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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HAVCR2 (ImmuneEditome ID:84868)

1. Gene summary of enriched editing regions for HAVCR2

check button Gene summary
Gene informationGene symbol

HAVCR2

Gene ID

84868

GeneSynonymsCD366|HAVcr-2|KIM-3|SPTCL|TIM3|TIMD-3|TIMD3|Tim-3
GeneCytomap

5q33.3

GeneTypeprotein-coding
GeneDescriptionhepatitis A virus cellular receptor 2|T cell immunoglobulin mucin 3|T-cell immunoglobulin and mucin domain 3|T-cell immunoglobulin and mucin domain-containing protein 3|T-cell immunoglobulin mucin family member 3|T-cell immunoglobulin mucin receptor 3|T-cell membrane protein 3|kidney injury molecule-3
GeneModificationdate20230521
UniprotIDQ8TDQ0;E5RHN3
PubMed ID

37182110

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:157090188-157091004:-ENST00000307851.7ENSG00000135077.7HAVCR2intronicAluJr,AluJb,AluJochr5:157090188-157091004:-.alignment
chr5:157090188-157091004:-ENST00000522593.4ENSG00000135077.7HAVCR2intronicAluJr,AluJb,AluJochr5:157090188-157091004:-.alignment
chr5:157092345-157092987:-ENST00000307851.7ENSG00000135077.7HAVCR2intronicAluSz6,AluJo,AluSpchr5:157092345-157092987:-.alignment
chr5:157092345-157092987:-ENST00000522593.4ENSG00000135077.7HAVCR2intronicAluSz6,AluJo,AluSpchr5:157092345-157092987:-.alignment
chr5:157101865-157103298:-ENST00000521665.1ENSG00000135077.7HAVCR2ncRNA_intronicAluY,AluJb,AluSx,L3,ORSL-2achr5:157101865-157103298:-.alignment
chr5:157133784-157134472:-ENST00000524219.1ENSG00000135077.7HAVCR2intronicFLAM_C,AluJo,AluSc5chr5:157133784-157134472:-.alignment
chr5:157135941-157137273:-ENST00000524219.1ENSG00000135077.7HAVCR2intronicAluSp,LTR78,AluSz6,AluJr4,(AT)nchr5:157135941-157137273:-.alignment


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2. Tumor-specific enriched editing regions for HAVCR2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr5:157133784-157134472:-HNSCEER1.1186e-02image
ENSG00000135077.7,HAVCR2HNSCEAG1.1707e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr5:157101865-157103298:-STADPathEER6.6056e-043.6695e-02-0.2401image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for HAVCR2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:157133784-157134472:-THYMEERENSG00000099284,H2AFY20.33474.2075e-035.2749e-060.4136imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ANGIOGENESIS
chr5:157133784-157134472:-THYMEERENSG00000264148,RP11-848P1.70.30948.5521e-035.2163e-070.4514imageNNNAMacrophages_M1GSVA_HALLMARK_G2M_CHECKPOINT
chr5:157133784-157134472:-THYMEERENSG00000196793,ZNF2390.29441.5291e-025.8989e-060.4117imageNNNADendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr5:157133784-157134472:-THYMEERENSG00000135094,SDS0.29011.7847e-023.3211e-060.4216imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_APOPTOSIS
chr5:157133784-157134472:-THYMEERENSG00000159182,PRAC10.14871.8026e-022.3049e-060.4277imageNNNANeutrophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:157133784-157134472:-THYMEERENSG00000114631,PODXL20.28111.9955e-023.1685e-070.4590imageNNPODXL2Macrophages_M1GSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
chr5:157133784-157134472:-THYMEERENSG00000171729,TMEM510.26832.0656e-028.6187e-060.4050imageNNNAMacrophages_M1GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr5:157133784-157134472:-THYMEERENSG00000169313,P2RY120.26042.5945e-021.3591e-060.4363imageNNP2RY12NK_cells_activatedGSVA_HALLMARK_SPERMATOGENESIS
chr5:157133784-157134472:-THYMEERENSG00000166387,PPFIBP20.26342.5961e-023.2108e-070.4588imageNNNAMacrophages_M1GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr5:157133784-157134472:-THYMEERENSG00000148120,C9orf30.27472.6195e-029.5191e-060.4032imageNNNADendritic_cells_activatedGSVA_HALLMARK_ANGIOGENESIS

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4. Enriched editing regions and immune related splicing for HAVCR2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000135077.7,HAVCR2
GBMEAGIRENSG00000102054.13chrX16852045:16852122:16852415:16852517-0.28862.4721e-025.6786e-06-0.4090imageNACIN1;ADAR;ALYREF;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;ZC3H7B;ZNF184NAMonocytesGSVA_HALLMARK_PEROXISOME
chr5:157133784-157134472:-
GBMEERIRENSG00000102054.13chrX16852045:16852122:16852415:16852517-0.27943.0064e-028.9270e-06-0.4010imageNNNAMonocytesGSVA_HALLMARK_PEROXISOME
ENSG00000135077.7,HAVCR2
THYMEAGESENSG00000214022.7chr7150368789:150368941:150369670:150370884:150371227:150374044-0.30022.5985e-022.7752e-05-0.4309imageNACIN1;ALYREF;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
ENSG00000135077.7,HAVCR2
THYMEAGIRENSG00000143851.11chr1202147014:202147575:202148553:2021486990.28841.5905e-021.2605e-050.4014imageNADAR;CPSF6;CSTF2T;DDX3X;DGCR8;DKC1;EIF4G2;ELAVL1;FAM120A;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;MSI2;PRPF8;PTBP1;SAFB2;SLTM;SND1;SRSF1;TAF15;TARDBP;TRA2A;U2AF1;U2AF2;XRN2PTPN7NK_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr5:157133784-157134472:-
THYMEERA3ENSG00000205531.8chr112951258:2951295:2944436:2945643:2944436:29492640.34361.6990e-021.1317e-050.4017imageNNNAT_cells_CD8GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000135077.7,HAVCR2
THYMEAGIRENSG00000138030.8chr227098922:27099284:27099419:270994680.28951.5389e-027.9528e-070.5031imageNBCCIP;BUD13;CNBP;CSTF2T;DDX3X;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP4B;LIN28;LIN28B;LSM11;MOV10;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SLTM;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_HYPOXIA
chr5:157133784-157134472:-
THYMEERA3ENSG00000213923.6chr2238298785:38298852:38296205:38296686:38296205:38297155-0.28552.2544e-027.5109e-05-0.4279imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr5:157133784-157134472:-
THYMEERESENSG00000214022.7chr7150368789:150368941:150369670:150370884:150371227:150374044-0.30212.3896e-023.2329e-05-0.4277imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
ENSG00000135077.7,HAVCR2
THYMEAGA3ENSG00000213923.6chr2238298785:38298852:38296205:38296686:38296205:38297155-0.26564.5264e-021.1386e-04-0.4181imageNACIN1;ADAR;ALYREF;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SLTM;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZFP36;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr5:157133784-157134472:-
THYMEERIRENSG00000138030.8chr227098922:27099284:27099419:270994680.28441.8464e-025.3206e-070.5125imageNNNADendritic_cells_activatedGSVA_HALLMARK_HYPOXIA

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5. Enriched editing regions and immune infiltration for HAVCR2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr5:157133784-157134472:-ACCEERDendritic_cells_resting1.4697e-020.2947image
ENSG00000135077.7,HAVCR2ACCEAGDendritic_cells_resting1.4534e-020.2952image
chr5:157133784-157134472:-BLCAEERMacrophages_M13.0757e-020.1269image
ENSG00000135077.7,HAVCR2BLCAEAGMacrophages_M12.9725e-020.1275image
chr5:157133784-157134472:-BRCAEERMast_cells_resting1.7593e-04-0.1202image
ENSG00000135077.7,HAVCR2BRCAEAGMast_cells_resting1.9152e-04-0.1193image
chr5:157133784-157134472:-CESCEERT_cells_CD4_naive5.2897e-030.1918image
ENSG00000135077.7,HAVCR2CESCEAGT_cells_CD4_naive6.7875e-030.1854image
chr5:157133784-157134472:-CHOLEERNK_cells_activated1.7805e-02-0.4040image
ENSG00000135077.7,HAVCR2CHOLEAGNK_cells_activated1.7881e-02-0.4038image
chr5:157133784-157134472:-COADEERT_cells_CD4_memory_resting3.6798e-02-0.1647image
ENSG00000135077.7,HAVCR2DLBCEAGDendritic_cells_activated1.9189e-020.3783image
chr5:157101865-157103298:-ESCAEERMast_cells_resting1.2414e-030.5171image
chr5:157133784-157134472:-GBMEERMacrophages_M15.4957e-030.2311image
ENSG00000135077.7,HAVCR2GBMEAGMacrophages_M15.5661e-030.2307image
chr5:157133784-157134472:-HNSCEERDendritic_cells_resting2.9672e-02-0.1688image
ENSG00000135077.7,HAVCR2HNSCEAGDendritic_cells_resting2.8252e-02-0.1698image
chr5:157090188-157091004:-KIRCEERT_cells_follicular_helper1.9333e-030.4869image
chr5:157133784-157134472:-KIRCEERT_cells_CD4_memory_activated1.1119e-020.1329image
ENSG00000135077.7,HAVCR2KIRCEAGT_cells_CD4_memory_activated6.3674e-030.1426image
ENSG00000135077.7,HAVCR2LAMLEAGEosinophils1.3323e-030.5505image
chr5:157133784-157134472:-LGGEERMacrophages_M13.7269e-030.1264image
ENSG00000135077.7,HAVCR2LGGEAGMacrophages_M13.7681e-030.1262image
chr5:157133784-157134472:-LUADEERMacrophages_M02.2480e-02-0.1324image
ENSG00000135077.7,HAVCR2LUADEAGMacrophages_M01.0917e-02-0.1463image
chr5:157133784-157134472:-MESOEERT_cells_follicular_helper4.4290e-020.2628image
ENSG00000135077.7,HAVCR2MESOEAGT_cells_follicular_helper4.1696e-020.2660image
chr5:157133784-157134472:-OVEERT_cells_CD83.2737e-030.2050image
ENSG00000135077.7,HAVCR2OVEAGT_cells_CD82.3469e-020.1574image
chr5:157133784-157134472:-PCPGEERMonocytes2.1040e-02-0.1753image
ENSG00000135077.7,HAVCR2PCPGEAGMonocytes2.1040e-02-0.1753image
chr5:157133784-157134472:-SARCEERMacrophages_M26.8908e-030.1891image
ENSG00000135077.7,HAVCR2SARCEAGMacrophages_M27.1758e-030.1882image
chr5:157133784-157134472:-SKCMEERPlasma_cells3.1179e-030.1698image
ENSG00000135077.7,HAVCR2SKCMEAGPlasma_cells3.1630e-030.1690image
chr5:157133784-157134472:-STADEERB_cells_memory7.2045e-03-0.1909image
ENSG00000135077.7,HAVCR2STADEAGB_cells_memory6.5644e-03-0.1761image
ENSG00000135077.7,HAVCR2TGCTEAGNK_cells_resting9.1052e-030.3096image
chr5:157133784-157134472:-THYMEERDendritic_cells_activated1.4407e-040.3501image
ENSG00000135077.7,HAVCR2THYMEAGDendritic_cells_activated1.8497e-040.3432image
chr5:157133784-157134472:-UCECEERMast_cells_resting9.2917e-040.2601image
ENSG00000135077.7,HAVCR2UCECEAGMast_cells_resting1.3189e-030.2510image


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6. Enriched editing regions and immune gene sets for HAVCR2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr5:157133784-157134472:-BRCAEER6.3778e-050.12806.2677e-050.12815.6976e-030.08875.4857e-040.1108image
ENSG00000135077.7,HAVCR2BRCAEAG1.6000e-050.13783.5300e-050.13222.8934e-030.09547.3489e-050.1268image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr5:157133784-157134472:-ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.7539e-020.2528image
ENSG00000135077.7,HAVCR2ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.6416e-020.2542image
ENSG00000135077.7,HAVCR2BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.8756e-060.1459image
chr5:157135941-157137273:-BRCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.7516e-020.2650image
chr5:157133784-157134472:-BRCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.6420e-050.1379image
ENSG00000135077.7,HAVCR2CESCGSVA_HALLMARK_GLYCOLYSISEAG1.3274e-020.1698image
chr5:157133784-157134472:-CESCGSVA_HALLMARK_GLYCOLYSISEER1.1830e-020.1734image
chr5:157133784-157134472:-COADGSVA_HALLMARK_APICAL_JUNCTIONEER1.5410e-020.1907image
ENSG00000135077.7,HAVCR2COADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.1125e-020.1811image
chr5:157101865-157103298:-ESCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER9.2447e-040.5284image
chr5:157133784-157134472:-GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.9249e-030.2572image
ENSG00000135077.7,HAVCR2GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.7708e-030.2592image
chr5:157133784-157134472:-KICHGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.7977e-030.3852image
ENSG00000135077.7,HAVCR2KICHGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.7977e-030.3852image
ENSG00000135077.7,HAVCR2KIRCGSVA_HALLMARK_E2F_TARGETSEAG4.7076e-050.2113image
chr5:157090188-157091004:-KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5203e-030.4760image
chr5:157133784-157134472:-KIRCGSVA_HALLMARK_E2F_TARGETSEER3.0688e-040.1881image
ENSG00000135077.7,HAVCR2KIRPGSVA_HALLMARK_MYOGENESISEAG3.0712e-020.1351image
chr5:157133784-157134472:-KIRPGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.0774e-020.1350image
chr5:157133784-157134472:-LGGGSVA_HALLMARK_PROTEIN_SECRETIONEER1.9187e-050.1854image
ENSG00000135077.7,HAVCR2LGGGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.9480e-050.1852image
chr5:157133784-157134472:-LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.9917e-020.1139image
ENSG00000135077.7,HAVCR2LUSCGSVA_HALLMARK_HYPOXIAEAG4.1161e-020.1290image
ENSG00000135077.7,HAVCR2OVGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.5944e-030.2181image
chr5:157133784-157134472:-OVGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER8.5568e-040.2317image
chr5:157133784-157134472:-PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.4593e-02-0.1854image
ENSG00000135077.7,HAVCR2PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.3731e-02-0.1865image
ENSG00000135077.7,HAVCR2PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.1316e-020.1922image
chr5:157133784-157134472:-PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER1.1316e-020.1922image
chr5:157133784-157134472:-PRADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.3165e-020.0968image
ENSG00000135077.7,HAVCR2PRADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.9822e-020.0988image
chr5:157133784-157134472:-READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.0779e-02-0.2585image
ENSG00000135077.7,HAVCR2READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.0954e-02-0.2583image
ENSG00000135077.7,HAVCR2SARCGSVA_HALLMARK_NOTCH_SIGNALINGEAG1.1798e-020.1764image
chr5:157133784-157134472:-SARCGSVA_HALLMARK_NOTCH_SIGNALINGEER1.1947e-020.1761image
chr5:157133784-157134472:-SKCMGSVA_HALLMARK_SPERMATOGENESISEER1.2432e-02-0.1439image
ENSG00000135077.7,HAVCR2SKCMGSVA_HALLMARK_SPERMATOGENESISEAG1.0532e-02-0.1468image
chr5:157101865-157103298:-STADGSVA_HALLMARK_PEROXISOMEEER1.1490e-020.2848image
ENSG00000135077.7,HAVCR2STADGSVA_HALLMARK_MYC_TARGETS_V2EAG1.8354e-020.1531image
chr5:157133784-157134472:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.7313e-030.2124image
ENSG00000135077.7,HAVCR2TGCTGSVA_HALLMARK_HEME_METABOLISMEAG5.6733e-03-0.3273image
chr5:157133784-157134472:-THCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.9647e-03-0.1241image
ENSG00000135077.7,HAVCR2THCAGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG7.2502e-030.1212image
chr5:157133784-157134472:-THYMGSVA_HALLMARK_HYPOXIAEER7.2733e-030.2512image
ENSG00000135077.7,HAVCR2THYMGSVA_HALLMARK_HYPOXIAEAG5.9569e-030.2561image
chr5:157133784-157134472:-UCECGSVA_HALLMARK_MITOTIC_SPINDLEEER3.1934e-020.1702image
ENSG00000135077.7,HAVCR2UCSGSVA_HALLMARK_MYC_TARGETS_V1EAG1.6914e-020.3433image
chr5:157133784-157134472:-UCSGSVA_HALLMARK_MYC_TARGETS_V1EER1.6936e-020.3432image


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7. Enriched editing regions and drugs for HAVCR2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr5:157133784-157134472:-ACCAMG.706EER1.6100e-020.2909image
ENSG00000135077.7,HAVCR2ACCAMG.706EAG1.6272e-020.2904image
ENSG00000135077.7,HAVCR2BLCACGP.60474EAG8.6509e-03-0.1537image
chr5:157133784-157134472:-BLCACGP.60474EER7.1408e-03-0.1577image
ENSG00000135077.7,HAVCR2BRCACGP.082996EAG4.2263e-04-0.1128image
chr5:157135941-157137273:-BRCAA.770041EER4.6480e-03-0.3134image
chr5:157133784-157134472:-BRCACGP.082996EER7.5401e-04-0.1080image
chr5:157133784-157134472:-CESCBicalutamideEER6.9217e-03-0.1858image
ENSG00000135077.7,HAVCR2CESCBicalutamideEAG3.0308e-03-0.2027image
chr5:157133784-157134472:-CHOLAZD.2281EER1.7868e-040.6073image
ENSG00000135077.7,HAVCR2CHOLAZD.2281EAG1.8329e-040.6064image
chr5:157133784-157134472:-COADDocetaxelEER1.6970e-040.2921image
ENSG00000135077.7,HAVCR2COADDocetaxelEAG1.1939e-040.2977image
ENSG00000135077.7,HAVCR2DLBCAS601245EAG3.2507e-020.3476image
ENSG00000135077.7,HAVCR2ESCALapatinibEAG3.5581e-02-0.1897image
chr5:157133784-157134472:-ESCALapatinibEER3.4454e-02-0.2047image
chr5:157101865-157103298:-ESCAKIN001.135EER2.1603e-02-0.3817image
ENSG00000135077.7,HAVCR2GBMBIBW2992EAG2.1037e-03-0.2551image
chr5:157133784-157134472:-GBMBIBW2992EER1.9528e-03-0.2569image
ENSG00000135077.7,HAVCR2HNSCLenalidomideEAG2.8942e-03-0.2291image
chr5:157133784-157134472:-HNSCLenalidomideEER3.1568e-03-0.2278image
chr5:157133784-157134472:-KICHCGP.60474EER3.5114e-020.2929image
ENSG00000135077.7,HAVCR2KICHCGP.60474EAG3.5114e-020.2929image
ENSG00000135077.7,HAVCR2KIRCCMKEAG2.6290e-06-0.2430image
chr5:157090188-157091004:-KIRCMetforminEER2.6103e-04-0.5594image
chr5:157133784-157134472:-KIRCCMKEER2.5108e-05-0.2189image
ENSG00000135077.7,HAVCR2KIRPDMOGEAG5.9625e-03-0.1714image
chr5:157133784-157134472:-KIRPDMOGEER3.9917e-03-0.1793image
ENSG00000135077.7,HAVCR2LGGElesclomolEAG2.2799e-050.1837image
chr5:157133784-157134472:-LGGElesclomolEER2.1859e-050.1841image
ENSG00000135077.7,HAVCR2LUADBleomycinEAG6.6047e-03-0.1560image
chr5:157133784-157134472:-LUADBleomycinEER4.0820e-03-0.1662image
ENSG00000135077.7,HAVCR2LUSCFH535EAG3.1845e-02-0.1355image
chr5:157133784-157134472:-MESODoxorubicinEER8.2733e-030.3407image
ENSG00000135077.7,HAVCR2MESODoxorubicinEAG7.9581e-030.3423image
ENSG00000135077.7,HAVCR2OVBortezomibEAG6.5820e-03-0.1883image
chr5:157133784-157134472:-OVDasatinibEER2.0570e-03-0.2151image
ENSG00000135077.7,HAVCR2PAADCEP.701EAG3.2621e-020.1770image
chr5:157133784-157134472:-PAADCEP.701EER3.2131e-020.1774image
ENSG00000135077.7,HAVCR2PCPGMethotrexateEAG1.2660e-020.1892image
chr5:157133784-157134472:-PCPGMethotrexateEER1.2660e-020.1892image
ENSG00000135077.7,HAVCR2PRADAMG.706EAG4.1141e-020.0929image
chr5:157133784-157134472:-PRADAMG.706EER3.0324e-020.0985image
ENSG00000135077.7,HAVCR2READJNK.9LEAG1.8344e-030.3850image
chr5:157133784-157134472:-READJNK.9LEER1.6858e-030.3878image
chr5:157133784-157134472:-SARCAP.24534EER1.5089e-04-0.2629image
ENSG00000135077.7,HAVCR2SARCAP.24534EAG1.0913e-04-0.2682image
chr5:157133784-157134472:-SKCMA.443654EER9.8551e-030.1485image
ENSG00000135077.7,HAVCR2SKCMCI.1040EAG1.8978e-02-0.1347image
chr5:157135941-157137273:-STADFH535EER2.4727e-020.3421image
chr5:157101865-157103298:-STADGDC0941EER8.9216e-030.2943image
chr5:157090188-157091004:-STADCisplatinEER7.1826e-03-0.4347image
ENSG00000135077.7,HAVCR2STADGDC0941EAG2.1002e-040.2386image
chr5:157133784-157134472:-STADAG.014699EER6.4710e-030.1934image
ENSG00000135077.7,HAVCR2THCAAxitinibEAG2.8003e-020.0993image
chr5:157133784-157134472:-THCALapatinibEER2.6351e-02-0.1003image
ENSG00000135077.7,HAVCR2THYMCMKEAG1.2015e-030.2996image
chr5:157133784-157134472:-THYMBMS.754807EER4.6367e-03-0.2645image
ENSG00000135077.7,HAVCR2UCECDocetaxelEAG4.8514e-030.2210image
chr5:157133784-157134472:-UCECBryostatin.1EER6.2731e-050.3119image
ENSG00000135077.7,HAVCR2UCSBI.D1870EAG4.1233e-03-0.4067image
chr5:157133784-157134472:-UCSBI.D1870EER3.9201e-03-0.4088image
ENSG00000135077.7,HAVCR2UVMBIRB.0796EAG4.2599e-020.3071image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType