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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ICE2 (ImmuneEditome ID:79664)

1. Gene summary of enriched editing regions for ICE2

check button Gene summary
Gene informationGene symbol

ICE2

Gene ID

79664

GeneSynonymsBRCC1|NARG2
GeneCytomap

15q22.2

GeneTypeprotein-coding
GeneDescriptionlittle elongation complex subunit 2|NMDA receptor regulated 2|NMDA receptor-regulated gene 2|NMDA receptor-regulated protein 2|breast cancer cell 1|interactor of little elongator complex ELL subunit 2
GeneModificationdate20230517
UniprotIDQ659A1;H0YN09;H0YL35;H0YMX6;H0YK14;H0YK97;H0YK96;H0YNU9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:60422176-60422776:-ENST00000558121.4ENSG00000128915.10ICE2ncRNA_exonicAluSx3,AluJbchr15:60422176-60422776:-.alignment
chr15:60432314-60432752:-ENST00000558121.4ENSG00000128915.10ICE2ncRNA_intronicAluY,AluSxchr15:60432314-60432752:-.alignment
chr15:60432314-60432752:-ENST00000561124.1ENSG00000128915.10ICE2ncRNA_intronicAluY,AluSxchr15:60432314-60432752:-.alignment
chr15:60436961-60437817:-ENST00000558121.4ENSG00000128915.10ICE2ncRNA_intronicAluSz6,AluSq,AluSx1chr15:60436961-60437817:-.alignment
chr15:60436961-60437817:-ENST00000561124.1ENSG00000128915.10ICE2ncRNA_intronicAluSz6,AluSq,AluSx1chr15:60436961-60437817:-.alignment
chr15:60464893-60465922:-ENST00000561087.4ENSG00000128915.10ICE2ncRNA_intronicAluJr,AluJb,(AT)n,AluSx1,L1MB2chr15:60464893-60465922:-.alignment


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2. Tumor-specific enriched editing regions for ICE2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr15:60422176-60422776:-BRCAEER2.0635e-20image
ENSG00000128915.10,ICE2BRCAEAG2.8462e-19image
chr15:60422176-60422776:-HNSCEER1.0073e-04image
ENSG00000128915.10,ICE2HNSCEAG1.0465e-04image
chr15:60422176-60422776:-LUADEER1.5958e-02image
ENSG00000128915.10,ICE2LUADEAG1.7563e-02image
chr15:60422176-60422776:-LUSCEER5.4307e-04image
ENSG00000128915.10,ICE2LUSCEAG5.9778e-04image
chr15:60422176-60422776:-THCAEER4.6338e-03image
ENSG00000128915.10,ICE2THCAEAG4.8946e-03image
chr15:60422176-60422776:-UCECEER2.0337e-09image
ENSG00000128915.10,ICE2UCECEAG3.9385e-10image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000128915.10,ICE2BLCAPathEAG3.4862e-022.4266e-020.1346image
chr15:60422176-60422776:-BLCAPathEER2.2550e-022.3852e-020.1350image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr15:60422176-60422776:-HNSCEER1.2195e-024.3323e-031.2636e-01image
ENSG00000128915.10,ICE2HNSCEAG1.4372e-025.1357e-031.3383e-01image

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3. Enriched editing regions and immune related genes for ICE2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:60422176-60422776:-GBMEERENSG00000168268,NT5DC2-0.43354.1860e-052.5909e-08-0.4314imageNNNAMonocytesGSVA_HALLMARK_BILE_ACID_METABOLISM
chr15:60422176-60422776:-KICHEERENSG00000131153,GINS2-0.52733.4714e-022.6165e-04-0.4446imageNNNAMonocytesGSVA_HALLMARK_E2F_TARGETS
chr15:60422176-60422776:-PAADEERENSG00000101311,FERMT10.37931.4076e-032.4972e-070.4167imageNNFERMT1T_cells_CD8GSVA_HALLMARK_MTORC1_SIGNALING
chr15:60422176-60422776:-PAADEERENSG00000159346,ADIPOR10.36962.6300e-031.9181e-070.4203imageNNNAT_cells_CD8GSVA_HALLMARK_MTORC1_SIGNALING
chr15:60422176-60422776:-PAADEERENSG00000143321,HDGF0.36502.7436e-031.4446e-070.4241imageNNNAT_cells_CD8GSVA_HALLMARK_MYC_TARGETS_V1
chr15:60422176-60422776:-PAADEERENSG00000143774,GUK10.32729.8183e-036.6893e-070.4028imageNNNAMacrophages_M0GSVA_HALLMARK_DNA_REPAIR
chr15:60422176-60422776:-UVMEERENSG00000123395,ATG1010.50524.3270e-033.7803e-040.4476imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_DNA_REPAIR
chr15:60422176-60422776:-UVMEERENSG00000164292,RHOBTB3-0.47051.0379e-025.4448e-04-0.4367imageNNNAEosinophilsGSVA_HALLMARK_KRAS_SIGNALING_DN
chr15:60422176-60422776:-UVMEERENSG00000141971,MVB12A0.45281.3757e-025.8651e-040.4344imageNNNAGSVA_HALLMARK_ANDROGEN_RESPONSE
chr15:60422176-60422776:-UVMEERENSG00000128641,MYO1B-0.43981.8475e-026.4176e-04-0.4316imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_DN

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4. Enriched editing regions and immune related splicing for ICE2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000128915.10,ICE2
TGCTEAGESENSG00000241852.5chr822602199:22602312:22602536:22602643:22603194:226041330.28491.0821e-021.4979e-050.4124imageNBUD13;CNBP;CSTF2T;DDX54;DGCR8;DICER1;EIF4A3;EWSR1;FAM120A;FBL;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPK;HNRNPL;HNRNPU;IGF2BP2;MOV10;NONO;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;SF3A3;SF3B4;SLTM;SRSF1;TAF15;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1NAB_cells_naiveGSVA_HALLMARK_ADIPOGENESIS
chr15:60422176-60422776:-
TGCTEERESENSG00000241852.5chr822602199:22602312:22602536:22602643:22603194:226041330.29009.6916e-034.8387e-060.4333imageNNNAB_cells_naiveGSVA_HALLMARK_ADIPOGENESIS
chr15:60422176-60422776:-
THYMEERESENSG00000141140.12chr1736501165:36501235:36501851:36501961:36503096:36503200-0.35977.6851e-033.1986e-05-0.4032imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr15:60422176-60422776:-
THYMEERA3ENSG00000165238.12chr993299114:93299261:93306776:93306821:93300050:93306821-0.41812.7088e-031.5349e-06-0.4473imageNNWNK2T_cells_CD4_memory_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000128915.10,ICE2
THYMEAGESENSG00000165238.12chr993299114:93299261:93306776:93306821:93308327:93308584-0.40136.7702e-031.4219e-05-0.4061imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS3;LIN28;LIN28A;LIN28B;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZNF184WNK2T_cells_CD4_memory_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000128915.10,ICE2
THYMEAGIRENSG00000105298.9chr193610644:3610971:3611903:3612413-0.41404.7709e-038.5671e-07-0.4529imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YTHDF2;YWHAG;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000128915.10,ICE2
THYMEAGMEXENSG00000135473.10chr1256317600:56317643:56318270:56318434:56319087:56319206:56319307:563194890.30331.0757e-029.2381e-050.4158imageNACIN1;ADAR;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RC3H1;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:60422176-60422776:-
THYMEERMEXENSG00000103978.11chr1542228711:42228820:42231191:42231260:42231843:42231915:42233212:42233306-0.31654.1408e-022.5487e-05-0.4021imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr15:60422176-60422776:-
THYMEERIRENSG00000103888.11chr1580946943:80947065:80948796:80949162-0.25833.9474e-025.0818e-05-0.4053imageNNNAMacrophages_M0GSVA_HALLMARK_HYPOXIA
ENSG00000128915.10,ICE2
THYMEAGESENSG00000141140.12chr1736501165:36501235:36501851:36501961:36503096:36503200-0.35629.1777e-033.6691e-05-0.4004imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for ICE2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:60422176-60422776:-BLCAEERMacrophages_M17.1899e-040.2010image
ENSG00000128915.10,ICE2BLCAEAGMacrophages_M14.8136e-040.2073image
chr15:60422176-60422776:-BRCAEERMacrophages_M19.9218e-060.1397image
ENSG00000128915.10,ICE2BRCAEAGMacrophages_M11.0895e-050.1386image
chr15:60422176-60422776:-CESCEERMacrophages_M04.4627e-02-0.1274image
ENSG00000128915.10,ICE2CESCEAGMacrophages_M04.5511e-02-0.1269image
ENSG00000128915.10,ICE2CHOLEAGT_cells_CD4_naive2.5327e-02-0.4296image
chr15:60422176-60422776:-COADEERMacrophages_M11.9882e-020.1595image
ENSG00000128915.10,ICE2COADEAGMast_cells_activated6.3182e-03-0.1848image
chr15:60422176-60422776:-DLBCEERMacrophages_M14.5517e-020.3505image
ENSG00000128915.10,ICE2DLBCEAGMacrophages_M14.5517e-020.3505image
ENSG00000128915.10,ICE2ESCAEAGT_cells_CD4_memory_activated4.0436e-02-0.1728image
chr15:60422176-60422776:-GBMEERMacrophages_M13.1429e-030.2373image
ENSG00000128915.10,ICE2GBMEAGMacrophages_M19.9502e-030.2078image
chr15:60422176-60422776:-HNSCEERMacrophages_M11.3862e-030.1756image
ENSG00000128915.10,ICE2HNSCEAGMacrophages_M11.3955e-030.1755image
chr15:60422176-60422776:-KICHEERMonocytes6.7093e-030.3382image
ENSG00000128915.10,ICE2KICHEAGMonocytes7.5028e-030.3338image
chr15:60422176-60422776:-KIRCEERT_cells_follicular_helper2.2750e-040.1939image
ENSG00000128915.10,ICE2KIRCEAGT_cells_follicular_helper1.2220e-030.1700image
chr15:60422176-60422776:-KIRPEERT_cells_CD4_memory_resting2.7481e-04-0.2314image
ENSG00000128915.10,ICE2KIRPEAGT_cells_CD4_memory_resting2.5760e-04-0.2324image
chr15:60422176-60422776:-LAMLEERNeutrophils4.0714e-020.2453image
ENSG00000128915.10,ICE2LAMLEAGNeutrophils1.5910e-020.2832image
chr15:60422176-60422776:-LGGEERT_cells_CD4_memory_activated1.6588e-030.1385image
ENSG00000128915.10,ICE2LGGEAGT_cells_CD4_memory_activated1.5395e-030.1395image
chr15:60422176-60422776:-LUADEERT_cells_CD4_memory_activated1.1367e-030.1745image
ENSG00000128915.10,ICE2LUADEAGT_cells_CD4_memory_activated1.6040e-030.1693image
chr15:60422176-60422776:-LUSCEERT_cells_CD4_memory_activated1.8379e-020.1174image
ENSG00000128915.10,ICE2LUSCEAGT_cells_CD81.7432e-020.1184image
chr15:60422176-60422776:-MESOEERDendritic_cells_activated3.9619e-020.2320image
ENSG00000128915.10,ICE2MESOEAGDendritic_cells_activated4.4074e-020.2272image
chr15:60422176-60422776:-OVEEREosinophils1.6901e-020.1516image
ENSG00000128915.10,ICE2OVEAGT_cells_gamma_delta1.5805e-020.1528image
chr15:60422176-60422776:-PAADEERMacrophages_M18.4900e-030.2201image
ENSG00000128915.10,ICE2PAADEAGMacrophages_M18.4900e-030.2201image
chr15:60422176-60422776:-PCPGEERPlasma_cells4.1840e-030.2192image
ENSG00000128915.10,ICE2PCPGEAGPlasma_cells2.9880e-030.2271image
chr15:60422176-60422776:-PRADEERMacrophages_M13.5310e-030.1324image
ENSG00000128915.10,ICE2PRADEAGMacrophages_M12.8175e-030.1355image
chr15:60422176-60422776:-SARCEERMacrophages_M29.7213e-030.1744image
ENSG00000128915.10,ICE2SARCEAGMacrophages_M29.2391e-030.1755image
chr15:60422176-60422776:-SKCMEERT_cells_follicular_helper2.8159e-030.1545image
ENSG00000128915.10,ICE2SKCMEAGT_cells_follicular_helper2.6573e-030.1554image
chr15:60422176-60422776:-STADEERMast_cells_resting6.5019e-030.1734image
ENSG00000128915.10,ICE2STADEAGMacrophages_M19.3490e-030.1609image
chr15:60422176-60422776:-TGCTEERMacrophages_M21.9461e-04-0.3099image
ENSG00000128915.10,ICE2TGCTEAGMacrophages_M22.2080e-04-0.3074image
chr15:60422176-60422776:-THCAEERB_cells_naive1.4278e-030.1432image
ENSG00000128915.10,ICE2THCAEAGB_cells_naive8.9378e-040.1492image
chr15:60422176-60422776:-THYMEERT_cells_CD4_memory_activated9.7966e-070.4508image
ENSG00000128915.10,ICE2THYMEAGT_cells_CD4_memory_activated7.3514e-070.4554image
chr15:60422176-60422776:-UVMEERT_cells_regulatory_(Tregs)4.0134e-020.2680image
ENSG00000128915.10,ICE2UVMEAGT_cells_regulatory_(Tregs)4.0134e-020.2680image


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6. Enriched editing regions and immune gene sets for ICE2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000128915.10,ICE2BRCAEAG1.7660e-050.13531.6142e-030.09966.4678e-040.10773.3643e-020.0672image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr15:60422176-60422776:-BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEER2.7656e-030.1782image
ENSG00000128915.10,ICE2BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG3.2778e-030.1752image
ENSG00000128915.10,ICE2BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG2.2992e-110.2093image
chr15:60422176-60422776:-BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEER3.2918e-110.2084image
ENSG00000128915.10,ICE2CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5320e-040.2206image
chr15:60422176-60422776:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6900e-040.2239image
ENSG00000128915.10,ICE2CHOLGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.4703e-020.3894image
ENSG00000128915.10,ICE2COADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.4699e-020.1434image
ENSG00000128915.10,ICE2ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.8323e-020.1847image
chr15:60422176-60422776:-ESCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.7558e-020.1690image
chr15:60422176-60422776:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER9.5696e-060.3494image
ENSG00000128915.10,ICE2GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.7271e-050.3322image
ENSG00000128915.10,ICE2HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.5437e-060.2497image
chr15:60422176-60422776:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.6119e-060.2495image
chr15:60422176-60422776:-KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER9.0155e-05-0.2057image
ENSG00000128915.10,ICE2KIRCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG9.4048e-05-0.2046image
ENSG00000128915.10,ICE2KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG9.4068e-060.2799image
chr15:60422176-60422776:-KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER9.1843e-060.2803image
ENSG00000128915.10,ICE2LAMLGSVA_HALLMARK_MYC_TARGETS_V2EAG2.3016e-02-0.2677image
chr15:60422176-60422776:-LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER3.0402e-02-0.2590image
ENSG00000128915.10,ICE2LGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG2.6775e-040.1603image
chr15:60422176-60422776:-LGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.5353e-040.1664image
ENSG00000128915.10,ICE2LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.5034e-030.1623image
chr15:60422176-60422776:-LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.2468e-030.1640image
ENSG00000128915.10,ICE2LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.3721e-020.1126image
chr15:60422176-60422776:-LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.3578e-020.1229image
ENSG00000128915.10,ICE2MESOGSVA_HALLMARK_APOPTOSISEAG2.2014e-020.2574image
chr15:60422176-60422776:-MESOGSVA_HALLMARK_APOPTOSISEER2.1257e-020.2588image
chr15:60422176-60422776:-PAADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER5.9879e-040.2846image
ENSG00000128915.10,ICE2PAADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG5.9879e-040.2846image
ENSG00000128915.10,ICE2PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.9072e-02-0.1802image
chr15:60422176-60422776:-PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.6312e-02-0.1612image
ENSG00000128915.10,ICE2PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.8832e-060.2060image
chr15:60422176-60422776:-PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.3674e-060.2036image
chr15:60422176-60422776:-READGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.1783e-020.2578image
ENSG00000128915.10,ICE2READGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.2953e-020.2557image
ENSG00000128915.10,ICE2SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.8107e-040.2431image
chr15:60422176-60422776:-SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.8111e-040.2431image
chr15:60422176-60422776:-SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.8423e-050.2068image
ENSG00000128915.10,ICE2SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.9834e-050.2065image
chr15:60422176-60422776:-STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.0797e-020.1308image
ENSG00000128915.10,ICE2STADGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.7363e-020.1368image
chr15:60422176-60422776:-TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.3319e-030.2397image
ENSG00000128915.10,ICE2TGCTGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.9455e-030.2422image
ENSG00000128915.10,ICE2THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.1681e-080.2459image
chr15:60422176-60422776:-THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER9.7311e-080.2373image
chr15:60422176-60422776:-THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER7.3909e-060.4164image
ENSG00000128915.10,ICE2THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG7.0385e-060.4173image
ENSG00000128915.10,ICE2UVMGSVA_HALLMARK_P53_PATHWAYEAG2.1161e-020.2996image
chr15:60422176-60422776:-UVMGSVA_HALLMARK_P53_PATHWAYEER2.1161e-020.2996image


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7. Enriched editing regions and drugs for ICE2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000128915.10,ICE2ACCGDC0941EAG8.6894e-040.4255image
chr15:60422176-60422776:-ACCGDC0941EER8.6894e-040.4255image
chr15:60422176-60422776:-BLCAKIN001.135EER2.4302e-04-0.2176image
ENSG00000128915.10,ICE2BLCAGSK.650394EAG1.1603e-030.1932image
chr15:60422176-60422776:-BRCAAP.24534EER2.0442e-040.1176image
ENSG00000128915.10,ICE2BRCACCT007093EAG5.9175e-050.1267image
ENSG00000128915.10,ICE2CESCImatinibEAG2.0420e-030.1946image
chr15:60422176-60422776:-CESCImatinibEER2.1957e-030.1932image
ENSG00000128915.10,ICE2CHOLBIRB.0796EAG1.8721e-030.5709image
chr15:60422176-60422776:-COADCisplatinEER3.3045e-02-0.1461image
chr15:60422176-60422776:-ESCAABT.263EER4.9316e-040.2928image
ENSG00000128915.10,ICE2ESCAABT.263EAG2.6244e-040.3028image
chr15:60422176-60422776:-GBMCytarabineEER1.1450e-060.3815image
ENSG00000128915.10,ICE2GBMCytarabineEAG5.6170e-060.3578image
ENSG00000128915.10,ICE2HNSCCytarabineEAG1.1450e-030.1785image
chr15:60422176-60422776:-HNSCCytarabineEER1.1392e-030.1786image
ENSG00000128915.10,ICE2KICHABT.263EAG1.8566e-030.3846image
chr15:60422176-60422776:-KICHABT.263EER1.7423e-030.3867image
ENSG00000128915.10,ICE2KIRCAS601245EAG1.3672e-050.2273image
chr15:60422176-60422776:-KIRCBicalutamideEER8.5537e-040.1757image
chr15:60422176-60422776:-KIRPDMOGEER4.7485e-05-0.2579image
ENSG00000128915.10,ICE2KIRPDMOGEAG5.0106e-05-0.2571image
ENSG00000128915.10,ICE2LAMLCytarabineEAG7.9823e-030.3103image
chr15:60422176-60422776:-LAMLCytarabineEER1.1964e-020.2989image
ENSG00000128915.10,ICE2LGGBMS.708163EAG5.0815e-06-0.1998image
chr15:60422176-60422776:-LGGBMS.708163EER1.9004e-06-0.2085image
ENSG00000128915.10,ICE2LUADABT.888EAG2.6201e-04-0.1953image
chr15:60422176-60422776:-LUADABT.888EER2.0734e-04-0.1985image
ENSG00000128915.10,ICE2LUSCGW.441756EAG2.2625e-04-0.1827image
chr15:60422176-60422776:-LUSCGW.441756EER1.7151e-04-0.1861image
ENSG00000128915.10,ICE2MESODMOGEAG2.1271e-02-0.2588image
chr15:60422176-60422776:-MESODMOGEER2.1892e-02-0.2576image
ENSG00000128915.10,ICE2OVLenalidomideEAG3.9100e-030.1826image
chr15:60422176-60422776:-OVBryostatin.1EER1.7786e-03-0.1975image
chr15:60422176-60422776:-PAADBX.795EER4.8347e-030.2352image
ENSG00000128915.10,ICE2PAADBX.795EAG4.8347e-030.2352image
chr15:60422176-60422776:-PRADCytarabineEER2.0232e-040.1681image
ENSG00000128915.10,ICE2PRADCytarabineEAG2.7660e-040.1646image
ENSG00000128915.10,ICE2SARCBortezomibEAG1.0980e-04-0.2584image
chr15:60422176-60422776:-SARCBortezomibEER1.2056e-04-0.2569image
chr15:60422176-60422776:-SKCMCGP.082996EER3.7429e-03-0.1500image
ENSG00000128915.10,ICE2SKCMCGP.082996EAG3.5874e-03-0.1506image
chr15:60422176-60422776:-STADCyclopamineEER1.0751e-020.1634image
ENSG00000128915.10,ICE2STADCyclopamineEAG1.4447e-020.1521image
ENSG00000128915.10,ICE2TGCTCI.1040EAG1.6035e-03-0.2643image
chr15:60422176-60422776:-TGCTDocetaxelEER1.2828e-030.2695image
chr15:60422176-60422776:-THCACI.1040EER1.1979e-09-0.2695image
ENSG00000128915.10,ICE2THCACI.1040EAG2.3703e-09-0.2647image
chr15:60422176-60422776:-THYMCCT018159EER1.8242e-06-0.4406image
ENSG00000128915.10,ICE2THYMCCT018159EAG1.8145e-06-0.4407image
chr15:60422176-60422776:-UCECDasatinibEER3.4010e-02-0.1756image
ENSG00000128915.10,ICE2UCECDasatinibEAG2.0382e-03-0.2524image
chr15:60422176-60422776:-UCSABT.888EER2.0312e-02-0.3242image
ENSG00000128915.10,ICE2UCSABT.888EAG1.3353e-02-0.3410image
chr15:60422176-60422776:-UVMGW843682XEER7.7244e-04-0.4258image
ENSG00000128915.10,ICE2UVMGW843682XEAG7.7244e-04-0.4258image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType