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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: APOL6 (ImmuneEditome ID:80830)

1. Gene summary of enriched editing regions for APOL6

check button Gene summary
Gene informationGene symbol

APOL6

Gene ID

80830

GeneSynonymsAPOL-VI|APOLVI
GeneCytomap

22q12.3

GeneTypeprotein-coding
GeneDescriptionapolipoprotein L6|apolipoprotein L, 6|apolipoprotein L-VI
GeneModificationdate20230517
UniprotIDQ9BWW8;B3KTP4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr22:35659744-35661357:+ENST00000409652.4ENSG00000221963.5APOL6UTR3MLT1A0,AluSz,(TGTT)n,LTR48,AluSx1,MLT1Bchr22:35659744-35661357:+.alignment


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2. Tumor-specific enriched editing regions for APOL6


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr22:35659744-35661357:+BRCAEER2.6761e-36image
ENSG00000221963.5,APOL6BRCAEAG4.4780e-36image
chr22:35659744-35661357:+COADEER3.7968e-13image
ENSG00000221963.5,APOL6COADEAG3.3663e-13image
chr22:35659744-35661357:+HNSCEER2.9016e-08image
ENSG00000221963.5,APOL6HNSCEAG3.1434e-08image
chr22:35659744-35661357:+KICHEER4.1454e-02image
ENSG00000221963.5,APOL6KICHEAG4.5068e-02image
chr22:35659744-35661357:+LIHCEER8.4832e-04image
ENSG00000221963.5,APOL6LIHCEAG1.1190e-03image
chr22:35659744-35661357:+LUADEER3.5366e-05image
ENSG00000221963.5,APOL6LUADEAG3.6704e-05image
chr22:35659744-35661357:+LUSCEER3.0459e-13image
ENSG00000221963.5,APOL6LUSCEAG3.0459e-13image
chr22:35659744-35661357:+PRADEER1.2947e-02image
ENSG00000221963.5,APOL6PRADEAG1.4103e-02image
chr22:35659744-35661357:+STADEER1.2833e-08image
ENSG00000221963.5,APOL6STADEAG1.3767e-08image
chr22:35659744-35661357:+THCAEER1.5980e-04image
ENSG00000221963.5,APOL6THCAEAG1.7468e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000221963.5,APOL6CHOLPathEAG3.2359e-023.3314e-020.3659image
chr22:35659744-35661357:+KIRCPathEER1.4313e-021.2455e-030.1401image
ENSG00000221963.5,APOL6KIRCPathEAG1.3797e-021.2015e-030.1406image
chr22:35659744-35661357:+UCECCliEER3.8587e-028.0544e-030.1477image
ENSG00000221963.5,APOL6UCECCliEAG3.8890e-028.1257e-030.1475image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for APOL6


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr22:35659744-35661357:+GBMEERENSG00000136895,GARNL30.33036.9029e-034.2875e-070.4132imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX54;DGCR8;DICER1;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;FUS;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SRSF1;SRSF9;TARDBP;TIA1;TNRC6A;U2AF2;UPF1;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_APOPTOSIS
chr22:35659744-35661357:+KICHEERENSG00000094975,SUCO-0.68623.0452e-032.0156e-05-0.5130imageNACIN1;ALYREF;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NAGSVA_HALLMARK_PROTEIN_SECRETION
chr22:35659744-35661357:+KICHEERENSG00000166136,NDUFB80.66894.9582e-031.3501e-080.6468imageNACIN1;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;ZNF184NAMonocytesGSVA_HALLMARK_UV_RESPONSE_DN
chr22:35659744-35661357:+KICHEERENSG00000138758,SEPT11-0.64414.9582e-031.0701e-04-0.4721imageNACIN1;ALKBH5;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NANeutrophilsGSVA_HALLMARK_UV_RESPONSE_DN
chr22:35659744-35661357:+KICHEERENSG00000136925,TSTD2-0.65139.2760e-033.9740e-06-0.5482imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr22:35659744-35661357:+KICHEERENSG00000167434,CA40.61451.1123e-026.9741e-070.5821imageNCSTF2T;DDX54;DGCR8;FBL;FUS;HNRNPL;NOP58;RBFOX2NAMonocytesGSVA_HALLMARK_G2M_CHECKPOINT
chr22:35659744-35661357:+KICHEERENSG00000145332,KLHL8-0.64231.1123e-025.2713e-04-0.4276imageNALKBH5;ALYREF;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr22:35659744-35661357:+KICHEERENSG00000138757,G3BP2-0.63121.7174e-022.3816e-06-0.5586imageNACIN1;ALYREF;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE
chr22:35659744-35661357:+KICHEERENSG00000163840,DTX3L-0.60121.7174e-025.1671e-05-0.4906imageNBUD13;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TROVE2;U2AF2;UPF1;YTHDF1NAMonocytesGSVA_HALLMARK_MYC_TARGETS_V1
chr22:35659744-35661357:+KICHEERENSG00000224051,CPTP0.61101.7174e-023.1044e-080.6343imageNBUD13;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G2;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF9;TARDBP;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NAMonocytesGSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for APOL6


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr22:35659744-35661357:+
GBMEERIRENSG00000080189.10chr2046355801:46356637:46358386:46358506-0.23184.6143e-021.4660e-06-0.4265imageNBUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NAGSVA_HALLMARK_NOTCH_SIGNALING
chr22:35659744-35661357:+
KIRPEERIRENSG00000197343.6chr799570198:99571792:99572244:995755360.34183.1622e-075.0795e-100.4168imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000221963.5,APOL6
KIRPEAGIRENSG00000197343.6chr799570198:99571792:99572244:995755360.34163.0814e-075.0795e-100.4168imageNADAR;AUH;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DDX42;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LIN28B;MBNL2;MOV10;MSI1;PRPF8;PTBP1;RBFOX2;RBM47;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000221963.5,APOL6
OVEAGIRENSG00000119787.9chr238295153:38296700:38298143:38298575-0.16882.4232e-022.0923e-11-0.4429imageNADAR;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LIN28B;MBNL2;MOV10;MSI1;PRPF8;PTBP1;RBFOX2;RBM47;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1ATL2Macrophages_M2GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr22:35659744-35661357:+
OVEERIRENSG00000119787.9chr238295153:38296700:38298143:38298575-0.16742.2443e-022.0596e-11-0.4431imageNACIN1;ALYREF;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;YTHDF1;ZNF184ATL2Macrophages_M2GSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr22:35659744-35661357:+
PAADEERMEXENSG00000076513.12chr12110019138:110019328:110021107:110021296:110024018:110024112:110025741:1100258230.37259.1007e-044.1250e-090.4490imageNACIN1;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28A;LIN28B;MOV10;MSI1;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr22:35659744-35661357:+
PAADEERMEXENSG00000180098.5chr128564702:28564834:28567293:28567431:28571178:28571338:28571866:28571900-0.41869.4646e-041.1809e-08-0.4201imageNBUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPL;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;MOV10;MSI2;NOP58;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SLTM;SMNDC1;SND1;SRSF1;SRSF9;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF2;UPF1;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000221963.5,APOL6
PAADEAGIRENSG00000244754.4chr1332521372:32527532:32537005:32537027-0.30782.0774e-024.2602e-07-0.4106imageNADAR;AUH;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DDX42;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LIN28B;MBNL2;MOV10;MSI1;PRPF8;PTBP1;RBFOX2;RBM47;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NAMonocytesGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
ENSG00000221963.5,APOL6
PAADEAGMEXENSG00000074800.9chr18863234:8863343:8863890:8863967:8865284:8865482:8866278:88665010.48803.7875e-053.0157e-080.4092imageNADAR;AUH;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DDX42;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LIN28B;MBNL2;MOV10;MSI1;PRPF8;PTBP1;RBFOX2;RBM47;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NAB_cells_memoryGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000221963.5,APOL6
PAADEAGMEXENSG00000111640.10chr126536919:6537010:6537100:6537189:6537583:6537996:6538100:6538117-0.48803.7875e-057.9581e-09-0.4245imageNADAR;AUH;BCCIP;BUD13;CELF2;CSTF2T;DDX3X;DDX42;DKC1;EIF4A3;ELAVL1;ELAVL3;FAM120A;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LIN28B;MBNL2;MOV10;MSI1;PRPF8;PTBP1;RBFOX2;RBM47;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN

More results



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5. Enriched editing regions and immune infiltration for APOL6


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr22:35659744-35661357:+ACCEERB_cells_naive1.3123e-02-0.5200image
ENSG00000221963.5,APOL6ACCEAGB_cells_naive1.3123e-02-0.5200image
chr22:35659744-35661357:+BRCAEERT_cells_follicular_helper2.1412e-040.1140image
ENSG00000221963.5,APOL6BRCAEAGT_cells_follicular_helper2.3089e-040.1133image
chr22:35659744-35661357:+CESCEERT_cells_CD4_naive1.4482e-030.1878image
ENSG00000221963.5,APOL6CESCEAGT_cells_CD4_naive1.4609e-030.1876image
chr22:35659744-35661357:+CHOLEERB_cells_memory1.5646e-030.5214image
ENSG00000221963.5,APOL6CHOLEAGB_cells_memory1.9173e-030.5130image
chr22:35659744-35661357:+COADEERNK_cells_resting2.7818e-030.1814image
ENSG00000221963.5,APOL6COADEAGNK_cells_resting2.6087e-030.1825image
chr22:35659744-35661357:+DLBCEERMacrophages_M05.3737e-030.4320image
ENSG00000221963.5,APOL6DLBCEAGMacrophages_M05.3737e-030.4320image
chr22:35659744-35661357:+ESCAEERDendritic_cells_resting6.2113e-03-0.2148image
ENSG00000221963.5,APOL6ESCAEAGDendritic_cells_resting6.8831e-03-0.2122image
chr22:35659744-35661357:+GBMEERT_cells_CD4_memory_activated3.5335e-02-0.1787image
ENSG00000221963.5,APOL6GBMEAGT_cells_CD4_memory_activated3.5335e-02-0.1787image
chr22:35659744-35661357:+HNSCEERT_cells_CD4_memory_resting1.1626e-04-0.1759image
ENSG00000221963.5,APOL6HNSCEAGT_cells_CD4_memory_resting1.3068e-04-0.1746image
chr22:35659744-35661357:+KICHEERT_cells_regulatory_(Tregs)4.3081e-02-0.2578image
ENSG00000221963.5,APOL6KICHEAGT_cells_regulatory_(Tregs)4.3081e-02-0.2578image
chr22:35659744-35661357:+KIRCEERMacrophages_M26.3491e-04-0.1745image
ENSG00000221963.5,APOL6KIRCEAGMacrophages_M24.4160e-04-0.1794image
chr22:35659744-35661357:+KIRPEERNK_cells_resting9.9555e-030.1611image
ENSG00000221963.5,APOL6KIRPEAGNK_cells_resting9.8689e-030.1613image
chr22:35659744-35661357:+LAMLEERT_cells_CD4_memory_activated2.8066e-020.1794image
ENSG00000221963.5,APOL6LAMLEAGT_cells_CD4_memory_activated2.9302e-020.1780image
chr22:35659744-35661357:+LGGEERT_cells_CD4_naive2.0299e-030.1743image
ENSG00000221963.5,APOL6LGGEAGT_cells_CD4_naive2.0208e-030.1744image
chr22:35659744-35661357:+LIHCEERT_cells_CD4_naive3.4408e-02-0.1134image
ENSG00000221963.5,APOL6LIHCEAGT_cells_CD4_naive3.5389e-02-0.1128image
chr22:35659744-35661357:+LUADEEREosinophils1.5349e-03-0.1401image
ENSG00000221963.5,APOL6LUADEAGEosinophils1.5094e-03-0.1403image
chr22:35659744-35661357:+LUSCEERT_cells_CD4_memory_resting2.3103e-03-0.1405image
ENSG00000221963.5,APOL6LUSCEAGT_cells_CD4_memory_resting2.3103e-03-0.1405image
chr22:35659744-35661357:+MESOEERMacrophages_M12.0303e-02-0.2873image
ENSG00000221963.5,APOL6MESOEAGMacrophages_M12.0303e-02-0.2873image
chr22:35659744-35661357:+PAADEERMast_cells_activated2.9575e-030.2266image
ENSG00000221963.5,APOL6PAADEAGMast_cells_activated3.1417e-030.2253image
chr22:35659744-35661357:+PCPGEEREosinophils7.0739e-030.2590image
ENSG00000221963.5,APOL6PCPGEAGEosinophils7.0739e-030.2590image
chr22:35659744-35661357:+PRADEERNeutrophils2.8369e-02-0.1056image
ENSG00000221963.5,APOL6PRADEAGNeutrophils2.7186e-02-0.1064image
chr22:35659744-35661357:+READEERT_cells_CD4_memory_activated1.9208e-03-0.3143image
ENSG00000221963.5,APOL6READEAGT_cells_CD4_memory_activated1.9208e-03-0.3143image
chr22:35659744-35661357:+SKCMEEREosinophils3.2550e-020.1046image
ENSG00000221963.5,APOL6SKCMEAGEosinophils3.2372e-020.1047image
chr22:35659744-35661357:+STADEERMacrophages_M15.1352e-040.1804image
ENSG00000221963.5,APOL6STADEAGMacrophages_M15.6300e-040.1792image
chr22:35659744-35661357:+TGCTEERNeutrophils2.9156e-040.3583image
ENSG00000221963.5,APOL6TGCTEAGNeutrophils2.9156e-040.3583image
chr22:35659744-35661357:+THCAEERNK_cells_activated3.6394e-040.1614image
ENSG00000221963.5,APOL6THCAEAGNK_cells_activated4.8406e-040.1580image
chr22:35659744-35661357:+UCECEERDendritic_cells_activated2.5563e-040.3109image
ENSG00000221963.5,APOL6UCECEAGDendritic_cells_activated2.5563e-040.3109image


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6. Enriched editing regions and immune gene sets for APOL6


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr22:35659744-35661357:+BRCAEER1.0473e-03image1.8684e-03-0.0958image
ENSG00000221963.5,APOL6BRCAEAG1.3127e-03image2.5613e-03-0.0929image
chr22:35659744-35661357:+LUSCEER9.9120e-07image7.4241e-06-0.2055image
ENSG00000221963.5,APOL6LUSCEAG9.9120e-07image7.4241e-06-0.2055image
chr22:35659744-35661357:+THCAEER4.3478e-03image4.1471e-03-0.1301image
ENSG00000221963.5,APOL6THCAEAG4.7163e-03image4.2672e-03-0.1297image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr22:35659744-35661357:+BLCAGSVA_HALLMARK_DNA_REPAIREER3.2331e-060.2429image
ENSG00000221963.5,APOL6BLCAGSVA_HALLMARK_DNA_REPAIREAG4.2449e-060.2400image
ENSG00000221963.5,APOL6BRCAGSVA_HALLMARK_DNA_REPAIREAG5.4243e-160.2462image
chr22:35659744-35661357:+BRCAGSVA_HALLMARK_DNA_REPAIREER9.1886e-170.2526image
ENSG00000221963.5,APOL6CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.2023e-03-0.1563image
chr22:35659744-35661357:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.8850e-03-0.1547image
ENSG00000221963.5,APOL6CHOLGSVA_HALLMARK_HEME_METABOLISMEAG2.1958e-04-0.5929image
chr22:35659744-35661357:+CHOLGSVA_HALLMARK_HEME_METABOLISMEER4.8072e-04-0.5663image
ENSG00000221963.5,APOL6COADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG5.7871e-04-0.2081image
chr22:35659744-35661357:+COADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.1283e-03-0.1972image
ENSG00000221963.5,APOL6DLBCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.0314e-030.4448image
chr22:35659744-35661357:+DLBCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.0314e-030.4448image
ENSG00000221963.5,APOL6ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.4046e-070.3752image
chr22:35659744-35661357:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0197e-060.3740image
chr22:35659744-35661357:+GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.2121e-06-0.3832image
ENSG00000221963.5,APOL6GBMGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.2121e-06-0.3832image
chr22:35659744-35661357:+HNSCGSVA_HALLMARK_APICAL_SURFACEEER1.2816e-11-0.3041image
ENSG00000221963.5,APOL6HNSCGSVA_HALLMARK_APICAL_SURFACEEAG8.7348e-12-0.3064image
chr22:35659744-35661357:+KICHGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.3250e-04-0.4512image
ENSG00000221963.5,APOL6KICHGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.3250e-04-0.4512image
chr22:35659744-35661357:+KIRCGSVA_HALLMARK_UV_RESPONSE_DNEER1.1791e-04-0.1963image
ENSG00000221963.5,APOL6KIRCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.7626e-04-0.1913image
ENSG00000221963.5,APOL6KIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG1.9091e-09-0.3648image
chr22:35659744-35661357:+KIRPGSVA_HALLMARK_UV_RESPONSE_DNEER1.7802e-09-0.3655image
chr22:35659744-35661357:+LAMLGSVA_HALLMARK_G2M_CHECKPOINTEER1.0831e-04-0.3108image
ENSG00000221963.5,APOL6LAMLGSVA_HALLMARK_G2M_CHECKPOINTEAG1.2561e-04-0.3081image
chr22:35659744-35661357:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER7.1638e-06-0.2514image
ENSG00000221963.5,APOL6LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.9336e-06-0.2518image
ENSG00000221963.5,APOL6LIHCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6568e-05-0.2286image
chr22:35659744-35661357:+LIHCGSVA_HALLMARK_UV_RESPONSE_DNEER1.4260e-05-0.2303image
chr22:35659744-35661357:+LUADGSVA_HALLMARK_DNA_REPAIREER2.0286e-080.2454image
ENSG00000221963.5,APOL6LUADGSVA_HALLMARK_DNA_REPAIREAG2.9994e-080.2425image
ENSG00000221963.5,APOL6LUSCGSVA_HALLMARK_COMPLEMENTEAG4.5242e-11-0.2983image
chr22:35659744-35661357:+LUSCGSVA_HALLMARK_COMPLEMENTEER4.5242e-11-0.2983image
ENSG00000221963.5,APOL6MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6103e-04-0.4292image
chr22:35659744-35661357:+MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6103e-04-0.4292image
ENSG00000221963.5,APOL6OVGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.0423e-03-0.1819image
chr22:35659744-35661357:+OVGSVA_HALLMARK_ANDROGEN_RESPONSEEER2.2043e-03-0.1806image
chr22:35659744-35661357:+PAADGSVA_HALLMARK_UV_RESPONSE_DNEER2.6492e-05-0.3163image
ENSG00000221963.5,APOL6PAADGSVA_HALLMARK_UV_RESPONSE_DNEAG2.7624e-05-0.3156image
chr22:35659744-35661357:+PRADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.7164e-09-0.2849image
ENSG00000221963.5,APOL6PRADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.2927e-09-0.2870image
chr22:35659744-35661357:+READGSVA_HALLMARK_BILE_ACID_METABOLISMEER8.9770e-05-0.3909image
ENSG00000221963.5,APOL6READGSVA_HALLMARK_BILE_ACID_METABOLISMEAG8.9770e-05-0.3909image
chr22:35659744-35661357:+SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.3136e-030.2083image
ENSG00000221963.5,APOL6SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.7203e-030.1995image
chr22:35659744-35661357:+SKCMGSVA_HALLMARK_UV_RESPONSE_DNEER4.9296e-06-0.2213image
ENSG00000221963.5,APOL6SKCMGSVA_HALLMARK_UV_RESPONSE_DNEAG4.4732e-06-0.2223image
ENSG00000221963.5,APOL6STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4844e-070.2701image
chr22:35659744-35661357:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2028e-070.2720image
chr22:35659744-35661357:+TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER2.0956e-02-0.2330image
ENSG00000221963.5,APOL6TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.0956e-02-0.2330image
ENSG00000221963.5,APOL6THCAGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6013e-10-0.2854image
chr22:35659744-35661357:+THCAGSVA_HALLMARK_UV_RESPONSE_DNEER1.3351e-10-0.2866image
ENSG00000221963.5,APOL6THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.1788e-02-0.2471image
chr22:35659744-35661357:+THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER2.1788e-02-0.2471image
ENSG00000221963.5,APOL6UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.9142e-020.1784image
chr22:35659744-35661357:+UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.9142e-020.1784image
chr22:35659744-35661357:+UVMGSVA_HALLMARK_DNA_REPAIREER6.2106e-030.5043image
ENSG00000221963.5,APOL6UVMGSVA_HALLMARK_DNA_REPAIREAG6.2106e-030.5043image


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7. Enriched editing regions and drugs for APOL6


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr22:35659744-35661357:+BLCAGW843682XEER1.4893e-06-0.2508image
ENSG00000221963.5,APOL6BLCAGW843682XEAG1.7377e-06-0.2492image
ENSG00000221963.5,APOL6BRCAAZD6482EAG2.9717e-100.1929image
chr22:35659744-35661357:+BRCAAZD6482EER8.9010e-110.1986image
ENSG00000221963.5,APOL6CESCMG.132EAG6.2361e-04-0.2018image
chr22:35659744-35661357:+CESCMG.132EER6.0569e-04-0.2023image
ENSG00000221963.5,APOL6CHOLBIRB.0796EAG2.7607e-04-0.5854image
chr22:35659744-35661357:+CHOLBIRB.0796EER5.1774e-04-0.5637image
ENSG00000221963.5,APOL6COADAZD6482EAG2.5478e-040.2208image
chr22:35659744-35661357:+COADAZD6482EER1.0582e-040.2338image
ENSG00000221963.5,APOL6DLBCMethotrexateEAG2.3661e-040.5562image
chr22:35659744-35661357:+DLBCMethotrexateEER2.3661e-040.5562image
ENSG00000221963.5,APOL6ESCACGP.60474EAG4.3073e-04-0.2742image
chr22:35659744-35661357:+ESCACGP.60474EER4.4547e-04-0.2736image
chr22:35659744-35661357:+GBMAP.24534EER2.2632e-040.3079image
ENSG00000221963.5,APOL6GBMAP.24534EAG2.2632e-040.3079image
chr22:35659744-35661357:+HNSCAZD6482EER1.2167e-100.2898image
ENSG00000221963.5,APOL6HNSCAZD6482EAG6.8591e-110.2935image
chr22:35659744-35661357:+KICHBryostatin.1EER1.5538e-03-0.3935image
ENSG00000221963.5,APOL6KICHBryostatin.1EAG1.5538e-03-0.3935image
chr22:35659744-35661357:+KIRCBMS.536924EER7.8017e-05-0.2020image
ENSG00000221963.5,APOL6KIRCBMS.536924EAG1.6197e-04-0.1931image
ENSG00000221963.5,APOL6KIRPAZD6482EAG2.1400e-060.2918image
chr22:35659744-35661357:+KIRPAZD6482EER2.0980e-060.2920image
chr22:35659744-35661357:+LAMLAZD.0530EER3.3126e-03-0.2383image
ENSG00000221963.5,APOL6LAMLAZD.0530EAG3.2835e-03-0.2386image
chr22:35659744-35661357:+LGGEHT.1864EER1.7208e-04-0.2115image
ENSG00000221963.5,APOL6LGGEHT.1864EAG1.6738e-04-0.2118image
ENSG00000221963.5,APOL6LIHCDasatinibEAG2.8681e-04-0.2087image
chr22:35659744-35661357:+LIHCDasatinibEER3.4052e-04-0.2062image
chr22:35659744-35661357:+LUADLFM.A13EER1.3209e-050.1918image
ENSG00000221963.5,APOL6LUADLFM.A13EAG1.3444e-050.1916image
ENSG00000221963.5,APOL6LUSCBIRB.0796EAG1.3001e-05-0.2000image
chr22:35659744-35661357:+LUSCBIRB.0796EER1.3001e-05-0.2000image
ENSG00000221963.5,APOL6MESOBMS.754807EAG5.0657e-04-0.4194image
chr22:35659744-35661357:+MESOBMS.754807EER5.0657e-04-0.4194image
ENSG00000221963.5,APOL6OVAICAREAG2.9806e-040.2127image
chr22:35659744-35661357:+OVAICAREER2.9814e-040.2127image
chr22:35659744-35661357:+PAADAZD6482EER2.4951e-040.2815image
ENSG00000221963.5,APOL6PAADAZD6482EAG2.6018e-040.2807image
chr22:35659744-35661357:+PRADBMS.536924EER2.1171e-08-0.2663image
ENSG00000221963.5,APOL6PRADBMS.536924EAG1.7188e-08-0.2680image
chr22:35659744-35661357:+READCyclopamineEER4.4641e-03-0.2908image
ENSG00000221963.5,APOL6READCyclopamineEAG4.4641e-03-0.2908image
chr22:35659744-35661357:+SARCBMS.708163EER4.2791e-030.2027image
ENSG00000221963.5,APOL6SARCBMS.708163EAG4.2318e-030.2019image
chr22:35659744-35661357:+SKCMAZD6482EER2.5350e-060.2286image
ENSG00000221963.5,APOL6SKCMAZD6482EAG2.3361e-060.2294image
ENSG00000221963.5,APOL6STADCamptothecinEAG1.0478e-03-0.1704image
chr22:35659744-35661357:+STADCamptothecinEER1.0337e-03-0.1706image
chr22:35659744-35661357:+TGCTATRAEER2.7877e-060.4532image
ENSG00000221963.5,APOL6TGCTATRAEAG2.7877e-060.4532image
ENSG00000221963.5,APOL6THCABAY.61.3606EAG2.5797e-080.2497image
chr22:35659744-35661357:+THCABAY.61.3606EER2.2657e-080.2507image
ENSG00000221963.5,APOL6THYMDocetaxelEAG2.2573e-03-0.3251image
chr22:35659744-35661357:+THYMDocetaxelEER2.2573e-03-0.3251image
ENSG00000221963.5,APOL6UCECBMS.708163EAG2.5105e-020.1935image
chr22:35659744-35661357:+UCECBMS.708163EER2.5105e-020.1935image
chr22:35659744-35661357:+UVMMethotrexateEER2.6980e-030.5452image
ENSG00000221963.5,APOL6UVMMethotrexateEAG2.6980e-030.5452image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType