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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: DNAJC22 (ImmuneEditome ID:79962)

1. Gene summary of enriched editing regions for DNAJC22

check button Gene summary
Gene informationGene symbol

DNAJC22

Gene ID

79962

GeneSynonymswus
GeneCytomap

12q13.12

GeneTypeprotein-coding
GeneDescriptiondnaJ homolog subfamily C member 22|DnaJ (Hsp40) homolog, subfamily C, member 22|wurst homolog
GeneModificationdate20230329
UniprotIDQ8N4W6
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:49351599-49357182:+ENST00000551153.1ENSG00000178401.13DNAJC22ncRNA_exonicL3,AluJb,FRAM,AluSc,L1ME3G,AluSx3,AluJo,AluSx,MIRb,(CTTT)n,MIR3,AluSc8chr12:49351599-49357182:+.alignment
chr12:49351599-49357182:+ENST00000552651.2ENSG00000178401.13DNAJC22ncRNA_exonicL3,AluJb,FRAM,AluSc,L1ME3G,AluSx3,AluJo,AluSx,MIRb,(CTTT)n,MIR3,AluSc8chr12:49351599-49357182:+.alignment


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2. Tumor-specific enriched editing regions for DNAJC22


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:49351599-49357182:+BRCAEER2.3872e-09image
ENSG00000178401.13,DNAJC22BRCAEAG2.3872e-09image
chr12:49351599-49357182:+COADEER7.0073e-10image
ENSG00000178401.13,DNAJC22COADEAG7.0073e-10image
chr12:49351599-49357182:+KIRPEER2.9366e-03image
ENSG00000178401.13,DNAJC22KIRPEAG2.9366e-03image
chr12:49351599-49357182:+LIHCEER7.0705e-04image
ENSG00000178401.13,DNAJC22LIHCEAG7.0705e-04image
chr12:49351599-49357182:+THCAEER4.1708e-02image
ENSG00000178401.13,DNAJC22THCAEAG4.1708e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr12:49351599-49357182:+UCECCliEER3.6237e-028.8173e-030.1221image
ENSG00000178401.13,DNAJC22UCECCliEAG3.6237e-028.8173e-030.1221image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr12:49351599-49357182:+CHOLEER3.6835e-021.2928e-023.2381e+06image
ENSG00000178401.13,DNAJC22CHOLEAG3.6835e-021.2741e-023.3330e+06image
chr12:49351599-49357182:+LGGEER8.7953e-034.1610e-021.3851e+01image
ENSG00000178401.13,DNAJC22LGGEAG8.7953e-034.1610e-021.3851e+01image

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3. Enriched editing regions and immune related genes for DNAJC22


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:49351599-49357182:+COADEERENSG00000036549,ZZZ30.30181.5367e-041.1132e-130.4316imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000166439,RNF1690.26711.2744e-038.1875e-120.4003imageNNNAEosinophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr12:49351599-49357182:+COADEERENSG00000143970,ASXL20.26051.7737e-031.7669e-120.4119imageNNNAEosinophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000055332,EIF2AK20.25372.4605e-032.9810e-140.4406imageNNEIF2AK2EosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:49351599-49357182:+COADEERENSG00000040933,INPP4A0.25382.5296e-032.5347e-120.4092imageNNNAEosinophilsGSVA_HALLMARK_PEROXISOME
chr12:49351599-49357182:+COADEERENSG00000186260,MKL20.24374.0997e-033.3902e-120.4070imageNNNAEosinophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000085788,DDHD20.23924.5878e-032.6214e-130.4256imageNNNAT_cells_follicular_helperGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000115904,SOS10.22927.6326e-034.4428e-120.4050imageNNSOS1EosinophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000009413,REV3L0.22648.6584e-037.8576e-120.4006imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000196776,CD470.22279.6959e-032.5538e-120.4091imageNNCD47EosinophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr12:49351599-49357182:+COADEERENSG00000036549,ZZZ30.30181.5367e-041.1132e-130.4316imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000166439,RNF1690.26711.2744e-038.1875e-120.4003imageNNNAEosinophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr12:49351599-49357182:+COADEERENSG00000143970,ASXL20.26051.7737e-031.7669e-120.4119imageNNNAEosinophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000055332,EIF2AK20.25372.4605e-032.9810e-140.4406imageNNEIF2AK2EosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:49351599-49357182:+COADEERENSG00000040933,INPP4A0.25382.5296e-032.5347e-120.4092imageNNNAEosinophilsGSVA_HALLMARK_PEROXISOME
chr12:49351599-49357182:+COADEERENSG00000186260,MKL20.24374.0997e-033.3902e-120.4070imageNNNAEosinophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000085788,DDHD20.23924.5878e-032.6214e-130.4256imageNNNAT_cells_follicular_helperGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000115904,SOS10.22927.6326e-034.4428e-120.4050imageNNSOS1EosinophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000009413,REV3L0.22648.6584e-037.8576e-120.4006imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+COADEERENSG00000196776,CD470.22279.6959e-032.5538e-120.4091imageNNCD47EosinophilsGSVA_HALLMARK_XENOBIOTIC_METABOLISM

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4. Enriched editing regions and immune related splicing for DNAJC22


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:49351599-49357182:+
COADEERIRENSG00000168010.6chr1172826702:72826823:72827187:728272720.21402.6064e-022.6280e-110.4139imageNNNANeutrophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000178401.13,DNAJC22
COADEAGIRENSG00000168010.6chr1172826702:72826823:72827187:728272720.21402.9700e-022.6280e-110.4139imageNADAR;AUH;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1NANeutrophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000178401.13,DNAJC22
COADEAGIRENSG00000111684.6chr126976185:6976891:6977133:69772620.34314.2206e-054.8652e-150.4526imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LARP7;LIN28;LIN28A;LIN28B;MOV10;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDF1NAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+
COADEERIRENSG00000111684.6chr126976185:6976891:6977133:69772620.34312.8924e-054.8652e-150.4526imageNNNAEosinophilsGSVA_HALLMARK_P53_PATHWAY
chr12:49351599-49357182:+
KIRCEERIRENSG00000110455.9chr1144075525:44079620:44081019:440810650.22521.4187e-031.1474e-410.6307imageNNNAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000178401.13,DNAJC22
KIRCEAGIRENSG00000188343.8chr893725847:93726513:93728204:937283370.26874.3117e-059.2148e-170.4121imageNADAR;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;LIN28A;MOV10;NOP58;PRPF8;RANGAP1;RBFOX2;SF3A3;SMNDC1;SRSF1;SRSF9;TAF15;TIA1;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000178401.13,DNAJC22
KIRCEAGMEXENSG00000105053.6chr1949989695:49989771:49992859:49992952:49997503:49997570:50000789:50000854-0.32639.8006e-081.9013e-16-0.4082imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;LIN28B;MOV10;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr12:49351599-49357182:+
KIRCEERIRENSG00000134072.6chr39757346:9759575:9759671:97597500.22251.8472e-035.1904e-600.7159imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000178401.13,DNAJC22
KIRCEAGIRENSG00000005436.9chr275662705:75666053:75670137:756702140.26854.7788e-057.4313e-220.4685imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;LIN28B;MOV10;NOP58;PCBP2;PRPF8;RANGAP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000178401.13,DNAJC22
KIRCEAGMEXENSG00000171311.8chr1097437259:97437275:97437699:97437750:97441163:97441259:97443236:97443311-0.31403.8863e-077.3729e-21-0.4581imageNADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;LARP7;LIN28;LIN28A;LIN28B;MOV10;NOP58;PRPF8;RANGAP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for DNAJC22


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:49351599-49357182:+BLCAEERMacrophages_M19.6007e-030.2953image
ENSG00000178401.13,DNAJC22BLCAEAGMacrophages_M19.6007e-030.2953image
chr12:49351599-49357182:+BRCAEERT_cells_follicular_helper1.0970e-02-0.0886image
ENSG00000178401.13,DNAJC22BRCAEAGT_cells_follicular_helper1.0970e-02-0.0886image
chr12:49351599-49357182:+CESCEERT_cells_CD4_memory_activated2.5796e-020.2061image
ENSG00000178401.13,DNAJC22CESCEAGT_cells_CD4_memory_activated2.5796e-020.2061image
chr12:49351599-49357182:+CHOLEERNeutrophils3.7832e-050.6453image
ENSG00000178401.13,DNAJC22CHOLEAGNeutrophils3.7285e-050.6457image
chr12:49351599-49357182:+COADEERT_cells_regulatory_(Tregs)3.3716e-03-0.1778image
ENSG00000178401.13,DNAJC22COADEAGT_cells_regulatory_(Tregs)3.3716e-03-0.1778image
chr12:49351599-49357182:+ESCAEERMonocytes4.6036e-030.2898image
ENSG00000178401.13,DNAJC22ESCAEAGMonocytes4.6121e-030.2898image
chr12:49351599-49357182:+GBMEERT_cells_CD4_naive2.2711e-02-0.1960image
ENSG00000178401.13,DNAJC22GBMEAGT_cells_CD4_naive2.2711e-02-0.1960image
chr12:49351599-49357182:+HNSCEEREosinophils2.8660e-020.3419image
ENSG00000178401.13,DNAJC22HNSCEAGEosinophils2.8660e-020.3419image
chr12:49351599-49357182:+KIRCEERT_cells_regulatory_(Tregs)1.4674e-06-0.2457image
ENSG00000178401.13,DNAJC22KIRCEAGT_cells_regulatory_(Tregs)1.4674e-06-0.2457image
chr12:49351599-49357182:+KIRPEERMacrophages_M12.6875e-020.1320image
ENSG00000178401.13,DNAJC22KIRPEAGMacrophages_M12.6875e-020.1320image
chr12:49351599-49357182:+LGGEERMast_cells_activated2.0049e-030.3180image
ENSG00000178401.13,DNAJC22LGGEAGMast_cells_activated2.0049e-030.3180image
chr12:49351599-49357182:+LIHCEERT_cells_regulatory_(Tregs)2.7029e-04-0.1885image
ENSG00000178401.13,DNAJC22LIHCEAGT_cells_regulatory_(Tregs)2.7029e-04-0.1885image
chr12:49351599-49357182:+LUADEERMast_cells_activated1.0617e-020.1657image
ENSG00000178401.13,DNAJC22LUADEAGMast_cells_activated1.0617e-020.1657image
chr12:49351599-49357182:+LUSCEEREosinophils2.0676e-040.4083image
ENSG00000178401.13,DNAJC22LUSCEAGEosinophils2.0676e-040.4083image
chr12:49351599-49357182:+MESOEERT_cells_follicular_helper1.6581e-020.2689image
ENSG00000178401.13,DNAJC22MESOEAGT_cells_follicular_helper1.6713e-020.2685image
chr12:49351599-49357182:+OVEERDendritic_cells_resting2.5743e-020.1517image
ENSG00000178401.13,DNAJC22OVEAGDendritic_cells_resting2.5743e-020.1517image
chr12:49351599-49357182:+PAADEERNK_cells_activated1.7596e-020.1819image
ENSG00000178401.13,DNAJC22PAADEAGNK_cells_activated1.7596e-020.1819image
chr12:49351599-49357182:+PCPGEERMast_cells_resting9.9948e-030.5151image
ENSG00000178401.13,DNAJC22PCPGEAGMast_cells_resting9.9948e-030.5151image
chr12:49351599-49357182:+PRADEERNK_cells_resting1.5081e-020.1794image
ENSG00000178401.13,DNAJC22PRADEAGNK_cells_resting1.5081e-020.1794image
chr12:49351599-49357182:+READEERNeutrophils1.7769e-030.3198image
ENSG00000178401.13,DNAJC22READEAGNeutrophils1.7769e-030.3198image
chr12:49351599-49357182:+SARCEERT_cells_gamma_delta4.8433e-030.2961image
ENSG00000178401.13,DNAJC22SARCEAGT_cells_gamma_delta4.8433e-030.2961image
chr12:49351599-49357182:+STADEERNK_cells_activated2.0463e-03-0.1620image
ENSG00000178401.13,DNAJC22STADEAGNK_cells_activated2.0463e-03-0.1620image
chr12:49351599-49357182:+TGCTEERMacrophages_M13.9658e-030.2644image
ENSG00000178401.13,DNAJC22TGCTEAGMacrophages_M13.9658e-030.2644image
chr12:49351599-49357182:+THCAEERNK_cells_activated9.4272e-06-0.1961image
ENSG00000178401.13,DNAJC22THCAEAGNK_cells_activated9.4272e-06-0.1961image
chr12:49351599-49357182:+UCECEERMacrophages_M28.8546e-030.2124image
ENSG00000178401.13,DNAJC22UCECEAGMacrophages_M28.8546e-030.2124image
chr12:49351599-49357182:+UCSEERNK_cells_activated2.5771e-02-0.4066image
ENSG00000178401.13,DNAJC22UCSEAGNK_cells_activated2.5771e-02-0.4066image


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6. Enriched editing regions and immune gene sets for DNAJC22


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr12:49351599-49357182:+LIHCEER5.1183e-03image1.0760e-02-0.1326image
ENSG00000178401.13,DNAJC22LIHCEAG5.1184e-03image1.0760e-02-0.1326image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000178401.13,DNAJC22BLCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.1247e-020.2893image
chr12:49351599-49357182:+BLCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.1247e-020.2893image
ENSG00000178401.13,DNAJC22BRCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG5.0866e-030.0976image
chr12:49351599-49357182:+BRCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER5.0866e-030.0976image
chr12:49351599-49357182:+CESCGSVA_HALLMARK_P53_PATHWAYEER1.7815e-020.2187image
ENSG00000178401.13,DNAJC22CESCGSVA_HALLMARK_P53_PATHWAYEAG1.7815e-020.2187image
ENSG00000178401.13,DNAJC22CHOLGSVA_HALLMARK_DNA_REPAIREAG1.7575e-02-0.4048image
chr12:49351599-49357182:+CHOLGSVA_HALLMARK_DNA_REPAIREER1.7722e-02-0.4043image
chr12:49351599-49357182:+COADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER6.3866e-05-0.2408image
ENSG00000178401.13,DNAJC22COADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.3866e-05-0.2408image
ENSG00000178401.13,DNAJC22ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG5.8198e-03-0.2824image
chr12:49351599-49357182:+ESCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.8514e-03-0.2822image
ENSG00000178401.13,DNAJC22HNSCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG6.3079e-040.5115image
chr12:49351599-49357182:+HNSCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER6.3079e-040.5115image
ENSG00000178401.13,DNAJC22KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.7020e-04-0.1829image
chr12:49351599-49357182:+KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.7020e-04-0.1829image
ENSG00000178401.13,DNAJC22KIRPGSVA_HALLMARK_HEME_METABOLISMEAG4.2335e-080.3198image
chr12:49351599-49357182:+KIRPGSVA_HALLMARK_HEME_METABOLISMEER4.2335e-080.3198image
chr12:49351599-49357182:+LGGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.1749e-02-0.2127image
ENSG00000178401.13,DNAJC22LGGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.1749e-02-0.2127image
ENSG00000178401.13,DNAJC22LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.0112e-130.3744image
chr12:49351599-49357182:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.0113e-130.3744image
chr12:49351599-49357182:+LUADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.5213e-030.1954image
ENSG00000178401.13,DNAJC22LUADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.5213e-030.1954image
chr12:49351599-49357182:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.6704e-040.2456image
ENSG00000178401.13,DNAJC22OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.6704e-040.2456image
ENSG00000178401.13,DNAJC22PAADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.2458e-04-0.2725image
chr12:49351599-49357182:+PAADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.2458e-04-0.2725image
ENSG00000178401.13,DNAJC22PCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.9547e-020.4731image
chr12:49351599-49357182:+PCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.9547e-020.4731image
ENSG00000178401.13,DNAJC22PRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.8882e-02-0.1734image
chr12:49351599-49357182:+PRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.8882e-02-0.1734image
ENSG00000178401.13,DNAJC22READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.5576e-020.2183image
chr12:49351599-49357182:+READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.5576e-020.2183image
chr12:49351599-49357182:+SARCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.1260e-020.2439image
ENSG00000178401.13,DNAJC22SARCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.1260e-020.2439image
ENSG00000178401.13,DNAJC22SKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG8.1427e-040.1917image
chr12:49351599-49357182:+SKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEER8.1427e-040.1917image
ENSG00000178401.13,DNAJC22STADGSVA_HALLMARK_HYPOXIAEAG1.1108e-040.2023image
chr12:49351599-49357182:+STADGSVA_HALLMARK_HYPOXIAEER1.1108e-040.2023image
ENSG00000178401.13,DNAJC22TGCTGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.5346e-050.3677image
chr12:49351599-49357182:+TGCTGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.5346e-050.3677image
chr12:49351599-49357182:+THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER3.8665e-120.3030image
ENSG00000178401.13,DNAJC22THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.8665e-120.3030image
ENSG00000178401.13,DNAJC22UCECGSVA_HALLMARK_UV_RESPONSE_UPEAG2.5333e-030.2440image
chr12:49351599-49357182:+UCECGSVA_HALLMARK_UV_RESPONSE_UPEER2.5333e-030.2440image
chr12:49351599-49357182:+UCSGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.4602e-02-0.4414image
ENSG00000178401.13,DNAJC22UCSGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.4602e-02-0.4414image


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7. Enriched editing regions and drugs for DNAJC22


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000178401.13,DNAJC22BLCAEpothilone.BEAG1.5463e-02-0.2769image
chr12:49351599-49357182:+BLCAEpothilone.BEER1.5463e-02-0.2769image
ENSG00000178401.13,DNAJC22BRCAA.443654EAG1.2849e-060.1678image
chr12:49351599-49357182:+BRCAA.443654EER1.2849e-060.1678image
chr12:49351599-49357182:+CESCKU.55933EER6.6297e-05-0.3602image
ENSG00000178401.13,DNAJC22CESCKU.55933EAG6.6297e-05-0.3602image
chr12:49351599-49357182:+CHOLLapatinibEER2.2045e-030.5072image
ENSG00000178401.13,DNAJC22CHOLLapatinibEAG2.2513e-030.5063image
chr12:49351599-49357182:+COADABT.263EER2.2266e-06-0.2834image
ENSG00000178401.13,DNAJC22COADABT.263EAG2.2266e-06-0.2834image
ENSG00000178401.13,DNAJC22ESCAATRAEAG3.9713e-03-0.2960image
chr12:49351599-49357182:+ESCAATRAEER3.9724e-03-0.2960image
ENSG00000178401.13,DNAJC22GBMKIN001.135EAG4.2235e-040.2992image
chr12:49351599-49357182:+GBMKIN001.135EER4.2235e-040.2992image
chr12:49351599-49357182:+HNSCBX.795EER4.0925e-03-0.4389image
ENSG00000178401.13,DNAJC22HNSCBX.795EAG4.0925e-03-0.4389image
ENSG00000178401.13,DNAJC22KIRCGW843682XEAG1.2935e-150.3971image
chr12:49351599-49357182:+KIRCGW843682XEER1.2935e-150.3971image
ENSG00000178401.13,DNAJC22KIRPAZD6244EAG2.7829e-110.3836image
chr12:49351599-49357182:+KIRPAZD6244EER2.7829e-110.3836image
chr12:49351599-49357182:+LGGBicalutamideEER1.5193e-020.2524image
ENSG00000178401.13,DNAJC22LGGBicalutamideEAG1.5193e-020.2524image
ENSG00000178401.13,DNAJC22LIHCKIN001.135EAG3.9602e-08-0.2811image
chr12:49351599-49357182:+LIHCKIN001.135EER3.9602e-08-0.2811image
ENSG00000178401.13,DNAJC22LUADEmbelinEAG2.5643e-04-0.2354image
chr12:49351599-49357182:+LUADEmbelinEER2.5643e-04-0.2354image
ENSG00000178401.13,DNAJC22LUSCFH535EAG4.6139e-02-0.2265image
chr12:49351599-49357182:+LUSCFH535EER4.6139e-02-0.2265image
ENSG00000178401.13,DNAJC22MESOElesclomolEAG2.2585e-030.3388image
chr12:49351599-49357182:+MESOElesclomolEER2.2443e-030.3390image
chr12:49351599-49357182:+OVErlotinibEER3.1469e-04-0.2429image
ENSG00000178401.13,DNAJC22OVErlotinibEAG3.1469e-04-0.2429image
ENSG00000178401.13,DNAJC22PAADAMG.706EAG6.1850e-07-0.3755image
chr12:49351599-49357182:+PAADAMG.706EER6.1850e-07-0.3755image
ENSG00000178401.13,DNAJC22PCPGCGP.60474EAG3.4376e-030.5728image
chr12:49351599-49357182:+PCPGCGP.60474EER3.4376e-030.5728image
ENSG00000178401.13,DNAJC22PRADEmbelinEAG3.0439e-03-0.2179image
chr12:49351599-49357182:+PRADEmbelinEER3.0439e-03-0.2179image
ENSG00000178401.13,DNAJC22READFH535EAG2.5973e-03-0.3088image
chr12:49351599-49357182:+READFH535EER2.5973e-03-0.3088image
chr12:49351599-49357182:+SARCEmbelinEER1.8258e-04-0.3866image
ENSG00000178401.13,DNAJC22SARCEmbelinEAG1.8258e-04-0.3866image
ENSG00000178401.13,DNAJC22SKCMEpothilone.BEAG1.3506e-02-0.1420image
chr12:49351599-49357182:+SKCMEpothilone.BEER1.3506e-02-0.1420image
ENSG00000178401.13,DNAJC22STADAZ628EAG6.8024e-07-0.2582image
chr12:49351599-49357182:+STADAZ628EER6.8024e-07-0.2582image
ENSG00000178401.13,DNAJC22TGCTEHT.1864EAG5.8177e-030.2535image
chr12:49351599-49357182:+TGCTEHT.1864EER5.8177e-030.2535image
chr12:49351599-49357182:+THCAAICAREER3.7342e-12-0.3032image
ENSG00000178401.13,DNAJC22THCAAICAREAG3.7342e-12-0.3032image
ENSG00000178401.13,DNAJC22UCECAG.014699EAG1.2340e-020.2032image
chr12:49351599-49357182:+UCECAG.014699EER1.2340e-020.2032image
ENSG00000178401.13,DNAJC22UCSEpothilone.BEAG2.8835e-030.5252image
chr12:49351599-49357182:+UCSEpothilone.BEER2.8835e-030.5252image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType