CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF141 (ImmuneEditome ID:7700)

1. Gene summary of enriched editing regions for ZNF141

check button Gene summary
Gene informationGene symbol

ZNF141

Gene ID

7700

GeneSynonymsD4S90|pHZ-44
GeneCytomap

4p16.3

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 141|zinc finger protein 141 (clone pHZ-44)
GeneModificationdate20230329
UniprotIDD6RIY0;Q15928;D6RB60
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:377856-382256:+ENST00000579770.1ENSG00000131127.12ZNF141ncRNA_exonicAluSc,AluSg,AluSq2,AluSz,L1MA8,MER52-int,L1MA3,MIRb,AluYchr4:377856-382256:+.alignment


Top

2. Tumor-specific enriched editing regions for ZNF141


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr4:377856-382256:+KIRPEER3.5962e-02image
ENSG00000131127.12,ZNF141KIRPEAG3.6443e-02image
chr4:377856-382256:+LUSCEER4.3058e-03image
ENSG00000131127.12,ZNF141LUSCEAG4.6826e-03image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

Top

3. Enriched editing regions and immune related genes for ZNF141


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:377856-382256:+THYMEERENSG00000105677,TMEM1470.48262.9656e-051.8217e-060.4463imageNTARDBPNANK_cells_restingGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:377856-382256:+THYMEERENSG00000167397,VKORC10.46785.6479e-053.1014e-070.4748imageNTARDBPVKORC1T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:377856-382256:+THYMEERENSG00000249592,RP11-440L14.1-0.46457.9126e-051.5774e-05-0.4078imageNTARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr4:377856-382256:+THYMEERENSG00000268357,VN1R81P-0.45328.7842e-054.3884e-06-0.4312imageNNNAT_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:377856-382256:+THYMEERENSG00000129083,COPB1-0.45619.6465e-058.9983e-08-0.4932imageNTARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:377856-382256:+THYMEERENSG00000120690,ELF1-0.45571.2885e-046.7201e-06-0.4236imageNTARDBPELF1T_cells_CD4_naiveGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:377856-382256:+THYMEERENSG00000272886,DCP1A-0.45301.4900e-049.8429e-06-0.4166imageNTARDBPNAT_cells_gamma_deltaGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:377856-382256:+THYMEERENSG00000174840,PDE12-0.44731.6051e-043.5012e-06-0.4352imageNTARDBPPDE12T_cells_CD8GSVA_HALLMARK_MITOTIC_SPINDLE
chr4:377856-382256:+THYMEERENSG00000109606,DHX15-0.44921.6686e-041.2143e-05-0.4127imageNTARDBPNAMast_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr4:377856-382256:+THYMEERENSG00000047315,POLR2B-0.44781.6695e-043.4173e-06-0.4356imageNTARDBPNAMast_cells_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE

More results



Top

4. Enriched editing regions and immune related splicing for ZNF141


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:377856-382256:+
THYMEERIRENSG00000156299.8chr2131118417:31118670:31124521:31124694-0.35941.2018e-022.3529e-07-0.5008imageNTARDBPTIAM1T_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
chr4:377856-382256:+
THYMEERIRENSG00000123737.8chr4121813754:121814047:121816143:121816194-0.40306.9296e-031.9121e-05-0.4134imageNTARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000131127.12,ZNF141
THYMEAGIRENSG00000117625.9chr1211312236:211312961:211313423:2113134740.35762.1152e-021.3770e-050.4140imageNADAR;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPL;HNRNPM;IGF2BP2;MBNL2;MSI1;MSI2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SRSF1;SRSF10;TAF15;TARDBP;TIAL1;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000131127.12,ZNF141
THYMEAGIRENSG00000104960.11chr1949856135:49858653:49859088:49859176-0.37861.1573e-021.9510e-06-0.4452imageNADAR;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;EWSR1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPL;HNRNPM;IGF2BP2;MSI1;MSI2;NOP56;NOP58;PTBP1;RBFOX2;RBM5;SRSF1;SRSF10;TAF15;TARDBP;TIAL1;U2AF2;UPF1;YTHDC1NANK_cells_activatedGSVA_HALLMARK_ANDROGEN_RESPONSE
ENSG00000131127.12,ZNF141
THYMEAGIRENSG00000166888.6chr1257102828:57102921:57104463:571045860.35163.2188e-022.5510e-050.4003imageNADAR;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPL;HNRNPM;IGF2BP2;MBNL2;MSI2;NOP56;NOP58;PTBP1;RBFOX2;RBM5;SRSF1;SRSF10;TAF15;TARDBP;TIAL1;U2AF2;UPF1;YTHDC1STAT6Macrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
chr4:377856-382256:+
THYMEERIRENSG00000087206.12chr5176968554:176969291:176969600:1769697060.40484.3116e-038.1872e-060.4336imageNTARDBPNAT_cells_CD4_memory_activatedGSVA_HALLMARK_HEME_METABOLISM
chr4:377856-382256:+
THYMEERMEXENSG00000179387.5chr4140527465:140527494:140535732:140535830:140540167:140540301:140542573:140542642-0.38601.1411e-023.6906e-07-0.4721imageNTARDBPELMOD2Macrophages_M1GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000131127.12,ZNF141
THYMEAGMEXENSG00000110321.11chr1110798991:10799113:10799212:10799309:10799551:10799756:10800089:108003480.38551.0740e-028.4927e-060.4193imageNADAR;CSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPL;HNRNPM;IGF2BP2;MBNL2;MSI1;MSI2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;RBM5;SRSF1;SRSF10;TAF15;TARBP2;TARDBP;TIAL1;U2AF2;UPF1;WTAP;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:377856-382256:+
THYMEERMEXENSG00000197070.9chr9137613614:137613769:137614031:137614898:137614898:137615000:137615073:137615360-0.37831.7643e-027.2054e-06-0.4223imageNTARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000131127.12,ZNF141
THYMEAGMEXENSG00000013306.11chr1744319994:44320116:44320195:44320436:44321178:44321231:44321433:443215580.37691.8967e-024.0651e-060.4325imageNCSTF2T;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FBL;FUS;HNRNPA1;HNRNPA2B1;HNRNPL;HNRNPM;IGF2BP2;MSI1;MSI2;NOP56;NOP58;PTBP1;RBFOX2;RBM47;RBM5;SRSF1;SRSF10;TAF15;TARDBP;TIAL1;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION

More results



Top

5. Enriched editing regions and immune infiltration for ZNF141


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:377856-382256:+ACCEERT_cells_CD4_naive5.2399e-030.5047image
ENSG00000131127.12,ZNF141ACCEAGT_cells_CD4_naive5.1982e-030.5051image
chr4:377856-382256:+BLCAEERDendritic_cells_resting1.8578e-040.3198image
ENSG00000131127.12,ZNF141BLCAEAGDendritic_cells_resting2.3085e-040.3142image
chr4:377856-382256:+BRCAEERDendritic_cells_activated2.4632e-020.0892image
ENSG00000131127.12,ZNF141BRCAEAGDendritic_cells_activated1.1490e-020.1001image
chr4:377856-382256:+CESCEERNK_cells_resting2.3228e-020.2490image
ENSG00000131127.12,ZNF141CESCEAGNK_cells_resting2.2246e-020.2507image
chr4:377856-382256:+COADEERT_cells_CD4_memory_activated3.5796e-020.2650image
chr4:377856-382256:+ESCAEERNeutrophils1.0822e-020.2689image
ENSG00000131127.12,ZNF141ESCAEAGMast_cells_resting1.1603e-02-0.2607image
chr4:377856-382256:+HNSCEEREosinophils1.2941e-020.4719image
ENSG00000131127.12,ZNF141HNSCEAGEosinophils1.2968e-020.4718image
chr4:377856-382256:+KICHEERMast_cells_resting4.2623e-020.2823image
ENSG00000131127.12,ZNF141KICHEAGMast_cells_resting3.9137e-020.2870image
chr4:377856-382256:+KIRCEERMast_cells_activated1.7960e-020.1640image
ENSG00000131127.12,ZNF141KIRCEAGT_cells_follicular_helper3.8756e-020.1434image
chr4:377856-382256:+KIRPEERNeutrophils1.0841e-020.2211image
ENSG00000131127.12,ZNF141KIRPEAGNeutrophils9.1444e-030.2261image
chr4:377856-382256:+LAMLEERDendritic_cells_activated6.2631e-03-0.2960image
ENSG00000131127.12,ZNF141LAMLEAGMonocytes8.3723e-030.2779image
chr4:377856-382256:+LGGEERMacrophages_M04.0543e-02-0.1204image
ENSG00000131127.12,ZNF141LGGEAGMacrophages_M04.8338e-02-0.1147image
ENSG00000131127.12,ZNF141LUADEAGNeutrophils9.2450e-050.2736image
chr4:377856-382256:+LUSCEERNK_cells_resting9.5562e-030.2674image
ENSG00000131127.12,ZNF141LUSCEAGNK_cells_resting8.8447e-030.2701image
chr4:377856-382256:+OVEERT_cells_CD83.5199e-050.2522image
ENSG00000131127.12,ZNF141OVEAGT_cells_CD83.8953e-050.2508image
chr4:377856-382256:+PAADEERT_cells_regulatory_(Tregs)2.5076e-02-0.2915image
ENSG00000131127.12,ZNF141PAADEAGT_cells_regulatory_(Tregs)2.1956e-02-0.2978image
chr4:377856-382256:+PCPGEERMonocytes1.8251e-03-0.2762image
ENSG00000131127.12,ZNF141PCPGEAGMonocytes1.5537e-03-0.2802image
chr4:377856-382256:+STADEERT_cells_CD4_naive4.4216e-02-0.1489image
chr4:377856-382256:+THCAEERT_cells_follicular_helper3.2462e-020.1075image
ENSG00000131127.12,ZNF141THCAEAGT_cells_follicular_helper3.2901e-020.1072image
chr4:377856-382256:+THYMEERMast_cells_activated3.1942e-02-0.2095image
ENSG00000131127.12,ZNF141THYMEAGMast_cells_activated3.1959e-02-0.2095image
chr4:377856-382256:+UCECEERT_cells_regulatory_(Tregs)3.5040e-020.2704image
ENSG00000131127.12,ZNF141UCECEAGNK_cells_activated2.9965e-02-0.2694image
chr4:377856-382256:+UCSEEREosinophils6.2667e-030.4470image
ENSG00000131127.12,ZNF141UCSEAGEosinophils6.3182e-030.4466image
chr4:377856-382256:+UVMEERT_cells_gamma_delta1.4203e-040.7496image
ENSG00000131127.12,ZNF141UVMEAGT_cells_gamma_delta1.4203e-040.7496image


Top

6. Enriched editing regions and immune gene sets for ZNF141


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr4:377856-382256:+BLCAGSVA_HALLMARK_P53_PATHWAYEER4.6688e-020.1735image
chr4:377856-382256:+BRCAGSVA_HALLMARK_GLYCOLYSISEER1.7273e-040.1485image
ENSG00000131127.12,ZNF141BRCAGSVA_HALLMARK_GLYCOLYSISEAG5.1993e-040.1371image
ENSG00000131127.12,ZNF141CESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG8.3046e-04-0.3600image
chr4:377856-382256:+CESCGSVA_HALLMARK_PROTEIN_SECRETIONEER9.1496e-04-0.3572image
chr4:377856-382256:+COADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.7087e-020.2995image
chr4:377856-382256:+ESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.6009e-020.2226image
ENSG00000131127.12,ZNF141GBMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG2.6644e-030.3003image
chr4:377856-382256:+GBMGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.0220e-030.2966image
ENSG00000131127.12,ZNF141HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9666e-020.3982image
chr4:377856-382256:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.9403e-020.3987image
chr4:377856-382256:+KICHGSVA_HALLMARK_MYC_TARGETS_V1EER1.0740e-02-0.3510image
ENSG00000131127.12,ZNF141KICHGSVA_HALLMARK_MYC_TARGETS_V1EAG1.1495e-02-0.3479image
chr4:377856-382256:+KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.6956e-02-0.1448image
ENSG00000131127.12,ZNF141KIRCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.5923e-02-0.1456image
ENSG00000131127.12,ZNF141KIRPGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG7.1085e-04-0.2910image
chr4:377856-382256:+KIRPGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.5209e-04-0.2930image
chr4:377856-382256:+LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.2311e-030.3090image
ENSG00000131127.12,ZNF141LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.6586e-040.3695image
chr4:377856-382256:+LUADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.9312e-030.2130image
ENSG00000131127.12,ZNF141LUADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.9289e-03-0.2036image
ENSG00000131127.12,ZNF141LUSCGSVA_HALLMARK_SPERMATOGENESISEAG4.4196e-020.2092image
ENSG00000131127.12,ZNF141MESOGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.4014e-02-0.4642image
chr4:377856-382256:+MESOGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.2680e-02-0.4673image
ENSG00000131127.12,ZNF141OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.9740e-030.1825image
chr4:377856-382256:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER2.4003e-030.1864image
chr4:377856-382256:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER2.0999e-04-0.3257image
ENSG00000131127.12,ZNF141PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.3215e-04-0.3236image
ENSG00000131127.12,ZNF141PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.1737e-030.1755image
chr4:377856-382256:+PRADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.0440e-030.1773image
ENSG00000131127.12,ZNF141READGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.6799e-020.4735image
chr4:377856-382256:+READGSVA_HALLMARK_PROTEIN_SECRETIONEER1.7264e-020.4718image
chr4:377856-382256:+SKCMGSVA_HALLMARK_ADIPOGENESISEER1.7206e-02-0.1924image
ENSG00000131127.12,ZNF141SKCMGSVA_HALLMARK_ADIPOGENESISEAG1.7498e-02-0.1919image
chr4:377856-382256:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5716e-020.1783image
ENSG00000131127.12,ZNF141STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.1436e-020.1664image
chr4:377856-382256:+TGCTGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER7.1060e-03-0.2745image
ENSG00000131127.12,ZNF141TGCTGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG7.1060e-03-0.2745image
ENSG00000131127.12,ZNF141THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.6406e-02-0.1205image
chr4:377856-382256:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.6876e-02-0.1200image
chr4:377856-382256:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER1.8934e-06-0.4457image
ENSG00000131127.12,ZNF141THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.9002e-06-0.4456image
chr4:377856-382256:+UCECGSVA_HALLMARK_HEME_METABOLISMEER4.8544e-02-0.2537image
ENSG00000131127.12,ZNF141UCECGSVA_HALLMARK_PEROXISOMEEAG1.5752e-02-0.2984image
ENSG00000131127.12,ZNF141UCSGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.7946e-020.3923image
chr4:377856-382256:+UCSGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.8793e-020.3897image


Top

7. Enriched editing regions and drugs for ZNF141


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000131127.12,ZNF141ACCCI.1040EAG1.5625e-020.4448image
chr4:377856-382256:+ACCCI.1040EER1.5719e-020.4444image
chr4:377856-382256:+BLCAGW.441756EER1.7145e-02-0.2072image
ENSG00000131127.12,ZNF141BLCAGW.441756EAG1.9689e-02-0.2020image
chr4:377856-382256:+BRCAATRAEER7.3207e-050.1570image
ENSG00000131127.12,ZNF141BRCAAICAREAG1.2544e-040.1514image
ENSG00000131127.12,ZNF141CESCBMS.509744EAG6.0422e-08-0.5527image
chr4:377856-382256:+CESCBMS.509744EER5.5068e-08-0.5541image
chr4:377856-382256:+COADLenalidomideEER1.4127e-020.3078image
chr4:377856-382256:+ESCALenalidomideEER4.8748e-020.2095image
ENSG00000131127.12,ZNF141HNSCCytarabineEAG1.3005e-020.4716image
chr4:377856-382256:+HNSCCytarabineEER1.2783e-020.4727image
chr4:377856-382256:+KICHBMS.754807EER1.1498e-030.4384image
ENSG00000131127.12,ZNF141KICHBMS.754807EAG1.1314e-030.4390image
ENSG00000131127.12,ZNF141KIRCEHT.1864EAG1.2428e-020.1731image
chr4:377856-382256:+KIRCEHT.1864EER1.2793e-020.1724image
ENSG00000131127.12,ZNF141KIRPAZD6244EAG4.1216e-03-0.2481image
chr4:377856-382256:+KIRPAZD6244EER4.1263e-03-0.2481image
chr4:377856-382256:+LAMLAP.24534EER5.6010e-030.2998image
ENSG00000131127.12,ZNF141LAMLABT.888EAG3.1008e-030.3101image
chr4:377856-382256:+LGGBX.795EER2.4685e-030.1771image
ENSG00000131127.12,ZNF141LGGBX.795EAG1.3505e-030.1852image
chr4:377856-382256:+LIHCAS601245EER2.1816e-030.4599image
ENSG00000131127.12,ZNF141LIHCAS601245EAG2.1816e-030.4599image
chr4:377856-382256:+LUADBMS.509744EER1.4186e-03-0.2281image
ENSG00000131127.12,ZNF141LUADBMS.708163EAG5.9403e-04-0.2414image
chr4:377856-382256:+LUSCElesclomolEER4.6625e-020.2069image
ENSG00000131127.12,ZNF141LUSCElesclomolEAG3.0376e-020.2247image
ENSG00000131127.12,ZNF141MESOGSK269962AEAG3.5765e-020.4603image
chr4:377856-382256:+MESOGSK269962AEER3.4388e-020.4634image
ENSG00000131127.12,ZNF141OVCyclopamineEAG7.7028e-05-0.2418image
chr4:377856-382256:+OVCyclopamineEER6.5855e-05-0.2440image
chr4:377856-382256:+PCPGBMS.754807EER3.6799e-04-0.3137image
ENSG00000131127.12,ZNF141PCPGBMS.754807EAG3.5724e-04-0.3143image
ENSG00000131127.12,ZNF141PRADCisplatinEAG2.3591e-03-0.1646image
chr4:377856-382256:+PRADCisplatinEER2.1945e-03-0.1658image
ENSG00000131127.12,ZNF141READFH535EAG1.4036e-03-0.6035image
chr4:377856-382256:+READFH535EER1.5972e-03-0.5979image
ENSG00000131127.12,ZNF141SARCBAY.61.3606EAG4.2641e-02-0.2191image
chr4:377856-382256:+SARCBAY.61.3606EER4.2789e-02-0.2190image
ENSG00000131127.12,ZNF141SKCMCHIR.99021EAG1.9269e-02-0.1890image
chr4:377856-382256:+SKCMCHIR.99021EER1.9460e-02-0.1887image
chr4:377856-382256:+STADBIRB.0796EER1.4910e-020.1797image
ENSG00000131127.12,ZNF141STADKIN001.135EAG1.4425e-02-0.1768image
chr4:377856-382256:+TGCTEmbelinEER1.7476e-020.2434image
ENSG00000131127.12,ZNF141TGCTEmbelinEAG1.7476e-020.2434image
ENSG00000131127.12,ZNF141THCACytarabineEAG5.3008e-04-0.1734image
chr4:377856-382256:+THCACytarabineEER5.4890e-04-0.1729image
chr4:377856-382256:+THYMEmbelinEER1.0118e-060.4561image
ENSG00000131127.12,ZNF141THYMEmbelinEAG9.5180e-070.4571image
ENSG00000131127.12,ZNF141UCECGW.441756EAG5.0019e-040.4197image
chr4:377856-382256:+UCECDasatinibEER5.0934e-05-0.4946image
ENSG00000131127.12,ZNF141UCSBMS.536924EAG2.9916e-02-0.3623image
chr4:377856-382256:+UCSBMS.536924EER2.9631e-02-0.3628image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType