:39293311-39295509:-LAMLEERENSG00000270555,RP11-1394O16.1-0.37974.7941e-021.2473e-05-0.4051imageNNNAPlasma_cellsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr17:39293311-39295509:-LAMLEERENSG00000142089,IFITM30.41761.8636e-021.4012e-070.4787imageNNIFITM3T_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000233674,RP11-184I16.3-0.42382.0281e-028.9762e-06-0.4111imageNNNAMonocytesGSVA_HALLMARK_NOTCH_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000146802,TMEM168-0.42642.0785e-022.0532e-07-0.4731imageNNNAT_cells_CD8GSVA_HALLMARK_KRAS_SIGNALING_DN
chr17:39293311-39295509:-LAMLEERENSG00000196757,ZNF700-0.41032.8929e-023.4343e-06-0.4280imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000207344,SNORA22-0.40572.9820e-029.2823e-07-0.4498imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr17:39293311-39295509:-LAMLEERENSG00000175395,ZNF25-0.40513.3606e-028.7412e-06-0.4116imageNNNAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr17:39293311-39295509:-LAMLEERENSG00000278206,RP1-20N2.8-0.40233.5120e-029.7252e-06-0.4096imageNNNAMast_cells_restingGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000105778,AVL9-0.39903.6719e-023.0215e-06-0.4302imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr17:39293311-39295509:-LAMLEERENSG00000267274,CTD-2006C1.12-0.37894.2937e-021.4183e-05-0.4027imageNNNAMonocytesGSVA_HALLMARK_UV_RESPONSE_UP
chr17:39293311-39295509:-LAMLEERENSG00000270555,RP11-1394O16.1-0.37974.7941e-021.2473e-05-0.4051imageNNNAPlasma_cellsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr17:39293311-39295509:-LAMLEERENSG00000142089,IFITM30.41761.8636e-021.4012e-070.4787imageNNIFITM3T_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000233674,RP11-184I16.3-0.42382.0281e-028.9762e-06-0.4111imageNNNAMonocytesGSVA_HALLMARK_NOTCH_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000146802,TMEM168-0.42642.0785e-022.0532e-07-0.4731imageNNNAT_cells_CD8GSVA_HALLMARK_KRAS_SIGNALING_DN
chr17:39293311-39295509:-LAMLEERENSG00000196757,ZNF700-0.41032.8929e-023.4343e-06-0.4280imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000207344,SNORA22-0.40572.9820e-029.2823e-07-0.4498imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr17:39293311-39295509:-LAMLEERENSG00000175395,ZNF25-0.40513.3606e-028.7412e-06-0.4116imageNNNAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr17:39293311-39295509:-LAMLEERENSG00000278206,RP1-20N2.8-0.40233.5120e-029.7252e-06-0.4096imageNNNAMast_cells_restingGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000105778,AVL9-0.39903.6719e-023.0215e-06-0.4302imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr17:39293311-39295509:-LAMLEERENSG00000267274,CTD-2006C1.12-0.37894.2937e-021.4183e-05-0.4027imageNNNAMonocytesGSVA_HALLMARK_UV_RESPONSE_UP
chr17:39293311-39295509:-LAMLEERENSG00000270555,RP11-1394O16.1-0.37974.7941e-021.2473e-05-0.4051imageNNNAPlasma_cellsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr17:39293311-39295509:-LAMLEERENSG00000142089,IFITM30.41761.8636e-021.4012e-070.4787imageNNIFITM3T_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000233674,RP11-184I16.3-0.42382.0281e-028.9762e-06-0.4111imageNNNAMonocytesGSVA_HALLMARK_NOTCH_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000146802,TMEM168-0.42642.0785e-022.0532e-07-0.4731imageNNNAT_cells_CD8GSVA_HALLMARK_KRAS_SIGNALING_DN
chr17:39293311-39295509:-LAMLEERENSG00000196757,ZNF700-0.41032.8929e-023.4343e-06-0.4280imageNNNAMonocytesGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr17:39293311-39295509:-LAMLEERENSG00000207344,SNORA22-0.40572.9820e-029.2823e-07-0.4498imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr17:39293311-39295509:-LAMLEERENSG00000175395,ZNF25-0.40513.3606e-028.7412e-06-0.4116imageNNNAB_cells_naiveGSVA_HALLMARK_PROTEIN_SECRETION
chr17:39293311-39295509:-LAMLEERENSG00000278206,RP1-20N2.8-0.40233.5120e-029.7252e-06-0.4096imageNNNAMast_cells_restingGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr17:39293311-39295509:-LAMLEERENSG00000105778,AVL9-0.39903.6719e-023.0215e-06-0.4302imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MYOGENESIS
chr17:39293311-39295509:-LAMLEERENSG00000267274,CTD-2006C1.12-0.37894.2937e-021.4183e-05-0.4027imageNNNAMonocytesGSVA_HALLMARK_UV_RESPONSE_UP
chr17:39293311-39295509:-LAMLEERENSG00000270555,RP11-1394O16.1-0.37974.7941e-021.2473e-05-0.4051imageNNNAPlasma_cellsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

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4. Enriched editing regions and immune related splicing for FBXL20


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000108306.10,FBXL20
BRCAEAGIRENSG00000090060.13chr1496532510:96534563:96535878:965359990.10953.4779e-021.1315e-330.4016imageNADAR;ALKBH5;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000108306.10,FBXL20
THCAEAGA3ENSG00000151148.9chr12109489918:109490004:109491044:109491127:109490489:109491127-0.34871.9500e-108.5177e-19-0.4093imageNADAR;ALKBH5;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000108306.10,FBXL20
THCAEAGIRENSG00000166912.12chr1530938940:30942072:30942889:309430720.39473.1508e-135.3052e-220.4366imageNADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI1;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RBFOX2;RBM10;RBM22;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZNF184NANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000108306.10,FBXL20
THCAEAGMEXENSG00000110321.11chr1110798991:10799113:10799212:10799266:10799551:10799756:10800089:108003480.39623.6439e-131.3849e-220.4422imageNADAR;ALKBH5;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000108306.10,FBXL20
THCAEAGMEXENSG00000134283.13chr1242335882:42335974:42355160:42355222:42398853:42398994:42441314:42441429-0.39563.7812e-136.8139e-21-0.4258imageNADAR;ALKBH5;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000108306.10,FBXL20
THCAEAGMEXENSG00000110321.11chr1110798991:10799113:10799212:10799309:10799551:10799756:10800089:108003480.39573.9444e-131.2102e-220.4428imageNADAR;ALKBH5;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000108306.10,FBXL20
THCAEAGMEXENSG00000110321.11chr1110798991:10799113:10799212:10799305:10799551:10799756:10800089:108003480.39435.1507e-131.4988e-220.4419imageNADAR;ALKBH5;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000108306.10,FBXL20
THCAEAGIRENSG00000090060.13chr1496532510:96534563:96535878:965359990.38491.9736e-123.3221e-220.4390imageNADAR;ALKBH5;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000108306.10,FBXL20
THCAEAGA3ENSG00000145740.14chr569103061:69103128:69104630:69104695:69103961:69104695-0.37941.9916e-129.0668e-21-0.4294imageNADAR;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000108306.10,FBXL20
THCAEAGIRENSG00000136709.7chr2127763061:127763159:127764827:1277649790.43141.9458e-169.1609e-240.4531imageNADAR;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NANK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_DN

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5. Enriched editing regions and immune infiltration for FBXL20


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000108306.10,FBXL20ACCEAGMonocytes1.1393e-02-0.4115image
ENSG00000108306.10,FBXL20BLCAEAGMacrophages_M23.5201e-020.1672image
chr17:39254067-39257260:-BRCAEERT_cells_CD4_memory_activated1.2604e-020.0872image
ENSG00000108306.10,FBXL20BRCAEAGNK_cells_activated3.3277e-030.1016image
ENSG00000108306.10,FBXL20COADEAGT_cells_CD4_naive4.5463e-080.5279image
chr17:39254067-39257260:-ESCAEERMacrophages_M23.5025e-020.1700image
chr17:39259690-39259950:-ESCAEERMast_cells_activated1.9367e-030.4930image
chr17:39293311-39295509:-ESCAEERMacrophages_M12.0070e-020.3860image
ENSG00000108306.10,FBXL20ESCAEAGT_cells_CD85.6259e-030.2214image
chr17:39254067-39257260:-GBMEERNK_cells_activated1.1579e-02-0.2389image
ENSG00000108306.10,FBXL20GBMEAGNK_cells_activated1.1018e-02-0.2394image
ENSG00000108306.10,FBXL20HNSCEAGT_cells_CD81.1957e-030.2114image
ENSG00000108306.10,FBXL20KICHEAGMacrophages_M04.9273e-040.6455image
chr17:39254067-39257260:-KIRCEERMonocytes7.6728e-04-0.1978image
ENSG00000108306.10,FBXL20KIRCEAGMonocytes1.9608e-02-0.1372image
chr17:39254067-39257260:-KIRPEERT_cells_follicular_helper8.6715e-050.2891image
ENSG00000108306.10,FBXL20KIRPEAGMast_cells_resting1.9220e-03-0.2214image
chr17:39254067-39257260:-LAMLEERMacrophages_M19.0083e-040.2980image
chr17:39273106-39274169:-LAMLEERMacrophages_M06.8004e-040.4979image
chr17:39293311-39295509:-LAMLEERT_cells_gamma_delta4.0032e-02-0.1970image
ENSG00000108306.10,FBXL20LAMLEAGT_cells_gamma_delta4.9650e-02-0.1656image
chr17:39254067-39257260:-LGGEERMacrophages_M08.9748e-04-0.1542image
ENSG00000108306.10,FBXL20LGGEAGMacrophages_M01.7032e-02-0.1110image
chr17:39254067-39257260:-LIHCEERT_cells_CD88.2968e-040.4046image
chr17:39254067-39257260:-LUADEERT_cells_CD4_memory_activated8.9652e-030.1387image
ENSG00000108306.10,FBXL20LUADEAGT_cells_CD4_memory_activated2.9356e-020.1148image
chr17:39254067-39257260:-LUSCEERT_cells_follicular_helper4.6152e-030.1793image
ENSG00000108306.10,FBXL20LUSCEAGDendritic_cells_activated8.2303e-030.1642image
chr17:39254067-39257260:-MESOEERMonocytes2.1533e-02-0.3580image
chr17:39254067-39257260:-OVEEREosinophils1.3442e-020.1607image
ENSG00000108306.10,FBXL20OVEAGEosinophils1.2467e-020.1601image
chr17:39254067-39257260:-PAADEERB_cells_memory1.7825e-020.2507image
chr17:39254067-39257260:-PCPGEEREosinophils2.3254e-020.2280image
ENSG00000108306.10,FBXL20PCPGEAGDendritic_cells_activated3.3026e-020.2145image
chr17:39254067-39257260:-PRADEERDendritic_cells_resting1.5098e-03-0.1724image
ENSG00000108306.10,FBXL20PRADEAGDendritic_cells_resting1.1008e-03-0.1765image
ENSG00000108306.10,FBXL20READEAGT_cells_CD4_naive7.3459e-070.7765image
chr17:39254067-39257260:-SARCEERNK_cells_activated1.4332e-02-0.2127image
ENSG00000108306.10,FBXL20SARCEAGT_cells_CD4_memory_activated4.8065e-040.2816image
chr17:39254067-39257260:-SKCMEEREosinophils4.6258e-02-0.1190image
ENSG00000108306.10,FBXL20SKCMEAGT_cells_CD4_memory_resting2.3768e-02-0.1286image
chr17:39254067-39257260:-STADEERDendritic_cells_activated1.1848e-020.1350image
chr17:39259690-39259950:-STADEERB_cells_memory4.3386e-020.2928image
chr17:39286332-39288109:-STADEERT_cells_CD4_memory_activated9.9146e-050.6103image
chr17:39316035-39317931:-STADEERT_cells_CD4_memory_activated4.2311e-020.3311image
chr17:39374410-39375000:-STADEERT_cells_CD85.0537e-030.3796image
chr17:39394352-39394738:-STADEERDendritic_cells_resting2.1711e-020.4320image
ENSG00000108306.10,FBXL20STADEAGDendritic_cells_activated8.4499e-030.1412image
chr17:39254067-39257260:-TGCTEERB_cells_naive8.6216e-03-0.2739image
ENSG00000108306.10,FBXL20TGCTEAGB_cells_naive2.9466e-02-0.2284image
chr17:39254067-39257260:-THCAEERB_cells_memory3.4706e-020.1068image
ENSG00000108306.10,FBXL20THCAEAGNeutrophils6.9788e-03-0.1282image
ENSG00000108306.10,FBXL20UCECEAGDendritic_cells_resting1.2275e-020.3138image
ENSG00000108306.10,FBXL20UCSEAGPlasma_cells1.3912e-020.5279image


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6. Enriched editing regions and immune gene sets for FBXL20


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr17:39254067-39257260:-BRCAEER6.0772e-060.15746.7951e-030.09463.3054e-030.10263.6687e-060.1610image
chr17:39254067-39257260:-LUADEER1.1265e-040.20381.2255e-020.13301.1992e-030.17154.6408e-060.2407image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000108306.10,FBXL20ACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.9105e-04-0.5276image
ENSG00000108306.10,FBXL20BLCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG6.1413e-050.3123image
chr17:39254067-39257260:-BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.4382e-020.1838image
chr17:39254067-39257260:-BRCAGSVA_HALLMARK_GLYCOLYSISEER8.3759e-100.2125image
ENSG00000108306.10,FBXL20BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.4674e-130.2472image
ENSG00000108306.10,FBXL20CESCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2929e-07-0.4638image
chr17:39254067-39257260:-CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5214e-02-0.2657image
ENSG00000108306.10,FBXL20COADGSVA_HALLMARK_SPERMATOGENESISEAG1.9978e-02-0.2397image
ENSG00000108306.10,FBXL20ESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG3.0377e-030.2366image
chr17:39259690-39259950:-ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEER7.7413e-040.5284image
chr17:39254067-39257260:-ESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER7.5971e-030.2144image
chr17:39254067-39257260:-GBMGSVA_HALLMARK_MITOTIC_SPINDLEEER4.1242e-02-0.1941image
ENSG00000108306.10,FBXL20HNSCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.8353e-04-0.2432image
chr17:39254067-39257260:-HNSCGSVA_HALLMARK_MYC_TARGETS_V2EER5.1571e-030.1919image
ENSG00000108306.10,FBXL20KICHGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.5873e-02-0.4448image
chr17:39254067-39257260:-KIRCGSVA_HALLMARK_UV_RESPONSE_UPEER8.0754e-040.1970image
ENSG00000108306.10,FBXL20KIRCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.3288e-030.1784image
ENSG00000108306.10,FBXL20KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.1388e-13-0.4900image
chr17:39254067-39257260:-KIRPGSVA_HALLMARK_MYC_TARGETS_V2EER1.2211e-030.2399image
chr17:39254067-39257260:-LAMLGSVA_HALLMARK_HEME_METABOLISMEER3.4732e-020.1921image
ENSG00000108306.10,FBXL20LAMLGSVA_HALLMARK_HEME_METABOLISMEAG2.9124e-020.1838image
chr17:39293311-39295509:-LAMLGSVA_HALLMARK_MYOGENESISEER4.4122e-050.3808image
chr17:39254067-39257260:-LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER1.4024e-06-0.2225image
ENSG00000108306.10,FBXL20LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.7394e-07-0.2287image
chr17:39254067-39257260:-LIHCGSVA_HALLMARK_COMPLEMENTEER1.2310e-020.3088image
ENSG00000108306.10,FBXL20LIHCGSVA_HALLMARK_P53_PATHWAYEAG3.0177e-020.2472image
chr17:39254067-39257260:-LUADGSVA_HALLMARK_UV_RESPONSE_UPEER2.1707e-100.3292image
ENSG00000108306.10,FBXL20LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.4694e-070.2679image
chr17:39254067-39257260:-LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.4526e-020.1277image
ENSG00000108306.10,FBXL20LUSCGSVA_HALLMARK_SPERMATOGENESISEAG4.5859e-03-0.1760image
chr17:39254067-39257260:-MESOGSVA_HALLMARK_COMPLEMENTEER3.4118e-030.4467image
ENSG00000108306.10,FBXL20MESOGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.7875e-030.4177image
ENSG00000108306.10,FBXL20OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.6139e-06-0.3020image
chr17:39254067-39257260:-OVGSVA_HALLMARK_MYC_TARGETS_V2EER2.7375e-050.2694image
chr17:39254067-39257260:-PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.4909e-020.2377image
ENSG00000108306.10,FBXL20PAADGSVA_HALLMARK_MYC_TARGETS_V2EAG2.5548e-030.3077image
ENSG00000108306.10,FBXL20PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.0517e-02-0.2063image
chr17:39254067-39257260:-PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.3195e-02-0.2143image
chr17:39254067-39257260:-PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER4.7818e-04-0.1895image
ENSG00000108306.10,FBXL20PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.7480e-07-0.2660image
ENSG00000108306.10,FBXL20SARCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.1142e-07-0.4169image
ENSG00000108306.10,FBXL20SKCMGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.9129e-11-0.3626image
chr17:39254067-39257260:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.9975e-080.2920image
chr17:39316035-39317931:-STADGSVA_HALLMARK_SPERMATOGENESISEER2.4258e-020.3650image
chr17:39266128-39266655:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1692e-02-0.4760image
chr17:39374410-39375000:-STADGSVA_HALLMARK_MYC_TARGETS_V1EER1.7713e-030.4194image
chr17:39290687-39291663:-STADGSVA_HALLMARK_ADIPOGENESISEER1.8734e-020.4576image
chr17:39293311-39295509:-STADGSVA_HALLMARK_UV_RESPONSE_DNEER1.3693e-02-0.3367image
ENSG00000108306.10,FBXL20STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.2653e-070.2675image
chr17:39286332-39288109:-STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER6.7566e-030.4494image
chr17:39394352-39394738:-STADGSVA_HALLMARK_SPERMATOGENESISEER3.6810e-02-0.3963image
chr17:39254067-39257260:-TGCTGSVA_HALLMARK_GLYCOLYSISEER2.7681e-040.3725image
ENSG00000108306.10,FBXL20TGCTGSVA_HALLMARK_GLYCOLYSISEAG1.4250e-030.3295image
chr17:39254067-39257260:-THCAGSVA_HALLMARK_UV_RESPONSE_DNEER2.2397e-03-0.1541image
ENSG00000108306.10,FBXL20THCAGSVA_HALLMARK_UV_RESPONSE_DNEAG9.9667e-14-0.3441image
ENSG00000108306.10,FBXL20THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.0196e-02-0.2854image
ENSG00000108306.10,FBXL20UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.1818e-020.2886image
chr17:39254067-39257260:-UCECGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.5315e-02-0.2926image
ENSG00000108306.10,FBXL20UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG9.4483e-030.5522image
ENSG00000108306.10,FBXL20UVMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.6734e-02-0.4136image


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7. Enriched editing regions and drugs for FBXL20


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000108306.10,FBXL20ACCFH535EAG5.4475e-030.4478image
ENSG00000108306.10,FBXL20BLCADocetaxelEAG1.3337e-04-0.2984image
chr17:39254067-39257260:-BLCAAxitinibEER8.1131e-030.2154image
chr17:39254067-39257260:-BRCACCT007093EER9.1125e-060.1544image
ENSG00000108306.10,FBXL20BRCAA.770041EAG1.2579e-11-0.2320image
chr17:39254067-39257260:-CESCAZD.2281EER4.0785e-02-0.2251image
ENSG00000108306.10,FBXL20CESCBMS.536924EAG2.8654e-04-0.3424image
ENSG00000108306.10,FBXL20COADGefitinibEAG6.8354e-04-0.3441image
chr17:39254067-39257260:-ESCACGP.60474EER4.0747e-03-0.2302image
ENSG00000108306.10,FBXL20ESCACGP.60474EAG3.0938e-03-0.2361image
chr17:39293311-39295509:-ESCAGDC0941EER1.7747e-03-0.5028image
chr17:39259690-39259950:-ESCACI.1040EER3.1219e-03-0.4729image
chr17:39254067-39257260:-GBMBMS.509744EER8.0793e-03-0.2502image
ENSG00000108306.10,FBXL20GBMBMS.509744EAG8.7601e-03-0.2466image
chr17:39254067-39257260:-HNSCABT.888EER2.3411e-03-0.2084image
ENSG00000108306.10,FBXL20HNSCCEP.701EAG2.5560e-06-0.3038image
ENSG00000108306.10,FBXL20KICHAZD.2281EAG2.2046e-07-0.8342image
chr17:39254067-39257260:-KIRCAS601245EER4.9279e-030.1658image
ENSG00000108306.10,FBXL20KIRCGSK269962AEAG2.0118e-03-0.1810image
ENSG00000108306.10,FBXL20KIRPGSK269962AEAG4.2743e-18-0.5698image
chr17:39254067-39257260:-KIRPCCT007093EER1.6403e-040.2781image
chr17:39254067-39257260:-LAMLFTI.277EER2.2387e-030.2753image
ENSG00000108306.10,FBXL20LAMLMidostaurinEAG3.7662e-030.2425image
chr17:39293311-39295509:-LAMLKU.55933EER1.6075e-05-0.4004image
chr17:39254067-39257260:-LGGMethotrexateEER1.1686e-060.2241image
ENSG00000108306.10,FBXL20LGGJNK.Inhibitor.VIIIEAG4.2086e-080.2516image
chr17:39254067-39257260:-LIHCAP.24534EER1.1764e-03-0.3937image
ENSG00000108306.10,FBXL20LIHCAP.24534EAG2.7414e-04-0.4035image
chr17:39254067-39257260:-LUADCCT007093EER4.7173e-050.2145image
ENSG00000108306.10,FBXL20LUADBMS.509744EAG1.0062e-03-0.1726image
chr17:39254067-39257260:-LUSCJW.7.52.1EER6.2345e-03-0.1732image
ENSG00000108306.10,FBXL20LUSCBryostatin.1EAG2.6639e-04-0.2252image
chr17:39254067-39257260:-MESOCGP.082996EER5.9407e-03-0.4224image
ENSG00000108306.10,FBXL20MESOKIN001.135EAG6.9640e-03-0.4011image
chr17:39254067-39257260:-OVImatinibEER1.5430e-050.2773image
ENSG00000108306.10,FBXL20OVImatinibEAG4.2373e-060.2902image
ENSG00000108306.10,FBXL20PAADAZD6482EAG6.0364e-040.3491image
ENSG00000108306.10,FBXL20PCPGBX.795EAG3.9204e-030.2874image
chr17:39254067-39257260:-PCPGBX.795EER7.1462e-030.2688image
chr17:39254067-39257260:-PRADBMS.509744EER4.0850e-05-0.2218image
ENSG00000108306.10,FBXL20PRADBMS.509744EAG2.4587e-09-0.3167image
chr17:39254067-39257260:-READAZD6244EER3.3422e-020.4031image
ENSG00000108306.10,FBXL20READBMS.536924EAG2.3520e-02-0.4268image
chr17:39254067-39257260:-SARCABT.263EER6.7803e-03-0.2346image
ENSG00000108306.10,FBXL20SARCDasatinibEAG1.2476e-09-0.4732image
chr17:39254067-39257260:-SKCMAxitinibEER2.5404e-030.1794image
ENSG00000108306.10,FBXL20SKCMDoxorubicinEAG1.3080e-140.4196image
chr17:39374410-39375000:-STADMG.132EER4.1796e-03-0.3872image
chr17:39293311-39295509:-STADBI.2536EER3.6721e-040.4714image
chr17:39259690-39259950:-STADAZD.2281EER3.5397e-02-0.3044image
chr17:39316035-39317931:-STADJNK.Inhibitor.VIIIEER1.9292e-03-0.4870image
ENSG00000108306.10,FBXL20STADAS601245EAG3.8151e-050.2192image
chr17:39254067-39257260:-STADAS601245EER5.1942e-050.2155image
chr17:39286332-39288109:-STADAZD.2281EER5.7341e-06-0.6846image
chr17:39394352-39394738:-STADAUY922EER4.5831e-04-0.6179image
ENSG00000108306.10,FBXL20TGCTJW.7.52.1EAG1.4465e-03-0.3291image
chr17:39254067-39257260:-TGCTErlotinibEER1.3979e-03-0.3301image
chr17:39254067-39257260:-THCAEmbelinEER3.8655e-070.2533image
ENSG00000108306.10,FBXL20THCAEmbelinEAG2.8448e-170.3874image
chr17:39254067-39257260:-THYMJNK.9LEER2.1673e-020.2844image
ENSG00000108306.10,FBXL20THYMJNK.9LEAG2.2149e-040.4396image
chr17:39254067-39257260:-UCECDMOGEER6.3461e-080.6679image
ENSG00000108306.10,FBXL20UCECCEP.701EAG4.8521e-05-0.4886image
ENSG00000108306.10,FBXL20UCSJNK.Inhibitor.VIIIEAG1.3521e-040.7377image
ENSG00000108306.10,FBXL20UVMDasatinibEAG1.0770e-05-0.6854image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType