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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: POLR2J4 (ImmuneEditome ID:84820)

1. Gene summary of enriched editing regions for POLR2J4

check button Gene summary
Gene informationGene symbol

POLR2J4

Gene ID

84820

GeneSynonymsRPB11-phi
GeneCytomap

7p13

GeneTypepseudo
GeneDescriptionpolymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa pseudogene|polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene|polymerase (RNA) II subunit J4, pseudogene
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:43963509-43965055:-ENST00000427076.4ENSG00000214783.8POLR2J4ncRNA_intronicAluSx1,MER53,AluSq2,AluSz,AluJr,AluSg7,AluSz6chr7:43963509-43965055:-.alignment
chr7:43969508-43971305:-ENST00000427076.4ENSG00000214783.8POLR2J4ncRNA_exonicAluSx1,MIRb,AluSx,AluJr,AluJb,AluSzchr7:43969508-43971305:-.alignment
chr7:43975613-43976610:-ENST00000422304.1ENSG00000214783.8POLR2J4ncRNA_intronicAluSx1,AluJo,AluSzchr7:43975613-43976610:-.alignment
chr7:43975613-43976610:-ENST00000427076.4ENSG00000214783.8POLR2J4ncRNA_intronicAluSx1,AluJo,AluSzchr7:43975613-43976610:-.alignment
chr7:43989451-43989773:-ENST00000422304.1ENSG00000214783.8POLR2J4ncRNA_intronicAluSg,AluJrchr7:43989451-43989773:-.alignment
chr7:43989451-43989773:-ENST00000427076.4ENSG00000214783.8POLR2J4ncRNA_intronicAluSg,AluJrchr7:43989451-43989773:-.alignment
chr7:43990850-43997503:-ENST00000422304.1ENSG00000214783.8POLR2J4ncRNA_intronic(GT)n,(GTAT)n,L2b,AluSq,AluSp,AluSx1,AluSq2,MLT1A,MIRc,AluJb,AluJr,AluSx3,AluSx,GA-richchr7:43990850-43997503:-.alignment
chr7:43990850-43997503:-ENST00000427076.4ENSG00000214783.8POLR2J4ncRNA_intronic(GT)n,(GTAT)n,L2b,AluSq,AluSp,AluSx1,AluSq2,MLT1A,MIRc,AluJb,AluJr,AluSx3,AluSx,GA-richchr7:43990850-43997503:-.alignment
chr7:44010294-44012817:-ENST00000422304.1ENSG00000214783.8POLR2J4ncRNA_intronicAluSg,FRAM,AluSg7,AluSx,FLAM_C,Alu,AluSx1,MER21C,AluYchr7:44010294-44012817:-.alignment
chr7:44010294-44012817:-ENST00000427076.4ENSG00000214783.8POLR2J4ncRNA_intronicAluSg,FRAM,AluSg7,AluSx,FLAM_C,Alu,AluSx1,MER21C,AluYchr7:44010294-44012817:-.alignment


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2. Tumor-specific enriched editing regions for POLR2J4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000214783.8,POLR2J4BRCAEAG3.7116e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr7:43963509-43965055:-LUSCPathEER1.2320e-021.6725e-030.4507image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000214783.8,POLR2J4COADEAG2.2066e-022.5651e-022.2260e+03image

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3. Enriched editing regions and immune related genes for POLR2J4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for POLR2J4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000214783.8,POLR2J4
THYMEAGA3ENSG00000168488.14chr1628836445:28836485:28836747:28836847:28836574:28836847-0.20281.7601e-021.2556e-07-0.5177imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAGSVA_HALLMARK_COMPLEMENT
ENSG00000214783.8,POLR2J4
THYMEAGA3ENSG00000168488.14chr1628836448:28836485:28836849:28836929:28836574:28836929-0.20461.4245e-022.5070e-10-0.6114imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NA
ENSG00000214783.8,POLR2J4
THYMEAGA3ENSG00000168488.14chr1628836448:28836485:28836727:28836847:28836574:28836847-0.20151.9727e-022.8938e-07-0.5023imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAGSVA_HALLMARK_XENOBIOTIC_METABOLISM
ENSG00000214783.8,POLR2J4
THYMEAGA3ENSG00000168488.14chr1628836448:28836485:28836750:28836847:28836574:28836847-0.19791.4388e-028.8000e-08-0.5711imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAGSVA_HALLMARK_COMPLEMENT
ENSG00000214783.8,POLR2J4
THYMEAGIRENSG00000180104.11chr5466726:468609:468869:4689420.33313.7746e-022.5848e-040.4050imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28B;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184EXOC3T_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION

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5. Enriched editing regions and immune infiltration for POLR2J4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000214783.8,POLR2J4BLCAEAGDendritic_cells_activated2.0072e-03-0.1862image
ENSG00000214783.8,POLR2J4BRCAEAGEosinophils7.5934e-030.1100image
chr7:43963509-43965055:-CESCEERT_cells_regulatory_(Tregs)1.0093e-020.4233image
ENSG00000214783.8,POLR2J4CHOLEAGB_cells_naive2.0221e-020.4913image
ENSG00000214783.8,POLR2J4COADEAGNeutrophils1.0242e-090.5863image
ENSG00000214783.8,POLR2J4DLBCEAGMast_cells_activated1.8658e-020.5082image
chr7:43963509-43965055:-ESCAEERMonocytes1.3724e-02-0.4525image
chr7:43989451-43989773:-ESCAEERNeutrophils4.1834e-020.3739image
chr7:43990850-43997503:-ESCAEERT_cells_CD4_memory_activated5.8006e-030.2626image
chr7:44010294-44012817:-ESCAEERT_cells_CD4_memory_resting1.3708e-02-0.2712image
ENSG00000214783.8,POLR2J4ESCAEAGT_cells_CD4_naive3.0488e-100.4913image
chr7:43963509-43965055:-GBMEERDendritic_cells_activated4.8532e-040.6158image
ENSG00000214783.8,POLR2J4GBMEAGB_cells_naive1.6644e-020.2210image
ENSG00000214783.8,POLR2J4HNSCEAGMast_cells_activated1.1285e-020.1377image
ENSG00000214783.8,POLR2J4KIRPEAGMonocytes3.9621e-020.1905image
chr7:43990850-43997503:-LAMLEERMacrophages_M21.3336e-02-0.2272image
ENSG00000214783.8,POLR2J4LAMLEAGMacrophages_M23.6230e-02-0.1825image
ENSG00000214783.8,POLR2J4LUADEAGNK_cells_activated4.4172e-020.1308image
ENSG00000214783.8,POLR2J4LUSCEAGMast_cells_activated3.1369e-060.2472image
ENSG00000214783.8,POLR2J4MESOEAGMonocytes4.7188e-020.3652image
chr7:44010294-44012817:-OVEERDendritic_cells_activated3.9236e-020.2470image
ENSG00000214783.8,POLR2J4PAADEAGDendritic_cells_activated3.7342e-020.2609image
ENSG00000214783.8,POLR2J4PCPGEAGMonocytes4.2802e-02-0.2105image
ENSG00000214783.8,POLR2J4PRADEAGT_cells_gamma_delta4.8052e-090.4057image
ENSG00000214783.8,POLR2J4SKCMEAGMonocytes6.5037e-040.1984image
chr7:43990850-43997503:-STADEERMast_cells_resting2.6116e-02-0.1706image
chr7:44010294-44012817:-STADEERT_cells_CD4_memory_activated2.5516e-040.3320image
ENSG00000214783.8,POLR2J4STADEAGMast_cells_resting1.3685e-02-0.1545image
ENSG00000214783.8,POLR2J4TGCTEAGNK_cells_activated8.8143e-030.3153image
ENSG00000214783.8,POLR2J4THCAEAGMacrophages_M06.0603e-03-0.1363image
ENSG00000214783.8,POLR2J4UCECEAGT_cells_CD4_memory_activated1.5521e-020.2439image
ENSG00000214783.8,POLR2J4UCSEAGEosinophils1.7490e-030.5034image
ENSG00000214783.8,POLR2J4UVMEAGNK_cells_activated4.5719e-020.3675image


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6. Enriched editing regions and immune gene sets for POLR2J4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000214783.8,POLR2J4THCAEAG8.9929e-03image8.1192e-05-0.1948image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000214783.8,POLR2J4THCAEAG3.4281e-02-0.10541.5827e-03-0.15676.1866e-03-0.13602.5953e-04-0.1808image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000214783.8,POLR2J4ACCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.7609e-02-0.4563image
ENSG00000214783.8,POLR2J4BLCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.7032e-040.2256image
ENSG00000214783.8,POLR2J4BRCAGSVA_HALLMARK_UV_RESPONSE_DNEAG2.6709e-040.1498image
chr7:43963509-43965055:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1752e-020.4154image
ENSG00000214783.8,POLR2J4CESCGSVA_HALLMARK_APICAL_SURFACEEAG3.1247e-03-0.1971image
ENSG00000214783.8,POLR2J4CHOLGSVA_HALLMARK_MYOGENESISEAG1.7587e-020.5008image
ENSG00000214783.8,POLR2J4COADGSVA_HALLMARK_PEROXISOMEEAG6.3801e-05-0.4065image
chr7:43963509-43965055:-ESCAGSVA_HALLMARK_SPERMATOGENESISEER3.9264e-02-0.3848image
chr7:44010294-44012817:-ESCAGSVA_HALLMARK_HEME_METABOLISMEER3.5453e-050.4399image
chr7:43990850-43997503:-ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.4284e-020.2157image
ENSG00000214783.8,POLR2J4ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.8487e-020.1715image
chr7:43963509-43965055:-GBMGSVA_HALLMARK_UV_RESPONSE_UPEER2.6403e-030.5462image
ENSG00000214783.8,POLR2J4HNSCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.9868e-05-0.2188image
ENSG00000214783.8,POLR2J4KIRCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG7.9712e-030.1961image
ENSG00000214783.8,POLR2J4KIRPGSVA_HALLMARK_APICAL_SURFACEEAG1.0192e-02-0.2367image
ENSG00000214783.8,POLR2J4LGGGSVA_HALLMARK_UV_RESPONSE_DNEAG4.4651e-020.1071image
ENSG00000214783.8,POLR2J4LIHCGSVA_HALLMARK_MYC_TARGETS_V1EAG4.6580e-020.1612image
ENSG00000214783.8,POLR2J4LUADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.9979e-02-0.1275image
ENSG00000214783.8,POLR2J4LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7481e-030.1552image
ENSG00000214783.8,POLR2J4MESOGSVA_HALLMARK_HYPOXIAEAG7.0047e-03-0.4819image
chr7:43990850-43997503:-OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.1788e-020.2237image
ENSG00000214783.8,POLR2J4OVGSVA_HALLMARK_COAGULATIONEAG4.6410e-03-0.1825image
chr7:44010294-44012817:-OVGSVA_HALLMARK_PEROXISOMEEER3.5880e-020.2513image
chr7:43975613-43976610:-OVGSVA_HALLMARK_MYC_TARGETS_V2EER9.9755e-030.5489image
ENSG00000214783.8,POLR2J4PCPGGSVA_HALLMARK_UV_RESPONSE_DNEAG2.7338e-030.3073image
ENSG00000214783.8,POLR2J4PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG7.7231e-03-0.1912image
ENSG00000214783.8,POLR2J4SARCGSVA_HALLMARK_E2F_TARGETSEAG7.1014e-030.2774image
ENSG00000214783.8,POLR2J4SKCMGSVA_HALLMARK_MYOGENESISEAG2.9829e-02-0.1272image
chr7:43990850-43997503:-STADGSVA_HALLMARK_HYPOXIAEER1.3943e-050.3265image
chr7:44010294-44012817:-STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.3641e-020.2275image
ENSG00000214783.8,POLR2J4TGCTGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.1584e-030.3433image
ENSG00000214783.8,POLR2J4THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.6171e-11-0.3215image
ENSG00000214783.8,POLR2J4THYMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG8.8868e-030.2685image
ENSG00000214783.8,POLR2J4UCECGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.2048e-020.2058image
ENSG00000214783.8,POLR2J4UCSGSVA_HALLMARK_SPERMATOGENESISEAG1.8412e-020.3909image


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7. Enriched editing regions and drugs for POLR2J4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000214783.8,POLR2J4ACCAS601245EAG1.2159e-02-0.5365image
ENSG00000214783.8,POLR2J4BLCAErlotinibEAG7.4920e-050.2373image
ENSG00000214783.8,POLR2J4BRCACCT007093EAG1.6689e-04-0.1546image
chr7:43963509-43965055:-CESCCEP.701EER1.7522e-04-0.5856image
ENSG00000214783.8,POLR2J4CESCJNJ.26854165EAG1.1345e-020.1693image
ENSG00000214783.8,POLR2J4COADGefitinibEAG2.0709e-06-0.4740image
ENSG00000214783.8,POLR2J4DLBCCCT018159EAG5.4661e-03-0.5838image
ENSG00000214783.8,POLR2J4ESCAKIN001.135EAG2.3882e-02-0.1869image
chr7:43963509-43965055:-ESCAAZ628EER1.9882e-02-0.4301image
chr7:43989451-43989773:-ESCABAY.61.3606EER9.7681e-030.4642image
chr7:44010294-44012817:-ESCACytarabineEER4.3453e-030.3118image
chr7:43990850-43997503:-ESCABexaroteneEER8.0082e-03-0.2528image
chr7:43963509-43965055:-GBMJW.7.52.1EER3.2561e-02-0.4049image
ENSG00000214783.8,POLR2J4GBMEtoposideEAG1.0554e-02-0.2356image
ENSG00000214783.8,POLR2J4HNSCGemcitabineEAG5.4200e-07-0.2685image
ENSG00000214783.8,POLR2J4KICHBX.795EAG2.6887e-02-0.3543image
ENSG00000214783.8,POLR2J4KIRCCI.1040EAG6.6890e-03-0.2004image
ENSG00000214783.8,POLR2J4KIRPCCT018159EAG2.3023e-030.2792image
chr7:43990850-43997503:-LAMLGW843682XEER5.0569e-030.2565image
ENSG00000214783.8,POLR2J4LAMLBX.795EAG6.8201e-03-0.2344image
ENSG00000214783.8,POLR2J4LUADBIBW2992EAG6.4781e-030.1764image
ENSG00000214783.8,POLR2J4LUSCA.443654EAG5.0861e-070.2658image
chr7:43963509-43965055:-LUSCKIN001.135EER1.7322e-02-0.3494image
chr7:43990850-43997503:-OVABT.263EER2.8141e-030.2640image
ENSG00000214783.8,POLR2J4OVCisplatinEAG2.4379e-02-0.1456image
chr7:44010294-44012817:-OVLenalidomideEER4.3879e-030.3366image
chr7:43975613-43976610:-OVCCT007093EER4.3652e-030.5959image
ENSG00000214783.8,POLR2J4PAADAZD.0530EAG1.0429e-02-0.3257image
ENSG00000214783.8,POLR2J4PCPGGW843682XEAG1.9671e-020.2416image
ENSG00000214783.8,POLR2J4PRADCCT007093EAG4.4831e-04-0.2502image
ENSG00000214783.8,POLR2J4READBMS.536924EAG1.5006e-020.4716image
ENSG00000214783.8,POLR2J4SARCAKT.inhibitor.VIIIEAG3.1005e-03-0.3035image
ENSG00000214783.8,POLR2J4SKCMGemcitabineEAG1.8559e-03-0.1814image
ENSG00000214783.8,POLR2J4STADElesclomolEAG3.1302e-02-0.1352image
chr7:43990850-43997503:-STADAS601245EER4.1078e-03-0.2190image
chr7:44010294-44012817:-STADBortezomibEER4.2954e-05-0.3688image
ENSG00000214783.8,POLR2J4TGCTKU.55933EAG2.1758e-04-0.4340image
ENSG00000214783.8,POLR2J4THCAErlotinibEAG3.0569e-130.3522image
ENSG00000214783.8,POLR2J4THYMABT.263EAG2.3941e-02-0.2328image
ENSG00000214783.8,POLR2J4UCECBMS.708163EAG4.0846e-02-0.2070image
ENSG00000214783.8,POLR2J4UCSCEP.701EAG3.5121e-030.4738image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType