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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TXNDC15 (ImmuneEditome ID:79770)

1. Gene summary of enriched editing regions for TXNDC15

check button Gene summary
Gene informationGene symbol

TXNDC15

Gene ID

79770

GeneSynonymsBUG|C5orf14|MKS14|UNQ335
GeneCytomap

5q31.1

GeneTypeprotein-coding
GeneDescriptionthioredoxin domain-containing protein 15|2310047H23Rik|disulfide isomerase
GeneModificationdate20230329
UniprotIDQ96J42;D6RAV9;D6RBD9;D6RB48;D6R962
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:134878063-134880107:+ENST00000358387.7ENSG00000113621.13TXNDC15intronicMIRb,(TCA)n,AluSz,AluSq2chr5:134878063-134880107:+.alignment
chr5:134878063-134880107:+ENST00000506916.1ENSG00000113621.13TXNDC15intronicMIRb,(TCA)n,AluSz,AluSq2chr5:134878063-134880107:+.alignment
chr5:134878063-134880107:+ENST00000507024.4ENSG00000113621.13TXNDC15intronicMIRb,(TCA)n,AluSz,AluSq2chr5:134878063-134880107:+.alignment
chr5:134878063-134880107:+ENST00000508779.1ENSG00000113621.13TXNDC15intronicMIRb,(TCA)n,AluSz,AluSq2chr5:134878063-134880107:+.alignment
chr5:134878063-134880107:+ENST00000508810.1ENSG00000113621.13TXNDC15intronicMIRb,(TCA)n,AluSz,AluSq2chr5:134878063-134880107:+.alignment
chr5:134878063-134880107:+ENST00000511070.4ENSG00000113621.13TXNDC15intronicMIRb,(TCA)n,AluSz,AluSq2chr5:134878063-134880107:+.alignment
chr5:134883261-134884549:+ENST00000358387.7ENSG00000113621.13TXNDC15intronicAluSz6,AluSg,AluSp,AluSx1chr5:134883261-134884549:+.alignment
chr5:134883261-134884549:+ENST00000506916.1ENSG00000113621.13TXNDC15intronicAluSz6,AluSg,AluSp,AluSx1chr5:134883261-134884549:+.alignment
chr5:134883261-134884549:+ENST00000507024.4ENSG00000113621.13TXNDC15intronicAluSz6,AluSg,AluSp,AluSx1chr5:134883261-134884549:+.alignment
chr5:134883261-134884549:+ENST00000508779.1ENSG00000113621.13TXNDC15intronicAluSz6,AluSg,AluSp,AluSx1chr5:134883261-134884549:+.alignment
chr5:134883261-134884549:+ENST00000508810.1ENSG00000113621.13TXNDC15intronicAluSz6,AluSg,AluSp,AluSx1chr5:134883261-134884549:+.alignment
chr5:134883261-134884549:+ENST00000511070.4ENSG00000113621.13TXNDC15intronicAluSz6,AluSg,AluSp,AluSx1chr5:134883261-134884549:+.alignment
chr5:134900369-134901111:+ENST00000502625.1ENSG00000113621.13TXNDC15ncRNA_exonicAluSx,AluSq,L2cchr5:134900369-134901111:+.alignment


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2. Tumor-specific enriched editing regions for TXNDC15


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr5:134900369-134901111:+BRCAEER1.5104e-40image
ENSG00000113621.13,TXNDC15BRCAEAG1.5105e-40image
chr5:134900369-134901111:+COADEER2.0129e-05image
ENSG00000113621.13,TXNDC15COADEAG2.0101e-05image
chr5:134900369-134901111:+HNSCEER4.4821e-11image
ENSG00000113621.13,TXNDC15HNSCEAG4.4821e-11image
chr5:134900369-134901111:+KIRCEER6.7418e-14image
ENSG00000113621.13,TXNDC15KIRCEAG7.4273e-14image
chr5:134900369-134901111:+KIRPEER1.3073e-03image
ENSG00000113621.13,TXNDC15KIRPEAG1.2932e-03image
chr5:134900369-134901111:+LIHCEER2.7583e-04image
ENSG00000113621.13,TXNDC15LIHCEAG2.7583e-04image
chr5:134900369-134901111:+LUADEER5.9223e-04image
ENSG00000113621.13,TXNDC15LUADEAG5.5560e-04image
chr5:134900369-134901111:+LUSCEER1.0721e-04image
ENSG00000113621.13,TXNDC15LUSCEAG1.0478e-04image
chr5:134900369-134901111:+THCAEER9.7536e-11image
ENSG00000113621.13,TXNDC15THCAEAG9.7361e-11image
chr5:134900369-134901111:+UCECEER2.3019e-13image
ENSG00000113621.13,TXNDC15UCECEAG2.3319e-13image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000113621.13,TXNDC15LUADPathEAG1.6279e-021.1524e-020.1118image
chr5:134900369-134901111:+LUADPathEER1.3959e-021.0179e-020.1138image
chr5:134900369-134901111:+READPathEER4.7646e-028.5567e-03-0.2214image
chr5:134900369-134901111:+THCAPathEER8.0569e-053.2804e-050.1840image
ENSG00000113621.13,TXNDC15THCAPathEAG8.3411e-053.3232e-050.1839image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr5:134900369-134901111:+LGGEER3.6663e-022.9490e-028.5222e+01image
ENSG00000113621.13,TXNDC15LGGEAG3.6663e-022.9350e-028.5527e+01image

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3. Enriched editing regions and immune related genes for TXNDC15


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:134900369-134901111:+BLCAEERENSG00000204267,TAP20.50181.3950e-222.8898e-250.4875imageNELAVL1TAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+BLCAEERENSG00000156587,UBE2L60.48062.0707e-201.8025e-240.4803imageNELAVL1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+BLCAEERENSG00000123609,NMI0.47141.4070e-191.4732e-250.4901imageNELAVL1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+BLCAEERENSG00000168394,TAP10.46962.2227e-191.6786e-210.4517imageNELAVL1TAP1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+BLCAEERENSG00000160710,ADAR0.46684.1512e-193.8035e-170.4041imageNELAVL1ADARMacrophages_M1GSVA_HALLMARK_MITOTIC_SPINDLE
chr5:134900369-134901111:+BLCAEERENSG00000115415,STAT10.46466.3522e-194.2639e-200.4371imageNELAVL1STAT1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+BLCAEERENSG00000059378,PARP120.44382.1280e-171.5001e-200.4419imageNELAVL1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+BLCAEERENSG00000143321,HDGF0.44442.4311e-178.1239e-200.4342imageNELAVL1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_E2F_TARGETS
chr5:134900369-134901111:+BLCAEERENSG00000204525,HLA-C0.43224.0510e-166.3479e-190.4244imageNELAVL1HLA-CT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+BLCAEERENSG00000164430,MB21D10.42689.3818e-162.4706e-180.4178imageNELAVL1MB21D1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE

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4. Enriched editing regions and immune related splicing for TXNDC15


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:134900369-134901111:+
BLCAEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.57802.5384e-301.2744e-34-0.5616imageNELAVL1PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000113621.13,TXNDC15
BLCAEAGESENSG00000204463.8chr631639040:31639226:31639499:31639646:31640198:31640282-0.42017.1060e-144.3301e-20-0.4371imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CSTF2T;DDX3X;DDX42;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184BAG6T_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT
ENSG00000113621.13,TXNDC15
BLCAEAGIRENSG00000160957.8chr8144511283:144512771:144512846:144513138-0.40891.8232e-131.0832e-16-0.4001imageNADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
chr5:134900369-134901111:+
BLCAEERESENSG00000204463.8chr631639040:31639226:31639499:31639646:31640198:31640282-0.42015.2366e-144.3301e-20-0.4371imageNELAVL1BAG6T_cells_CD4_memory_activatedGSVA_HALLMARK_G2M_CHECKPOINT
chr5:134900369-134901111:+
BLCAEERIRENSG00000160957.8chr8144511283:144512771:144512846:144513138-0.40891.3243e-131.0832e-16-0.4001imageNELAVL1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_E2F_TARGETS
ENSG00000113621.13,TXNDC15
BLCAEAGIRENSG00000187741.10chr1689737548:89738974:89739132:89739289-0.39057.5585e-126.3117e-18-0.4132imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184FANCAT_cells_CD4_memory_activatedGSVA_HALLMARK_E2F_TARGETS
ENSG00000113621.13,TXNDC15
BLCAEAGIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.57802.3097e-301.2744e-34-0.5616imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;RNF219;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184PRKCSHMacrophages_M1GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+
BLCAEERIRENSG00000187741.10chr1689737548:89738974:89739132:89739289-0.39055.3188e-126.3117e-18-0.4132imageNELAVL1FANCAT_cells_CD4_memory_activatedGSVA_HALLMARK_E2F_TARGETS
chr5:134900369-134901111:+
CESCEERIRENSG00000130175.5chr1911449265:11449882:11450428:11450716-0.44441.4911e-109.2649e-15-0.4288imageNELAVL1PRKCSHMacrophages_M0GSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr5:134900369-134901111:+
CESCEERIRENSG00000139725.3chr12121777757:121779662:121780871:121781006-0.41585.7282e-102.7127e-13-0.4098imageNELAVL1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_COMPLEMENT

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5. Enriched editing regions and immune infiltration for TXNDC15


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr5:134900369-134901111:+ACCEERB_cells_memory4.1452e-030.3192image
ENSG00000113621.13,TXNDC15ACCEAGB_cells_memory4.1452e-030.3192image
chr5:134900369-134901111:+BLCAEERT_cells_CD4_memory_activated1.9178e-130.3567image
ENSG00000113621.13,TXNDC15BLCAEAGT_cells_CD4_memory_activated1.9178e-130.3567image
chr5:134900369-134901111:+BRCAEERMacrophages_M11.7860e-140.2306image
ENSG00000113621.13,TXNDC15BRCAEAGMacrophages_M11.7223e-140.2307image
chr5:134900369-134901111:+CESCEERMacrophages_M11.2330e-030.1863image
ENSG00000113621.13,TXNDC15CESCEAGMacrophages_M11.2389e-030.1862image
chr5:134900369-134901111:+CHOLEERNK_cells_activated3.2985e-020.3613image
ENSG00000113621.13,TXNDC15CHOLEAGNK_cells_activated3.2985e-020.3613image
chr5:134900369-134901111:+COADEERDendritic_cells_activated2.1123e-060.2892image
ENSG00000113621.13,TXNDC15COADEAGDendritic_cells_activated2.0810e-060.2894image
chr5:134900369-134901111:+DLBCEERMacrophages_M16.7921e-030.3856image
ENSG00000113621.13,TXNDC15DLBCEAGMacrophages_M16.7837e-030.3857image
chr5:134900369-134901111:+ESCAEERDendritic_cells_resting4.5914e-02-0.1581image
chr5:134900369-134901111:+GBMEERMacrophages_M05.1638e-09-0.4340image
ENSG00000113621.13,TXNDC15GBMEAGMacrophages_M05.3620e-09-0.4336image
chr5:134900369-134901111:+HNSCEERMacrophages_M11.0790e-090.2770image
ENSG00000113621.13,TXNDC15HNSCEAGMacrophages_M11.0790e-090.2770image
chr5:134900369-134901111:+KICHEEREosinophils4.4486e-030.3484image
ENSG00000113621.13,TXNDC15KICHEAGEosinophils4.4486e-030.3484image
chr5:134900369-134901111:+KIRCEERT_cells_gamma_delta1.3681e-060.2432image
ENSG00000113621.13,TXNDC15KIRCEAGT_cells_gamma_delta1.2168e-060.2444image
chr5:134900369-134901111:+KIRPEERMacrophages_M23.0287e-020.1279image
ENSG00000113621.13,TXNDC15KIRPEAGMacrophages_M22.9829e-020.1283image
ENSG00000113621.13,TXNDC15LAMLEAGT_cells_regulatory_(Tregs)1.5518e-040.4767image
chr5:134900369-134901111:+LGGEERT_cells_CD4_naive6.7198e-08-0.2321image
ENSG00000113621.13,TXNDC15LGGEAGT_cells_CD4_naive6.9104e-08-0.2318image
chr5:134900369-134901111:+LIHCEERMacrophages_M16.5054e-040.1760image
ENSG00000113621.13,TXNDC15LIHCEAGMacrophages_M16.5054e-040.1760image
chr5:134900369-134901111:+LUADEERMacrophages_M11.5418e-060.2113image
ENSG00000113621.13,TXNDC15LUADEAGMacrophages_M12.3860e-060.2073image
chr5:134900369-134901111:+LUSCEERT_cells_CD4_memory_activated7.6166e-070.2216image
ENSG00000113621.13,TXNDC15LUSCEAGT_cells_CD4_memory_activated7.6166e-070.2216image
chr5:134900369-134901111:+MESOEERT_cells_follicular_helper2.6966e-030.3272image
ENSG00000113621.13,TXNDC15MESOEAGT_cells_follicular_helper2.6966e-030.3272image
chr5:134900369-134901111:+OVEERMacrophages_M13.1906e-040.2092image
ENSG00000113621.13,TXNDC15OVEAGMacrophages_M13.3670e-040.2084image
chr5:134900369-134901111:+PAADEERMacrophages_M12.9551e-030.2216image
ENSG00000113621.13,TXNDC15PAADEAGMacrophages_M12.9415e-030.2217image
chr5:134900369-134901111:+PCPGEERT_cells_CD82.7939e-060.3384image
ENSG00000113621.13,TXNDC15PCPGEAGT_cells_CD82.5569e-060.3396image
chr5:134900369-134901111:+PRADEERT_cells_regulatory_(Tregs)1.9019e-050.1902image
ENSG00000113621.13,TXNDC15PRADEAGT_cells_regulatory_(Tregs)2.1872e-050.1888image
chr5:134900369-134901111:+READEERMast_cells_resting1.1684e-020.2591image
ENSG00000113621.13,TXNDC15READEAGMast_cells_resting3.1121e-020.2213image
chr5:134900369-134901111:+SARCEERMacrophages_M12.4515e-050.2599image
ENSG00000113621.13,TXNDC15SARCEAGMacrophages_M12.5139e-050.2596image
chr5:134900369-134901111:+SKCMEERT_cells_CD88.7569e-170.3770image
ENSG00000113621.13,TXNDC15SKCMEAGT_cells_CD88.6078e-170.3771image
chr5:134900369-134901111:+STADEERMacrophages_M19.9803e-050.2048image
ENSG00000113621.13,TXNDC15STADEAGMacrophages_M15.1153e-050.2130image
chr5:134900369-134901111:+TGCTEERMacrophages_M21.9927e-10-0.4828image
ENSG00000113621.13,TXNDC15TGCTEAGMacrophages_M22.0053e-10-0.4827image
chr5:134900369-134901111:+THCAEERT_cells_CD4_memory_activated6.1151e-080.2383image
ENSG00000113621.13,TXNDC15THCAEAGT_cells_CD4_memory_activated6.1411e-080.2383image
chr5:134900369-134901111:+THYMEERMacrophages_M12.2062e-110.5669image
ENSG00000113621.13,TXNDC15THYMEAGMacrophages_M12.4712e-110.5657image
chr5:134900369-134901111:+UCECEERDendritic_cells_activated9.3786e-040.2480image
ENSG00000113621.13,TXNDC15UCECEAGDendritic_cells_activated9.5360e-040.2476image
chr5:134900369-134901111:+UCSEERB_cells_naive7.6636e-03-0.3528image
ENSG00000113621.13,TXNDC15UCSEAGB_cells_naive7.6636e-03-0.3528image
chr5:134900369-134901111:+UVMEERT_cells_regulatory_(Tregs)6.1554e-040.4198image
ENSG00000113621.13,TXNDC15UVMEAGT_cells_regulatory_(Tregs)6.1554e-040.4198image


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6. Enriched editing regions and immune gene sets for TXNDC15


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000113621.13,TXNDC15BLCAEAG5.2738e-110.32051.0418e-090.29912.7239e-100.30891.5579e-050.2142image
chr5:134900369-134901111:+BLCAEER5.2738e-110.32051.0418e-090.29912.7239e-100.30891.5579e-050.2142image
ENSG00000113621.13,TXNDC15HNSCEAG4.2735e-020.09371.3038e-03-0.14824.8230e-030.13012.7278e-040.1675image
chr5:134900369-134901111:+HNSCEER4.2735e-020.09371.3038e-03-0.14824.8230e-030.13012.7278e-040.1675image
ENSG00000113621.13,TXNDC15LUADEAG1.3790e-090.26445.0708e-120.29978.2159e-100.26782.7804e-040.1605image
chr5:134900369-134901111:+LUADEER8.7525e-100.26772.5337e-120.30405.7026e-100.27052.4045e-040.1622image
ENSG00000113621.13,TXNDC15PRADEAG2.8021e-030.13356.7665e-050.17741.7469e-020.10644.1878e-020.0911image
chr5:134900369-134901111:+PRADEER2.3328e-030.13605.7970e-050.17901.5406e-020.10843.8451e-020.0927image
ENSG00000113621.13,TXNDC15STADEAG3.3628e-050.21799.2621e-030.13776.1904e-040.18066.3631e-030.1444image
ENSG00000113621.13,TXNDC15THYMEAG2.2638e-04-0.33339.7432e-09-0.49782.9310e-030.27161.1994e-090.5233image
chr5:134900369-134901111:+THYMEER2.5258e-04-0.33091.2969e-08-0.49412.5508e-030.27531.0537e-090.5249image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000113621.13,TXNDC15ACCGSVA_HALLMARK_HEME_METABOLISMEAG4.7545e-020.2237image
chr5:134900369-134901111:+ACCGSVA_HALLMARK_HEME_METABOLISMEER4.7545e-020.2237image
chr5:134900369-134901111:+BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.6764e-210.4471image
ENSG00000113621.13,TXNDC15BLCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.6764e-210.4471image
ENSG00000113621.13,TXNDC15BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.3143e-720.5089image
chr5:134900369-134901111:+BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.9838e-720.5083image
chr5:134900369-134901111:+CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.8803e-190.4856image
ENSG00000113621.13,TXNDC15CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.8164e-190.4857image
chr5:134900369-134901111:+COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2340e-040.2359image
ENSG00000113621.13,TXNDC15COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2442e-040.2358image
ENSG00000113621.13,TXNDC15DLBCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG3.2716e-030.4160image
chr5:134900369-134901111:+DLBCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER3.2586e-030.4162image
chr5:134900369-134901111:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6931e-040.2931image
ENSG00000113621.13,TXNDC15ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG9.7073e-040.2576image
chr5:134900369-134901111:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.8051e-140.5493image
ENSG00000113621.13,TXNDC15GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.8779e-140.5490image
chr5:134900369-134901111:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2553e-250.4578image
ENSG00000113621.13,TXNDC15HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2553e-250.4578image
chr5:134900369-134901111:+KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.1889e-140.3762image
ENSG00000113621.13,TXNDC15KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.2005e-140.3797image
chr5:134900369-134901111:+KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.4590e-050.2528image
ENSG00000113621.13,TXNDC15KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.5120e-050.2524image
ENSG00000113621.13,TXNDC15LAMLGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG3.7799e-02-0.2735image
chr5:134900369-134901111:+LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5979e-540.6068image
ENSG00000113621.13,TXNDC15LGGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.9002e-540.6065image
chr5:134900369-134901111:+LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.9670e-120.3514image
ENSG00000113621.13,TXNDC15LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.9670e-120.3514image
chr5:134900369-134901111:+LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER1.2003e-160.3562image
ENSG00000113621.13,TXNDC15LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.0983e-160.3514image
ENSG00000113621.13,TXNDC15LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.1804e-130.3191image
chr5:134900369-134901111:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.1804e-130.3191image
chr5:134900369-134901111:+MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.5758e-080.5634image
ENSG00000113621.13,TXNDC15MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.5758e-080.5634image
ENSG00000113621.13,TXNDC15OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.5861e-190.4933image
chr5:134900369-134901111:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.8883e-190.4927image
chr5:134900369-134901111:+PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6219e-060.3504image
ENSG00000113621.13,TXNDC15PAADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.6642e-060.3501image
chr5:134900369-134901111:+PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4941e-110.4722image
ENSG00000113621.13,TXNDC15PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4532e-110.4725image
ENSG00000113621.13,TXNDC15PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.3184e-180.3802image
chr5:134900369-134901111:+PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.7962e-190.3825image
ENSG00000113621.13,TXNDC15READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4311e-030.3226image
chr5:134900369-134901111:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.4998e-040.3812image
chr5:134900369-134901111:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.0136e-140.4505image
ENSG00000113621.13,TXNDC15SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8888e-140.4508image
ENSG00000113621.13,TXNDC15SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.3720e-170.3835image
chr5:134900369-134901111:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0859e-170.3841image
chr5:134900369-134901111:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER9.2078e-090.2986image
ENSG00000113621.13,TXNDC15STADGSVA_HALLMARK_UV_RESPONSE_UPEAG4.1064e-100.3234image
chr5:134883261-134884549:+STADGSVA_HALLMARK_APICAL_JUNCTIONEER8.4686e-030.3649image
chr5:134900369-134901111:+TGCTGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER8.5295e-09-0.4420image
ENSG00000113621.13,TXNDC15TGCTGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG8.6020e-09-0.4419image
chr5:134900369-134901111:+THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.1899e-220.4101image
ENSG00000113621.13,TXNDC15THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.0936e-220.4102image
ENSG00000113621.13,TXNDC15THYMGSVA_HALLMARK_E2F_TARGETSEAG8.0100e-11-0.5535image
chr5:134900369-134901111:+THYMGSVA_HALLMARK_E2F_TARGETSEER9.5522e-11-0.5516image
chr5:134900369-134901111:+UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.9068e-130.5083image
ENSG00000113621.13,TXNDC15UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.2773e-130.5105image
ENSG00000113621.13,TXNDC15UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.1505e-050.5137image
chr5:134900369-134901111:+UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.1505e-050.5137image
ENSG00000113621.13,TXNDC15UVMGSVA_HALLMARK_APICAL_SURFACEEAG1.8804e-050.5109image
chr5:134900369-134901111:+UVMGSVA_HALLMARK_APICAL_SURFACEEER1.8804e-050.5109image


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7. Enriched editing regions and drugs for TXNDC15


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000113621.13,TXNDC15ACCABT.263EAG1.7009e-020.2678image
chr5:134900369-134901111:+ACCABT.263EER1.7009e-020.2678image
ENSG00000113621.13,TXNDC15BLCACMKEAG4.9018e-17-0.4028image
chr5:134900369-134901111:+BLCACMKEER4.9018e-17-0.4028image
ENSG00000113621.13,TXNDC15BRCAJNK.Inhibitor.VIIIEAG3.1584e-11-0.2005image
chr5:134900369-134901111:+BRCAJNK.Inhibitor.VIIIEER3.3355e-11-0.2002image
chr5:134900369-134901111:+CESCCI.1040EER7.0150e-10-0.3474image
ENSG00000113621.13,TXNDC15CESCCI.1040EAG6.9201e-10-0.3476image
ENSG00000113621.13,TXNDC15COADGefitinibEAG8.3047e-05-0.2416image
chr5:134900369-134901111:+COADGefitinibEER8.3895e-05-0.2415image
ENSG00000113621.13,TXNDC15DLBCBosutinibEAG8.5960e-030.3791image
chr5:134900369-134901111:+DLBCBosutinibEER8.5878e-030.3791image
chr5:134883261-134884549:+ESCAJNK.9LEER3.2481e-03-0.5986image
chr5:134900369-134901111:+ESCABMS.708163EER2.9739e-03-0.2334image
ENSG00000113621.13,TXNDC15ESCABMS.708163EAG3.2087e-03-0.2309image
chr5:134900369-134901111:+GBMBIBW2992EER2.8174e-11-0.4872image
ENSG00000113621.13,TXNDC15GBMBIBW2992EAG2.9559e-11-0.4867image
ENSG00000113621.13,TXNDC15HNSCCI.1040EAG1.1548e-13-0.3341image
chr5:134900369-134901111:+HNSCCI.1040EER1.1548e-13-0.3341image
chr5:134900369-134901111:+KICHAUY922EER4.4247e-020.2504image
ENSG00000113621.13,TXNDC15KICHAUY922EAG4.4247e-020.2504image
chr5:134900369-134901111:+KIRCCisplatinEER7.5708e-12-0.3396image
ENSG00000113621.13,TXNDC15KIRCCisplatinEAG7.0328e-12-0.3401image
ENSG00000113621.13,TXNDC15KIRPFTI.277EAG1.3274e-050.2540image
chr5:134900369-134901111:+KIRPFTI.277EER1.3259e-050.2540image
ENSG00000113621.13,TXNDC15LAMLAZ628EAG3.1706e-02-0.2824image
ENSG00000113621.13,TXNDC15LGGBexaroteneEAG1.8826e-38-0.5229image
chr5:134900369-134901111:+LGGBexaroteneEER1.8218e-38-0.5229image
chr5:134900369-134901111:+LIHCAUY922EER5.6639e-150.3901image
ENSG00000113621.13,TXNDC15LIHCAUY922EAG5.6639e-150.3901image
ENSG00000113621.13,TXNDC15LUADJW.7.52.1EAG1.7163e-09-0.2629image
chr5:134900369-134901111:+LUADJW.7.52.1EER1.3995e-09-0.2645image
chr5:134900369-134901111:+LUSCBleomycinEER6.0590e-05-0.1805image
ENSG00000113621.13,TXNDC15LUSCBleomycinEAG6.0590e-05-0.1805image
chr5:134900369-134901111:+MESOGDC0941EER3.1256e-040.3883image
ENSG00000113621.13,TXNDC15MESOGDC0941EAG3.1256e-040.3883image
ENSG00000113621.13,TXNDC15OVAxitinibEAG6.7891e-080.3094image
chr5:134900369-134901111:+OVAxitinibEER6.5279e-080.3098image
chr5:134900369-134901111:+PAADBIBW2992EER1.6143e-08-0.4077image
ENSG00000113621.13,TXNDC15PAADBIBW2992EAG1.6885e-08-0.4072image
chr5:134900369-134901111:+PCPGGSK269962AEER2.3697e-040.2686image
ENSG00000113621.13,TXNDC15PCPGGSK269962AEAG2.3770e-040.2685image
ENSG00000113621.13,TXNDC15PRADJNK.Inhibitor.VIIIEAG3.7047e-10-0.2757image
chr5:134900369-134901111:+PRADJNK.Inhibitor.VIIIEER6.4987e-10-0.2720image
chr5:134900369-134901111:+READAMG.706EER3.8269e-050.4133image
ENSG00000113621.13,TXNDC15READAMG.706EAG7.9284e-040.3402image
chr5:134900369-134901111:+SARCMethotrexateEER1.5621e-09-0.3660image
ENSG00000113621.13,TXNDC15SARCMethotrexateEAG1.4417e-09-0.3667image
ENSG00000113621.13,TXNDC15SKCMGNF.2EAG3.4917e-12-0.3188image
chr5:134900369-134901111:+SKCMGNF.2EER4.0050e-12-0.3180image
ENSG00000113621.13,TXNDC15STADCCT007093EAG4.9396e-060.2394image
chr5:134900369-134901111:+STADCCT007093EER4.8072e-050.2137image
chr5:134883261-134884549:+STADAZD.0530EER1.7457e-02-0.3453image
chr5:134900369-134901111:+TGCTBMS.754807EER2.5336e-110.5031image
ENSG00000113621.13,TXNDC15TGCTBMS.754807EAG2.5493e-110.5030image
ENSG00000113621.13,TXNDC15THCACI.1040EAG1.2085e-27-0.4591image
chr5:134900369-134901111:+THCACI.1040EER1.2597e-27-0.4590image
ENSG00000113621.13,TXNDC15THYMABT.263EAG1.5159e-140.6327image
chr5:134900369-134901111:+THYMABT.263EER1.5732e-140.6324image
ENSG00000113621.13,TXNDC15UCECCGP.60474EAG1.7532e-05-0.3184image
chr5:134900369-134901111:+UCECCGP.60474EER1.7039e-05-0.3188image
ENSG00000113621.13,TXNDC15UCSCisplatinEAG4.4469e-05-0.5174image
chr5:134900369-134901111:+UCSCisplatinEER4.4469e-05-0.5174image
chr5:134900369-134901111:+UVMCGP.60474EER1.2629e-07-0.6079image
ENSG00000113621.13,TXNDC15UVMCGP.60474EAG1.2629e-07-0.6079image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType