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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF347 (ImmuneEditome ID:84671)

1. Gene summary of enriched editing regions for ZNF347

check button Gene summary
Gene informationGene symbol

ZNF347

Gene ID

84671

GeneSynonymsZNF1111
GeneCytomap

19q13.42

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 347|CTD-2620I22.7|zinc finger 1111|zinc finger protein 1111
GeneModificationdate20230518
UniprotIDQ96SE7;M0QZE2;M0R1E9;M0QXR8;M0QZJ6;A0A024R4L7
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:53135153-53137207:-ENST00000334197.10ENSG00000197937.11ZNF347UTR3AluSx,FLAM_C,L1M,(AT)n,AluSx1,(AG)n,MIRb,MIRchr19:53135153-53137207:-.alignment


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2. Tumor-specific enriched editing regions for ZNF347


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:53135153-53137207:-BRCAEER8.7578e-06image
ENSG00000197937.11,ZNF347BRCAEAG1.0297e-05image
chr19:53135153-53137207:-KICHEER3.0891e-03image
ENSG00000197937.11,ZNF347KICHEAG2.8796e-03image
chr19:53135153-53137207:-THCAEER4.8407e-07image
ENSG00000197937.11,ZNF347THCAEAG5.3773e-07image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr19:53135153-53137207:-BRCAEER2.1873e-021.3536e-026.1538e+00image
ENSG00000197937.11,ZNF347BRCAEAG2.8265e-021.3870e-026.9120e+00image
chr19:53135153-53137207:-KIRCEER3.1120e-031.0284e-021.3325e-01image
ENSG00000197937.11,ZNF347KIRCEAG6.8937e-031.1281e-021.3724e-01image

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3. Enriched editing regions and immune related genes for ZNF347


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:53135153-53137207:-GBMEERENSG00000150893,FREM2-0.45636.2994e-051.1825e-06-0.4096imageNEIF4A3;MSI1FREM2MonocytesGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:53135153-53137207:-GBMEERENSG00000177674,AGTRAP0.43022.2691e-042.2082e-070.4342imageNDDX42;EIF4A3;FAM120A;MSI1NAMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:53135153-53137207:-GBMEERENSG00000101384,JAG1-0.40826.5324e-042.1407e-06-0.4005imageNEIF4A3;FAM120A;MSI1JAG1MonocytesGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:53135153-53137207:-GBMEERENSG00000105323,HNRNPUL1-0.40427.4686e-041.0239e-06-0.4118imageNDDX42;EIF4A3;FAM120A;MSI1NAMonocytesGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:53135153-53137207:-GBMEERENSG00000136504,KAT7-0.39959.0308e-041.8280e-07-0.4368imageNDDX42;EIF4A3;FAM120A;MSI1NAMonocytesGSVA_HALLMARK_G2M_CHECKPOINT
chr19:53135153-53137207:-GBMEERENSG00000135486,HNRNPA1-0.39141.0136e-031.2999e-07-0.4415imageNDDX42;EIF4A3;FAM120A;MSI1NAT_cells_follicular_helperGSVA_HALLMARK_G2M_CHECKPOINT
chr19:53135153-53137207:-GBMEERENSG00000105605,CACNG7-0.38481.5018e-035.8696e-07-0.4201imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr19:53135153-53137207:-THYMEERENSG00000139734,DIAPH3-0.55751.1393e-051.4444e-05-0.4540imageNEIF4A3;FAM120A;MSI1NAMast_cells_restingGSVA_HALLMARK_G2M_CHECKPOINT
chr19:53135153-53137207:-THYMEERENSG00000137812,CASC5-0.54891.3482e-054.1311e-05-0.4317imageNDDX42;EIF4A3;FAM120A;MSI1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_G2M_CHECKPOINT
chr19:53135153-53137207:-THYMEERENSG00000109685,WHSC1-0.54581.3488e-053.4901e-05-0.4354imageNDDX42;EIF4A3;FAM120A;MSI1NAMast_cells_restingGSVA_HALLMARK_G2M_CHECKPOINT

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4. Enriched editing regions and immune related splicing for ZNF347


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:53135153-53137207:-
THYMEERIRENSG00000158106.8chr8143378695:143378911:143379005:1433790780.36999.3873e-031.4650e-040.4049imageNDDX42;EIF4A3;FAM120A;MSI1NAMast_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:53135153-53137207:-
THYMEERIRENSG00000100813.10chr1423064104:23064221:23064354:230644190.41031.4654e-026.2100e-050.4250imageNDDX42;EIF4A3;FAM120AACIN1T_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
chr19:53135153-53137207:-
THYMEERMEXENSG00000129657.10chr1777215792:77215805:77215831:77215857:77215857:77215935:77216023:772160360.26753.4012e-025.2325e-040.4125imageNDDX42;EIF4A3;FAM120A;MSI1NAGSVA_HALLMARK_PANCREAS_BETA_CELLS
ENSG00000197937.11,ZNF347
THYMEAGIRENSG00000136305.7chr1424305095:24305765:24305946:24306137-0.39693.3381e-026.2268e-05-0.4226imageNAUH;BCCIP;BUD13;CSTF2T;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;LIN28B;MSI2;PCBP2;PRPF8;RBFOX2;SND1;SRSF1;SRSF9;TAF15;TRA2A;U2AF1;UPF1CIDEBMast_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:53135153-53137207:-
THYMEERIRENSG00000048140.13chr5176652737:176652913:176654894:1766550200.34872.7715e-023.2631e-070.5528imageNDDX42;EIF4A3;FAM120A;MSI1NAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALING
chr19:53135153-53137207:-
THYMEERA3ENSG00000126777.13chr1455661521:55661612:55667240:55667309:55663954:556673090.42849.8789e-031.1727e-050.4582imageNDDX42;EIF4A3;FAM120A;MSI1NAPlasma_cellsGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000197937.11,ZNF347
THYMEAGIRENSG00000187741.10chr1689737548:89740099:89740803:897408660.51421.1751e-036.4766e-060.4700imageNACIN1;ADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM22;RBM27;SAFB2;SLTM;SND1;SRSF1;SRSF9;TAF15;TARDBP;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2FANCAMast_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:53135153-53137207:-
THYMEERIRENSG00000101199.8chr2063284291:63284512:63284865:632849220.36333.1402e-021.7662e-040.4074imageNDDX42;EIF4A3;FAM120A;MSI1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
ENSG00000197937.11,ZNF347
THYMEAGIRENSG00000160957.8chr8144511901:144513480:144513570:1445137120.46394.9880e-032.5885e-050.4442imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;MSI1;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM22;RBM27;SAFB2;SLTM;SND1;SRSF1;SRSF9;TAF15;TARDBP;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2NAT_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000197937.11,ZNF347
THYMEAGIRENSG00000101199.8chr2063284291:63284512:63284865:632849220.36273.4554e-021.7950e-040.4070imageNACIN1;ADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;MBNL2;MSI1;MSI2;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM22;RBM27;SAFB2;SLTM;SND1;SRSF1;SRSF9;TAF15;TARDBP;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR

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5. Enriched editing regions and immune infiltration for ZNF347


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:53135153-53137207:-ACCEERPlasma_cells1.5207e-020.3318image
ENSG00000197937.11,ZNF347ACCEAGPlasma_cells1.5208e-020.3318image
chr19:53135153-53137207:-BLCAEERMacrophages_M18.5513e-040.2345image
ENSG00000197937.11,ZNF347BLCAEAGMacrophages_M12.7104e-030.2105image
chr19:53135153-53137207:-BRCAEERT_cells_gamma_delta3.6589e-02-0.0695image
ENSG00000197937.11,ZNF347BRCAEAGT_cells_gamma_delta3.8772e-02-0.0686image
chr19:53135153-53137207:-CESCEERT_cells_CD81.2830e-020.2493image
ENSG00000197937.11,ZNF347CESCEAGT_cells_CD81.2830e-020.2493image
ENSG00000197937.11,ZNF347COADEAGDendritic_cells_activated4.8442e-050.6716image
chr19:53135153-53137207:-ESCAEERMacrophages_M24.2461e-020.3860image
ENSG00000197937.11,ZNF347ESCAEAGMacrophages_M21.7399e-020.4311image
chr19:53135153-53137207:-GBMEERMonocytes1.8000e-020.2064image
ENSG00000197937.11,ZNF347GBMEAGMonocytes1.7947e-020.2065image
chr19:53135153-53137207:-KICHEERB_cells_naive4.8896e-04-0.5891image
ENSG00000197937.11,ZNF347KICHEAGB_cells_naive5.5961e-04-0.5842image
chr19:53135153-53137207:-KIRCEERMacrophages_M24.8127e-03-0.1629image
ENSG00000197937.11,ZNF347KIRCEAGMacrophages_M24.5014e-03-0.1641image
chr19:53135153-53137207:-KIRPEERT_cells_CD81.0011e-020.2178image
ENSG00000197937.11,ZNF347KIRPEAGT_cells_CD4_memory_activated1.4973e-040.3162image
chr19:53135153-53137207:-LGGEERMacrophages_M08.7315e-03-0.1326image
ENSG00000197937.11,ZNF347LGGEAGMacrophages_M09.0026e-03-0.1321image
chr19:53135153-53137207:-LIHCEERT_cells_regulatory_(Tregs)1.7695e-02-0.4613image
chr19:53135153-53137207:-LUADEERDendritic_cells_activated1.1508e-020.1728image
ENSG00000197937.11,ZNF347LUADEAGDendritic_cells_activated1.1961e-020.1711image
chr19:53135153-53137207:-LUSCEERT_cells_regulatory_(Tregs)1.5370e-020.1901image
ENSG00000197937.11,ZNF347LUSCEAGT_cells_regulatory_(Tregs)1.5370e-020.1901image
chr19:53135153-53137207:-OVEERT_cells_gamma_delta4.6109e-02-0.1584image
chr19:53135153-53137207:-PAADEERNK_cells_activated2.0906e-02-0.2776image
ENSG00000197937.11,ZNF347PAADEAGNK_cells_activated2.0906e-02-0.2776image
chr19:53135153-53137207:-PRADEEREosinophils6.7432e-030.1363image
ENSG00000197937.11,ZNF347PRADEAGEosinophils6.5105e-030.1367image
chr19:53135153-53137207:-SARCEERMacrophages_M11.1940e-030.2588image
ENSG00000197937.11,ZNF347SARCEAGMacrophages_M12.2455e-030.2429image
chr19:53135153-53137207:-SKCMEERT_cells_gamma_delta4.4912e-030.2271image
ENSG00000197937.11,ZNF347SKCMEAGT_cells_gamma_delta4.3017e-030.2282image
chr19:53135153-53137207:-STADEERNK_cells_activated4.0285e-020.1977image
ENSG00000197937.11,ZNF347STADEAGNK_cells_activated4.4480e-020.1929image
chr19:53135153-53137207:-TGCTEERMacrophages_M23.7562e-09-0.5384image
ENSG00000197937.11,ZNF347TGCTEAGMacrophages_M24.2702e-10-0.5624image
chr19:53135153-53137207:-THCAEERT_cells_CD4_memory_activated5.0390e-040.1628image
ENSG00000197937.11,ZNF347THCAEAGT_cells_CD4_memory_activated4.1557e-040.1650image
chr19:53135153-53137207:-THYMEERT_cells_CD4_naive1.1104e-02-0.2758image
ENSG00000197937.11,ZNF347THYMEAGT_cells_gamma_delta1.1282e-020.2752image
chr19:53135153-53137207:-UCECEERMonocytes1.0440e-02-0.2644image
ENSG00000197937.11,ZNF347UCECEAGMonocytes7.7928e-03-0.2729image
chr19:53135153-53137207:-UCSEEREosinophils4.9334e-02-0.3560image


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6. Enriched editing regions and immune gene sets for ZNF347


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:53135153-53137207:-BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.4107e-040.2575image
ENSG00000197937.11,ZNF347BLCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.0353e-040.2432image
chr19:53135153-53137207:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.3439e-050.1442image
ENSG00000197937.11,ZNF347BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4548e-050.1432image
ENSG00000197937.11,ZNF347CESCGSVA_HALLMARK_UV_RESPONSE_UPEAG2.1433e-02-0.2310image
chr19:53135153-53137207:-CESCGSVA_HALLMARK_UV_RESPONSE_UPEER2.1433e-02-0.2310image
ENSG00000197937.11,ZNF347COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG6.4746e-04-0.5872image
chr19:53135153-53137207:-GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.8014e-030.2702image
ENSG00000197937.11,ZNF347GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.7910e-030.2703image
ENSG00000197937.11,ZNF347HNSCGSVA_HALLMARK_GLYCOLYSISEAG4.0123e-020.3259image
ENSG00000197937.11,ZNF347KICHGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG4.7250e-020.3591image
chr19:53135153-53137207:-KICHGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER4.3774e-020.3645image
chr19:53135153-53137207:-KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.9678e-040.3107image
ENSG00000197937.11,ZNF347KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2678e-030.2707image
chr19:53135153-53137207:-LGGGSVA_HALLMARK_E2F_TARGETSEER6.7852e-05-0.2003image
ENSG00000197937.11,ZNF347LGGGSVA_HALLMARK_E2F_TARGETSEAG5.9995e-05-0.2017image
ENSG00000197937.11,ZNF347LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.4248e-02-0.4088image
chr19:53135153-53137207:-LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.9751e-020.4266image
chr19:53135153-53137207:-LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER7.3367e-030.1832image
ENSG00000197937.11,ZNF347LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG6.2432e-030.1860image
chr19:53135153-53137207:-PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.2488e-03-0.3401image
ENSG00000197937.11,ZNF347PAADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.2488e-03-0.3401image
chr19:53135153-53137207:-PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER3.6971e-060.4461image
ENSG00000197937.11,ZNF347PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.6971e-060.4461image
chr19:53135153-53137207:-PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.3665e-03-0.1608image
ENSG00000197937.11,ZNF347PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.8597e-03-0.1561image
ENSG00000197937.11,ZNF347SARCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.2900e-02-0.1623image
ENSG00000197937.11,ZNF347SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.4144e-030.2338image
chr19:53135153-53137207:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.0896e-030.2294image
chr19:53135153-53137207:-STADGSVA_HALLMARK_APOPTOSISEER1.4885e-040.3570image
ENSG00000197937.11,ZNF347STADGSVA_HALLMARK_APOPTOSISEAG7.6884e-050.3695image
chr19:53135153-53137207:-TGCTGSVA_HALLMARK_ANGIOGENESISEER1.4834e-10-0.5767image
ENSG00000197937.11,ZNF347TGCTGSVA_HALLMARK_ANGIOGENESISEAG4.3738e-11-0.5877image
ENSG00000197937.11,ZNF347THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3269e-060.2247image
chr19:53135153-53137207:-THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.5735e-060.2188image
ENSG00000197937.11,ZNF347THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.3677e-06-0.4890image
chr19:53135153-53137207:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.1927e-06-0.4904image
ENSG00000197937.11,ZNF347UCECGSVA_HALLMARK_DNA_REPAIREAG1.3749e-02-0.2533image
chr19:53135153-53137207:-UCECGSVA_HALLMARK_DNA_REPAIREER1.1434e-02-0.2612image


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7. Enriched editing regions and drugs for ZNF347


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000197937.11,ZNF347ACCBleomycinEAG7.2364e-030.3648image
chr19:53135153-53137207:-ACCBleomycinEER7.2317e-030.3648image
chr19:53135153-53137207:-BLCAAxitinibEER4.6201e-040.2460image
ENSG00000197937.11,ZNF347BLCAAxitinibEAG2.9397e-040.2528image
chr19:53135153-53137207:-BRCACGP.082996EER1.8221e-03-0.1036image
ENSG00000197937.11,ZNF347BRCAABT.263EAG5.8139e-040.1141image
ENSG00000197937.11,ZNF347CESCMG.132EAG1.0352e-020.2579image
chr19:53135153-53137207:-CESCMG.132EER1.0352e-020.2579image
ENSG00000197937.11,ZNF347COADABT.263EAG4.0374e-02-0.3764image
ENSG00000197937.11,ZNF347ESCAMidostaurinEAG2.2981e-02-0.4139image
chr19:53135153-53137207:-ESCAMidostaurinEER2.0572e-02-0.4354image
chr19:53135153-53137207:-GBMBosutinibEER1.7355e-040.3223image
ENSG00000197937.11,ZNF347GBMBosutinibEAG1.7184e-040.3225image
chr19:53135153-53137207:-KICHKIN001.135EER8.1322e-03-0.4667image
ENSG00000197937.11,ZNF347KICHKIN001.135EAG8.1460e-03-0.4666image
chr19:53135153-53137207:-KIRCCyclopamineEER1.9040e-03-0.1794image
ENSG00000197937.11,ZNF347KIRCCyclopamineEAG1.6268e-03-0.1821image
chr19:53135153-53137207:-KIRPCCT007093EER2.3505e-050.3504image
ENSG00000197937.11,ZNF347KIRPCCT007093EAG2.4577e-050.3496image
chr19:53135153-53137207:-LGGMidostaurinEER1.1019e-040.1946image
ENSG00000197937.11,ZNF347LGGMidostaurinEAG9.2750e-050.1966image
ENSG00000197937.11,ZNF347LIHCBIRB.0796EAG3.6322e-030.5402image
ENSG00000197937.11,ZNF347LUSCJNK.9LEAG8.4098e-03-0.2064image
chr19:53135153-53137207:-LUSCJNK.9LEER8.4098e-03-0.2064image
ENSG00000197937.11,ZNF347MESOKU.55933EAG2.6073e-020.3758image
chr19:53135153-53137207:-MESOKU.55933EER2.6073e-020.3758image
ENSG00000197937.11,ZNF347OVAG.014699EAG3.5835e-020.1650image
chr19:53135153-53137207:-OVAG.014699EER5.1735e-030.2207image
chr19:53135153-53137207:-PAADEmbelinEER4.6217e-02-0.2408image
ENSG00000197937.11,ZNF347PAADEmbelinEAG4.6217e-02-0.2408image
chr19:53135153-53137207:-PRADDasatinibEER9.3578e-05-0.1968image
ENSG00000197937.11,ZNF347PRADDasatinibEAG1.0511e-04-0.1951image
ENSG00000197937.11,ZNF347SARCBosutinibEAG1.7240e-02-0.1905image
chr19:53135153-53137207:-SARCBosutinibEER1.9448e-02-0.1882image
ENSG00000197937.11,ZNF347SKCMDMOGEAG3.6138e-03-0.2324image
chr19:53135153-53137207:-SKCMDMOGEER3.8116e-03-0.2311image
chr19:53135153-53137207:-STADBIBW2992EER1.5546e-020.2334image
ENSG00000197937.11,ZNF347STADBIBW2992EAG9.8105e-030.2475image
ENSG00000197937.11,ZNF347TGCTGSK269962AEAG1.0932e-070.4904image
chr19:53135153-53137207:-TGCTGSK269962AEER5.0820e-070.4691image
ENSG00000197937.11,ZNF347THCAAICAREAG8.1878e-09-0.2664image
chr19:53135153-53137207:-THCACI.1040EER8.9656e-09-0.2660image
ENSG00000197937.11,ZNF347THYMEmbelinEAG1.6995e-040.3990image
chr19:53135153-53137207:-THYMEmbelinEER1.7247e-040.3987image
ENSG00000197937.11,ZNF347UCECAUY922EAG2.6379e-040.3679image
chr19:53135153-53137207:-UCECAUY922EER2.2398e-040.3738image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType