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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: FOXRED2 (ImmuneEditome ID:80020)

1. Gene summary of enriched editing regions for FOXRED2

check button Gene summary
Gene informationGene symbol

FOXRED2

Gene ID

80020

GeneSynonymsERFAD
GeneCytomap

22q12.3

GeneTypeprotein-coding
GeneDescriptionFAD-dependent oxidoreductase domain-containing protein 2|ER flavoprotein associated with degradation|endoplasmic reticulum flavoprotein associated with degradation
GeneModificationdate20230329
UniprotIDQ8IWF2;A0A8I5KV30;A0A8I5KTD3;A0A8I5KVQ6;B0QYA2;A0A8I5KZ46
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr22:36487786-36488880:-ENST00000366463.6ENSG00000100350.13FOXRED2ncRNA_exonicAluSx,AluSq2,AluSpchr22:36487786-36488880:-.alignment


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2. Tumor-specific enriched editing regions for FOXRED2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr22:36487786-36488880:-KIRCEER7.7191e-06image
ENSG00000100350.13,FOXRED2KIRCEAG7.7191e-06image
chr22:36487786-36488880:-KIRPEER5.1552e-03image
ENSG00000100350.13,FOXRED2KIRPEAG5.1552e-03image
chr22:36487786-36488880:-LIHCEER4.0761e-02image
ENSG00000100350.13,FOXRED2LIHCEAG4.0761e-02image
chr22:36487786-36488880:-THCAEER9.6466e-03image
ENSG00000100350.13,FOXRED2THCAEAG9.6466e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000100350.13,FOXRED2HNSCCliEAG1.5448e-021.6780e-03-0.1509image
chr22:36487786-36488880:-HNSCCliEER1.9598e-022.1831e-03-0.1472image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr22:36487786-36488880:-ACCEER4.7066e-022.9061e-021.3083e-04image
ENSG00000100350.13,FOXRED2ACCEAG4.7066e-022.9061e-021.3083e-04image
chr22:36487786-36488880:-SARCEER5.6838e-041.6193e-046.4656e+04image
ENSG00000100350.13,FOXRED2SARCEAG5.6838e-041.6193e-046.4656e+04image

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3. Enriched editing regions and immune related genes for FOXRED2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr22:36487786-36488880:-UCECEERENSG00000204264,PSMB80.32445.5843e-031.5640e-090.4520imageNNPSMB8T_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000206503,HLA-A0.31009.9763e-031.3699e-100.4771imageNNHLA-AT_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000234745,HLA-B0.30191.2948e-025.6830e-100.4627imageNEWSR1HLA-BT_cells_regulatory_(Tregs)GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000169564,PCBP1-0.30051.4701e-023.6774e-08-0.4160imageNEWSR1PCBP1T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
chr22:36487786-36488880:-UCECEERENSG00000204592,HLA-E0.29101.6025e-027.5546e-080.4072imageNNHLA-ET_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000204642,HLA-F0.29201.6638e-021.6546e-080.4255imageNEWSR1HLA-FT_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000165949,IFI270.29251.7359e-024.4435e-080.4137imageNEWSR1IFI27T_cells_CD4_memory_restingGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000133321,RARRES30.29181.7955e-027.6602e-080.4070imageNNNAT_cells_CD8GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000225131,PSME2P20.27153.0810e-024.7903e-110.4874imageNNPSME2P2T_cells_CD8GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr22:36487786-36488880:-UCECEERENSG00000100911,PSME20.27003.2159e-021.4155e-110.4989imageNNPSME2T_cells_CD8GSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for FOXRED2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000100350.13,FOXRED2
LIHCEAGIRENSG00000168906.8chr285541082:85541377:85541632:855417450.20995.6499e-034.5615e-140.4039imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MBNL2;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr22:36487786-36488880:-
LIHCEERIRENSG00000168906.8chr285541082:85541377:85541632:855417450.20996.3014e-034.5615e-140.4039imageNEWSR1NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr22:36487786-36488880:-
PCPGEERA3ENSG00000135424.11chr1255697215:55697277:55696898:55697050:55696898:556970680.25233.4658e-022.2164e-060.4028imageNEWSR1ITGA7T_cells_follicular_helperGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000100350.13,FOXRED2
PCPGEAGA3ENSG00000135424.11chr1255697215:55697277:55696898:55697050:55696898:556970680.25233.2283e-022.2164e-060.4028imageNACIN1;ADAR;CNBP;CSTF2T;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPK;HNRNPM;HNRNPU;IGF2BP2;KHSRP;LIN28;MBNL2;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SRSF1;SRSF3;TAF15;TARDBP;TROVE2;U2AF1;U2AF2;UPF1;ZNF184ITGA7T_cells_follicular_helperGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000100350.13,FOXRED2
SARCEAGIRENSG00000048740.13chr1011328925:11329097:11330455:113306390.23832.2317e-021.5412e-110.4674imageNADAR;AIFM1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;TAF15;TARDBP;TIA1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;ZC3H7BNAT_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000100350.13,FOXRED2
SARCEAGMEXENSG00000072682.14chr5132207707:132207884:132209137:132209331:132210368:132210523:132213915:1322140530.27402.9633e-021.4337e-120.4338imageNACIN1;ADAR;AUH;BCCIP;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr22:36487786-36488880:-
SARCEERIRENSG00000048740.13chr1011328925:11329097:11330455:113306390.23832.2186e-021.5412e-110.4674imageNEWSR1NAT_cells_CD8GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr22:36487786-36488880:-
SARCEERMEXENSG00000072682.14chr5132207707:132207884:132209137:132209331:132210368:132210523:132213915:1322140530.27402.9634e-021.4337e-120.4338imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000100350.13,FOXRED2
SARCEAGIRENSG00000101158.8chr2058990094:58992020:58992997:589930570.35002.8791e-043.7663e-170.5053imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr22:36487786-36488880:-
SARCEERIRENSG00000101158.8chr2058990094:58992020:58992997:589930570.35002.9476e-043.7663e-170.5053imageNEWSR1NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for FOXRED2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr22:36487786-36488880:-ACCEERMast_cells_activated3.2263e-030.3380image
ENSG00000100350.13,FOXRED2ACCEAGMast_cells_activated3.2263e-030.3380image
chr22:36487786-36488880:-BRCAEERNK_cells_activated2.3754e-020.0692image
ENSG00000100350.13,FOXRED2BRCAEAGNK_cells_activated2.3754e-020.0692image
chr22:36487786-36488880:-CESCEERMonocytes6.9869e-030.1568image
ENSG00000100350.13,FOXRED2CESCEAGMonocytes6.9869e-030.1568image
chr22:36487786-36488880:-CHOLEERT_cells_CD4_naive4.9952e-030.4914image
ENSG00000100350.13,FOXRED2CHOLEAGT_cells_CD4_naive4.9952e-030.4914image
chr22:36487786-36488880:-COADEERB_cells_memory3.6244e-020.1413image
ENSG00000100350.13,FOXRED2COADEAGB_cells_memory3.6244e-020.1413image
chr22:36487786-36488880:-DLBCEERT_cells_gamma_delta2.0499e-020.3958image
ENSG00000100350.13,FOXRED2DLBCEAGT_cells_gamma_delta2.0499e-020.3958image
chr22:36487786-36488880:-ESCAEERT_cells_regulatory_(Tregs)5.9015e-03-0.2161image
ENSG00000100350.13,FOXRED2ESCAEAGT_cells_regulatory_(Tregs)5.9541e-03-0.2159image
chr22:36487786-36488880:-GBMEERMonocytes2.2275e-050.3237image
ENSG00000100350.13,FOXRED2GBMEAGMonocytes2.2275e-050.3237image
chr22:36487786-36488880:-HNSCEERMacrophages_M12.6863e-030.1424image
ENSG00000100350.13,FOXRED2HNSCEAGMacrophages_M11.7962e-030.1481image
chr22:36487786-36488880:-KICHEERT_cells_CD4_memory_resting3.2425e-040.4486image
ENSG00000100350.13,FOXRED2KICHEAGT_cells_CD4_memory_resting3.2425e-040.4486image
chr22:36487786-36488880:-KIRCEERMast_cells_resting3.8442e-02-0.1210image
ENSG00000100350.13,FOXRED2KIRCEAGMast_cells_resting3.8442e-02-0.1210image
chr22:36487786-36488880:-LIHCEERT_cells_CD4_memory_activated5.4574e-030.1508image
ENSG00000100350.13,FOXRED2LIHCEAGT_cells_CD4_memory_activated5.4574e-030.1508image
chr22:36487786-36488880:-LUADEERT_cells_CD4_memory_resting1.0851e-02-0.1200image
ENSG00000100350.13,FOXRED2LUADEAGT_cells_CD4_memory_resting1.0851e-02-0.1200image
chr22:36487786-36488880:-LUSCEERT_cells_CD87.2800e-040.1532image
ENSG00000100350.13,FOXRED2LUSCEAGT_cells_CD87.0699e-040.1536image
chr22:36487786-36488880:-OVEEREosinophils3.0021e-030.1734image
ENSG00000100350.13,FOXRED2OVEAGEosinophils3.0075e-030.1734image
chr22:36487786-36488880:-PCPGEERDendritic_cells_activated2.0269e-02-0.1795image
ENSG00000100350.13,FOXRED2PCPGEAGDendritic_cells_activated2.0269e-02-0.1795image
chr22:36487786-36488880:-PRADEERDendritic_cells_activated7.0480e-100.2725image
ENSG00000100350.13,FOXRED2PRADEAGDendritic_cells_activated7.0480e-100.2725image
chr22:36487786-36488880:-SARCEERT_cells_CD4_memory_activated2.4273e-020.1445image
ENSG00000100350.13,FOXRED2SARCEAGT_cells_CD4_memory_activated2.4273e-020.1445image
chr22:36487786-36488880:-SKCMEERT_cells_CD85.5199e-060.2081image
ENSG00000100350.13,FOXRED2SKCMEAGT_cells_CD85.5199e-060.2081image
chr22:36487786-36488880:-STADEERT_cells_CD4_naive6.4261e-03-0.1432image
ENSG00000100350.13,FOXRED2STADEAGT_cells_CD4_naive6.4130e-03-0.1432image
chr22:36487786-36488880:-TGCTEERMacrophages_M22.0428e-02-0.1951image
ENSG00000100350.13,FOXRED2TGCTEAGMacrophages_M22.0428e-02-0.1951image
chr22:36487786-36488880:-THCAEERDendritic_cells_resting1.0559e-020.1265image
ENSG00000100350.13,FOXRED2THCAEAGDendritic_cells_resting1.0559e-020.1265image
chr22:36487786-36488880:-UCECEERT_cells_CD84.9665e-020.1545image
ENSG00000100350.13,FOXRED2UCECEAGT_cells_CD84.9665e-020.1545image
chr22:36487786-36488880:-UCSEERMacrophages_M01.7835e-030.4083image
ENSG00000100350.13,FOXRED2UCSEAGMacrophages_M01.7835e-030.4083image
chr22:36487786-36488880:-UVMEERT_cells_CD83.4729e-020.2364image
ENSG00000100350.13,FOXRED2UVMEAGT_cells_CD83.4729e-020.2364image


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6. Enriched editing regions and immune gene sets for FOXRED2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr22:36487786-36488880:-HNSCEER1.8661e-02image4.9685e-050.1917image
ENSG00000100350.13,FOXRED2HNSCEAG1.8661e-02image6.1844e-050.1893image
chr22:36487786-36488880:-LIHCEER1.0881e-02image8.4092e-050.2122image
ENSG00000100350.13,FOXRED2LIHCEAG1.0881e-02image8.4092e-050.2122image
chr22:36487786-36488880:-LUSCEER4.8712e-02image2.5071e-020.1019image
ENSG00000100350.13,FOXRED2LUSCEAG4.8712e-02image2.3893e-020.1028image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000100350.13,FOXRED2LIHCEAG2.2401e-02-0.12422.9819e-04-0.19568.4323e-03-0.14316.1164e-050.2162image
chr22:36487786-36488880:-LIHCEER2.2401e-02-0.12422.9819e-04-0.19568.4323e-03-0.14316.1164e-050.2162image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr22:36487786-36488880:-ACCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.7612e-03-0.3328image
ENSG00000100350.13,FOXRED2ACCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.7612e-03-0.3328image
ENSG00000100350.13,FOXRED2BLCAGSVA_HALLMARK_COAGULATIONEAG1.1784e-040.2021image
chr22:36487786-36488880:-BLCAGSVA_HALLMARK_COAGULATIONEER1.1784e-040.2021image
ENSG00000100350.13,FOXRED2BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.7816e-07-0.1564image
chr22:36487786-36488880:-BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER2.7816e-07-0.1564image
ENSG00000100350.13,FOXRED2CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2636e-050.2512image
chr22:36487786-36488880:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2636e-050.2512image
chr22:36487786-36488880:-CHOLGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.7754e-02-0.4230image
ENSG00000100350.13,FOXRED2CHOLGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.7754e-02-0.4230image
ENSG00000100350.13,FOXRED2COADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.6489e-03-0.1902image
chr22:36487786-36488880:-COADGSVA_HALLMARK_MITOTIC_SPINDLEEER4.6489e-03-0.1902image
ENSG00000100350.13,FOXRED2DLBCGSVA_HALLMARK_ANGIOGENESISEAG3.1470e-02-0.3696image
chr22:36487786-36488880:-DLBCGSVA_HALLMARK_ANGIOGENESISEER3.1470e-02-0.3696image
chr22:36487786-36488880:-ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.5990e-030.2358image
ENSG00000100350.13,FOXRED2ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5735e-030.2360image
ENSG00000100350.13,FOXRED2GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG5.3420e-060.3459image
chr22:36487786-36488880:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER5.3420e-060.3459image
ENSG00000100350.13,FOXRED2HNSCGSVA_HALLMARK_SPERMATOGENESISEAG3.9521e-11-0.3074image
chr22:36487786-36488880:-HNSCGSVA_HALLMARK_SPERMATOGENESISEER8.8447e-11-0.3021image
chr22:36487786-36488880:-KIRCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.8931e-04-0.2103image
ENSG00000100350.13,FOXRED2KIRCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.8931e-04-0.2103image
ENSG00000100350.13,FOXRED2LAMLGSVA_HALLMARK_DNA_REPAIREAG1.1813e-03-0.3907image
chr22:36487786-36488880:-LAMLGSVA_HALLMARK_DNA_REPAIREER1.1813e-03-0.3907image
chr22:36487786-36488880:-LGGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.0500e-140.3198image
ENSG00000100350.13,FOXRED2LGGGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.0500e-140.3198image
ENSG00000100350.13,FOXRED2LIHCGSVA_HALLMARK_COAGULATIONEAG9.9227e-090.3054image
chr22:36487786-36488880:-LIHCGSVA_HALLMARK_COAGULATIONEER9.9227e-090.3054image
ENSG00000100350.13,FOXRED2LUADGSVA_HALLMARK_COAGULATIONEAG6.4464e-030.1282image
chr22:36487786-36488880:-LUADGSVA_HALLMARK_COAGULATIONEER6.4464e-030.1282image
ENSG00000100350.13,FOXRED2LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.7357e-060.2019image
chr22:36487786-36488880:-LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER8.5397e-060.2010image
chr22:36487786-36488880:-MESOGSVA_HALLMARK_UV_RESPONSE_DNEER4.3967e-02-0.2702image
ENSG00000100350.13,FOXRED2MESOGSVA_HALLMARK_UV_RESPONSE_DNEAG4.3967e-02-0.2702image
chr22:36487786-36488880:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER5.2241e-11-0.3725image
ENSG00000100350.13,FOXRED2OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.5559e-11-0.3720image
chr22:36487786-36488880:-PAADGSVA_HALLMARK_MITOTIC_SPINDLEEER3.5621e-02-0.2025image
ENSG00000100350.13,FOXRED2PAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.5621e-02-0.2025image
chr22:36487786-36488880:-PCPGGSVA_HALLMARK_KRAS_SIGNALING_UPEER4.3075e-050.3110image
ENSG00000100350.13,FOXRED2PCPGGSVA_HALLMARK_KRAS_SIGNALING_UPEAG4.3075e-050.3110image
chr22:36487786-36488880:-PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEER6.2190e-08-0.2403image
ENSG00000100350.13,FOXRED2PRADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG6.2190e-08-0.2403image
chr22:36487786-36488880:-READGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER6.6971e-030.3085image
ENSG00000100350.13,FOXRED2READGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG6.6971e-030.3085image
ENSG00000100350.13,FOXRED2SARCGSVA_HALLMARK_COAGULATIONEAG1.2483e-050.2762image
chr22:36487786-36488880:-SARCGSVA_HALLMARK_COAGULATIONEER1.2483e-050.2762image
chr22:36487786-36488880:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0303e-100.2926image
ENSG00000100350.13,FOXRED2SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.0303e-100.2926image
chr22:36487786-36488880:-STADGSVA_HALLMARK_P53_PATHWAYEER2.4930e-040.1917image
ENSG00000100350.13,FOXRED2STADGSVA_HALLMARK_P53_PATHWAYEAG2.4782e-040.1917image
ENSG00000100350.13,FOXRED2TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.7829e-030.2424image
chr22:36487786-36488880:-TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.7829e-030.2424image
ENSG00000100350.13,FOXRED2THCAGSVA_HALLMARK_ADIPOGENESISEAG4.2655e-04-0.1736image
chr22:36487786-36488880:-THCAGSVA_HALLMARK_ADIPOGENESISEER4.2655e-04-0.1736image
ENSG00000100350.13,FOXRED2THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0561e-04-0.3409image
chr22:36487786-36488880:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER3.0561e-04-0.3409image
ENSG00000100350.13,FOXRED2UCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.2600e-05-0.3157image
chr22:36487786-36488880:-UCECGSVA_HALLMARK_MITOTIC_SPINDLEEER4.2600e-05-0.3157image
ENSG00000100350.13,FOXRED2UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.7112e-020.3175image
chr22:36487786-36488880:-UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.7112e-020.3175image
ENSG00000100350.13,FOXRED2UVMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.2976e-020.2540image
chr22:36487786-36488880:-UVMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.2976e-020.2540image


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7. Enriched editing regions and drugs for FOXRED2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000100350.13,FOXRED2BLCAAZD6244EAG8.0420e-08-0.2789image
chr22:36487786-36488880:-BLCAAZD6244EER8.0420e-08-0.2789image
ENSG00000100350.13,FOXRED2BRCAA.770041EAG8.7148e-09-0.1750image
chr22:36487786-36488880:-BRCAA.770041EER8.7148e-09-0.1750image
ENSG00000100350.13,FOXRED2CESCFH535EAG8.7309e-060.2556image
chr22:36487786-36488880:-CESCFH535EER8.7309e-060.2556image
chr22:36487786-36488880:-CHOLImatinibEER9.7669e-050.6424image
ENSG00000100350.13,FOXRED2CHOLImatinibEAG9.7669e-050.6424image
chr22:36487786-36488880:-COADCI.1040EER8.7786e-03-0.1763image
ENSG00000100350.13,FOXRED2COADCI.1040EAG8.7786e-03-0.1763image
chr22:36487786-36488880:-DLBCDasatinibEER7.0273e-03-0.4538image
ENSG00000100350.13,FOXRED2DLBCDasatinibEAG7.0273e-03-0.4538image
ENSG00000100350.13,FOXRED2ESCABMS.536924EAG7.5754e-04-0.2628image
chr22:36487786-36488880:-ESCABMS.536924EER7.5912e-04-0.2628image
ENSG00000100350.13,FOXRED2GBMBIBW2992EAG5.0287e-07-0.3794image
chr22:36487786-36488880:-GBMBIBW2992EER5.0287e-07-0.3794image
ENSG00000100350.13,FOXRED2HNSCCI.1040EAG7.2987e-11-0.3034image
chr22:36487786-36488880:-HNSCCI.1040EER1.3752e-10-0.2991image
ENSG00000100350.13,FOXRED2KICHDMOGEAG3.7427e-02-0.2694image
chr22:36487786-36488880:-KICHDMOGEER3.7427e-02-0.2694image
chr22:36487786-36488880:-KIRCCytarabineEER3.6950e-03-0.1691image
ENSG00000100350.13,FOXRED2KIRCCytarabineEAG3.6950e-03-0.1691image
chr22:36487786-36488880:-KIRPABT.263EER3.7501e-04-0.2383image
ENSG00000100350.13,FOXRED2KIRPABT.263EAG3.7501e-04-0.2383image
chr22:36487786-36488880:-LAMLBX.795EER3.3107e-02-0.2627image
ENSG00000100350.13,FOXRED2LAMLBX.795EAG3.3107e-02-0.2627image
chr22:36487786-36488880:-LGGGNF.2EER4.0541e-15-0.3328image
ENSG00000100350.13,FOXRED2LGGGNF.2EAG4.0541e-15-0.3328image
chr22:36487786-36488880:-LIHCDasatinibEER5.4749e-05-0.2300image
ENSG00000100350.13,FOXRED2LIHCDasatinibEAG5.4749e-05-0.2300image
ENSG00000100350.13,FOXRED2LUADAZD6244EAG1.2710e-06-0.2260image
chr22:36487786-36488880:-LUADAZD6244EER1.2710e-06-0.2260image
chr22:36487786-36488880:-LUSCAZ628EER1.6809e-06-0.2159image
ENSG00000100350.13,FOXRED2LUSCAZ628EAG1.7295e-06-0.2156image
ENSG00000100350.13,FOXRED2MESOFTI.277EAG3.9914e-020.2754image
chr22:36487786-36488880:-MESOFTI.277EER3.9914e-020.2754image
ENSG00000100350.13,FOXRED2OVBexaroteneEAG4.5509e-090.3351image
chr22:36487786-36488880:-OVBexaroteneEER4.7416e-090.3348image
chr22:36487786-36488880:-PAADBI.D1870EER2.9831e-02-0.2111image
ENSG00000100350.13,FOXRED2PAADBI.D1870EAG2.9831e-02-0.2111image
chr22:36487786-36488880:-PCPGImatinibEER3.5436e-05-0.3142image
ENSG00000100350.13,FOXRED2PCPGImatinibEAG3.5436e-05-0.3142image
ENSG00000100350.13,FOXRED2PRADAP.24534EAG5.6550e-07-0.2226image
chr22:36487786-36488880:-PRADAP.24534EER5.6550e-07-0.2226image
chr22:36487786-36488880:-READABT.888EER2.2507e-030.3453image
ENSG00000100350.13,FOXRED2READABT.888EAG2.2507e-030.3453image
ENSG00000100350.13,FOXRED2SARCA.770041EAG3.8571e-09-0.3665image
chr22:36487786-36488880:-SARCA.770041EER3.8571e-09-0.3665image
chr22:36487786-36488880:-SKCMCI.1040EER1.9813e-07-0.2374image
ENSG00000100350.13,FOXRED2SKCMCI.1040EAG1.9813e-07-0.2374image
ENSG00000100350.13,FOXRED2STADABT.263EAG1.0520e-040.2035image
chr22:36487786-36488880:-STADABT.263EER1.0562e-040.2035image
ENSG00000100350.13,FOXRED2TGCTGefitinibEAG3.1571e-03-0.2469image
chr22:36487786-36488880:-TGCTGefitinibEER3.1571e-03-0.2469image
ENSG00000100350.13,FOXRED2THCADasatinibEAG3.8255e-06-0.2267image
chr22:36487786-36488880:-THCADasatinibEER3.8255e-06-0.2267image
ENSG00000100350.13,FOXRED2THYMDasatinibEAG7.5788e-06-0.4159image
chr22:36487786-36488880:-THYMDasatinibEER7.5788e-06-0.4159image
ENSG00000100350.13,FOXRED2UCECJNK.9LEAG1.1815e-070.4016image
chr22:36487786-36488880:-UCECJNK.9LEER1.1815e-070.4016image
ENSG00000100350.13,FOXRED2UCSCisplatinEAG7.2903e-04-0.4383image
chr22:36487786-36488880:-UCSCisplatinEER7.2903e-04-0.4383image
ENSG00000100350.13,FOXRED2UVMGDC.0449EAG2.4233e-03-0.3345image
chr22:36487786-36488880:-UVMGDC.0449EER2.4233e-03-0.3345image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType