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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: LINC00467 (ImmuneEditome ID:84791)

1. Gene summary of enriched editing regions for LINC00467

check button Gene summary
Gene informationGene symbol

LINC00467

Gene ID

84791

GeneSynonymsASAP|C1orf97
GeneCytomap

1q32.3

GeneTypencRNA
GeneDescriptionATP synthase-associated peptide
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr1:211432829-211434998:+ENST00000423222.4ENSG00000153363.11LINC00467ncRNA_exonicAluSx,AluJo,AluJb,AluJr,AluSq2,(AC)n,(TTAT)n,L1PA16chr1:211432829-211434998:+.alignment


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2. Tumor-specific enriched editing regions for LINC00467


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr1:211432829-211434998:+KIRCEER2.5782e-02image
ENSG00000153363.11,LINC00467KIRCEAG2.8798e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr1:211432829-211434998:+UCECEER1.4876e-023.8634e-028.2852e+01image
ENSG00000153363.11,LINC00467UCECEAG1.4876e-023.8634e-028.2852e+01image

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3. Enriched editing regions and immune related genes for LINC00467


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for LINC00467


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for LINC00467


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr1:211432829-211434998:+BRCAEEREosinophils6.6748e-040.1390image
ENSG00000153363.11,LINC00467BRCAEAGEosinophils5.9236e-040.1401image
chr1:211432829-211434998:+COADEERT_cells_regulatory_(Tregs)3.3200e-020.3898image
ENSG00000153363.11,LINC00467COADEAGT_cells_regulatory_(Tregs)3.3200e-020.3898image
chr1:211432829-211434998:+ESCAEERB_cells_memory4.8127e-020.2500image
chr1:211432829-211434998:+HNSCEERPlasma_cells4.6997e-020.3856image
ENSG00000153363.11,LINC00467HNSCEAGPlasma_cells3.0372e-020.4097image
chr1:211432829-211434998:+KIRPEERPlasma_cells7.1381e-050.3195image
ENSG00000153363.11,LINC00467KIRPEAGPlasma_cells7.1381e-050.3195image
chr1:211432829-211434998:+LGGEERPlasma_cells4.5734e-02-0.1238image
ENSG00000153363.11,LINC00467LGGEAGPlasma_cells4.5734e-02-0.1238image
chr1:211432829-211434998:+LIHCEERT_cells_CD81.9974e-02-0.2738image
ENSG00000153363.11,LINC00467LIHCEAGT_cells_CD81.9974e-02-0.2738image
chr1:211432829-211434998:+LUADEERT_cells_CD4_memory_activated3.4791e-020.1482image
ENSG00000153363.11,LINC00467LUADEAGT_cells_CD4_memory_activated3.4063e-020.1488image
ENSG00000153363.11,LINC00467OVEAGMacrophages_M04.3338e-020.1605image
chr1:211432829-211434998:+SARCEERMacrophages_M21.4678e-02-0.3615image
ENSG00000153363.11,LINC00467SARCEAGMacrophages_M23.4663e-02-0.3088image
chr1:211432829-211434998:+STADEERT_cells_CD4_memory_activated1.3404e-030.2621image
ENSG00000153363.11,LINC00467STADEAGT_cells_CD4_memory_activated2.5512e-030.2430image
chr1:211432829-211434998:+TGCTEERT_cells_CD81.6840e-02-0.2487image
ENSG00000153363.11,LINC00467TGCTEAGT_cells_CD81.6840e-02-0.2487image
chr1:211432829-211434998:+THCAEERMacrophages_M02.2006e-020.1235image
ENSG00000153363.11,LINC00467THCAEAGMacrophages_M02.2006e-020.1235image


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6. Enriched editing regions and immune gene sets for LINC00467


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000153363.11,LINC00467ACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.3188e-02-0.4150image
chr1:211432829-211434998:+ACCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.3188e-02-0.4150image
ENSG00000153363.11,LINC00467BLCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG8.0174e-040.4086image
chr1:211432829-211434998:+BLCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.3440e-030.3953image
chr1:211432829-211434998:+BRCAGSVA_HALLMARK_UV_RESPONSE_UPEER1.6474e-030.1287image
ENSG00000153363.11,LINC00467BRCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.0988e-030.1332image
ENSG00000153363.11,LINC00467COADGSVA_HALLMARK_PEROXISOMEEAG1.7153e-020.4319image
chr1:211432829-211434998:+COADGSVA_HALLMARK_PEROXISOMEEER1.7153e-020.4319image
ENSG00000153363.11,LINC00467ESCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.6242e-020.3018image
chr1:211432829-211434998:+ESCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.3589e-020.3095image
ENSG00000153363.11,LINC00467GBMGSVA_HALLMARK_DNA_REPAIREAG1.6770e-02-0.2603image
chr1:211432829-211434998:+GBMGSVA_HALLMARK_DNA_REPAIREER1.6770e-02-0.2603image
chr1:211432829-211434998:+KIRPGSVA_HALLMARK_P53_PATHWAYEER6.1382e-030.2235image
ENSG00000153363.11,LINC00467KIRPGSVA_HALLMARK_P53_PATHWAYEAG6.1382e-030.2235image
ENSG00000153363.11,LINC00467LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.6044e-030.3497image
chr1:211432829-211434998:+LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.6044e-030.3497image
chr1:211432829-211434998:+LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER8.1391e-030.1853image
ENSG00000153363.11,LINC00467LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG7.5295e-030.1871image
ENSG00000153363.11,LINC00467LUSCGSVA_HALLMARK_PEROXISOMEEAG7.2988e-03-0.2545image
chr1:211432829-211434998:+LUSCGSVA_HALLMARK_PEROXISOMEEER7.6501e-03-0.2530image
ENSG00000153363.11,LINC00467OVGSVA_HALLMARK_MTORC1_SIGNALINGEAG3.2431e-020.1697image
chr1:211432829-211434998:+OVGSVA_HALLMARK_MTORC1_SIGNALINGEER3.8165e-020.1646image
ENSG00000153363.11,LINC00467PCPGGSVA_HALLMARK_ANGIOGENESISEAG2.6206e-020.4730image
chr1:211432829-211434998:+PCPGGSVA_HALLMARK_ANGIOGENESISEER2.6206e-020.4730image
ENSG00000153363.11,LINC00467SARCGSVA_HALLMARK_UV_RESPONSE_DNEAG5.0583e-030.4023image
chr1:211432829-211434998:+SARCGSVA_HALLMARK_UV_RESPONSE_DNEER2.4739e-030.4403image
ENSG00000153363.11,LINC00467SKCMGSVA_HALLMARK_HEME_METABOLISMEAG3.8117e-03-0.2275image
chr1:211432829-211434998:+SKCMGSVA_HALLMARK_HEME_METABOLISMEER4.4049e-03-0.2240image
chr1:211432829-211434998:+STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.5761e-030.2584image
ENSG00000153363.11,LINC00467STADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.6226e-020.1947image
ENSG00000153363.11,LINC00467TGCTGSVA_HALLMARK_BILE_ACID_METABOLISMEAG9.7358e-030.2682image
chr1:211432829-211434998:+TGCTGSVA_HALLMARK_BILE_ACID_METABOLISMEER9.7358e-030.2682image
ENSG00000153363.11,LINC00467THCAGSVA_HALLMARK_APOPTOSISEAG1.4389e-030.1712image
chr1:211432829-211434998:+THCAGSVA_HALLMARK_APOPTOSISEER1.4389e-030.1712image
chr1:211432829-211434998:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER1.2963e-020.2978image
ENSG00000153363.11,LINC00467THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2963e-020.2978image


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7. Enriched editing regions and drugs for LINC00467


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000153363.11,LINC00467ACCBI.D1870EAG4.1727e-030.4723image
chr1:211432829-211434998:+ACCBI.D1870EER4.1727e-030.4723image
ENSG00000153363.11,LINC00467BLCAA.443654EAG3.9355e-02-0.2583image
chr1:211432829-211434998:+BLCAA.443654EER1.9855e-02-0.2928image
chr1:211432829-211434998:+BRCACMKEER6.7715e-04-0.1391image
ENSG00000153363.11,LINC00467BRCAAG.014699EAG6.7697e-040.1386image
ENSG00000153363.11,LINC00467CESCCHIR.99021EAG2.4030e-020.2491image
chr1:211432829-211434998:+CESCCHIR.99021EER2.0041e-020.2564image
ENSG00000153363.11,LINC00467COADABT.263EAG1.4045e-020.4437image
chr1:211432829-211434998:+COADABT.263EER1.4045e-020.4437image
chr1:211432829-211434998:+ESCABAY.61.3606EER4.8030e-03-0.3509image
ENSG00000153363.11,LINC00467ESCABAY.61.3606EAG5.0488e-03-0.3491image
ENSG00000153363.11,LINC00467GBMA.443654EAG1.0599e-030.3510image
chr1:211432829-211434998:+GBMA.443654EER1.0599e-030.3510image
ENSG00000153363.11,LINC00467KIRCBX.795EAG1.2401e-020.2671image
chr1:211432829-211434998:+KIRCBX.795EER1.2401e-020.2671image
chr1:211432829-211434998:+KIRPJNK.9LEER1.2025e-02-0.2053image
ENSG00000153363.11,LINC00467KIRPJNK.9LEAG1.2025e-02-0.2053image
ENSG00000153363.11,LINC00467LIHCImatinibEAG3.2704e-02-0.2520image
chr1:211432829-211434998:+LIHCImatinibEER3.2704e-02-0.2520image
ENSG00000153363.11,LINC00467LUADAZD7762EAG3.9122e-03-0.2017image
chr1:211432829-211434998:+LUADAZD7762EER4.2538e-03-0.1998image
ENSG00000153363.11,LINC00467LUSCGW.441756EAG6.2993e-030.2590image
chr1:211432829-211434998:+LUSCGW.441756EER6.2494e-030.2592image
chr1:211432829-211434998:+OVGW843682XEER3.2975e-02-0.1692image
ENSG00000153363.11,LINC00467OVGW843682XEAG2.7034e-02-0.1754image
chr1:211432829-211434998:+PRADGDC0941EER3.1004e-02-0.1318image
ENSG00000153363.11,LINC00467PRADGDC0941EAG2.5351e-02-0.1363image
ENSG00000153363.11,LINC00467SARCBMS.708163EAG3.0953e-02-0.3152image
chr1:211432829-211434998:+SARCCamptothecinEER1.0502e-020.3778image
ENSG00000153363.11,LINC00467SKCMCamptothecinEAG1.2538e-02-0.1970image
chr1:211432829-211434998:+SKCMCamptothecinEER1.2329e-02-0.1974image
chr1:211432829-211434998:+STADCisplatinEER6.1455e-04-0.2792image
ENSG00000153363.11,LINC00467STADCisplatinEAG3.1873e-03-0.2377image
chr1:211432829-211434998:+THCACI.1040EER3.8764e-05-0.2199image
ENSG00000153363.11,LINC00467THCACI.1040EAG3.8764e-05-0.2199image
chr1:211432829-211434998:+THYMElesclomolEER2.7020e-030.3557image
ENSG00000153363.11,LINC00467THYMElesclomolEAG2.7020e-030.3557image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType