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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: COG8 (ImmuneEditome ID:84342)

1. Gene summary of enriched editing regions for COG8

check button Gene summary
Gene informationGene symbol

COG8

Gene ID

84342

GeneSynonymsCDG2H|DOR1
GeneCytomap

16q22.1

GeneTypeprotein-coding
GeneDescriptionconserved oligomeric Golgi complex subunit 8|COG complex subunit 8|conserved oligomeric golgi complex component 8|dependent on RIC1
GeneModificationdate20230329
UniprotIDQ96MW5;J3QRV3;H3BQV3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr16:69327148-69328268:-ENST00000564419.1ENSG00000213380.12COG8ncRNA_intronicAluSx1,AluSg7,FLAM_Cchr16:69327148-69328268:-.alignment
chr16:69333256-69333793:-ENST00000306875.7ENSG00000213380.12COG8intronicMIR,AluJr,AluJochr16:69333256-69333793:-.alignment
chr16:69333256-69333793:-ENST00000562081.2ENSG00000213380.12COG8intronicMIR,AluJr,AluJochr16:69333256-69333793:-.alignment
chr16:69333256-69333793:-ENST00000562595.4ENSG00000213380.12COG8intronicMIR,AluJr,AluJochr16:69333256-69333793:-.alignment


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2. Tumor-specific enriched editing regions for COG8


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000213380.12,COG8KIRCEAG4.9854e-02image
chr16:69327148-69328268:-PRADEER3.1038e-02image
ENSG00000213380.12,COG8PRADEAG4.4811e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr16:69327148-69328268:-UCECCliEER2.2759e-023.4711e-02-0.1607image
ENSG00000213380.12,COG8UCECCliEAG8.7950e-033.3636e-02-0.1598image
ENSG00000213380.12,COG8UVMPathEAG3.4795e-022.2413e-020.3516image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000213380.12,COG8PAADEAG1.6031e-032.9949e-023.1377e+02image

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3. Enriched editing regions and immune related genes for COG8


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for COG8


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for COG8


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000213380.12,COG8ACCEAGNK_cells_resting7.9376e-030.4190image
chr16:69327148-69328268:-BRCAEERT_cells_regulatory_(Tregs)1.7607e-030.1127image
ENSG00000213380.12,COG8BRCAEAGNK_cells_resting2.5250e-020.0801image
chr16:69327148-69328268:-COADEERMast_cells_activated1.3172e-020.1810image
ENSG00000213380.12,COG8COADEAGMast_cells_activated1.7345e-020.1729image
ENSG00000213380.12,COG8DLBCEAGEosinophils1.5625e-040.6115image
chr16:69327148-69328268:-ESCAEERT_cells_CD4_naive1.4519e-020.1948image
ENSG00000213380.12,COG8ESCAEAGT_cells_CD4_naive1.3759e-020.1963image
ENSG00000213380.12,COG8KICHEAGEosinophils3.5606e-020.2921image
chr16:69327148-69328268:-KIRCEERDendritic_cells_resting3.6446e-020.1206image
ENSG00000213380.12,COG8KIRCEAGDendritic_cells_resting4.4805e-020.1156image
chr16:69327148-69328268:-KIRPEERT_cells_CD4_memory_resting1.7553e-020.1469image
ENSG00000213380.12,COG8LAMLEAGNK_cells_activated2.1561e-030.4280image
chr16:69327148-69328268:-LGGEERB_cells_memory4.4212e-040.1561image
ENSG00000213380.12,COG8LGGEAGB_cells_memory4.7706e-040.1552image
chr16:69327148-69328268:-LUADEERT_cells_CD84.7258e-020.1222image
chr16:69327148-69328268:-MESOEERT_cells_gamma_delta1.9247e-030.5200image
ENSG00000213380.12,COG8MESOEAGT_cells_gamma_delta8.7560e-030.4491image
chr16:69327148-69328268:-OVEERB_cells_naive3.6275e-02-0.1322image
ENSG00000213380.12,COG8OVEAGB_cells_naive3.7411e-02-0.1314image
ENSG00000213380.12,COG8PAADEAGT_cells_CD4_naive1.0469e-020.3282image
chr16:69327148-69328268:-PCPGEERT_cells_CD4_memory_activated7.3671e-030.2614image
ENSG00000213380.12,COG8PCPGEAGT_cells_CD4_memory_activated1.3703e-020.2377image
chr16:69327148-69328268:-PRADEERB_cells_naive9.9126e-030.1420image
ENSG00000213380.12,COG8PRADEAGB_cells_naive1.1949e-020.1380image
chr16:69327148-69328268:-READEERMacrophages_M01.3326e-02-0.2988image
ENSG00000213380.12,COG8READEAGDendritic_cells_resting1.6065e-020.2910image
chr16:69327148-69328268:-SARCEERT_cells_CD81.3029e-020.2290image
ENSG00000213380.12,COG8SARCEAGT_cells_CD82.4325e-020.2073image
chr16:69327148-69328268:-SKCMEERNK_cells_resting7.0612e-03-0.1465image
ENSG00000213380.12,COG8SKCMEAGNK_cells_resting4.8643e-03-0.1526image
chr16:69327148-69328268:-TGCTEERB_cells_naive4.1066e-03-0.2860image
ENSG00000213380.12,COG8TGCTEAGB_cells_naive4.1066e-03-0.2860image
chr16:69327148-69328268:-THCAEERNK_cells_resting2.5744e-02-0.1083image
ENSG00000213380.12,COG8THCAEAGNK_cells_resting3.5888e-02-0.1019image
ENSG00000213380.12,COG8THYMEAGT_cells_regulatory_(Tregs)1.4148e-020.2700image
chr16:69327148-69328268:-UCECEERT_cells_regulatory_(Tregs)3.2686e-02-0.2194image
ENSG00000213380.12,COG8UCSEAGT_cells_follicular_helper2.0905e-020.3641image
ENSG00000213380.12,COG8UVMEAGMast_cells_activated2.6700e-020.3379image


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6. Enriched editing regions and immune gene sets for COG8


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr16:69327148-69328268:-BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.5972e-050.3090image
ENSG00000213380.12,COG8BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG9.6122e-050.2955image
ENSG00000213380.12,COG8BRCAGSVA_HALLMARK_HYPOXIAEAG7.2466e-050.1416image
chr16:69327148-69328268:-BRCAGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.4358e-050.1558image
ENSG00000213380.12,COG8CESCGSVA_HALLMARK_DNA_REPAIREAG3.4780e-02-0.1913image
chr16:69327148-69328268:-COADGSVA_HALLMARK_DNA_REPAIREER1.6932e-04-0.2716image
ENSG00000213380.12,COG8COADGSVA_HALLMARK_DNA_REPAIREAG3.3895e-04-0.2580image
ENSG00000213380.12,COG8DLBCGSVA_HALLMARK_SPERMATOGENESISEAG1.0492e-020.4395image
ENSG00000213380.12,COG8ESCAGSVA_HALLMARK_ANGIOGENESISEAG3.6994e-030.2304image
chr16:69327148-69328268:-ESCAGSVA_HALLMARK_ANGIOGENESISEER3.9990e-030.2285image
ENSG00000213380.12,COG8GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.3826e-020.2154image
chr16:69327148-69328268:-GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.3593e-020.2158image
ENSG00000213380.12,COG8HNSCGSVA_HALLMARK_HYPOXIAEAG1.0999e-020.1773image
chr16:69327148-69328268:-HNSCGSVA_HALLMARK_HYPOXIAEER1.1409e-020.1772image
ENSG00000213380.12,COG8KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.0641e-04-0.2274image
chr16:69327148-69328268:-KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.2690e-04-0.2350image
ENSG00000213380.12,COG8LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.9031e-07-0.2192image
chr16:69327148-69328268:-LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER6.7467e-07-0.2194image
ENSG00000213380.12,COG8LIHCGSVA_HALLMARK_MYC_TARGETS_V2EAG3.6402e-02-0.1656image
chr16:69327148-69328268:-LIHCGSVA_HALLMARK_MYC_TARGETS_V2EER3.7173e-02-0.1649image
chr16:69327148-69328268:-LUADGSVA_HALLMARK_APICAL_SURFACEEER1.5991e-030.1933image
ENSG00000213380.12,COG8LUADGSVA_HALLMARK_APICAL_SURFACEEAG1.6215e-030.1920image
chr16:69327148-69328268:-MESOGSVA_HALLMARK_MYC_TARGETS_V2EER3.5898e-020.3665image
ENSG00000213380.12,COG8MESOGSVA_HALLMARK_MYC_TARGETS_V2EAG2.2855e-020.3951image
chr16:69327148-69328268:-OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.8635e-030.1875image
ENSG00000213380.12,COG8OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.8878e-030.1873image
ENSG00000213380.12,COG8PCPGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.7110e-030.2655image
chr16:69327148-69328268:-PCPGGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.0117e-020.2276image
ENSG00000213380.12,COG8PRADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG7.9075e-05-0.2152image
chr16:69327148-69328268:-PRADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.2474e-04-0.2100image
ENSG00000213380.12,COG8READGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.7321e-020.2414image
chr16:69327148-69328268:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4604e-030.2910image
ENSG00000213380.12,COG8SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4450e-030.2900image
chr16:69327148-69328268:-SKCMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.0746e-030.1672image
ENSG00000213380.12,COG8SKCMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.8414e-030.1616image
ENSG00000213380.12,COG8STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG3.4128e-030.1612image
chr16:69327148-69328268:-STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER3.5950e-030.1606image
ENSG00000213380.12,COG8TGCTGSVA_HALLMARK_GLYCOLYSISEAG3.6412e-030.2896image
chr16:69327148-69328268:-TGCTGSVA_HALLMARK_GLYCOLYSISEER3.6412e-030.2896image
chr16:69327148-69328268:-THCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.1059e-030.1489image
ENSG00000213380.12,COG8THCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.6110e-030.1527image
chr16:69327148-69328268:-UCECGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.3210e-06-0.4629image
ENSG00000213380.12,COG8UCECGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG8.3362e-06-0.4353image
ENSG00000213380.12,COG8UCSGSVA_HALLMARK_E2F_TARGETSEAG5.1638e-030.4338image


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7. Enriched editing regions and drugs for COG8


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000213380.12,COG8ACCBMS.536924EAG2.5731e-020.3569image
ENSG00000213380.12,COG8BLCABortezomibEAG8.9346e-04-0.2532image
chr16:69327148-69328268:-BLCABortezomibEER1.2375e-03-0.2472image
ENSG00000213380.12,COG8BRCAJNK.9LEAG6.1531e-03-0.0980image
chr16:69327148-69328268:-BRCAAS601245EER4.0848e-03-0.1035image
ENSG00000213380.12,COG8CESCAS601245EAG2.4747e-02-0.2033image
chr16:69327148-69328268:-CHOLFTI.277EER3.4503e-02-0.4631image
ENSG00000213380.12,COG8CHOLFTI.277EAG3.4503e-02-0.4631image
chr16:69327148-69328268:-COADBMS.708163EER4.1808e-04-0.2554image
ENSG00000213380.12,COG8COADBMS.708163EAG4.2432e-04-0.2538image
ENSG00000213380.12,COG8DLBCCEP.701EAG9.0624e-030.4473image
ENSG00000213380.12,COG8ESCACGP.60474EAG3.9950e-03-0.2285image
chr16:69327148-69328268:-ESCACGP.60474EER4.4951e-03-0.2256image
ENSG00000213380.12,COG8GBMBMS.754807EAG5.0181e-04-0.3264image
chr16:69327148-69328268:-GBMBMS.754807EER5.2297e-04-0.3254image
ENSG00000213380.12,COG8HNSCABT.263EAG9.0205e-05-0.2707image
chr16:69327148-69328268:-HNSCABT.263EER6.4524e-05-0.2773image
ENSG00000213380.12,COG8KIRCCCT018159EAG3.5847e-04-0.2040image
chr16:69327148-69328268:-KIRCCCT018159EER2.8463e-04-0.2077image
ENSG00000213380.12,COG8KIRPAMG.706EAG1.6771e-04-0.2305image
chr16:69327148-69328268:-KIRPBI.2536EER3.7601e-04-0.2185image
ENSG00000213380.12,COG8LAMLGDC.0449EAG3.6371e-020.2998image
ENSG00000213380.12,COG8LGGEpothilone.BEAG7.1476e-060.1987image
chr16:69327148-69328268:-LGGEpothilone.BEER6.9209e-060.1990image
ENSG00000213380.12,COG8LIHCGSK269962AEAG1.2811e-020.2008image
chr16:69327148-69328268:-LIHCGSK269962AEER1.2983e-020.2004image
ENSG00000213380.12,COG8LUADGW.441756EAG2.0566e-020.1417image
chr16:69327148-69328268:-LUADGW.441756EER1.4347e-020.1506image
ENSG00000213380.12,COG8LUSCGSK.650394EAG3.2090e-020.1548image
chr16:69327148-69328268:-LUSCGSK.650394EER3.3545e-020.1539image
ENSG00000213380.12,COG8MESOBI.2536EAG1.3373e-03-0.5350image
chr16:69327148-69328268:-MESOBI.2536EER7.6716e-03-0.4559image
chr16:69327148-69328268:-OVBMS.536924EER4.0134e-04-0.2217image
ENSG00000213380.12,COG8OVBMS.536924EAG4.2816e-04-0.2207image
ENSG00000213380.12,COG8PAADBMS.536924EAG5.0987e-030.3571image
ENSG00000213380.12,COG8PCPGAKT.inhibitor.VIIIEAG2.4633e-030.2898image
chr16:69327148-69328268:-PCPGMethotrexateEER5.1690e-03-0.2723image
ENSG00000213380.12,COG8PRADAP.24534EAG3.9781e-06-0.2504image
chr16:69327148-69328268:-PRADAP.24534EER3.7676e-06-0.2518image
chr16:69327148-69328268:-READAZ628EER2.2156e-030.3649image
ENSG00000213380.12,COG8READAZ628EAG2.5102e-030.3608image
chr16:69327148-69328268:-SARCAxitinibEER6.2901e-040.3115image
ENSG00000213380.12,COG8SARCAZ628EAG4.8161e-040.3164image
ENSG00000213380.12,COG8SKCMDasatinibEAG1.9939e-03-0.1681image
chr16:69327148-69328268:-SKCMDasatinibEER3.9849e-03-0.1572image
ENSG00000213380.12,COG8STADJNJ.26854165EAG1.7566e-04-0.2057image
chr16:69327148-69328268:-STADJNJ.26854165EER2.4335e-04-0.2016image
ENSG00000213380.12,COG8TGCTErlotinibEAG5.0882e-04-0.3430image
chr16:69327148-69328268:-TGCTErlotinibEER5.0882e-04-0.3430image
chr16:69327148-69328268:-THCAGW.441756EER7.3035e-030.1301image
ENSG00000213380.12,COG8THCAGW.441756EAG4.9884e-030.1361image
ENSG00000213380.12,COG8THYMCisplatinEAG9.0621e-03-0.2865image
chr16:69327148-69328268:-UCECCCT018159EER3.4016e-050.4117image
ENSG00000213380.12,COG8UCECCCT018159EAG5.4493e-050.3978image
ENSG00000213380.12,COG8UCSCGP.082996EAG2.2720e-04-0.5513image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType