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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF527 (ImmuneEditome ID:84503)

1. Gene summary of enriched editing regions for ZNF527

check button Gene summary
Gene informationGene symbol

ZNF527

Gene ID

84503

GeneSynonyms-
GeneCytomap

19q13.12

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 527
GeneModificationdate20230518
UniprotIDQ8NB42;Q0P6G1;K7ELI5;A0A0A0MRD3;K7ES26;K7ENX6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:37390080-37390330:+ENST00000356178.7ENSG00000189164.13ZNF527UTR3AluSx1chr19:37390080-37390330:+.alignment
chr19:37390080-37390330:+ENST00000436120.5ENSG00000189164.13ZNF527UTR3AluSx1chr19:37390080-37390330:+.alignment
chr19:37391306-37392700:+ENST00000356178.7ENSG00000189164.13ZNF527UTR3(AAAT)n,AluSp,AluJbchr19:37391306-37392700:+.alignment
chr19:37391306-37392700:+ENST00000587349.1ENSG00000189164.13ZNF527UTR3(AAAT)n,AluSp,AluJbchr19:37391306-37392700:+.alignment


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2. Tumor-specific enriched editing regions for ZNF527


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000189164.13,ZNF527THCAEAG3.9236e-05image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000189164.13,ZNF527OVCliEAG3.6441e-029.9040e-03-0.2417image
chr19:37391306-37392700:+UCECCliEER2.4426e-023.3552e-020.2661image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000189164.13,ZNF527THCAEAG1.0739e-034.3335e-021.4873e+06image

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3. Enriched editing regions and immune related genes for ZNF527


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for ZNF527


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ZNF527


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000189164.13,ZNF527ACCEAGMonocytes1.0893e-02-0.4820image
chr19:37390080-37390330:+BRCAEERMacrophages_M14.7934e-020.1817image
chr19:37391306-37392700:+BRCAEERT_cells_CD81.3596e-020.1339image
ENSG00000189164.13,ZNF527CESCEAGDendritic_cells_activated1.3698e-020.3610image
chr19:37391306-37392700:+GBMEERB_cells_memory2.2291e-020.2085image
ENSG00000189164.13,ZNF527KICHEAGMast_cells_activated8.7262e-030.5698image
ENSG00000189164.13,ZNF527KIRCEAGT_cells_gamma_delta2.9439e-030.3283image
chr19:37391306-37392700:+KIRPEERMast_cells_activated3.6691e-030.3854image
ENSG00000189164.13,ZNF527KIRPEAGMast_cells_activated2.9658e-030.3867image
chr19:37391306-37392700:+LUSCEERDendritic_cells_activated1.5056e-020.4547image
ENSG00000189164.13,ZNF527LUSCEAGT_cells_gamma_delta1.3142e-030.4596image
chr19:37390080-37390330:+OVEERMast_cells_resting7.4769e-030.3979image
chr19:37391306-37392700:+OVEERB_cells_memory1.7775e-02-0.3103image
ENSG00000189164.13,ZNF527PRADEAGT_cells_regulatory_(Tregs)1.2133e-02-0.1685image
ENSG00000189164.13,ZNF527SARCEAGT_cells_CD4_naive4.5753e-040.3600image
ENSG00000189164.13,ZNF527SKCMEAGPlasma_cells4.8489e-030.4718image
chr19:37390080-37390330:+STADEERMacrophages_M14.7085e-020.3332image
chr19:37391306-37392700:+STADEERMacrophages_M03.9317e-02-0.3500image
ENSG00000189164.13,ZNF527STADEAGMacrophages_M12.0225e-020.2920image
chr19:37391306-37392700:+TGCTEERB_cells_memory3.4286e-020.3443image
ENSG00000189164.13,ZNF527TGCTEAGB_cells_memory3.2746e-030.4079image
ENSG00000189164.13,ZNF527THCAEAGNK_cells_activated1.0211e-03-0.1881image
ENSG00000189164.13,ZNF527THYMEAGPlasma_cells4.9767e-030.3496image
chr19:37391306-37392700:+UCECEERDendritic_cells_activated3.9793e-020.2861image
ENSG00000189164.13,ZNF527UCECEAGDendritic_cells_activated3.1636e-020.2956image


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6. Enriched editing regions and immune gene sets for ZNF527


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000189164.13,ZNF527ACCGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.7448e-030.5269image
chr19:37390080-37390330:+BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER3.7085e-03-0.2641image
ENSG00000189164.13,ZNF527CESCGSVA_HALLMARK_GLYCOLYSISEAG1.5678e-020.3544image
ENSG00000189164.13,ZNF527ESCAGSVA_HALLMARK_MYC_TARGETS_V2EAG6.5453e-03-0.5615image
ENSG00000189164.13,ZNF527GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.5720e-020.2123image
chr19:37391306-37392700:+GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.9867e-020.1879image
ENSG00000189164.13,ZNF527KIRPGSVA_HALLMARK_DNA_REPAIREAG2.8898e-020.2896image
chr19:37391306-37392700:+KIRPGSVA_HALLMARK_DNA_REPAIREER2.8767e-020.2950image
ENSG00000189164.13,ZNF527LGGGSVA_HALLMARK_KRAS_SIGNALING_UPEAG5.8977e-030.1636image
ENSG00000189164.13,ZNF527LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG8.6145e-030.4953image
chr19:37391306-37392700:+LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0891e-020.5434image
chr19:37391306-37392700:+LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.1640e-020.3074image
ENSG00000189164.13,ZNF527LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.7907e-030.3459image
chr19:37391306-37392700:+LUSCGSVA_HALLMARK_MYOGENESISEER3.9216e-02-0.3918image
chr19:37391306-37392700:+OVGSVA_HALLMARK_KRAS_SIGNALING_UPEER1.1378e-040.4851image
chr19:37390080-37390330:+OVGSVA_HALLMARK_KRAS_SIGNALING_UPEER2.6663e-02-0.3341image
chr19:37391306-37392700:+PCPGGSVA_HALLMARK_HYPOXIAEER2.6029e-02-0.2260image
ENSG00000189164.13,ZNF527PCPGGSVA_HALLMARK_HYPOXIAEAG2.2814e-02-0.2298image
ENSG00000189164.13,ZNF527SARCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.3751e-030.2895image
ENSG00000189164.13,ZNF527SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.5154e-02-0.4132image
ENSG00000189164.13,ZNF527STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7160e-020.2632image
ENSG00000189164.13,ZNF527TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.1708e-02-0.3240image
chr19:37391306-37392700:+TGCTGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.0916e-020.3332image
ENSG00000189164.13,ZNF527THCAGSVA_HALLMARK_COAGULATIONEAG1.0645e-030.1874image
ENSG00000189164.13,ZNF527THYMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG4.5604e-04-0.4287image
chr19:37391306-37392700:+UCECGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER4.4950e-020.2793image
ENSG00000189164.13,ZNF527UCECGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG3.4404e-020.2912image


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7. Enriched editing regions and drugs for ZNF527


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000189164.13,ZNF527ACCIPA.3EAG4.5167e-03-0.5294image
chr19:37390080-37390330:+BRCABryostatin.1EER3.9822e-02-0.1887image
ENSG00000189164.13,ZNF527BRCAElesclomolEAG1.6242e-02-0.1216image
ENSG00000189164.13,ZNF527CESCATRAEAG4.5757e-030.4108image
ENSG00000189164.13,ZNF527ESCAAZD.2281EAG2.0509e-02-0.4904image
chr19:37391306-37392700:+GBMCytarabineEER1.0116e-020.2340image
ENSG00000189164.13,ZNF527GBMGDC0941EAG3.7666e-030.2534image
ENSG00000189164.13,ZNF527KICHCGP.082996EAG7.0379e-030.5825image
ENSG00000189164.13,ZNF527KIRCErlotinibEAG4.3800e-04-0.3840image
ENSG00000189164.13,ZNF527KIRPDasatinibEAG3.6470e-02-0.2827image
chr19:37391306-37392700:+KIRPDasatinibEER4.4331e-02-0.2774image
ENSG00000189164.13,ZNF527LGGGDC0941EAG1.1513e-020.1503image
ENSG00000189164.13,ZNF527LIHCAZD7762EAG3.0067e-05-0.7129image
chr19:37391306-37392700:+LIHCBosutinibEER3.1644e-040.7094image
chr19:37391306-37392700:+LUSCCamptothecinEER1.0671e-02-0.4748image
ENSG00000189164.13,ZNF527LUSCA.770041EAG5.4027e-04-0.4904image
ENSG00000189164.13,ZNF527OVDoxorubicinEAG3.9057e-020.2180image
chr19:37391306-37392700:+OVDoxorubicinEER4.2995e-040.4474image
chr19:37390080-37390330:+OVErlotinibEER1.2368e-03-0.4714image
chr19:37391306-37392700:+PCPGImatinibEER8.0137e-030.2678image
ENSG00000189164.13,ZNF527PCPGImatinibEAG1.1670e-020.2538image
ENSG00000189164.13,ZNF527PRADAG.014699EAG3.4296e-02-0.1425image
ENSG00000189164.13,ZNF527SARCElesclomolEAG3.2796e-03-0.3051image
ENSG00000189164.13,ZNF527SKCMGSK269962AEAG1.0081e-03-0.5389image
chr19:37391306-37392700:+STADDasatinibEER3.8106e-03-0.4898image
ENSG00000189164.13,ZNF527STADAZD.0530EAG4.6239e-02-0.2628image
ENSG00000189164.13,ZNF527TGCTGDC.0449EAG1.6471e-02-0.3377image
chr19:37391306-37392700:+TGCTBMS.754807EER1.7948e-020.3820image
ENSG00000189164.13,ZNF527THCACI.1040EAG1.0766e-04-0.2210image
ENSG00000189164.13,ZNF527THYMAZD6244EAG3.3343e-05-0.4976image
chr19:37391306-37392700:+UCECIPA.3EER9.7602e-030.3552image
ENSG00000189164.13,ZNF527UCECGefitinibEAG1.2385e-02-0.3413image
chr19:37391306-37392700:+UCSBosutinibEER1.4704e-02-0.4090image
ENSG00000189164.13,ZNF527UCSCI.1040EAG8.4844e-03-0.4381image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType