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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: HM13 (ImmuneEditome ID:81502)

1. Gene summary of enriched editing regions for HM13

check button Gene summary
Gene informationGene symbol

HM13

Gene ID

81502

GeneSynonymsH13|IMP1|IMPAS|IMPAS-1|MSTP086|PSENL3|PSL3|SPP|SPPL1
GeneCytomap

20q11.21

GeneTypeprotein-coding
GeneDescriptionminor histocompatibility antigen H13|intramembrane protease 1|minor histocompatibility antigen 13|presenilin-like protein 3|signal peptide peptidase beta|signal peptide peptidase like 1
GeneModificationdate20230329
UniprotIDA0A0S2Z6F0;A0A0C4DGU3;Q8TCT9;A0A3B3IUB5;A0A3B3IT72;A0A0S2Z5V7;A0A075B6F6;A0A087WVH6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr20:31538938-31539656:+ENST00000460225.4ENSG00000101294.15HM13ncRNA_intronicMIRb,AluScchr20:31538938-31539656:+.alignment
chr20:31538938-31539656:+ENST00000469126.4ENSG00000101294.15HM13ncRNA_intronicMIRb,AluScchr20:31538938-31539656:+.alignment
chr20:31538938-31539656:+ENST00000492709.4ENSG00000101294.15HM13ncRNA_intronicMIRb,AluScchr20:31538938-31539656:+.alignment
chr20:31538938-31539656:+ENST00000496438.4ENSG00000101294.15HM13ncRNA_intronicMIRb,AluScchr20:31538938-31539656:+.alignment
chr20:31545900-31546648:+ENST00000460225.4ENSG00000101294.15HM13ncRNA_intronicAluSz,AluSz6,AluYchr20:31545900-31546648:+.alignment
chr20:31545900-31546648:+ENST00000469097.4ENSG00000101294.15HM13ncRNA_intronicAluSz,AluSz6,AluYchr20:31545900-31546648:+.alignment
chr20:31545900-31546648:+ENST00000469126.4ENSG00000101294.15HM13ncRNA_intronicAluSz,AluSz6,AluYchr20:31545900-31546648:+.alignment
chr20:31545900-31546648:+ENST00000492709.4ENSG00000101294.15HM13ncRNA_intronicAluSz,AluSz6,AluYchr20:31545900-31546648:+.alignment
chr20:31545900-31546648:+ENST00000496438.4ENSG00000101294.15HM13ncRNA_intronicAluSz,AluSz6,AluYchr20:31545900-31546648:+.alignment
chr20:31555710-31556921:+ENST00000460389.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000468559.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000469097.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000469126.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000472128.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000474466.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000483310.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000487964.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000492709.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment
chr20:31555710-31556921:+ENST00000494153.4ENSG00000101294.15HM13ncRNA_intronicAluJr,MIRb,AluSp,AluYm1chr20:31555710-31556921:+.alignment


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2. Tumor-specific enriched editing regions for HM13


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000101294.15,HM13UCECCliEAG2.1949e-023.0997e-020.3880image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for HM13


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for HM13


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000101294.15,HM13
ESCAEAGIRENSG00000054523.12chr110374315:10375046:10375254:103753730.34143.2009e-021.0676e-070.4149imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184KIF1BT_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000101294.15,HM13
ESCAEAGMEXENSG00000188643.6chr1153607998:153608177:153608898:153609030:153612016:153612044:153612951:153613083-0.32533.2396e-023.7371e-08-0.4282imageNADAR;AUH;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;FAM120A;FBL;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MBNL1;MOV10;MSI1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000101294.15,HM13
ESCAEAGIRENSG00000095539.11chr10100978294:100978388:100978526:1009786400.35011.6866e-031.6237e-080.4988imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;ZNF184SEMA4GDendritic_cells_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000101294.15,HM13
ESCAEAGMEXENSG00000188643.6chr1153607998:153608177:153608898:153608985:153612016:153612044:153612951:153613083-0.33502.2315e-029.5744e-09-0.4446imageNADAR;AUH;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;FAM120A;FBL;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MBNL1;MOV10;MSI1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000101294.15,HM13
ESCAEAGESENSG00000174373.11chr1435539634:35539690:35548507:35548538:35549109:355492340.35111.4453e-022.2259e-070.4065imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28B;LSM11;MBNL2;METTL14;METTL3;MOV10;MSI1;NCBP3;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM6;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;YTHDC1;YWHAG;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000101294.15,HM13
ESCAEAGMEXENSG00000188643.6chr1153607998:153608177:153608898:153608961:153612016:153612044:153612951:153613083-0.32383.4120e-024.0934e-08-0.4271imageNADAR;AUH;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;FAM120A;FBL;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MBNL1;MOV10;MSI1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000101294.15,HM13
ESCAEAGESENSG00000143367.11chr1151540308:151540426:151561717:151562165:151562584:1515626860.26723.5815e-025.5487e-070.4350imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;SAFB2;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000101294.15,HM13
ESCAEAGIRENSG00000055950.12chr10100981375:100983817:100983947:100984074-0.32223.6043e-022.9919e-07-0.4142imageNACIN1;ADAR;AIFM1;AUH;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP4B;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM47;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000101294.15,HM13
ESCAEAGMEXENSG00000188643.6chr1153607998:153608177:153608898:153608987:153612016:153612044:153612951:153613083-0.32213.6237e-025.8464e-08-0.4226imageNADAR;AUH;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;FAM120A;FBL;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MBNL1;MOV10;MSI1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_KRAS_SIGNALING_DN
ENSG00000101294.15,HM13
ESCAEAGIRENSG00000054523.12chr110374315:10374465:10374853:103750100.33084.5205e-022.8721e-070.4019imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;WTAP;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184KIF1BT_cells_CD4_memory_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE

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5. Enriched editing regions and immune infiltration for HM13


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000101294.15,HM13BLCAEAGPlasma_cells3.1075e-020.2834image
ENSG00000101294.15,HM13BRCAEAGDendritic_cells_activated2.8928e-030.1432image
ENSG00000101294.15,HM13CESCEAGB_cells_memory2.9426e-02-0.3853image
ENSG00000101294.15,HM13COADEAGDendritic_cells_activated2.3474e-020.3200image
chr20:31555710-31556921:+ESCAEERT_cells_follicular_helper1.6760e-020.3588image
ENSG00000101294.15,HM13ESCAEAGT_cells_regulatory_(Tregs)2.6724e-03-0.2412image
ENSG00000101294.15,HM13GBMEAGMacrophages_M02.1836e-020.4242image
ENSG00000101294.15,HM13KIRCEAGMonocytes5.1773e-04-0.2765image
chr20:31555710-31556921:+LAMLEERNK_cells_resting4.1593e-020.2535image
chr20:31538938-31539656:+OVEERNK_cells_resting1.5541e-020.2697image
ENSG00000101294.15,HM13PRADEAGNK_cells_activated7.6385e-030.3440image
chr20:31555710-31556921:+STADEERT_cells_CD4_memory_activated6.6036e-030.2995image
ENSG00000101294.15,HM13STADEAGT_cells_gamma_delta6.4282e-030.1649image
ENSG00000101294.15,HM13THCAEAGNK_cells_resting2.0631e-020.2724image
ENSG00000101294.15,HM13UCECEAGDendritic_cells_activated4.2426e-020.4174image


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6. Enriched editing regions and immune gene sets for HM13


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000101294.15,HM13BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG8.2509e-030.3437image
ENSG00000101294.15,HM13BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3713e-030.1370image
ENSG00000101294.15,HM13CESCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.6705e-02-0.3708image
ENSG00000101294.15,HM13COADGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.8448e-02-0.3100image
chr20:31555710-31556921:+ESCAGSVA_HALLMARK_COAGULATIONEER2.4079e-02-0.3397image
ENSG00000101294.15,HM13ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.8111e-030.2268image
ENSG00000101294.15,HM13GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.4395e-020.3760image
ENSG00000101294.15,HM13HNSCGSVA_HALLMARK_SPERMATOGENESISEAG3.7326e-020.4026image
ENSG00000101294.15,HM13KIRCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG6.4851e-06-0.3544image
ENSG00000101294.15,HM13KIRPGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.4189e-03-0.5254image
ENSG00000101294.15,HM13LAMLGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG8.5061e-03-0.2256image
ENSG00000101294.15,HM13LGGGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.8337e-020.4590image
ENSG00000101294.15,HM13LUADGSVA_HALLMARK_APICAL_JUNCTIONEAG1.2917e-030.2630image
chr20:31538938-31539656:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0391e-03-0.3273image
chr20:31555710-31556921:+OVGSVA_HALLMARK_P53_PATHWAYEER3.6083e-020.4210image
ENSG00000101294.15,HM13OVGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG7.6120e-050.2584image
ENSG00000101294.15,HM13PAADGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.2328e-02-0.5129image
ENSG00000101294.15,HM13PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.8803e-02-0.3051image
ENSG00000101294.15,HM13SKCMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG9.7049e-03-0.2601image
ENSG00000101294.15,HM13STADGSVA_HALLMARK_HYPOXIAEAG9.8458e-030.1563image
chr20:31538938-31539656:+STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.0274e-04-0.2825image
chr20:31555710-31556921:+STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.5318e-050.4425image
ENSG00000101294.15,HM13UCECGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.1806e-020.5052image


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7. Enriched editing regions and drugs for HM13


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000101294.15,HM13BLCAKIN001.135EAG1.4867e-02-0.3184image
ENSG00000101294.15,HM13BRCAAMG.706EAG2.6416e-020.1069image
ENSG00000101294.15,HM13CESCBMS.754807EAG1.3104e-020.4339image
ENSG00000101294.15,HM13COADAZD.0530EAG1.4152e-02-0.3450image
chr20:31555710-31556921:+ESCAMethotrexateEER4.8092e-03-0.4175image
ENSG00000101294.15,HM13ESCAErlotinibEAG3.5480e-05-0.3277image
ENSG00000101294.15,HM13GBMAICAREAG2.2394e-02-0.4226image
ENSG00000101294.15,HM13KIRCAS601245EAG1.0403e-040.3076image
ENSG00000101294.15,HM13KIRPCCT018159EAG1.3660e-04-0.6080image
chr20:31555710-31556921:+LAMLCisplatinEER2.0585e-03-0.3754image
ENSG00000101294.15,HM13LAMLBleomycinEAG3.2956e-03-0.2512image
ENSG00000101294.15,HM13LGGJNK.Inhibitor.VIIIEAG1.2034e-04-0.6830image
ENSG00000101294.15,HM13LUADBexaroteneEAG6.7845e-03-0.2224image
ENSG00000101294.15,HM13LUSCBMS.754807EAG2.4862e-02-0.2031image
chr20:31538938-31539656:+OVAZD6482EER2.8807e-030.3311image
ENSG00000101294.15,HM13OVABT.263EAG2.0784e-030.2024image
ENSG00000101294.15,HM13PAADAICAREAG2.4627e-020.4671image
ENSG00000101294.15,HM13PRADCisplatinEAG1.5864e-020.3128image
ENSG00000101294.15,HM13STADFTI.277EAG1.3479e-03-0.1934image
chr20:31538938-31539656:+STADABT.263EER3.5198e-040.2861image
chr20:31555710-31556921:+STADAUY922EER2.4082e-03-0.3327image
ENSG00000101294.15,HM13THCALapatinibEAG1.3965e-020.2886image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType