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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF426 (ImmuneEditome ID:79088)

1. Gene summary of enriched editing regions for ZNF426

check button Gene summary
Gene informationGene symbol

ZNF426

Gene ID

79088

GeneSynonymsK-RBP
GeneCytomap

19p13.2

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 426|CTC-543D15.7|KSHV RTA binding protein
GeneModificationdate20230518
UniprotIDQ9BUY5;K7ER43;A0A1B0GUG0;K7EME3;A0A024R7D7
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:9524481-9526011:-ENST00000253115.5ENSG00000130818.9ZNF426UTR3(TTG)n,AluYh3,L1MCa,AluSx,AluSp,AluYchr19:9524481-9526011:-.alignment
chr19:9531691-9532619:-ENST00000253115.5ENSG00000130818.9ZNF426intronicAluJb,(T)n,MER44B,AluYchr19:9531691-9532619:-.alignment
chr19:9531691-9532619:-ENST00000535489.4ENSG00000130818.9ZNF426intronicAluJb,(T)n,MER44B,AluYchr19:9531691-9532619:-.alignment
chr19:9531691-9532619:-ENST00000589289.1ENSG00000130818.9ZNF426intronicAluJb,(T)n,MER44B,AluYchr19:9531691-9532619:-.alignment
chr19:9531691-9532619:-ENST00000593003.4ENSG00000130818.9ZNF426intronicAluJb,(T)n,MER44B,AluYchr19:9531691-9532619:-.alignment


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2. Tumor-specific enriched editing regions for ZNF426


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000130818.9,ZNF426BRCAEAG1.0075e-05image
chr19:9524481-9526011:-HNSCEER6.5760e-05image
ENSG00000130818.9,ZNF426HNSCEAG1.1985e-03image
ENSG00000130818.9,ZNF426KICHEAG3.7873e-03image
ENSG00000130818.9,ZNF426LUSCEAG4.0384e-04image
ENSG00000130818.9,ZNF426THCAEAG5.3526e-06image
chr19:9524481-9526011:-UCECEER1.0459e-03image
ENSG00000130818.9,ZNF426UCECEAG5.9091e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000130818.9,ZNF426ESCACliEAG2.2399e-023.1864e-02-0.3241image
chr19:9531691-9532619:-ESCAPathEER1.5722e-022.7355e-020.4324image
ENSG00000130818.9,ZNF426KIRCPathEAG3.4546e-034.5989e-030.1359image
ENSG00000130818.9,ZNF426LUSCPathEAG5.4906e-031.1925e-030.1720image
ENSG00000130818.9,ZNF426THCAPathEAG3.3822e-021.7545e-020.1122image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000130818.9,ZNF426COADEAG1.0298e-026.4669e-034.5294e+02image
chr19:9524481-9526011:-LUADEER1.0343e-023.2477e-024.7078e-02image
ENSG00000130818.9,ZNF426LUADEAG2.7764e-024.1107e-028.5118e-02image

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3. Enriched editing regions and immune related genes for ZNF426


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:9524481-9526011:-OVEERENSG00000092010,PSME10.44662.3257e-091.4481e-110.4172imageNBCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;EIF4A3;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;SAFB2;SLBP;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1PSME1T_cells_CD8GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr19:9524481-9526011:-MESOEERENSG00000196646,ZNF136-0.53632.9401e-021.0568e-06-0.5419imageNBCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLTM;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDF1NAMonocytesGSVA_HALLMARK_COAGULATION
chr19:9524481-9526011:-MESOEERENSG00000281490,CICP14-0.52433.3055e-023.1873e-05-0.4724imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:9524481-9526011:-MESOEERENSG00000207721,MIR186-0.50343.7250e-027.7279e-05-0.4516imageNNNAMonocytesGSVA_HALLMARK_UV_RESPONSE_UP
chr19:9524481-9526011:-MESOEERENSG00000221184,MIR1254-1-0.50854.1013e-022.2951e-05-0.4798imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr19:9524481-9526011:-TGCTEERENSG00000119048,UBE2B0.40141.7869e-046.1857e-070.4223imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1UBE2BNK_cells_activatedGSVA_HALLMARK_UV_RESPONSE_UP
chr19:9524481-9526011:-TGCTEERENSG00000100426,ZBED4-0.40142.3836e-041.3742e-06-0.4103imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLBP;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NAMacrophages_M2GSVA_HALLMARK_HEDGEHOG_SIGNALING
chr19:9524481-9526011:-TGCTEERENSG00000204138,PHACTR4-0.39312.4127e-045.4684e-07-0.4242imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NAMacrophages_M2GSVA_HALLMARK_UV_RESPONSE_DN
chr19:9524481-9526011:-TGCTEERENSG00000178449,COX140.38044.8235e-043.6169e-070.4302imageNBUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;MSI2;NOP56;NOP58;RBFOX2;RBM10;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1NAT_cells_CD8GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:9524481-9526011:-TGCTEERENSG00000118873,RAB3GAP2-0.37786.5839e-041.4528e-06-0.4094imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLBP;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NAMacrophages_M2GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

More results



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4. Enriched editing regions and immune related splicing for ZNF426


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000130818.9,ZNF426
GBMEAGA5ENSG00000006576.12chr777942699:77942786:77940029:77940302:77940029:77940659-0.32014.0156e-036.7003e-06-0.4045imageNACIN1;ADAR;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBM10;RBM22;RBM47;RC3H1;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZNF184NAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
ENSG00000130818.9,ZNF426
GBMEAGMEXENSG00000196405.8chr14100137739:100137802:100138847:100138897:100139051:100139369:100141179:1001412290.31435.1358e-038.9829e-060.4026imageNACIN1;ADAR;BUD13;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBM10;RBM27;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;XRN2;ZNF184NANK_cells_activatedGSVA_HALLMARK_NOTCH_SIGNALING
chr19:9524481-9526011:-
MESOEERIRENSG00000111011.13chr12122518838:122519029:122520503:122520581-0.49073.1215e-028.3516e-07-0.6038imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NAT_cells_follicular_helperGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr19:9524481-9526011:-
SARCEERIRENSG00000140455.12chr1563590660:63591373:63593781:63593915-0.30802.8526e-035.4035e-08-0.4067imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:9524481-9526011:-
SARCEERESENSG00000172869.10chr5119237321:119237414:119238988:119239080:119240418:119240471-0.24711.7892e-026.1629e-09-0.4309imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLBP;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NAGSVA_HALLMARK_IL2_STAT5_SIGNALING
chr19:9524481-9526011:-
SARCEERIRENSG00000164190.12chr537063789:37063978:37064526:370655020.29472.8824e-021.5709e-090.4095imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLBP;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NIPBLMacrophages_M2GSVA_HALLMARK_ALLOGRAFT_REJECTION
chr19:9524481-9526011:-
TGCTEERIRENSG00000154743.13chr312529761:12529873:12531569:12531659-0.38012.3947e-039.9450e-07-0.4229imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLBP;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NANK_cells_restingGSVA_HALLMARK_DNA_REPAIR
chr19:9524481-9526011:-
TGCTEERIRENSG00000141551.10chr1782245975:82246039:82246197:82246591-0.45271.6930e-041.6860e-09-0.5012imageNALYREF;BCCIP;BUD13;CNBP;CPSF6;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;IGF2BP1;IGF2BP2;IGF2BP3;LARP7;LIN28;LIN28B;LSM11;MSI2;NOP56;NOP58;RBFOX2;RBM10;SAFB2;SLBP;SLTM;SMNDC1;SRSF1;SRSF7;SRSF9;TAF15;U2AF2;UPF1;YTHDC1;YTHDF1NAMacrophages_M2GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000130818.9,ZNF426
TGCTEAGIRENSG00000172366.15chr16642119:646608:647416:647544-0.41196.7509e-041.3161e-06-0.4051imageNADAR;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;RANGAP1;RBM10;RBM27;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZNF184NANK_cells_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000130818.9,ZNF426
TGCTEAGIRENSG00000141551.10chr1782245975:82246039:82246197:82246591-0.37982.0901e-037.2231e-07-0.4127imageNACIN1;ADAR;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;LSM11;MBNL1;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PRPF8;PTBP1;QKI;RANGAP1;RBM10;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIAL1;TNRC6A;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YTHDF1;ZNF184NAMacrophages_M2GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

More results



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5. Enriched editing regions and immune infiltration for ZNF426


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000130818.9,ZNF426ACCEAGPlasma_cells1.4352e-020.3891image
ENSG00000130818.9,ZNF426BLCAEAGB_cells_memory8.7030e-03-0.1568image
ENSG00000130818.9,ZNF426BRCAEAGB_cells_naive2.1763e-04-0.1189image
chr19:9524481-9526011:-CESCEERMacrophages_M13.2820e-020.1805image
ENSG00000130818.9,ZNF426CHOLEAGT_cells_regulatory_(Tregs)4.1872e-020.3942image
chr19:9531691-9532619:-ESCAEERT_cells_gamma_delta3.7081e-020.4031image
ENSG00000130818.9,ZNF426GBMEAGPlasma_cells7.8759e-040.2678image
chr19:9524481-9526011:-HNSCEERMacrophages_M19.8471e-030.1478image
ENSG00000130818.9,ZNF426HNSCEAGB_cells_naive2.7557e-02-0.1221image
ENSG00000130818.9,ZNF426KICHEAGMonocytes9.1969e-030.3421image
ENSG00000130818.9,ZNF426KIRCEAGMast_cells_resting2.4142e-04-0.2068image
ENSG00000130818.9,ZNF426KIRPEAGT_cells_CD81.5130e-030.2488image
ENSG00000130818.9,ZNF426LAMLEAGDendritic_cells_activated9.5699e-030.5642image
ENSG00000130818.9,ZNF426LGGEAGB_cells_memory2.8318e-030.1414image
ENSG00000130818.9,ZNF426LIHCEAGMacrophages_M01.3634e-02-0.2142image
chr19:9524481-9526011:-LUADEERT_cells_CD4_memory_activated1.6005e-020.1431image
ENSG00000130818.9,ZNF426LUSCEAGT_cells_CD86.8138e-030.1442image
chr19:9524481-9526011:-MESOEERMonocytes3.6347e-02-0.2489image
ENSG00000130818.9,ZNF426MESOEAGMacrophages_M02.4807e-020.2540image
chr19:9524481-9526011:-OVEERT_cells_CD85.0442e-070.3169image
ENSG00000130818.9,ZNF426OVEAGT_cells_CD4_memory_activated2.9094e-050.2552image
ENSG00000130818.9,ZNF426PAADEAGNeutrophils1.7331e-02-0.2297image
chr19:9524481-9526011:-PRADEERDendritic_cells_resting6.3581e-04-0.1680image
ENSG00000130818.9,ZNF426PRADEAGDendritic_cells_resting4.2481e-04-0.1686image
ENSG00000130818.9,ZNF426READEAGDendritic_cells_activated4.2421e-020.2698image
chr19:9524481-9526011:-SARCEERT_cells_CD88.3416e-030.1856image
ENSG00000130818.9,ZNF426SKCMEAGT_cells_CD83.1802e-050.2183image
chr19:9524481-9526011:-STADEERT_cells_CD4_memory_activated1.6643e-020.1735image
chr19:9531691-9532619:-STADEERPlasma_cells1.1939e-02-0.4605image
ENSG00000130818.9,ZNF426STADEAGT_cells_CD4_memory_activated9.3814e-030.1748image
chr19:9524481-9526011:-TGCTEERMacrophages_M23.6109e-02-0.1847image
ENSG00000130818.9,ZNF426THCAEAGT_cells_CD4_memory_activated2.5243e-030.1422image
ENSG00000130818.9,ZNF426THYMEAGNeutrophils1.7583e-02-0.2370image
chr19:9524481-9526011:-UCECEERPlasma_cells2.1909e-020.2136image
ENSG00000130818.9,ZNF426UCECEAGPlasma_cells5.2301e-030.2382image
ENSG00000130818.9,ZNF426UVMEAGNK_cells_resting1.2180e-02-0.3791image


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6. Enriched editing regions and immune gene sets for ZNF426


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr19:9524481-9526011:-HNSCEER1.3121e-02image6.6115e-030.1554image
ENSG00000130818.9,ZNF426HNSCEAG3.2495e-02image4.7196e-030.1561image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000130818.9,ZNF426BLCAEAG2.2858e-030.18193.6469e-020.12532.6038e-040.21702.2973e-030.1818image
ENSG00000130818.9,ZNF426BRCAEAG1.9135e-050.13731.6527e-020.07723.2393e-020.06909.1826e-040.1066image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000130818.9,ZNF426ACCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG4.6468e-020.3208image
ENSG00000130818.9,ZNF426BLCAGSVA_HALLMARK_GLYCOLYSISEAG5.3114e-040.2061image
ENSG00000130818.9,ZNF426BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG9.8319e-110.2065image
chr19:9524481-9526011:-CESCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2288e-040.3189image
ENSG00000130818.9,ZNF426CESCGSVA_HALLMARK_PEROXISOMEEAG1.6327e-020.1829image
chr19:9524481-9526011:-CHOLGSVA_HALLMARK_HEME_METABOLISMEER4.0727e-03-0.5754image
ENSG00000130818.9,ZNF426CHOLGSVA_HALLMARK_COAGULATIONEAG1.3966e-02-0.4674image
ENSG00000130818.9,ZNF426COADGSVA_HALLMARK_COMPLEMENTEAG4.2454e-020.1863image
chr19:9531691-9532619:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.6301e-030.5555image
ENSG00000130818.9,ZNF426GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.7907e-04-0.2680image
ENSG00000130818.9,ZNF426HNSCGSVA_HALLMARK_COMPLEMENTEAG3.9185e-040.1952image
chr19:9524481-9526011:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.9489e-050.2244image
ENSG00000130818.9,ZNF426KICHGSVA_HALLMARK_ANGIOGENESISEAG3.5763e-030.3797image
ENSG00000130818.9,ZNF426KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.6328e-040.2055image
ENSG00000130818.9,ZNF426KIRPGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG5.3783e-030.2191image
ENSG00000130818.9,ZNF426LGGGSVA_HALLMARK_G2M_CHECKPOINTEAG3.4417e-08-0.2581image
ENSG00000130818.9,ZNF426LIHCGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.0006e-02-0.1890image
chr19:9524481-9526011:-LUADGSVA_HALLMARK_UV_RESPONSE_UPEER2.0302e-060.2780image
ENSG00000130818.9,ZNF426LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.7994e-050.2340image
ENSG00000130818.9,ZNF426LUSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG3.7513e-040.1888image
chr19:9524481-9526011:-MESOGSVA_HALLMARK_UV_RESPONSE_UPEER2.0394e-020.2748image
chr19:9524481-9526011:-OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.5662e-080.3542image
ENSG00000130818.9,ZNF426OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5693e-050.2633image
ENSG00000130818.9,ZNF426PAADGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.9743e-020.2251image
chr19:9524481-9526011:-PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.4732e-05-0.3978image
ENSG00000130818.9,ZNF426PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.4816e-03-0.2715image
chr19:9524481-9526011:-PRADGSVA_HALLMARK_UV_RESPONSE_UPEER5.4584e-040.1700image
ENSG00000130818.9,ZNF426PRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG8.8044e-03-0.1258image
ENSG00000130818.9,ZNF426READGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.0576e-02-0.2721image
ENSG00000130818.9,ZNF426SARCGSVA_HALLMARK_HYPOXIAEAG5.2383e-040.2335image
chr19:9524481-9526011:-SARCGSVA_HALLMARK_COAGULATIONEER6.7355e-070.3420image
ENSG00000130818.9,ZNF426SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.4542e-070.2598image
chr19:9524481-9526011:-STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.5176e-050.2882image
chr19:9531691-9532619:-STADGSVA_HALLMARK_PROTEIN_SECRETIONEER7.9253e-030.4832image
ENSG00000130818.9,ZNF426STADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.9935e-050.2774image
ENSG00000130818.9,ZNF426TGCTGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.5542e-030.2366image
chr19:9524481-9526011:-TGCTGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.4845e-040.3101image
ENSG00000130818.9,ZNF426THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.6170e-050.1910image
ENSG00000130818.9,ZNF426THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG4.2590e-020.2032image
ENSG00000130818.9,ZNF426UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.4300e-030.2708image
chr19:9524481-9526011:-UCECGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.0837e-030.2842image
ENSG00000130818.9,ZNF426UCSGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.1174e-02-0.3466image
ENSG00000130818.9,ZNF426UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG6.2177e-050.5717image


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7. Enriched editing regions and drugs for ZNF426


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000130818.9,ZNF426BLCAEHT.1864EAG6.7827e-050.2362image
ENSG00000130818.9,ZNF426BRCACGP.082996EAG1.2643e-05-0.1402image
chr19:9524481-9526011:-CESCCI.1040EER1.8141e-03-0.2614image
ENSG00000130818.9,ZNF426CESCJW.7.52.1EAG3.6356e-02-0.1597image
chr19:9524481-9526011:-CHOLDMOGEER4.3223e-040.6731image
ENSG00000130818.9,ZNF426CHOLDMOGEAG2.7006e-020.4253image
ENSG00000130818.9,ZNF426COADCisplatinEAG2.0330e-04-0.3342image
ENSG00000130818.9,ZNF426ESCAFH535EAG8.9521e-030.2320image
chr19:9531691-9532619:-ESCABX.795EER2.6328e-05-0.7164image
ENSG00000130818.9,ZNF426GBMCGP.082996EAG3.3043e-05-0.3279image
ENSG00000130818.9,ZNF426HNSCEpothilone.BEAG8.9271e-040.1832image
chr19:9524481-9526011:-HNSCBMS.509744EER1.3903e-05-0.2464image
ENSG00000130818.9,ZNF426KICHA.443654EAG4.0083e-040.4531image
ENSG00000130818.9,ZNF426KIRCCyclopamineEAG4.5036e-05-0.2296image
ENSG00000130818.9,ZNF426KIRPCCT007093EAG1.2416e-030.2531image
ENSG00000130818.9,ZNF426LGGEmbelinEAG1.7833e-060.2244image
ENSG00000130818.9,ZNF426LIHCGW.441756EAG8.0962e-03-0.2296image
chr19:9524481-9526011:-LUADLFM.A13EER7.4456e-030.1588image
ENSG00000130818.9,ZNF426LUADLFM.A13EAG2.6135e-020.1226image
ENSG00000130818.9,ZNF426LUSCCI.1040EAG3.6905e-03-0.1546image
ENSG00000130818.9,ZNF426MESOEHT.1864EAG1.2880e-020.2805image
chr19:9524481-9526011:-MESOGNF.2EER4.0034e-03-0.3375image
chr19:9524481-9526011:-OVBIBW2992EER1.5741e-05-0.2742image
ENSG00000130818.9,ZNF426OVBexaroteneEAG1.1297e-040.2363image
ENSG00000130818.9,ZNF426PAADCI.1040EAG4.7958e-02-0.1917image
chr19:9524481-9526011:-PCPGMidostaurinEER3.3059e-040.3486image
ENSG00000130818.9,ZNF426PCPGErlotinibEAG4.5566e-030.2639image
chr19:9524481-9526011:-PRADEmbelinEER4.2895e-090.2849image
ENSG00000130818.9,ZNF426PRADBAY.61.3606EAG3.0309e-050.1990image
ENSG00000130818.9,ZNF426SARCEHT.1864EAG4.8389e-030.1906image
chr19:9524481-9526011:-SARCDasatinibEER5.8276e-05-0.2796image
ENSG00000130818.9,ZNF426SKCMCI.1040EAG3.1074e-09-0.3071image
chr19:9524481-9526011:-STADCisplatinEER1.7050e-04-0.2694image
chr19:9531691-9532619:-STADCMKEER1.6298e-02-0.4422image
ENSG00000130818.9,ZNF426STADCisplatinEAG3.8750e-04-0.2372image
ENSG00000130818.9,ZNF426TGCTAG.014699EAG4.9011e-030.2399image
chr19:9524481-9526011:-TGCTFTI.277EER1.3174e-040.3303image
ENSG00000130818.9,ZNF426THCAEmbelinEAG8.9435e-090.2671image
ENSG00000130818.9,ZNF426THYMABT.263EAG5.0624e-040.3415image
ENSG00000130818.9,ZNF426UCECBAY.61.3606EAG2.7074e-020.1896image
chr19:9524481-9526011:-UCECABT.888EER1.3259e-02-0.2304image
ENSG00000130818.9,ZNF426UCSGDC.0449EAG8.0688e-030.3944image
ENSG00000130818.9,ZNF426UVMGSK269962AEAG1.2135e-03-0.4772image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType