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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ORAI2 (ImmuneEditome ID:80228)

1. Gene summary of enriched editing regions for ORAI2

check button Gene summary
Gene informationGene symbol

ORAI2

Gene ID

80228

GeneSynonymsC7orf19|CBCIP2|MEM142B|TMEM142B
GeneCytomap

7q22.1

GeneTypeprotein-coding
GeneDescriptionprotein orai-2|CAP-binding protein complex interacting protein 2|H_NH0514P08.8|putative protein ORAI2-2|transmembrane protein 142B
GeneModificationdate20230329
UniprotIDQ96SN7;C9JUY6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:102440961-102441508:+ENST00000488996.1ENSG00000160991.14ORAI2ncRNA_intronicAluSx1,AluSxchr7:102440961-102441508:+.alignment
chr7:102448458-102455172:+ENST00000356387.5ENSG00000160991.14ORAI2UTR3AluSp,AluSx1,(TTTGT)n,AluSz,AluSg,AluSq2,AluJr,(TTCTCG)n,AluJo,AluSxchr7:102448458-102455172:+.alignment
chr7:102448458-102455172:+ENST00000403646.6ENSG00000160991.14ORAI2UTR3AluSp,AluSx1,(TTTGT)n,AluSz,AluSg,AluSq2,AluJr,(TTCTCG)n,AluJo,AluSxchr7:102448458-102455172:+.alignment
chr7:102448458-102455172:+ENST00000473939.1ENSG00000160991.14ORAI2UTR3AluSp,AluSx1,(TTTGT)n,AluSz,AluSg,AluSq2,AluJr,(TTCTCG)n,AluJo,AluSxchr7:102448458-102455172:+.alignment
chr7:102448458-102455172:+ENST00000478730.5ENSG00000160991.14ORAI2UTR3AluSp,AluSx1,(TTTGT)n,AluSz,AluSg,AluSq2,AluJr,(TTCTCG)n,AluJo,AluSxchr7:102448458-102455172:+.alignment
chr7:102448458-102455172:+ENST00000611770.3ENSG00000160991.14ORAI2UTR3AluSp,AluSx1,(TTTGT)n,AluSz,AluSg,AluSq2,AluJr,(TTCTCG)n,AluJo,AluSxchr7:102448458-102455172:+.alignment


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2. Tumor-specific enriched editing regions for ORAI2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr7:102448458-102455172:+BRCAEER1.1667e-02image
ENSG00000160991.14,ORAI2BRCAEAG1.1556e-02image
ENSG00000160991.14,ORAI2KIRCEAG2.1093e-02image
ENSG00000160991.14,ORAI2LUSCEAG2.6202e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000160991.14,ORAI2CESCCliEAG7.2418e-071.5710e-020.3159image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ORAI2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ORAI2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for ORAI2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000160991.14,ORAI2ACCEAGT_cells_regulatory_(Tregs)2.0847e-020.4507image
ENSG00000160991.14,ORAI2BLCAEAGB_cells_naive3.8137e-020.2338image
chr7:102448458-102455172:+BRCAEERMast_cells_activated2.7904e-030.1288image
ENSG00000160991.14,ORAI2BRCAEAGMast_cells_activated3.0052e-030.1276image
ENSG00000160991.14,ORAI2CESCEAGNeutrophils2.0546e-020.3010image
ENSG00000160991.14,ORAI2COADEAGDendritic_cells_activated5.7343e-100.7548image
chr7:102448458-102455172:+GBMEERDendritic_cells_resting2.7748e-020.1816image
ENSG00000160991.14,ORAI2GBMEAGDendritic_cells_resting2.7748e-020.1816image
ENSG00000160991.14,ORAI2HNSCEAGMacrophages_M26.2742e-030.3283image
ENSG00000160991.14,ORAI2KIRCEAGMonocytes3.3185e-02-0.1808image
chr7:102448458-102455172:+LAMLEERMast_cells_resting2.9789e-020.2231image
ENSG00000160991.14,ORAI2LAMLEAGMast_cells_resting2.9897e-020.2173image
chr7:102448458-102455172:+LGGEERDendritic_cells_activated4.4313e-030.1350image
ENSG00000160991.14,ORAI2LGGEAGDendritic_cells_activated4.3885e-030.1351image
chr7:102448458-102455172:+LUADEERMacrophages_M01.9778e-020.1901image
ENSG00000160991.14,ORAI2LUADEAGMacrophages_M23.4300e-020.1724image
ENSG00000160991.14,ORAI2MESOEAGT_cells_CD4_naive2.3552e-030.5426image
chr7:102448458-102455172:+OVEERMacrophages_M04.3398e-020.1294image
ENSG00000160991.14,ORAI2OVEAGDendritic_cells_resting2.8056e-020.1401image
ENSG00000160991.14,ORAI2PAADEAGT_cells_CD4_naive3.8230e-050.4334image
chr7:102448458-102455172:+PCPGEERT_cells_CD4_memory_resting1.5180e-020.2758image
ENSG00000160991.14,ORAI2PCPGEAGT_cells_CD4_memory_resting1.5180e-020.2758image
ENSG00000160991.14,ORAI2PRADEAGDendritic_cells_activated5.7604e-110.4470image
ENSG00000160991.14,ORAI2SARCEAGMacrophages_M19.0902e-030.2096image
chr7:102448458-102455172:+SKCMEERT_cells_CD4_memory_activated4.0159e-02-0.1667image
ENSG00000160991.14,ORAI2SKCMEAGT_cells_CD4_memory_activated3.4728e-02-0.1708image
chr7:102448458-102455172:+STADEERT_cells_CD82.8878e-020.1371image
ENSG00000160991.14,ORAI2STADEAGT_cells_CD4_memory_resting1.7677e-02-0.1479image
ENSG00000160991.14,ORAI2TGCTEAGDendritic_cells_activated2.1773e-020.4478image
chr7:102448458-102455172:+THCAEERMacrophages_M15.8379e-03-0.1526image
ENSG00000160991.14,ORAI2THCAEAGMacrophages_M16.0426e-03-0.1520image
ENSG00000160991.14,ORAI2UCSEAGPlasma_cells1.5568e-030.5990image


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6. Enriched editing regions and immune gene sets for ORAI2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000160991.14,ORAI2MESOEAG1.7882e-03-0.55484.0066e-03-0.51792.9610e-02-0.40434.5596e-03-0.5116image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000160991.14,ORAI2ACCGSVA_HALLMARK_GLYCOLYSISEAG3.4580e-03-0.5520image
ENSG00000160991.14,ORAI2BLCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.5368e-02-0.2719image
ENSG00000160991.14,ORAI2BRCAGSVA_HALLMARK_MYC_TARGETS_V2EAG5.6964e-030.1189image
chr7:102448458-102455172:+BRCAGSVA_HALLMARK_MYC_TARGETS_V2EER8.4729e-030.1135image
ENSG00000160991.14,ORAI2COADGSVA_HALLMARK_P53_PATHWAYEAG8.4695e-03-0.3759image
ENSG00000160991.14,ORAI2GBMGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.8314e-030.2222image
chr7:102448458-102455172:+GBMGSVA_HALLMARK_MITOTIC_SPINDLEEER6.8314e-030.2222image
ENSG00000160991.14,ORAI2HNSCGSVA_HALLMARK_NOTCH_SIGNALINGEAG6.6237e-03-0.3263image
ENSG00000160991.14,ORAI2KIRCGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG2.1319e-02-0.1952image
ENSG00000160991.14,ORAI2KIRPGSVA_HALLMARK_DNA_REPAIREAG1.6638e-03-0.2978image
chr7:102448458-102455172:+LAMLGSVA_HALLMARK_MITOTIC_SPINDLEEER1.1469e-020.2584image
ENSG00000160991.14,ORAI2LAMLGSVA_HALLMARK_HEME_METABOLISMEAG6.6787e-030.2696image
ENSG00000160991.14,ORAI2LGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG9.4248e-04-0.1566image
chr7:102448458-102455172:+LGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEER9.6589e-04-0.1563image
ENSG00000160991.14,ORAI2LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3280e-02-0.2011image
chr7:102448458-102455172:+LUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.5123e-02-0.1639image
ENSG00000160991.14,ORAI2MESOGSVA_HALLMARK_UV_RESPONSE_UPEAG5.9285e-04-0.5992image
chr7:102448458-102455172:+OVGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.2557e-02-0.1460image
ENSG00000160991.14,ORAI2OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.7947e-02-0.1402image
ENSG00000160991.14,ORAI2PAADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.3656e-02-0.2467image
chr7:102448458-102455172:+PCPGGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER6.8818e-04-0.3785image
ENSG00000160991.14,ORAI2PCPGGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG6.8818e-04-0.3785image
ENSG00000160991.14,ORAI2PRADGSVA_HALLMARK_PEROXISOMEEAG1.2781e-04-0.2709image
ENSG00000160991.14,ORAI2SARCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.5559e-04-0.2791image
ENSG00000160991.14,ORAI2SKCMGSVA_HALLMARK_HEME_METABOLISMEAG7.4244e-04-0.2699image
chr7:102448458-102455172:+SKCMGSVA_HALLMARK_HEME_METABOLISMEER5.6927e-04-0.2763image
chr7:102448458-102455172:+STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.9808e-02-0.1232image
ENSG00000160991.14,ORAI2STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG5.2619e-03-0.1736image
chr7:102448458-102455172:+THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.5387e-06-0.2576image
ENSG00000160991.14,ORAI2THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.6296e-06-0.2572image
ENSG00000160991.14,ORAI2THYMGSVA_HALLMARK_ADIPOGENESISEAG2.8662e-04-0.4669image
ENSG00000160991.14,ORAI2UCECGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG2.6945e-02-0.2626image


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7. Enriched editing regions and drugs for ORAI2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000160991.14,ORAI2ACCElesclomolEAG7.6553e-03-0.5109image
ENSG00000160991.14,ORAI2BLCACI.1040EAG5.4146e-030.3101image
ENSG00000160991.14,ORAI2BRCAMethotrexateEAG1.9076e-04-0.1600image
chr7:102448458-102455172:+BRCAMethotrexateEER2.1599e-04-0.1590image
ENSG00000160991.14,ORAI2CESCBI.2536EAG2.3791e-02-0.2940image
ENSG00000160991.14,ORAI2COADAZ628EAG1.1765e-030.4544image
ENSG00000160991.14,ORAI2GBMEmbelinEAG2.4473e-03-0.2481image
chr7:102448458-102455172:+GBMEmbelinEER2.4473e-03-0.2481image
ENSG00000160991.14,ORAI2HNSCBleomycinEAG7.1134e-03-0.3236image
ENSG00000160991.14,ORAI2KIRPErlotinibEAG1.3737e-020.2354image
ENSG00000160991.14,ORAI2LAMLBI.D1870EAG2.4730e-03-0.2994image
chr7:102448458-102455172:+LAMLImatinibEER2.5687e-02-0.2289image
ENSG00000160991.14,ORAI2LGGFTI.277EAG1.1040e-05-0.2072image
chr7:102448458-102455172:+LGGFTI.277EER1.1443e-05-0.2068image
ENSG00000160991.14,ORAI2LUADImatinibEAG3.0956e-03-0.2392image
chr7:102448458-102455172:+LUADImatinibEER5.4407e-04-0.2790image
ENSG00000160991.14,ORAI2MESOGefitinibEAG3.9649e-02-0.3842image
chr7:102448458-102455172:+OVErlotinibEER1.3476e-020.1580image
ENSG00000160991.14,ORAI2OVAKT.inhibitor.VIIIEAG2.4893e-02-0.1430image
ENSG00000160991.14,ORAI2PAADCCT007093EAG1.4101e-020.2670image
chr7:102448458-102455172:+PCPGBI.D1870EER2.1282e-02-0.2621image
ENSG00000160991.14,ORAI2PCPGBI.D1870EAG2.1282e-02-0.2621image
ENSG00000160991.14,ORAI2PRADLenalidomideEAG5.0352e-07-0.3506image
ENSG00000160991.14,ORAI2SARCCI.1040EAG6.6561e-050.3157image
chr7:102448458-102455172:+SKCMDocetaxelEER1.1454e-02-0.2046image
ENSG00000160991.14,ORAI2SKCMDocetaxelEAG1.1361e-02-0.2042image
ENSG00000160991.14,ORAI2STADAS601245EAG1.8054e-030.1938image
chr7:102448458-102455172:+STADAS601245EER4.2498e-030.1788image
ENSG00000160991.14,ORAI2TGCTEpothilone.BEAG3.3959e-03-0.5529image
chr7:102448458-102455172:+THCAKU.55933EER3.4340e-050.2280image
ENSG00000160991.14,ORAI2THCAKU.55933EAG3.3682e-050.2282image
ENSG00000160991.14,ORAI2THYMGW.441756EAG1.4075e-030.4165image
ENSG00000160991.14,ORAI2UCECA.443654EAG2.7942e-020.2610image
ENSG00000160991.14,ORAI2UCSABT.263EAG7.7041e-04-0.6283image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType