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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ACBD4 (ImmuneEditome ID:79777)

1. Gene summary of enriched editing regions for ACBD4

check button Gene summary
Gene informationGene symbol

ACBD4

Gene ID

79777

GeneSynonymsHMFT0700
GeneCytomap

17q21.31

GeneTypeprotein-coding
GeneDescriptionacyl-CoA-binding domain-containing protein 4|acyl-Coenzyme A binding domain containing 4
GeneModificationdate20230517
UniprotIDQ8NC06;K7EM05;A0A0S2Z5Q0;A0A0S2Z5Y4;K7EMH4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:45140160-45142876:+ENST00000376955.7ENSG00000181513.13ACBD4exonicL1MC5a,AluSc,FLAM_C,AluJo,AluSg7,SVA_B,AluSx1chr17:45140160-45142876:+.alignment
chr17:45140160-45142876:+ENST00000619916.3ENSG00000181513.13ACBD4exonicL1MC5a,AluSc,FLAM_C,AluJo,AluSg7,SVA_B,AluSx1chr17:45140160-45142876:+.alignment


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2. Tumor-specific enriched editing regions for ACBD4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr17:45140160-45142876:+CHOLEER1.8509e-021.0975e-021.6175e+03image
ENSG00000181513.13,ACBD4CHOLEAG1.8509e-021.0975e-021.6175e+03image

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3. Enriched editing regions and immune related genes for ACBD4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ACBD4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for ACBD4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr17:45140160-45142876:+BLCAEERT_cells_regulatory_(Tregs)6.3920e-03-0.2247image
ENSG00000181513.13,ACBD4BLCAEAGT_cells_regulatory_(Tregs)6.7473e-03-0.2233image
chr17:45140160-45142876:+BRCAEERDendritic_cells_activated1.0125e-020.1216image
ENSG00000181513.13,ACBD4BRCAEAGDendritic_cells_activated1.0125e-020.1216image
chr17:45140160-45142876:+CESCEERNK_cells_activated8.8540e-03-0.2823image
ENSG00000181513.13,ACBD4CESCEAGNK_cells_activated8.8304e-03-0.2824image
chr17:45140160-45142876:+CHOLEERMast_cells_activated6.1022e-030.4815image
ENSG00000181513.13,ACBD4CHOLEAGMast_cells_activated6.1022e-030.4815image
chr17:45140160-45142876:+ESCAEERDendritic_cells_resting5.8062e-040.3365image
ENSG00000181513.13,ACBD4ESCAEAGDendritic_cells_resting5.7805e-040.3366image
chr17:45140160-45142876:+GBMEERNeutrophils1.5335e-02-0.2395image
ENSG00000181513.13,ACBD4GBMEAGNeutrophils1.5079e-02-0.2401image
chr17:45140160-45142876:+KIRCEERDendritic_cells_activated1.4584e-030.1839image
ENSG00000181513.13,ACBD4KIRCEAGDendritic_cells_activated1.3855e-030.1847image
chr17:45140160-45142876:+KIRPEERPlasma_cells2.0439e-02-0.1634image
ENSG00000181513.13,ACBD4KIRPEAGPlasma_cells2.0901e-02-0.1628image
ENSG00000181513.13,ACBD4LAMLEAGMacrophages_M02.8682e-030.5424image
chr17:45140160-45142876:+LGGEERMacrophages_M12.5698e-020.1215image
ENSG00000181513.13,ACBD4LGGEAGMacrophages_M12.3682e-020.1232image
chr17:45140160-45142876:+LIHCEERMacrophages_M21.7418e-02-0.1413image
ENSG00000181513.13,ACBD4LIHCEAGMacrophages_M21.7225e-02-0.1415image
chr17:45140160-45142876:+LUADEERDendritic_cells_activated5.6493e-030.1908image
ENSG00000181513.13,ACBD4LUADEAGDendritic_cells_activated5.5491e-030.1912image
chr17:45140160-45142876:+LUSCEERT_cells_CD4_naive2.5890e-02-0.2682image
ENSG00000181513.13,ACBD4LUSCEAGT_cells_CD4_naive2.5893e-02-0.2682image
ENSG00000181513.13,ACBD4MESOEAGNK_cells_activated1.0786e-020.4199image
chr17:45140160-45142876:+OVEERT_cells_CD89.1794e-030.1655image
ENSG00000181513.13,ACBD4OVEAGT_cells_CD89.0577e-030.1658image
ENSG00000181513.13,ACBD4PAADEAGT_cells_CD4_memory_resting8.8039e-050.4146image
chr17:45140160-45142876:+PCPGEERMacrophages_M14.6595e-020.2152image
ENSG00000181513.13,ACBD4PCPGEAGMacrophages_M14.5363e-020.2164image
ENSG00000181513.13,ACBD4READEAGB_cells_naive3.3069e-020.3719image
chr17:45140160-45142876:+SARCEERPlasma_cells1.5307e-020.2868image
ENSG00000181513.13,ACBD4SARCEAGPlasma_cells8.7828e-030.3067image
chr17:45140160-45142876:+SKCMEERDendritic_cells_resting2.5903e-030.2884image
ENSG00000181513.13,ACBD4SKCMEAGDendritic_cells_resting3.1485e-030.2829image
chr17:45140160-45142876:+STADEERT_cells_CD4_memory_resting6.9760e-03-0.1759image
ENSG00000181513.13,ACBD4STADEAGT_cells_CD4_memory_resting5.9151e-03-0.1794image
chr17:45140160-45142876:+THYMEERNK_cells_activated4.1343e-020.3089image
ENSG00000181513.13,ACBD4THYMEAGNK_cells_activated4.0852e-020.3096image
chr17:45140160-45142876:+UCECEEREosinophils1.5518e-020.3037image
ENSG00000181513.13,ACBD4UCECEAGEosinophils1.5518e-020.3037image


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6. Enriched editing regions and immune gene sets for ACBD4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr17:45140160-45142876:+BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER7.7531e-050.1860image
ENSG00000181513.13,ACBD4BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG7.7531e-050.1860image
ENSG00000181513.13,ACBD4CESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.5308e-060.4645image
chr17:45140160-45142876:+CESCGSVA_HALLMARK_PROTEIN_SECRETIONEER7.5758e-060.4644image
ENSG00000181513.13,ACBD4ESCAGSVA_HALLMARK_MYOGENESISEAG2.8805e-030.2936image
chr17:45140160-45142876:+ESCAGSVA_HALLMARK_MYOGENESISEER2.9222e-030.2932image
ENSG00000181513.13,ACBD4GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.7520e-03-0.2548image
chr17:45140160-45142876:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.9674e-03-0.2541image
chr17:45140160-45142876:+KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER9.9006e-050.2240image
ENSG00000181513.13,ACBD4KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG6.8668e-050.2289image
chr17:45140160-45142876:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.5556e-030.1879image
ENSG00000181513.13,ACBD4KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG7.5256e-030.1880image
chr17:45140160-45142876:+LGGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER6.8279e-030.1471image
ENSG00000181513.13,ACBD4LGGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG5.9739e-030.1495image
chr17:45140160-45142876:+LIHCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER8.3654e-050.2317image
ENSG00000181513.13,ACBD4LIHCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG7.7932e-050.2326image
ENSG00000181513.13,ACBD4LUADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.4138e-020.1695image
chr17:45140160-45142876:+LUADGSVA_HALLMARK_PROTEIN_SECRETIONEER1.6975e-020.1650image
ENSG00000181513.13,ACBD4MESOGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG4.1720e-020.3412image
ENSG00000181513.13,ACBD4OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.0118e-050.2768image
chr17:45140160-45142876:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.1890e-050.2747image
ENSG00000181513.13,ACBD4PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.1868e-02-0.2344image
ENSG00000181513.13,ACBD4PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.9347e-020.2351image
chr17:45140160-45142876:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.1615e-020.2320image
chr17:45140160-45142876:+PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER5.2777e-060.3338image
ENSG00000181513.13,ACBD4PRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.2777e-060.3338image
ENSG00000181513.13,ACBD4READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9014e-020.4061image
chr17:45140160-45142876:+SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.5021e-040.4216image
ENSG00000181513.13,ACBD4SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG6.9534e-050.4512image
chr17:45140160-45142876:+SKCMGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER6.6908e-040.3238image
ENSG00000181513.13,ACBD4SKCMGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG5.4948e-040.3286image
ENSG00000181513.13,ACBD4STADGSVA_HALLMARK_UV_RESPONSE_UPEAG8.1962e-070.3157image
chr17:45140160-45142876:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER6.2236e-070.3190image
ENSG00000181513.13,ACBD4THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.4764e-060.2346image
chr17:45140160-45142876:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.5730e-060.2343image
ENSG00000181513.13,ACBD4UCECGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG3.6851e-040.4349image
chr17:45140160-45142876:+UCECGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.6851e-040.4349image


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7. Enriched editing regions and drugs for ACBD4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr17:45140160-45142876:+BLCAGW.441756EER6.7091e-03-0.2234image
ENSG00000181513.13,ACBD4BLCAGW.441756EAG6.5754e-03-0.2240image
chr17:45140160-45142876:+BRCAKIN001.135EER1.3265e-03-0.1515image
ENSG00000181513.13,ACBD4BRCAKIN001.135EAG1.3265e-03-0.1515image
ENSG00000181513.13,ACBD4CESCAZD6244EAG4.4466e-050.4277image
chr17:45140160-45142876:+CESCAZD6244EER4.4523e-050.4277image
chr17:45140160-45142876:+CHOLBIBW2992EER1.1108e-02-0.4499image
ENSG00000181513.13,ACBD4CHOLBIBW2992EAG1.1108e-02-0.4499image
chr17:45140160-45142876:+COADIPA.3EER6.3932e-03-0.2854image
ENSG00000181513.13,ACBD4COADIPA.3EAG4.5984e-03-0.2961image
chr17:45140160-45142876:+ESCAGSK269962AEER4.5273e-04-0.3426image
ENSG00000181513.13,ACBD4ESCAGSK269962AEAG4.5326e-04-0.3426image
ENSG00000181513.13,ACBD4GBMKU.55933EAG6.6059e-030.2673image
chr17:45140160-45142876:+GBMKU.55933EER6.5032e-030.2678image
chr17:45140160-45142876:+KIRCGefitinibEER1.4421e-040.2192image
ENSG00000181513.13,ACBD4KIRCGefitinibEAG1.1326e-040.2225image
chr17:45140160-45142876:+KIRPAZD6244EER1.4416e-030.2233image
ENSG00000181513.13,ACBD4KIRPAZD6244EAG1.3553e-030.2245image
ENSG00000181513.13,ACBD4LGGEmbelinEAG1.4570e-02-0.1330image
chr17:45140160-45142876:+LGGEmbelinEER1.5293e-02-0.1320image
ENSG00000181513.13,ACBD4LIHCAZD.2281EAG6.4321e-040.2034image
chr17:45140160-45142876:+LIHCAZD.2281EER6.9632e-040.2022image
chr17:45140160-45142876:+LUADCEP.701EER1.3818e-030.2198image
ENSG00000181513.13,ACBD4LUADCEP.701EAG1.1895e-030.2227image
ENSG00000181513.13,ACBD4LUSCAG.014699EAG3.4259e-020.2553image
chr17:45140160-45142876:+LUSCAG.014699EER3.4249e-020.2553image
ENSG00000181513.13,ACBD4MESOCamptothecinEAG4.5404e-020.3356image
ENSG00000181513.13,ACBD4OVDocetaxelEAG2.7876e-04-0.2293image
chr17:45140160-45142876:+OVDocetaxelEER2.7130e-04-0.2298image
ENSG00000181513.13,ACBD4PAADA.770041EAG3.8380e-030.3140image
ENSG00000181513.13,ACBD4PCPGBMS.754807EAG3.3667e-020.2293image
chr17:45140160-45142876:+PCPGBMS.754807EER3.3247e-020.2299image
ENSG00000181513.13,ACBD4PRADGW843682XEAG9.0187e-040.2467image
chr17:45140160-45142876:+PRADGW843682XEER9.0187e-040.2467image
ENSG00000181513.13,ACBD4READJNK.9LEAG7.9129e-03-0.4543image
chr17:45140160-45142876:+SARCAZD7762EER6.3134e-04-0.3959image
ENSG00000181513.13,ACBD4SARCDasatinibEAG1.3520e-04-0.4348image
chr17:45140160-45142876:+SKCMAUY922EER2.6565e-02-0.2144image
ENSG00000181513.13,ACBD4SKCMAUY922EAG2.8212e-02-0.2122image
chr17:45140160-45142876:+STADAG.014699EER6.1152e-030.1787image
ENSG00000181513.13,ACBD4STADAG.014699EAG5.8580e-030.1796image
ENSG00000181513.13,ACBD4THCAAMG.706EAG2.2585e-030.1556image
chr17:45140160-45142876:+THCAAMG.706EER1.6212e-030.1605image
chr17:45140160-45142876:+UCECBryostatin.1EER1.1466e-020.3166image
ENSG00000181513.13,ACBD4UCECBryostatin.1EAG1.1466e-020.3166image
ENSG00000181513.13,ACBD4UVMGefitinibEAG2.8010e-020.4228image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType