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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HOOK3 (ImmuneEditome ID:84376)

1. Gene summary of enriched editing regions for HOOK3

check button Gene summary
Gene informationGene symbol

HOOK3

Gene ID

84376

GeneSynonymsHK3
GeneCytomap

8p11.21

GeneTypeprotein-coding
GeneDescriptionprotein Hook homolog 3|h-hook3|hHK3|hook homolog 3
GeneModificationdate20230329
UniprotIDQ86VS8
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr8:42940991-42941499:+ENST00000527306.1ENSG00000168172.7HOOK3ncRNA_intronicAluY,AluSx1chr8:42940991-42941499:+.alignment
chr8:43004153-43004651:+ENST00000524839.1ENSG00000168172.7HOOK3ncRNA_intronicAluSzchr8:43004153-43004651:+.alignment
chr8:43014075-43017567:+ENST00000307602.7ENSG00000168172.7HOOK3intronic(ATTT)n,AluJb,AluSg7,FLAM_C,AluSz6,AluSg,Kanga2_a,AluSx4,AluSx1,AluYchr8:43014075-43017567:+.alignment
chr8:43014075-43017567:+ENST00000533539.1ENSG00000168172.7HOOK3intronic(ATTT)n,AluJb,AluSg7,FLAM_C,AluSz6,AluSg,Kanga2_a,AluSx4,AluSx1,AluYchr8:43014075-43017567:+.alignment
chr8:43020409-43023772:+ENST00000307602.7ENSG00000168172.7HOOK3UTR3(TCAA)n,(CTTTC)n,(A)n,AluSq,AluSx1,AluY,(T)n,(CTTTT)n,(TCCT)n,AluSg,AluSq2,AluSzchr8:43020409-43023772:+.alignment
chr8:43026917-43027180:+ENST00000307602.7ENSG00000168172.7HOOK3UTR3AluSqchr8:43026917-43027180:+.alignment
chr8:43028184-43029473:+ENST00000307602.7ENSG00000168172.7HOOK3UTR3AluSc,AluJbchr8:43028184-43029473:+.alignment


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2. Tumor-specific enriched editing regions for HOOK3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr8:43020409-43023772:+BRCAEER1.2322e-21image
chr8:43028184-43029473:+BRCAEER7.3276e-08image
ENSG00000168172.7,HOOK3BRCAEAG5.6789e-20image
chr8:43020409-43023772:+HNSCEER8.8221e-05image
ENSG00000168172.7,HOOK3HNSCEAG2.7216e-04image
chr8:43028184-43029473:+KICHEER3.6905e-02image
chr8:43026917-43027180:+KIRPEER2.7001e-02image
chr8:43020409-43023772:+LUADEER1.3641e-02image
chr8:43020409-43023772:+LUSCEER8.7664e-05image
ENSG00000168172.7,HOOK3LUSCEAG3.2739e-02image
chr8:43028184-43029473:+PRADEER2.0106e-02image
ENSG00000168172.7,HOOK3PRADEAG1.9196e-03image
chr8:43020409-43023772:+THCAEER5.7806e-04image
chr8:43020409-43023772:+UCECEER1.9090e-02image
ENSG00000168172.7,HOOK3UCECEAG1.7399e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000168172.7,HOOK3ESCAPathEAG3.8725e-023.8029e-020.1737image
chr8:43028184-43029473:+LUADPathEER1.6825e-024.7907e-030.1296image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr8:43028184-43029473:+READEER1.7081e-022.5892e-023.6425e+07image

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3. Enriched editing regions and immune related genes for HOOK3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr8:43020409-43023772:+PRADEERENSG00000237807,RP11-400K9.40.15221.1313e-021.5088e-190.4125imageNCSTF2T;IGF2BP2NAT_cells_CD4_memory_restingGSVA_HALLMARK_HEME_METABOLISM
chr8:43020409-43023772:+STADEERENSG00000102144,PGK10.37171.1210e-092.1505e-150.4007imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAMast_cells_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr8:43020409-43023772:+STADEERENSG00000115159,GPD20.23713.4171e-041.5005e-230.4928imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SLTM;U2AF2NAEosinophilsGSVA_HALLMARK_PROTEIN_SECRETION
chr8:43020409-43023772:+STADEERENSG00000144283,PKP40.16702.0115e-023.6931e-210.4686imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184PKP4EosinophilsGSVA_HALLMARK_PROTEIN_SECRETION
chr8:43020409-43023772:+UCECEERENSG00000101935,AMMECR10.29662.7975e-025.0434e-070.4069imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SLTM;U2AF2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MYOGENESIS
chr8:43020409-43023772:+DLBCEERENSG00000147853,AK30.55042.9001e-026.1382e-030.4024imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
chr8:43020409-43023772:+DLBCEERENSG00000132128,LRRC410.55513.2462e-021.6951e-040.5319imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAGSVA_HALLMARK_MITOTIC_SPINDLE
chr8:43020409-43023772:+LAMLEERENSG00000110497,AMBRA10.41011.1037e-028.2170e-070.4066imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAMonocytesGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr8:43020409-43023772:+PCPGEERENSG00000092108,SCFD10.44741.4749e-056.1046e-080.4273imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184SCFD1Mast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr8:43020409-43023772:+PCPGEERENSG00000100883,SRP540.44551.7770e-057.6113e-080.4244imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAPlasma_cellsGSVA_HALLMARK_PROTEIN_SECRETION
chr8:43028184-43029473:+KICHEERENSG00000204580,DDR10.51914.2969e-021.5091e-040.4737imageNBUD13;CELF2;CSTF2T;EIF4A3;ELAVL1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHSRP;LIN28;LIN28B;PRPF8;RBM22;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF1;U2AF2;XRN2DDR1GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr8:43028184-43029473:+KICHEERENSG00000109452,INPP4B0.54884.6228e-021.9451e-050.5252imageNCSTF2T;EIF4A3;ELAVL1;FUS;HNRNPA1;HNRNPC;HNRNPM;IGF2BP2;TAF15;TARDBP;U2AF2NAMast_cells_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr8:43028184-43029473:+KIRCEERENSG00000085365,SCAMP10.17611.2416e-023.9848e-150.4023imageNBUD13;CELF2;CSTF2T;EIF4A3;ELAVL1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHSRP;LIN28;LIN28B;PRPF8;RBM22;SF3A3;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF1;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr8:43028184-43029473:+KIRCEERENSG00000109929,SC5D0.17381.3404e-022.1829e-150.4058imageNBUD13;CELF2;CSTF2T;EIF4A3;ELAVL1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHSRP;LIN28;LIN28B;PRPF8;RBM22;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF1;U2AF2NADendritic_cells_activatedGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr8:43028184-43029473:+KIRCEERENSG00000161813,LARP40.16472.2967e-028.1685e-160.4115imageNBUD13;CELF2;CSTF2T;EIF4A3;ELAVL1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHSRP;LIN28;LIN28B;PRPF8;RBM22;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF1;U2AF2;XRN2NAEosinophilsGSVA_HALLMARK_PROTEIN_SECRETION
chr8:43028184-43029473:+KIRCEERENSG00000015153,YAF20.15872.8403e-021.8312e-210.4777imageNBUD13;CELF2;CSTF2T;EIF4A3;ELAVL1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;IGF2BP2;ILF3;KHSRP;LIN28;LIN28B;PRPF8;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;TAF15;TARDBP;U2AF1;U2AF2;XRN2NAEosinophilsGSVA_HALLMARK_MYOGENESIS
chr8:43028184-43029473:+KIRCEERENSG00000278189,RNA5-8S50.05624.2579e-024.4452e-230.4942imageNNNADendritic_cells_activatedGSVA_HALLMARK_P53_PATHWAY

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4. Enriched editing regions and immune related splicing for HOOK3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr8:43020409-43023772:+
GBMEERMEXENSG00000108846.11chr1750659236:50659368:50660922:50661114:50665159:50665245:50667553:506675940.35943.2732e-037.0800e-070.4102imageNCSTF2T;DDX54;ELAVL1;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SLTM;U2AF2NAPlasma_cellsGSVA_HALLMARK_HEME_METABOLISM
chr8:43020409-43023772:+
GBMEERMEXENSG00000108846.11chr1750659236:50659368:50660922:50661256:50665152:50665245:50667553:506675940.35603.8006e-031.0992e-060.4037imageNCSTF2T;DDX54;ELAVL1;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SLTM;U2AF2NAPlasma_cellsGSVA_HALLMARK_HEME_METABOLISM
chr8:43020409-43023772:+
PCPGEERIRENSG00000137409.14chr636968140:36968968:36970038:36970082-0.13643.0542e-024.3315e-10-0.4891imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184MTCH1Dendritic_cells_restingGSVA_HALLMARK_HYPOXIA
chr8:43020409-43023772:+
PRADEERIRENSG00000244754.4chr1332521372:32521449:32527457:32527532-0.04624.9256e-023.5868e-17-0.4391imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000168172.7,HOOK3
TGCTEAGA3ENSG00000116670.10chr111676808:11676948:11675699:11676109:11675699:116761400.14815.6587e-035.1065e-090.5258imageNACIN1;ADAR;AIFM1;AUH;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;YWHAG;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr8:43020409-43023772:+
TGCTEERA3ENSG00000116670.10chr111676808:11676948:11675699:11676109:11675699:116761400.15337.4461e-032.1026e-070.5003imageNCNBP;CSTF2T;DDX54;ELAVL1;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr8:43020409-43023772:+
TGCTEERA3ENSG00000009413.11chr6111313351:111313489:111309852:111310099:111309852:1113112590.24624.9265e-021.6919e-050.4011imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAGSVA_HALLMARK_MITOTIC_SPINDLE
chr8:43020409-43023772:+
THYMEERESENSG00000052723.7chr1114779201:114779284:114780109:114780215:114780448:1147805120.41481.2728e-028.8492e-050.4100imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_PROTEIN_SECRETION
chr8:43020409-43023772:+
THYMEERIRENSG00000267426.1chr1775920006:75920107:75920273:75920429-0.36661.3480e-027.0501e-05-0.4660imageNCNBP;CSTF2T;DDX54;DHX9;ELAVL1;ELAVL3;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;SLTM;U2AF2;ZNF184NANeutrophilsGSVA_HALLMARK_HEME_METABOLISM
chr8:43020409-43023772:+
THYMEERMEXENSG00000143578.11chr1153968521:153968699:153968929:153969097:153969338:153969455:153972743:1539727680.39432.1370e-021.2717e-040.4016imageNCSTF2T;DDX54;DHX9;ELAVL1;FBL;FUS;HNRNPC;IGF2BP2;NOP58;SAFB2;U2AF2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for HOOK3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr8:43028184-43029473:+ACCEERMonocytes1.8726e-02-0.3417image
ENSG00000168172.7,HOOK3ACCEAGMast_cells_resting4.8830e-020.2576image
chr8:43020409-43023772:+BLCAEERNeutrophils5.6443e-03-0.1460image
ENSG00000168172.7,HOOK3BLCAEAGDendritic_cells_resting2.3738e-030.1541image
chr8:43014075-43017567:+BRCAEERMacrophages_M11.4747e-020.1968image
chr8:43020409-43023772:+BRCAEERT_cells_regulatory_(Tregs)1.9808e-040.1174image
chr8:43028184-43029473:+BRCAEERMast_cells_activated1.5628e-030.1003image
ENSG00000168172.7,HOOK3BRCAEAGNK_cells_activated5.3117e-030.0855image
chr8:43020409-43023772:+CESCEERT_cells_follicular_helper1.8355e-030.1923image
chr8:43028184-43029473:+CESCEERMacrophages_M05.6268e-030.1857image
chr8:43020409-43023772:+CHOLEERT_cells_follicular_helper3.6742e-030.4986image
ENSG00000168172.7,HOOK3CHOLEAGNeutrophils2.0820e-02-0.3949image
chr8:43020409-43023772:+COADEEREosinophils4.5780e-030.2210image
ENSG00000168172.7,HOOK3COADEAGT_cells_follicular_helper2.5060e-020.1553image
chr8:43020409-43023772:+DLBCEERT_cells_follicular_helper4.6464e-02-0.2984image
chr8:43004153-43004651:+ESCAEERMacrophages_M01.7640e-040.7042image
chr8:43014075-43017567:+ESCAEERT_cells_CD81.0778e-020.3243image
chr8:43020409-43023772:+ESCAEERMonocytes1.0833e-02-0.2003image
chr8:43028184-43029473:+ESCAEERT_cells_CD4_memory_activated4.4889e-03-0.2229image
ENSG00000168172.7,HOOK3ESCAEAGDendritic_cells_resting5.2401e-03-0.2191image
chr8:43020409-43023772:+HNSCEERT_cells_regulatory_(Tregs)1.0805e-02-0.1216image
chr8:43028184-43029473:+HNSCEERT_cells_CD4_memory_activated7.1130e-030.1410image
chr8:43020409-43023772:+KIRCEERMacrophages_M23.1541e-02-0.1118image
chr8:43028184-43029473:+KIRCEERDendritic_cells_activated5.3121e-040.1837image
ENSG00000168172.7,HOOK3KIRCEAGMacrophages_M22.0597e-03-0.1582image
chr8:43020409-43023772:+KIRPEERB_cells_memory1.9923e-02-0.1528image
chr8:43026917-43027180:+KIRPEERT_cells_CD4_memory_activated6.3777e-060.4227image
chr8:43028184-43029473:+KIRPEERNK_cells_resting1.9485e-020.1567image
chr8:43020409-43023772:+LAMLEERMonocytes8.6753e-03-0.2234image
chr8:43028184-43029473:+LAMLEERT_cells_regulatory_(Tregs)3.7373e-020.2317image
ENSG00000168172.7,HOOK3LAMLEAGMonocytes9.8784e-04-0.2764image
chr8:43020409-43023772:+LGGEERMonocytes2.1572e-040.1628image
ENSG00000168172.7,HOOK3LGGEAGMonocytes1.1683e-020.1100image
chr8:43028184-43029473:+LIHCEERMast_cells_resting2.5310e-020.1586image
chr8:43014075-43017567:+LUADEERPlasma_cells3.8724e-02-0.2495image
chr8:43020409-43023772:+LUADEERDendritic_cells_resting1.7098e-03-0.1421image
chr8:43028184-43029473:+LUADEEREosinophils1.2270e-020.1152image
ENSG00000168172.7,HOOK3LUADEAGT_cells_gamma_delta5.4826e-050.1787image
chr8:43020409-43023772:+LUSCEERT_cells_CD4_memory_resting2.6643e-02-0.1082image
ENSG00000168172.7,HOOK3LUSCEAGT_cells_follicular_helper2.7359e-020.1021image
chr8:43020409-43023772:+MESOEERT_cells_follicular_helper2.3901e-020.2590image
chr8:43028184-43029473:+MESOEERT_cells_gamma_delta2.8754e-020.2653image
chr8:43020409-43023772:+OVEERMast_cells_resting1.1529e-03-0.1899image
chr8:43028184-43029473:+OVEERB_cells_memory3.8639e-020.1243image
ENSG00000168172.7,HOOK3OVEAGMast_cells_resting3.6822e-04-0.2071image
chr8:43020409-43023772:+PAADEERT_cells_CD4_memory_resting7.4047e-030.2072image
chr8:43028184-43029473:+PAADEERNK_cells_activated1.5095e-020.1895image
ENSG00000168172.7,HOOK3PAADEAGT_cells_CD4_memory_resting2.0349e-030.2317image
chr8:43020409-43023772:+PCPGEERDendritic_cells_resting2.9786e-040.2932image
chr8:43028184-43029473:+PCPGEERDendritic_cells_activated9.1420e-030.2061image
chr8:43020409-43023772:+PRADEERMacrophages_M11.6727e-020.1139image
chr8:43028184-43029473:+PRADEERT_cells_CD4_memory_resting2.0677e-02-0.1130image
ENSG00000168172.7,HOOK3PRADEAGMacrophages_M13.3307e-020.0970image
chr8:43020409-43023772:+READEERT_cells_CD4_naive3.3130e-020.2852image
ENSG00000168172.7,HOOK3READEAGDendritic_cells_resting1.3303e-02-0.2810image
chr8:43020409-43023772:+SARCEERB_cells_memory1.4464e-02-0.1587image
chr8:43026917-43027180:+SARCEERMacrophages_M03.5827e-02-0.2241image
chr8:43020409-43023772:+SKCMEERT_cells_CD82.7585e-020.1091image
chr8:43028184-43029473:+SKCMEERT_cells_gamma_delta3.8361e-020.1071image
ENSG00000168172.7,HOOK3SKCMEAGT_cells_regulatory_(Tregs)7.4244e-030.1279image
chr8:43004153-43004651:+STADEERMast_cells_activated4.1860e-02-0.2658image
chr8:43014075-43017567:+STADEEREosinophils2.2517e-040.2785image
chr8:43020409-43023772:+STADEEREosinophils1.7751e-080.2906image
chr8:43028184-43029473:+STADEERMast_cells_resting5.2975e-04-0.1833image
ENSG00000168172.7,HOOK3STADEAGT_cells_CD4_memory_activated5.0575e-080.2793image
chr8:43028184-43029473:+TGCTEERMacrophages_M28.6310e-030.2551image
chr8:43020409-43023772:+THCAEERNeutrophils5.2081e-03-0.1249image
chr8:43028184-43029473:+THCAEEREosinophils1.5620e-030.1422image
ENSG00000168172.7,HOOK3THCAEAGPlasma_cells2.5761e-040.1623image
chr8:43020409-43023772:+THYMEERT_cells_CD4_naive1.1779e-020.2674image
chr8:43028184-43029473:+THYMEERMast_cells_activated4.3417e-020.2439image
ENSG00000168172.7,HOOK3THYMEAGNeutrophils3.1427e-030.2897image
chr8:43020409-43023772:+UCECEERMast_cells_activated1.4611e-020.2046image
chr8:43028184-43029473:+UCECEERDendritic_cells_resting2.2071e-02-0.1991image
ENSG00000168172.7,HOOK3UCECEAGT_cells_CD4_memory_resting5.8822e-030.2162image


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6. Enriched editing regions and immune gene sets for HOOK3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr8:43028184-43029473:+KIRPEER7.3733e-03image1.6005e-03-0.2106image
chr8:43028184-43029473:+STADEER6.5489e-07image1.1150e-02-0.1348image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr8:43014075-43017567:+STADEER1.8877e-020.17942.2658e-030.23202.6668e-020.16959.7625e-030.1971image
ENSG00000168172.7,HOOK3STADEAG5.6484e-090.29783.9488e-040.18385.4889e-040.17935.7451e-040.1787image
chr8:43020409-43023772:+STADEER8.9870e-100.31499.0415e-050.20431.3710e-040.19914.6578e-060.2380image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr8:43028184-43029473:+ACCGSVA_HALLMARK_GLYCOLYSISEER2.7288e-020.3220image
ENSG00000168172.7,HOOK3ACCGSVA_HALLMARK_MYC_TARGETS_V1EAG1.0121e-02-0.3323image
ENSG00000168172.7,HOOK3BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.3282e-030.1489image
chr8:43020409-43023772:+BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.9896e-040.1831image
chr8:43020409-43023772:+BRCAGSVA_HALLMARK_DNA_REPAIREER5.6548e-080.1706image
chr8:43014075-43017567:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.8872e-040.2660image
ENSG00000168172.7,HOOK3BRCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.8314e-050.1281image
chr8:43028184-43029473:+BRCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.1795e-06-0.1535image
chr8:43020409-43023772:+CESCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER8.6038e-030.1626image
chr8:43028184-43029473:+CESCGSVA_HALLMARK_UV_RESPONSE_UPEER5.2322e-04-0.2315image
chr8:43028184-43029473:+CHOLGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.8102e-02-0.3882image
chr8:43028184-43029473:+COADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.2903e-020.1737image
chr8:43020409-43023772:+COADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER6.1010e-04-0.2656image
ENSG00000168172.7,HOOK3COADGSVA_HALLMARK_HEME_METABOLISMEAG2.3709e-02-0.1568image
chr8:43020409-43023772:+DLBCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.6298e-020.3130image
chr8:43014075-43017567:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.7282e-020.2827image
chr8:43004153-43004651:+ESCAGSVA_HALLMARK_HYPOXIAEER1.4738e-030.6237image
chr8:43020409-43023772:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0911e-040.3002image
ENSG00000168172.7,HOOK3ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.0868e-050.3106image
chr8:43028184-43029473:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.1119e-020.1612image
chr8:43028184-43029473:+GBMGSVA_HALLMARK_DNA_REPAIREER3.0001e-020.1779image
chr8:43020409-43023772:+GBMGSVA_HALLMARK_HEME_METABOLISMEER2.3943e-040.2957image
ENSG00000168172.7,HOOK3HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8512e-040.1672image
chr8:43020409-43023772:+HNSCGSVA_HALLMARK_P53_PATHWAYEER2.4520e-050.1999image
chr8:43028184-43029473:+HNSCGSVA_HALLMARK_E2F_TARGETSEER7.6580e-030.1398image
chr8:43028184-43029473:+KICHGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.1168e-020.2996image
ENSG00000168172.7,HOOK3KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.4309e-03-0.1636image
chr8:43020409-43023772:+KIRCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.6122e-050.2102image
chr8:43028184-43029473:+KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER8.5996e-04-0.1769image
chr8:43028184-43029473:+KIRPGSVA_HALLMARK_ANGIOGENESISEER1.0661e-03-0.2182image
chr8:43020409-43023772:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.1849e-040.2404image
chr8:43026917-43027180:+KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEER2.3899e-05-0.3980image
ENSG00000168172.7,HOOK3LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.7185e-03-0.2524image
chr8:43028184-43029473:+LAMLGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.4870e-030.3474image
chr8:43020409-43023772:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.0331e-02-0.2185image
chr8:43020409-43023772:+LGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.9804e-040.1592image
ENSG00000168172.7,HOOK3LGGGSVA_HALLMARK_APICAL_SURFACEEAG1.3970e-02-0.1072image
ENSG00000168172.7,HOOK3LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.3919e-09-0.3588image
chr8:43020409-43023772:+LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.3590e-03-0.2158image
chr8:43028184-43029473:+LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER5.0768e-07-0.3471image
chr8:43020409-43023772:+LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.2921e-030.1295image
ENSG00000168172.7,HOOK3LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.5622e-040.1480image
chr8:43028184-43029473:+LUADGSVA_HALLMARK_PROTEIN_SECRETIONEER9.4874e-030.1193image
chr8:43014075-43017567:+LUADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.7966e-040.4361image
chr8:43028184-43029473:+LUSCGSVA_HALLMARK_APICAL_SURFACEEER4.0122e-03-0.1400image
chr8:43028184-43029473:+MESOGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER2.2443e-040.4332image
ENSG00000168172.7,HOOK3MESOGSVA_HALLMARK_COAGULATIONEAG1.3497e-020.2804image
chr8:43020409-43023772:+OVGSVA_HALLMARK_ADIPOGENESISEER4.0914e-070.2922image
ENSG00000168172.7,HOOK3OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG4.1178e-070.2911image
chr8:43028184-43029473:+OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.7057e-040.2172image
chr8:43028184-43029473:+PAADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER9.6809e-04-0.2553image
ENSG00000168172.7,HOOK3PAADGSVA_HALLMARK_MYOGENESISEAG9.6367e-03-0.1952image
chr8:43020409-43023772:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER5.2453e-050.3261image
chr8:43028184-43029473:+PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER8.2498e-04-0.2626image
ENSG00000168172.7,HOOK3PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.0761e-03-0.2092image
ENSG00000168172.7,HOOK3PRADGSVA_HALLMARK_APICAL_JUNCTIONEAG8.9402e-04-0.1508image
chr8:43028184-43029473:+PRADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.8472e-070.2412image
chr8:43020409-43023772:+PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER7.0116e-030.1282image
chr8:43020409-43023772:+READGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.9770e-020.2756image
chr8:43026917-43027180:+SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.8664e-03-0.3271image
ENSG00000168172.7,HOOK3SARCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.6749e-02-0.1410image
chr8:43020409-43023772:+SARCGSVA_HALLMARK_PROTEIN_SECRETIONEER6.1094e-030.1776image
chr8:43028184-43029473:+SARCGSVA_HALLMARK_HYPOXIAEER5.6756e-03-0.1859image
chr8:43020409-43023772:+SKCMGSVA_HALLMARK_ANGIOGENESISEER1.6673e-03-0.1552image
ENSG00000168172.7,HOOK3SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.5103e-030.1513image
chr8:43028184-43029473:+SKCMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER7.5336e-040.1735image
chr8:42940991-42941499:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.7820e-020.3306image
chr8:43028184-43029473:+STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER6.3391e-090.3025image
chr8:43004153-43004651:+STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.2694e-020.3226image
chr8:43014075-43017567:+STADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.3496e-040.2878image
ENSG00000168172.7,HOOK3STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.0565e-150.3957image
chr8:43020409-43023772:+STADGSVA_HALLMARK_MTORC1_SIGNALINGEER2.9825e-140.3852image
chr8:43028184-43029473:+TGCTGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.7231e-020.2036image
ENSG00000168172.7,HOOK3TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.2901e-02-0.1936image
chr8:43028184-43029473:+THCAGSVA_HALLMARK_COAGULATIONEER2.3673e-07-0.2304image
chr8:43020409-43023772:+THCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.1256e-100.2769image
ENSG00000168172.7,HOOK3THCAGSVA_HALLMARK_UV_RESPONSE_DNEAG1.2602e-05-0.1934image
chr8:43028184-43029473:+THYMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.9617e-04-0.4227image
ENSG00000168172.7,HOOK3THYMGSVA_HALLMARK_MYC_TARGETS_V1EAG9.7088e-030.2550image
chr8:43020409-43023772:+THYMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER9.0797e-060.4536image
chr8:43020409-43023772:+UCECGSVA_HALLMARK_G2M_CHECKPOINTEER8.3184e-030.2207image
chr8:43028184-43029473:+UCECGSVA_HALLMARK_NOTCH_SIGNALINGEER5.6770e-04-0.2961image
ENSG00000168172.7,HOOK3UCECGSVA_HALLMARK_NOTCH_SIGNALINGEAG9.2605e-03-0.2045image
ENSG00000168172.7,HOOK3UVMGSVA_HALLMARK_MYC_TARGETS_V2EAG1.0928e-020.3888image


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7. Enriched editing regions and drugs for HOOK3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000168172.7,HOOK3ACCGW.441756EAG4.9000e-040.4399image
chr8:43020409-43023772:+ACCBI.2536EER1.9429e-040.5278image
chr8:43028184-43029473:+ACCBMS.754807EER3.5193e-02-0.3080image
chr8:43020409-43023772:+BLCAAMG.706EER2.2391e-030.1610image
chr8:43028184-43029473:+BLCAGNF.2EER2.7691e-030.1713image
chr8:43020409-43023772:+BRCAGW843682XEER1.2242e-03-0.1020image
chr8:43014075-43017567:+BRCAMG.132EER1.4778e-03-0.2548image
chr8:43028184-43029473:+BRCABX.795EER1.3015e-090.1912image
ENSG00000168172.7,HOOK3BRCABX.795EAG3.4900e-050.1267image
chr8:43020409-43023772:+CESCBortezomibEER2.0627e-03-0.1903image
ENSG00000168172.7,HOOK3CESCAICAREAG1.0759e-020.1506image
chr8:43028184-43029473:+CESCGW843682XEER7.7901e-040.2244image
chr8:43020409-43023772:+CHOLCCT007093EER8.1948e-04-0.5618image
chr8:43028184-43029473:+CHOLJW.7.52.1EER8.9860e-040.5583image
ENSG00000168172.7,HOOK3COADElesclomolEAG5.1085e-030.1935image
chr8:43028184-43029473:+COADIPA.3EER4.6109e-02-0.1626image
chr8:43020409-43023772:+COADBMS.509744EER1.0213e-030.2550image
chr8:43020409-43023772:+DLBCGW843682XEER4.4639e-020.3008image
ENSG00000168172.7,HOOK3DLBCLFM.A13EAG1.4667e-02-0.3616image
chr8:43028184-43029473:+ESCACMKEER1.7699e-030.2445image
chr8:43014075-43017567:+ESCAIPA.3EER3.3708e-04-0.4475image
chr8:43004153-43004651:+ESCABI.D1870EER2.3780e-02-0.4696image
chr8:43020409-43023772:+ESCAABT.263EER7.8035e-040.2630image
ENSG00000168172.7,HOOK3ESCAGDC.0449EAG1.3852e-04-0.2968image
chr8:43028184-43029473:+GBMDasatinibEER4.4596e-020.1648image
chr8:43020409-43023772:+GBMDMOGEER1.9572e-04-0.2996image
chr8:43028184-43029473:+HNSCEtoposideEER3.9856e-03-0.1508image
chr8:43020409-43023772:+HNSCJW.7.52.1EER1.8241e-060.2255image
ENSG00000168172.7,HOOK3HNSCMidostaurinEAG1.5299e-040.1743image
chr8:43028184-43029473:+KICHBosutinibEER1.4833e-030.4046image
chr8:43020409-43023772:+KICHMG.132EER7.9025e-030.3679image
ENSG00000168172.7,HOOK3KICHKU.55933EAG4.8499e-030.3561image
ENSG00000168172.7,HOOK3KIRCImatinibEAG3.4087e-040.1835image
chr8:43020409-43023772:+KIRCAG.014699EER4.0959e-030.1489image
chr8:43028184-43029473:+KIRCBMS.708163EER2.5203e-05-0.2225image
chr8:43026917-43027180:+KIRPAZD6482EER7.0668e-040.3239image
chr8:43020409-43023772:+KIRPAZD6244EER1.2835e-050.2821image
ENSG00000168172.7,HOOK3KIRPBosutinibEAG6.5377e-030.1667image
chr8:43028184-43029473:+KIRPBMS.708163EER4.8968e-04-0.2321image
chr8:43020409-43023772:+LAMLEmbelinEER1.0110e-05-0.3673image
chr8:43028184-43029473:+LAMLGW843682XEER4.5214e-04-0.3809image
ENSG00000168172.7,HOOK3LAMLEmbelinEAG5.3270e-08-0.4415image
chr8:43020409-43023772:+LGGCamptothecinEER1.3481e-040.1679image
ENSG00000168172.7,HOOK3LGGAG.014699EAG3.5397e-02-0.0918image
ENSG00000168172.7,HOOK3LIHCDoxorubicinEAG1.6342e-060.2944image
chr8:43028184-43029473:+LIHCDoxorubicinEER3.5394e-040.2507image
chr8:43020409-43023772:+LIHCAUY922EER5.0639e-030.2122image
chr8:43020409-43023772:+LUADImatinibEER4.7386e-030.1280image
ENSG00000168172.7,HOOK3LUADBMS.536924EAG3.9461e-03-0.1287image
chr8:43028184-43029473:+LUADJNJ.26854165EER2.0326e-030.1417image
chr8:43028184-43029473:+LUSCBIRB.0796EER9.8613e-03-0.1257image
chr8:43020409-43023772:+LUSCAxitinibEER2.8274e-020.1070image
ENSG00000168172.7,HOOK3LUSCImatinibEAG1.8514e-020.1090image
chr8:43020409-43023772:+MESODMOGEER2.5573e-02-0.2561image
chr8:43028184-43029473:+MESOAZD6482EER8.2642e-04-0.3961image
ENSG00000168172.7,HOOK3MESOAP.24534EAG1.7308e-03-0.3513image
chr8:43028184-43029473:+OVErlotinibEER8.0276e-05-0.2347image
ENSG00000168172.7,HOOK3OVBMS.536924EAG9.1194e-09-0.3283image
chr8:43020409-43023772:+OVAG.014699EER9.9680e-060.2562image
ENSG00000168172.7,HOOK3PAADIPA.3EAG6.4146e-040.2662image
chr8:43028184-43029473:+PAADAP.24534EER1.3651e-050.3325image
chr8:43020409-43023772:+PAADBIBW2992EER4.3030e-04-0.2702image
chr8:43020409-43023772:+PCPGDasatinibEER2.5805e-040.3011image
chr8:43028184-43029473:+PCPGBosutinibEER1.7460e-050.3335image
ENSG00000168172.7,HOOK3PCPGMidostaurinEAG9.7235e-030.1933image
ENSG00000168172.7,HOOK3PRADKU.55933EAG1.0398e-050.1993image
chr8:43028184-43029473:+PRADCCT007093EER1.8488e-050.2076image
chr8:43020409-43023772:+PRADKU.55933EER5.7120e-040.1634image
chr8:43028184-43029473:+READBMS.708163EER1.4699e-04-0.4672image
chr8:43020409-43023772:+READBryostatin.1EER1.3825e-020.3272image
ENSG00000168172.7,HOOK3READBryostatin.1EAG7.2869e-030.3035image
ENSG00000168172.7,HOOK3SARCFTI.277EAG8.3906e-040.2112image
chr8:43020409-43023772:+SARCAKT.inhibitor.VIIIEER2.8676e-02-0.1422image
chr8:43028184-43029473:+SARCBleomycinEER1.9791e-040.2484image
chr8:43026917-43027180:+SARCAxitinibEER1.2372e-020.2656image
chr8:43020409-43023772:+SKCMJNK.9LEER6.0415e-05-0.1972image
ENSG00000168172.7,HOOK3SKCMCEP.701EAG1.3892e-06-0.2285image
chr8:43028184-43029473:+SKCMA.770041EER4.6035e-05-0.2091image
chr8:43028184-43029473:+STADAP.24534EER2.1650e-090.3113image
chr8:42940991-42941499:+STADCisplatinEER4.7950e-020.2784image
chr8:43004153-43004651:+STADAxitinibEER2.9035e-02-0.2844image
chr8:43014075-43017567:+STADA.770041EER1.8857e-020.1794image
ENSG00000168172.7,HOOK3STADCCT007093EAG1.0041e-100.3288image
chr8:43020409-43023772:+STADCCT007093EER2.3514e-060.2452image
ENSG00000168172.7,HOOK3TGCTCEP.701EAG2.1212e-02-0.1960image
chr8:43020409-43023772:+TGCTBosutinibEER3.5443e-03-0.2600image
chr8:43028184-43029473:+TGCTAZD8055EER2.9349e-020.2127image
ENSG00000168172.7,HOOK3THCABexaroteneEAG9.1104e-060.1964image
chr8:43014075-43017567:+THCAAMG.706EER2.1135e-02-0.1380image
chr8:43028184-43029473:+THCAAZD.0530EER7.0290e-080.2401image
chr8:43020409-43023772:+THCABryostatin.1EER1.4595e-050.1927image
chr8:43028184-43029473:+THYMAG.014699EER6.4577e-040.4007image
chr8:43020409-43023772:+THYMBAY.61.3606EER1.8001e-04-0.3890image
ENSG00000168172.7,HOOK3THYMJNJ.26854165EAG7.3128e-030.2641image
chr8:43028184-43029473:+UCECKIN001.135EER5.4042e-040.2971image
chr8:43020409-43023772:+UCECBAY.61.3606EER2.7805e-03-0.2492image
ENSG00000168172.7,HOOK3UCECBryostatin.1EAG1.1815e-020.1980image
ENSG00000168172.7,HOOK3UCSElesclomolEAG2.4627e-02-0.3114image
ENSG00000168172.7,HOOK3UVMAZ628EAG2.2496e-02-0.3514image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType