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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NEIL1 (ImmuneEditome ID:79661)

1. Gene summary of enriched editing regions for NEIL1

check button Gene summary
Gene informationGene symbol

NEIL1

Gene ID

79661

GeneSynonymsFPG1|NEI1|hFPG1
GeneCytomap

15q24.2

GeneTypeprotein-coding
GeneDescriptionendonuclease 8-like 1|DNA endonuclease eight-like glycosylase 1|DNA glycosylase/AP lyase Neil1|DNA-(apurinic or apyrimidinic site) lyase Neil1|NEH1|endonuclease VIII|endonuclease VIII-like 1|nei endonuclease VIII-like 1|nei homolog 1|nei-like protein 1
GeneModificationdate20230329
UniprotIDQ96FI4;H3BTX5;H3BQU8;H3BN83;H3BST2;H3BRZ2;H3BM98;H3BT75;H3BSZ5;H3BT94;H3BQE8;H3BU98
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:75349517-75349813:+ENST00000564951.1ENSG00000140398.12NEIL1ncRNA_exonicAluSgchr15:75349517-75349813:+.alignment
chr15:75351291-75353536:+ENST00000355059.7ENSG00000140398.12NEIL1exonicAluSq2,(AC)n,AluJb,AluSx1,MIR1_Amn,AluYh3a3chr15:75351291-75353536:+.alignment
chr15:75351291-75353536:+ENST00000564784.4ENSG00000140398.12NEIL1exonicAluSq2,(AC)n,AluJb,AluSx1,MIR1_Amn,AluYh3a3chr15:75351291-75353536:+.alignment
chr15:75351291-75353536:+ENST00000565051.4ENSG00000140398.12NEIL1exonicAluSq2,(AC)n,AluJb,AluSx1,MIR1_Amn,AluYh3a3chr15:75351291-75353536:+.alignment
chr15:75351291-75353536:+ENST00000567005.1ENSG00000140398.12NEIL1exonicAluSq2,(AC)n,AluJb,AluSx1,MIR1_Amn,AluYh3a3chr15:75351291-75353536:+.alignment
chr15:75351291-75353536:+ENST00000567657.4ENSG00000140398.12NEIL1exonicAluSq2,(AC)n,AluJb,AluSx1,MIR1_Amn,AluYh3a3chr15:75351291-75353536:+.alignment
chr15:75351291-75353536:+ENST00000568519.4ENSG00000140398.12NEIL1exonicAluSq2,(AC)n,AluJb,AluSx1,MIR1_Amn,AluYh3a3chr15:75351291-75353536:+.alignment
chr15:75351291-75353536:+ENST00000569035.4ENSG00000140398.12NEIL1exonicAluSq2,(AC)n,AluJb,AluSx1,MIR1_Amn,AluYh3a3chr15:75351291-75353536:+.alignment


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2. Tumor-specific enriched editing regions for NEIL1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000140398.12,NEIL1BRCAEAG1.5068e-07image
ENSG00000140398.12,NEIL1KICHEAG5.3209e-07image
ENSG00000140398.12,NEIL1KIRCEAG2.1046e-25image
ENSG00000140398.12,NEIL1KIRPEAG9.4927e-04image
ENSG00000140398.12,NEIL1LIHCEAG1.3136e-08image
ENSG00000140398.12,NEIL1LUADEAG2.6607e-02image
chr15:75351291-75353536:+LUSCEER3.9970e-02image
chr15:75351291-75353536:+PRADEER4.9231e-02image
ENSG00000140398.12,NEIL1PRADEAG3.1480e-07image
ENSG00000140398.12,NEIL1THCAEAG3.8566e-02image
chr15:75351291-75353536:+UCECEER4.3918e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000140398.12,NEIL1KIRCPathEAG3.1301e-024.7586e-02-0.0989image
ENSG00000140398.12,NEIL1UVMCliEAG4.5502e-036.2388e-030.4017image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr15:75349517-75349813:+STADEER1.3784e-022.4669e-021.8297e-08image

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3. Enriched editing regions and immune related genes for NEIL1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:75351291-75353536:+THYMEERENSG00000124733,MEA10.50973.3722e-055.4965e-070.4992imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000204272,LINC014200.48484.5439e-052.1562e-060.4757imageNNNAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:75351291-75353536:+THYMEERENSG00000255328,RP11-326C3.120.46171.0273e-045.4401e-070.4994imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000174021,GNG50.47111.0867e-047.0157e-060.4539imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000272047,GTF2H50.46871.5767e-041.8433e-060.4785imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000144026,ZNF514-0.47651.7830e-041.0063e-05-0.4469imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:75351291-75353536:+THYMEERENSG00000272667,RP11-395A13.20.46531.8209e-048.5994e-060.4500imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr15:75351291-75353536:+THYMEERENSG00000168286,THAP110.46821.8505e-043.9624e-060.4646imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000267595,RP11-242D8.2-0.45042.1155e-041.7592e-05-0.4358imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124177,CHD6-0.46382.3784e-048.4711e-07-0.4919imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124733,MEA10.50973.3722e-055.4965e-070.4992imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000204272,LINC014200.48484.5439e-052.1562e-060.4757imageNNNAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:75351291-75353536:+THYMEERENSG00000255328,RP11-326C3.120.46171.0273e-045.4401e-070.4994imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000174021,GNG50.47111.0867e-047.0157e-060.4539imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000272047,GTF2H50.46871.5767e-041.8433e-060.4785imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000144026,ZNF514-0.47651.7830e-041.0063e-05-0.4469imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:75351291-75353536:+THYMEERENSG00000272667,RP11-395A13.20.46531.8209e-048.5994e-060.4500imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr15:75351291-75353536:+THYMEERENSG00000168286,THAP110.46821.8505e-043.9624e-060.4646imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000267595,RP11-242D8.2-0.45042.1155e-041.7592e-05-0.4358imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124177,CHD6-0.46382.3784e-048.4711e-07-0.4919imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124733,MEA10.50973.3722e-055.4965e-070.4992imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000204272,LINC014200.48484.5439e-052.1562e-060.4757imageNNNAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:75351291-75353536:+THYMEERENSG00000255328,RP11-326C3.120.46171.0273e-045.4401e-070.4994imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000174021,GNG50.47111.0867e-047.0157e-060.4539imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000272047,GTF2H50.46871.5767e-041.8433e-060.4785imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000144026,ZNF514-0.47651.7830e-041.0063e-05-0.4469imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:75351291-75353536:+THYMEERENSG00000272667,RP11-395A13.20.46531.8209e-048.5994e-060.4500imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr15:75351291-75353536:+THYMEERENSG00000168286,THAP110.46821.8505e-043.9624e-060.4646imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000267595,RP11-242D8.2-0.45042.1155e-041.7592e-05-0.4358imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124177,CHD6-0.46382.3784e-048.4711e-07-0.4919imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124733,MEA10.50973.3722e-055.4965e-070.4992imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000204272,LINC014200.48484.5439e-052.1562e-060.4757imageNNNAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:75351291-75353536:+THYMEERENSG00000255328,RP11-326C3.120.46171.0273e-045.4401e-070.4994imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000174021,GNG50.47111.0867e-047.0157e-060.4539imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000272047,GTF2H50.46871.5767e-041.8433e-060.4785imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000144026,ZNF514-0.47651.7830e-041.0063e-05-0.4469imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:75351291-75353536:+THYMEERENSG00000272667,RP11-395A13.20.46531.8209e-048.5994e-060.4500imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr15:75351291-75353536:+THYMEERENSG00000168286,THAP110.46821.8505e-043.9624e-060.4646imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000267595,RP11-242D8.2-0.45042.1155e-041.7592e-05-0.4358imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124177,CHD6-0.46382.3784e-048.4711e-07-0.4919imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124733,MEA10.50973.3722e-055.4965e-070.4992imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000204272,LINC014200.48484.5439e-052.1562e-060.4757imageNNNAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:75351291-75353536:+THYMEERENSG00000255328,RP11-326C3.120.46171.0273e-045.4401e-070.4994imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000174021,GNG50.47111.0867e-047.0157e-060.4539imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000272047,GTF2H50.46871.5767e-041.8433e-060.4785imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000144026,ZNF514-0.47651.7830e-041.0063e-05-0.4469imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:75351291-75353536:+THYMEERENSG00000272667,RP11-395A13.20.46531.8209e-048.5994e-060.4500imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr15:75351291-75353536:+THYMEERENSG00000168286,THAP110.46821.8505e-043.9624e-060.4646imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000267595,RP11-242D8.2-0.45042.1155e-041.7592e-05-0.4358imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124177,CHD6-0.46382.3784e-048.4711e-07-0.4919imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124733,MEA10.50973.3722e-055.4965e-070.4992imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000204272,LINC014200.48484.5439e-052.1562e-060.4757imageNNNAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:75351291-75353536:+THYMEERENSG00000255328,RP11-326C3.120.46171.0273e-045.4401e-070.4994imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000174021,GNG50.47111.0867e-047.0157e-060.4539imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000272047,GTF2H50.46871.5767e-041.8433e-060.4785imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000144026,ZNF514-0.47651.7830e-041.0063e-05-0.4469imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:75351291-75353536:+THYMEERENSG00000272667,RP11-395A13.20.46531.8209e-048.5994e-060.4500imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr15:75351291-75353536:+THYMEERENSG00000168286,THAP110.46821.8505e-043.9624e-060.4646imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000267595,RP11-242D8.2-0.45042.1155e-041.7592e-05-0.4358imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124177,CHD6-0.46382.3784e-048.4711e-07-0.4919imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124733,MEA10.50973.3722e-055.4965e-070.4992imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000204272,LINC014200.48484.5439e-052.1562e-060.4757imageNNNAT_cells_follicular_helperGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:75351291-75353536:+THYMEERENSG00000255328,RP11-326C3.120.46171.0273e-045.4401e-070.4994imageNNNAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000174021,GNG50.47111.0867e-047.0157e-060.4539imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000272047,GTF2H50.46871.5767e-041.8433e-060.4785imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr15:75351291-75353536:+THYMEERENSG00000144026,ZNF514-0.47651.7830e-041.0063e-05-0.4469imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr15:75351291-75353536:+THYMEERENSG00000272667,RP11-395A13.20.46531.8209e-048.5994e-060.4500imageNNNAMacrophages_M1GSVA_HALLMARK_E2F_TARGETS
chr15:75351291-75353536:+THYMEERENSG00000168286,THAP110.46821.8505e-043.9624e-060.4646imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_DNA_REPAIR
chr15:75351291-75353536:+THYMEERENSG00000267595,RP11-242D8.2-0.45042.1155e-041.7592e-05-0.4358imageNNNAMast_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr15:75351291-75353536:+THYMEERENSG00000124177,CHD6-0.46382.3784e-048.4711e-07-0.4919imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

More results



Top

4. Enriched editing regions and immune related splicing for NEIL1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000087274.12chr42904763:2905108:2907742:2907813-0.34904.3365e-098.5180e-13-0.4076imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_APICAL_JUNCTION
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000128309.12chr2237024191:37024810:37026998:37027053-0.32641.5438e-089.1867e-13-0.4202imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000110237.3chr1173364451:73364600:73365389:73365564-0.30636.0318e-083.9286e-12-0.4160imageNACIN1;AUH;BCCIP;BUD13;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;KHDRBS2;LARP7;LIN28;MBNL2;MOV10;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;YTHDC1;ZNF184ARHGEF17T_cells_CD4_naiveGSVA_HALLMARK_APICAL_JUNCTION
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000163320.6chr388055413:88057292:88058018:88058223-0.30036.4200e-081.9384e-11-0.4172imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000092841.14chr1256158683:56158711:56158901:56158940-0.32027.3408e-086.2323e-13-0.4125imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_MYOGENESIS
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000013374.11chr7151368734:151374243:151375847:151375943-0.30868.0021e-085.3762e-11-0.4010imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184NUB1T_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000162910.14chr1228107667:228108321:228108436:228108474-0.32758.7883e-081.0827e-12-0.4020imageNADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;LIN28;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;VIM;XRN2;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000139625.8chr1253481940:53482369:53482564:53483189-0.31429.5631e-081.0564e-12-0.4171imageNACIN1;ADAR;BUD13;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;LIN28;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SF3B4;SLTM;SMNDC1;SRSF1;SRSF7;TAF15;TARDBP;TIA1;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184MAP3K12T_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000182473.16chr1776089174:76091235:76094413:76094489-0.29861.0492e-074.0512e-13-0.4441imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28;LSM11;MBNL2;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184EXOC7T_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000140398.12,NEIL1
BLCAEAGIRENSG00000267216.1chr1958306034:58306216:58312196:58312462-0.31211.0939e-071.1041e-11-0.4015imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP7;LIN28;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;VIM;XRN2;YTHDC1;ZNF184NAT_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP

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5. Enriched editing regions and immune infiltration for NEIL1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:75351291-75353536:+ACCEERNK_cells_activated3.6648e-030.5397image
chr15:75351291-75353536:+BLCAEERT_cells_CD4_memory_resting3.9146e-02-0.1414image
ENSG00000140398.12,NEIL1BLCAEAGT_cells_CD4_memory_resting1.1553e-02-0.1393image
chr15:75351291-75353536:+BRCAEERB_cells_naive8.6571e-03-0.0969image
ENSG00000140398.12,NEIL1BRCAEAGB_cells_naive3.0170e-05-0.1352image
chr15:75351291-75353536:+CESCEERT_cells_CD4_memory_activated4.4687e-020.1771image
ENSG00000140398.12,NEIL1CESCEAGB_cells_naive1.0887e-03-0.2218image
ENSG00000140398.12,NEIL1COADEAGT_cells_CD4_memory_activated3.0750e-020.1477image
ENSG00000140398.12,NEIL1DLBCEAGNeutrophils1.8313e-020.3760image
chr15:75351291-75353536:+ESCAEERB_cells_naive2.1116e-02-0.2292image
chr15:75351291-75353536:+GBMEERMacrophages_M23.5256e-020.2274image
ENSG00000140398.12,NEIL1GBMEAGT_cells_CD82.0509e-020.2168image
chr15:75351291-75353536:+HNSCEERT_cells_follicular_helper7.8943e-030.5288image
chr15:75351291-75353536:+KIRCEERPlasma_cells1.3644e-040.2868image
ENSG00000140398.12,NEIL1KIRCEAGB_cells_naive4.9749e-030.1668image
chr15:75351291-75353536:+KIRPEERMacrophages_M24.8669e-020.1576image
ENSG00000140398.12,NEIL1KIRPEAGNK_cells_activated4.7215e-03-0.1837image
ENSG00000140398.12,NEIL1LAMLEAGT_cells_follicular_helper1.3322e-030.4017image
chr15:75351291-75353536:+LGGEERNK_cells_resting3.3347e-02-0.1067image
ENSG00000140398.12,NEIL1LGGEAGT_cells_CD4_naive4.2739e-04-0.1589image
ENSG00000140398.12,NEIL1LIHCEAGMacrophages_M11.1520e-02-0.1455image
chr15:75351291-75353536:+LUADEERMast_cells_activated5.3288e-030.1589image
ENSG00000140398.12,NEIL1LUADEAGT_cells_CD87.0214e-030.1330image
chr15:75351291-75353536:+LUSCEERDendritic_cells_resting8.3358e-030.1884image
ENSG00000140398.12,NEIL1LUSCEAGDendritic_cells_resting2.0113e-020.1266image
chr15:75351291-75353536:+MESOEERDendritic_cells_activated1.0538e-020.3906image
ENSG00000140398.12,NEIL1MESOEAGDendritic_cells_activated3.9873e-020.2661image
chr15:75351291-75353536:+OVEERT_cells_follicular_helper1.0093e-020.1974image
ENSG00000140398.12,NEIL1OVEAGT_cells_follicular_helper2.6054e-020.1562image
chr15:75351291-75353536:+PAADEEREosinophils2.6686e-020.2032image
ENSG00000140398.12,NEIL1PAADEAGT_cells_CD4_memory_activated4.5757e-020.1628image
chr15:75351291-75353536:+PCPGEERDendritic_cells_resting5.8429e-040.2999image
ENSG00000140398.12,NEIL1PCPGEAGT_cells_CD4_memory_resting8.4298e-04-0.2530image
chr15:75351291-75353536:+PRADEERT_cells_regulatory_(Tregs)8.6112e-03-0.1359image
ENSG00000140398.12,NEIL1PRADEAGDendritic_cells_resting7.1737e-030.1222image
chr15:75351291-75353536:+READEERB_cells_memory1.3550e-02-0.3826image
chr15:75351291-75353536:+SARCEERT_cells_CD4_memory_activated3.0804e-020.2970image
ENSG00000140398.12,NEIL1SARCEAGT_cells_regulatory_(Tregs)2.0416e-02-0.2250image
chr15:75351291-75353536:+SKCMEERDendritic_cells_resting4.4778e-020.1859image
ENSG00000140398.12,NEIL1SKCMEAGB_cells_memory7.0661e-03-0.1836image
chr15:75349517-75349813:+STADEERT_cells_follicular_helper2.1162e-02-0.5115image
chr15:75351291-75353536:+STADEERT_cells_regulatory_(Tregs)4.5169e-04-0.2495image
ENSG00000140398.12,NEIL1STADEAGB_cells_naive4.5103e-04-0.2144image
ENSG00000140398.12,NEIL1TGCTEAGT_cells_CD4_memory_resting2.3367e-020.2052image
ENSG00000140398.12,NEIL1THCAEAGT_cells_follicular_helper1.7920e-02-0.1079image
chr15:75351291-75353536:+THYMEERMacrophages_M01.2113e-02-0.2634image
ENSG00000140398.12,NEIL1THYMEAGMast_cells_resting1.3824e-030.2999image
chr15:75351291-75353536:+UCECEERPlasma_cells8.1599e-03-0.2742image
ENSG00000140398.12,NEIL1UCSEAGMast_cells_resting2.2299e-020.4091image
ENSG00000140398.12,NEIL1UVMEAGT_cells_CD4_memory_resting1.7890e-02-0.3515image


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6. Enriched editing regions and immune gene sets for NEIL1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000140398.12,NEIL1KIRPEAG6.7040e-03image7.7621e-070.3157image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr15:75351291-75353536:+BRCAEER4.3754e-050.15037.6925e-030.09841.0502e-020.09452.0745e-030.1136image
ENSG00000140398.12,NEIL1BRCAEAG1.7803e-210.30263.4708e-060.15026.6573e-110.21024.8786e-180.2763image
ENSG00000140398.12,NEIL1STADEAG3.6272e-040.21788.7477e-030.16112.6194e-030.18458.4728e-070.2976image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr15:75351291-75353536:+ACCGSVA_HALLMARK_NOTCH_SIGNALINGEER5.4413e-03-0.5199image
ENSG00000140398.12,NEIL1BLCAGSVA_HALLMARK_COAGULATIONEAG8.6989e-080.2902image
chr15:75351291-75353536:+BLCAGSVA_HALLMARK_MYC_TARGETS_V2EER3.0280e-020.1485image
chr15:75351291-75353536:+BRCAGSVA_HALLMARK_MTORC1_SIGNALINGEER1.7238e-090.2201image
ENSG00000140398.12,NEIL1BRCAGSVA_HALLMARK_GLYCOLYSISEAG9.6449e-450.4340image
chr15:75349517-75349813:+BRCAGSVA_HALLMARK_MITOTIC_SPINDLEEER1.7783e-030.2824image
chr15:75351291-75353536:+CESCGSVA_HALLMARK_APOPTOSISEER1.5046e-030.2766image
ENSG00000140398.12,NEIL1CESCGSVA_HALLMARK_COAGULATIONEAG2.0585e-080.3716image
ENSG00000140398.12,NEIL1CHOLGSVA_HALLMARK_P53_PATHWAYEAG1.2783e-030.5873image
chr15:75351291-75353536:+COADGSVA_HALLMARK_PROTEIN_SECRETIONEER1.6821e-030.2739image
ENSG00000140398.12,NEIL1COADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.1739e-050.2946image
ENSG00000140398.12,NEIL1DLBCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6443e-020.3361image
chr15:75351291-75353536:+DLBCGSVA_HALLMARK_UV_RESPONSE_UPEER1.6843e-030.6560image
ENSG00000140398.12,NEIL1ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.3254e-040.3118image
chr15:75351291-75353536:+ESCAGSVA_HALLMARK_PEROXISOMEEER5.8527e-03-0.2724image
chr15:75351291-75353536:+GBMGSVA_HALLMARK_HYPOXIAEER7.4675e-040.3568image
ENSG00000140398.12,NEIL1GBMGSVA_HALLMARK_ADIPOGENESISEAG5.3934e-060.4115image
ENSG00000140398.12,NEIL1HNSCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.0366e-030.2610image
chr15:75351291-75353536:+HNSCGSVA_HALLMARK_SPERMATOGENESISEER7.5475e-030.5313image
ENSG00000140398.12,NEIL1KICHGSVA_HALLMARK_MYOGENESISEAG3.7701e-020.3143image
ENSG00000140398.12,NEIL1KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.3428e-390.6799image
chr15:75351291-75353536:+KIRCGSVA_HALLMARK_MTORC1_SIGNALINGEER1.4354e-060.3579image
ENSG00000140398.12,NEIL1KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.5927e-170.5179image
chr15:75351291-75353536:+KIRPGSVA_HALLMARK_PEROXISOMEEER2.8965e-030.2362image
ENSG00000140398.12,NEIL1LAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.7615e-020.2547image
ENSG00000140398.12,NEIL1LGGGSVA_HALLMARK_ADIPOGENESISEAG6.5913e-180.3768image
chr15:75351291-75353536:+LGGGSVA_HALLMARK_PROTEIN_SECRETIONEER4.5479e-080.2698image
ENSG00000140398.12,NEIL1LIHCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG6.2801e-120.3826image
chr15:75351291-75353536:+LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.0170e-040.2052image
ENSG00000140398.12,NEIL1LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.4640e-260.4936image
chr15:75351291-75353536:+LUSCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.5194e-020.1603image
ENSG00000140398.12,NEIL1LUSCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG1.7921e-090.3202image
chr15:75351291-75353536:+MESOGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER1.9798e-02-0.3583image
ENSG00000140398.12,NEIL1MESOGSVA_HALLMARK_SPERMATOGENESISEAG4.0444e-02-0.2654image
chr15:75351291-75353536:+OVGSVA_HALLMARK_MTORC1_SIGNALINGEER1.1323e-050.3306image
ENSG00000140398.12,NEIL1OVGSVA_HALLMARK_UV_RESPONSE_UPEAG7.5655e-070.3389image
ENSG00000140398.12,NEIL1PAADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.1565e-070.4018image
chr15:75351291-75353536:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER1.1800e-020.2220image
ENSG00000140398.12,NEIL1PCPGGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.6508e-040.2695image
chr15:75351291-75353536:+PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER4.8400e-050.2088image
ENSG00000140398.12,NEIL1PRADGSVA_HALLMARK_ADIPOGENESISEAG2.0974e-220.4232image
chr15:75351291-75353536:+READGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.0217e-020.3968image
ENSG00000140398.12,NEIL1SARCGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.6653e-040.3398image
chr15:75351291-75353536:+SKCMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.4101e-030.2780image
ENSG00000140398.12,NEIL1SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.2849e-100.4161image
chr15:75349517-75349813:+STADGSVA_HALLMARK_UV_RESPONSE_UPEER2.4851e-020.4998image
chr15:75351291-75353536:+STADGSVA_HALLMARK_ADIPOGENESISEER1.9675e-050.3013image
ENSG00000140398.12,NEIL1STADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.8997e-110.3979image
ENSG00000140398.12,NEIL1TGCTGSVA_HALLMARK_G2M_CHECKPOINTEAG2.1861e-03-0.2748image
chr15:75351291-75353536:+THCAGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER2.3046e-030.1655image
ENSG00000140398.12,NEIL1THCAGSVA_HALLMARK_GLYCOLYSISEAG1.4109e-250.4518image
ENSG00000140398.12,NEIL1THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.3973e-04-0.3232image
chr15:75351291-75353536:+THYMGSVA_HALLMARK_DNA_REPAIREER4.8573e-040.3603image
chr15:75351291-75353536:+UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.1115e-030.2896image
ENSG00000140398.12,NEIL1UCECGSVA_HALLMARK_UV_RESPONSE_UPEAG7.4285e-030.2163image
ENSG00000140398.12,NEIL1UCSGSVA_HALLMARK_E2F_TARGETSEAG1.2279e-020.4443image
ENSG00000140398.12,NEIL1UVMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.0808e-020.3765image


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7. Enriched editing regions and drugs for NEIL1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000140398.12,NEIL1ACCAMG.706EAG2.3172e-03-0.4338image
chr15:75351291-75353536:+ACCCCT007093EER5.5534e-03-0.5189image
ENSG00000140398.12,NEIL1BLCAA.770041EAG5.3345e-07-0.2726image
chr15:75351291-75353536:+BLCAAKT.inhibitor.VIIIEER8.4684e-040.2270image
chr15:75351291-75353536:+BRCABMS.708163EER6.9306e-04-0.1251image
chr15:75349517-75349813:+BRCABI.D1870EER6.7898e-03-0.2459image
ENSG00000140398.12,NEIL1BRCACCT007093EAG8.1331e-210.2977image
chr15:75351291-75353536:+CESCGSK.650394EER3.6021e-03-0.2546image
ENSG00000140398.12,NEIL1CESCDasatinibEAG1.8188e-12-0.4594image
ENSG00000140398.12,NEIL1CHOLDasatinibEAG9.6184e-03-0.4891image
ENSG00000140398.12,NEIL1COADBMS.509744EAG8.8388e-07-0.3286image
chr15:75351291-75353536:+COADMG.132EER9.3987e-03-0.2279image
ENSG00000140398.12,NEIL1DLBCAZD.2281EAG1.3464e-02-0.3925image
chr15:75351291-75353536:+DLBCDocetaxelEER1.3964e-02-0.5401image
ENSG00000140398.12,NEIL1ESCACisplatinEAG2.4466e-07-0.4268image
chr15:75351291-75353536:+ESCACisplatinEER1.0249e-05-0.4234image
ENSG00000140398.12,NEIL1GBMGNF.2EAG5.4627e-03-0.2586image
chr15:75351291-75353536:+GBMGDC.0449EER2.2658e-03-0.3250image
ENSG00000140398.12,NEIL1HNSCJNK.Inhibitor.VIIIEAG1.4447e-030.2798image
chr15:75351291-75353536:+HNSCBexaroteneEER5.4007e-030.5496image
ENSG00000140398.12,NEIL1KICHCytarabineEAG3.4286e-03-0.4318image
chr15:75351291-75353536:+KIRCDasatinibEER1.3513e-04-0.2878image
ENSG00000140398.12,NEIL1KIRCMG.132EAG7.4646e-12-0.3943image
ENSG00000140398.12,NEIL1KIRPMG.132EAG4.5470e-12-0.4322image
chr15:75351291-75353536:+KIRPEpothilone.BEER1.1092e-030.2579image
ENSG00000140398.12,NEIL1LAMLMethotrexateEAG2.5912e-030.3790image
ENSG00000140398.12,NEIL1LGGABT.888EAG1.8747e-100.2832image
chr15:75351291-75353536:+LGGBX.795EER1.4496e-02-0.1225image
ENSG00000140398.12,NEIL1LIHCCI.1040EAG7.9341e-08-0.3034image
chr15:75351291-75353536:+LUADAUY922EER1.1984e-02-0.1435image
ENSG00000140398.12,NEIL1LUADBMS.509744EAG1.9815e-08-0.2728image
ENSG00000140398.12,NEIL1LUSCABT.888EAG2.4672e-060.2534image
chr15:75351291-75353536:+LUSCJNK.Inhibitor.VIIIEER7.9404e-040.2383image
chr15:75351291-75353536:+MESOGW.441756EER1.6601e-02-0.3677image
ENSG00000140398.12,NEIL1MESOATRAEAG4.5805e-030.3612image
chr15:75351291-75353536:+OVAS601245EER1.8024e-030.2384image
ENSG00000140398.12,NEIL1OVA.443654EAG2.7251e-04-0.2529image
ENSG00000140398.12,NEIL1PAADLapatinibEAG5.0986e-04-0.2880image
ENSG00000140398.12,NEIL1PCPGDocetaxelEAG2.6490e-06-0.3503image
chr15:75351291-75353536:+PCPGBMS.708163EER4.2676e-04-0.3068image
ENSG00000140398.12,NEIL1PRADABT.888EAG6.1073e-110.2922image
chr15:75351291-75353536:+PRADBMS.708163EER3.5272e-05-0.2124image
chr15:75351291-75353536:+READCyclopamineEER3.1981e-020.3355image
ENSG00000140398.12,NEIL1READGSK.650394EAG2.6777e-030.3511image
ENSG00000140398.12,NEIL1SARCBexaroteneEAG1.7341e-03-0.3007image
chr15:75351291-75353536:+SARCJNK.9LEER7.8269e-030.3615image
ENSG00000140398.12,NEIL1SKCMABT.888EAG1.5637e-030.2149image
chr15:75351291-75353536:+SKCMMidostaurinEER2.8936e-02-0.2020image
chr15:75351291-75353536:+STADJNK.Inhibitor.VIIIEER4.1392e-020.1466image
ENSG00000140398.12,NEIL1STADCCT007093EAG7.8547e-030.1633image
chr15:75349517-75349813:+STADBAY.61.3606EER3.3611e-030.6227image
ENSG00000140398.12,NEIL1TGCTBMS.536924EAG1.4164e-03-0.2858image
ENSG00000140398.12,NEIL1THCAATRAEAG2.2438e-140.3390image
chr15:75351291-75353536:+THCABI.D1870EER1.2778e-02-0.1355image
chr15:75351291-75353536:+THYMJW.7.52.1EER2.0056e-06-0.4770image
ENSG00000140398.12,NEIL1THYMAZ628EAG8.3155e-04-0.3128image
chr15:75351291-75353536:+UCECJNJ.26854165EER3.1449e-03-0.3047image
ENSG00000140398.12,NEIL1UCECAZD.0530EAG1.0584e-05-0.3489image
ENSG00000140398.12,NEIL1UCSAZD7762EAG7.4049e-030.4716image
ENSG00000140398.12,NEIL1UVMJNJ.26854165EAG3.1930e-02-0.3203image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType
chr15:75351291-75353536:+ENST00000355059.7Q96FI4DB01592IronSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000355059.7Q96FI4DB09130CopperSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000355059.7Q96FI4DB14488Ferrous gluconateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000355059.7Q96FI4DB14489Ferrous succinateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000355059.7Q96FI4DB14490Ferrous ascorbateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000355059.7Q96FI4DB14491Ferrous fumarateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000355059.7Q96FI4DB14501Ferrous glycine sulfateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000564784.4Q96FI4DB01592IronSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000564784.4Q96FI4DB09130CopperSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000564784.4Q96FI4DB14488Ferrous gluconateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000564784.4Q96FI4DB14489Ferrous succinateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000564784.4Q96FI4DB14490Ferrous ascorbateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000564784.4Q96FI4DB14491Ferrous fumarateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000564784.4Q96FI4DB14501Ferrous glycine sulfateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000569035.4Q96FI4DB01592IronSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000569035.4Q96FI4DB09130CopperSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000569035.4Q96FI4DB14488Ferrous gluconateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000569035.4Q96FI4DB14489Ferrous succinateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000569035.4Q96FI4DB14490Ferrous ascorbateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000569035.4Q96FI4DB14491Ferrous fumarateSmallMoleculeDrug
chr15:75351291-75353536:+ENST00000569035.4Q96FI4DB14501Ferrous glycine sulfateSmallMoleculeDrug