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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF121 (ImmuneEditome ID:7675)

1. Gene summary of enriched editing regions for ZNF121

check button Gene summary
Gene informationGene symbol

ZNF121

Gene ID

7675

GeneSynonymsD19S204|ZHC32|ZNF20
GeneCytomap

19p13.2

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 121|zinc finger protein 121 (clone ZHC32)|zinc finger protein 20
GeneModificationdate20230518
UniprotIDP58317;K7EQI1
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:9561594-9564391:-ENST00000586602.4ENSG00000197961.10ZNF121UTR3AluJr,AluJr4,AluSx3,AluJo,Tigger1,L1MC4achr19:9561594-9564391:-.alignment
chr19:9565497-9565663:-ENST00000586602.4ENSG00000197961.10ZNF121UTR3AluSq2chr19:9565497-9565663:-.alignment


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2. Tumor-specific enriched editing regions for ZNF121


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000197961.10,ZNF121KICHEAG4.6605e-03image
chr19:9561594-9564391:-KIRCEER2.4364e-04image
ENSG00000197961.10,ZNF121KIRCEAG2.0449e-04image
chr19:9561594-9564391:-KIRPEER5.3432e-04image
ENSG00000197961.10,ZNF121KIRPEAG5.3231e-04image
chr19:9561594-9564391:-THCAEER1.0973e-02image
ENSG00000197961.10,ZNF121THCAEAG1.0903e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000197961.10,ZNF121KIRCPathEAG8.6327e-032.7944e-020.1056image
chr19:9561594-9564391:-KIRCPathEER2.1279e-024.7025e-020.0955image
ENSG00000197961.10,ZNF121KIRPCliEAG4.8792e-025.3442e-030.2549image
chr19:9561594-9564391:-KIRPCliEER4.9113e-025.3818e-030.2547image
chr19:9561594-9564391:-THCAPathEER1.4579e-024.9475e-030.1441image
ENSG00000197961.10,ZNF121THCAPathEAG1.4714e-025.0193e-030.1438image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ZNF121


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:9561594-9564391:-COADEERENSG00000114491,UMPS-0.41421.9730e-079.3259e-11-0.4071imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr19:9561594-9564391:-COADEERENSG00000220205,VAMP20.27701.6638e-031.3884e-130.4588imageNNNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V2
chr19:9561594-9564391:-COADEERENSG00000039523,FAM65A0.23739.1222e-034.6070e-130.4499imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr19:9561594-9564391:-COADEERENSG00000105419,MEIS30.23419.7656e-036.3294e-120.4296imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr19:9561594-9564391:-COADEERENSG00000267523,CTD-2537I9.12-0.22771.3434e-026.0484e-110.4109imageNNNADendritic_cells_activatedGSVA_HALLMARK_ADIPOGENESIS
chr19:9561594-9564391:-COADEERENSG00000151176,PLBD20.21492.1418e-022.2931e-150.4874imageNNNADendritic_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr19:9561594-9564391:-COADEERENSG00000179954,SSC5D0.20782.5478e-023.4529e-130.4521imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr19:9561594-9564391:-COADEERENSG00000263050,RP11-667K14.30.20972.5647e-021.6660e-110.4217imageNNNANeutrophilsGSVA_HALLMARK_PEROXISOME
chr19:9561594-9564391:-COADEERENSG00000177464,GPR40.19514.2109e-029.5278e-110.4070imageNNNANeutrophilsGSVA_HALLMARK_ANGIOGENESIS
chr19:9561594-9564391:-PRADEERENSG00000244242,IFITM100.27481.1776e-064.1040e-210.4404imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ANDROGEN_RESPONSE

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4. Enriched editing regions and immune related splicing for ZNF121


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000197961.10,ZNF121
COADEAGA3ENSG00000008294.16chr1750977107:50977221:50974770:50974947:50974770:50975901-0.27469.0054e-031.8358e-10-0.4020imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184NAT_cells_CD4_memory_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000197961.10,ZNF121
STADEAGIRENSG00000174939.6chr1629900685:29900885:29901551:29901920-0.12213.7364e-021.3732e-11-0.4047imageNACIN1;ADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DDX54;DGCR8;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28;LIN28B;MOV10;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1;YTHDF1;ZNF184NAMacrophages_M2GSVA_HALLMARK_INFLAMMATORY_RESPONSE
chr19:9561594-9564391:-
STADEERIRENSG00000174939.6chr1629900685:29900885:29901551:29901920-0.12452.8304e-021.7724e-11-0.4027imageNNNAMacrophages_M2GSVA_HALLMARK_INFLAMMATORY_RESPONSE
ENSG00000197961.10,ZNF121
UCECEAGMEXENSG00000198034.6chrX72273231:72273389:72273800:72273867:72273867:72273972:72275052:722751500.36814.3434e-024.6496e-090.4892imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000197961.10,ZNF121
UCECEAGMEXENSG00000101294.12chr2031554746:31554829:31559610:31559647:31566209:31566295:31569119:31569174-0.39671.8655e-022.8814e-11-0.5451imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YTHDF2;YWHAG;ZC3H7B;ZNF184HM13T_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000197961.10,ZNF121
UCECEAGMEXENSG00000197157.6chr7127707556:127707647:127721286:127721400:127990946:127991056:128074501:128074622-0.36374.3491e-021.7210e-09-0.5010imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BUD13;CELF2;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;MBNL2;METTL3;MOV10;MSI1;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RTCB;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TRA2A;TROVE2;U2AF2;UPF1;VIM;YTHDC1;YTHDF1;ZC3H7BNAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000197961.10,ZNF121
UCECEAGMEXENSG00000109736.10chr42930602:2931150:2931226:2931274:2931554:2931936:2932044:29321530.41231.0790e-021.4015e-070.4468imageNACIN1;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184MFSD10T_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000197961.10,ZNF121
UCECEAGMEXENSG00000105698.11chr1935269600:35269699:35269802:35269823:35269922:35270003:35270446:35270517-0.37663.0230e-023.1029e-09-0.4957imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_follicular_helperGSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000197961.10,ZNF121
UCECEAGMEXENSG00000123159.11chr1914480592:14480778:14482688:14482819:14482864:14483006:14491655:144917430.36564.3826e-023.5308e-070.4321imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZNF184GIPC1T_cells_regulatory_(Tregs)GSVA_HALLMARK_TGF_BETA_SIGNALING
ENSG00000197961.10,ZNF121
UCECEAGMEXENSG00000197958.8chr9127449280:127449362:127449609:127450679:127450730:127450804:127451280:1274513730.38023.0485e-021.6426e-080.4736imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION

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5. Enriched editing regions and immune infiltration for ZNF121


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:9561594-9564391:-ACCEERMacrophages_M21.9458e-02-0.3878image
ENSG00000197961.10,ZNF121ACCEAGMacrophages_M21.9458e-02-0.3878image
chr19:9561594-9564391:-BLCAEERT_cells_CD4_memory_activated1.4472e-030.1802image
ENSG00000197961.10,ZNF121BLCAEAGT_cells_CD4_memory_activated1.6863e-030.1777image
chr19:9561594-9564391:-BRCAEERT_cells_CD4_memory_activated1.4722e-03-0.1019image
ENSG00000197961.10,ZNF121BRCAEAGT_cells_CD4_memory_activated1.3256e-03-0.1028image
chr19:9561594-9564391:-CESCEERDendritic_cells_activated1.6891e-02-0.1667image
ENSG00000197961.10,ZNF121CESCEAGDendritic_cells_activated1.3434e-02-0.1720image
chr19:9561594-9564391:-CHOLEERT_cells_regulatory_(Tregs)2.2756e-020.4215image
ENSG00000197961.10,ZNF121CHOLEAGT_cells_regulatory_(Tregs)2.2879e-020.4212image
chr19:9561594-9564391:-COADEERT_cells_CD4_memory_activated1.3316e-02-0.1616image
ENSG00000197961.10,ZNF121COADEAGT_cells_CD4_memory_activated1.1858e-02-0.1643image
chr19:9561594-9564391:-ESCAEERB_cells_naive7.6683e-03-0.2141image
ENSG00000197961.10,ZNF121ESCAEAGT_cells_regulatory_(Tregs)1.4589e-02-0.1965image
chr19:9561594-9564391:-GBMEERT_cells_follicular_helper4.8308e-02-0.1784image
chr19:9561594-9564391:-HNSCEERMacrophages_M27.6303e-030.1442image
ENSG00000197961.10,ZNF121HNSCEAGMacrophages_M27.6466e-030.1442image
ENSG00000197961.10,ZNF121KICHEAGT_cells_gamma_delta3.8396e-020.3169image
chr19:9561594-9564391:-KIRCEERT_cells_regulatory_(Tregs)9.3070e-030.1475image
ENSG00000197961.10,ZNF121KIRCEAGT_cells_regulatory_(Tregs)1.1020e-020.1442image
chr19:9561594-9564391:-KIRPEERNK_cells_activated3.9294e-03-0.2182image
ENSG00000197961.10,ZNF121KIRPEAGNK_cells_activated3.9029e-03-0.2183image
chr19:9561594-9564391:-LUADEERT_cells_follicular_helper3.8630e-020.1001image
ENSG00000197961.10,ZNF121LUADEAGMast_cells_resting3.9871e-02-0.0995image
chr19:9561594-9564391:-LUSCEERT_cells_CD4_memory_activated1.5221e-030.1490image
ENSG00000197961.10,ZNF121LUSCEAGT_cells_CD4_memory_activated1.4547e-030.1496image
chr19:9561594-9564391:-MESOEERB_cells_naive1.4819e-020.3213image
ENSG00000197961.10,ZNF121MESOEAGB_cells_naive1.4819e-020.3213image
chr19:9561594-9564391:-OVEERNeutrophils1.3641e-040.2241image
ENSG00000197961.10,ZNF121OVEAGNeutrophils1.6240e-040.2216image
chr19:9561594-9564391:-PCPGEERT_cells_CD4_memory_resting2.6916e-02-0.1964image
ENSG00000197961.10,ZNF121PCPGEAGT_cells_CD4_memory_resting2.3280e-02-0.2013image
chr19:9561594-9564391:-PRADEERMacrophages_M21.4038e-020.1205image
ENSG00000197961.10,ZNF121PRADEAGMacrophages_M21.6528e-020.1175image
chr19:9561594-9564391:-READEEREosinophils2.8059e-030.3496image
ENSG00000197961.10,ZNF121READEAGEosinophils4.7971e-030.3311image
chr19:9561594-9564391:-SARCEERMast_cells_activated4.9843e-040.2791image
ENSG00000197961.10,ZNF121SARCEAGMast_cells_activated5.0237e-040.2789image
chr19:9561594-9564391:-SKCMEERPlasma_cells3.8016e-030.1532image
ENSG00000197961.10,ZNF121SKCMEAGPlasma_cells4.0041e-030.1524image
chr19:9561594-9564391:-STADEERMacrophages_M22.1142e-030.1631image
chr19:9565497-9565663:-STADEERT_cells_CD4_memory_resting3.1958e-03-0.5373image
ENSG00000197961.10,ZNF121STADEAGMacrophages_M23.6834e-030.1538image
chr19:9561594-9564391:-THCAEERB_cells_naive6.6984e-030.1389image
ENSG00000197961.10,ZNF121THCAEAGB_cells_naive6.8204e-030.1386image
chr19:9561594-9564391:-THYMEERT_cells_CD84.4679e-020.2602image
ENSG00000197961.10,ZNF121UCECEAGT_cells_regulatory_(Tregs)1.2228e-020.2209image
chr19:9561594-9564391:-UCSEERMast_cells_activated1.0680e-020.4668image
ENSG00000197961.10,ZNF121UCSEAGMast_cells_activated1.0680e-020.4668image


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6. Enriched editing regions and immune gene sets for ZNF121


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr19:9561594-9564391:-THCAEER3.6367e-02image4.0272e-020.1053image
ENSG00000197961.10,ZNF121THCAEAG3.6059e-02image4.0590e-020.1051image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000197961.10,ZNF121BRCAEAG2.0673e-02-0.07422.0149e-05-0.13621.6345e-02-0.07701.8325e-050.1369image
chr19:9561594-9564391:-BRCAEER2.0852e-02-0.07422.3425e-05-0.13531.4827e-02-0.07821.7937e-050.1372image
ENSG00000197961.10,ZNF121SKCMEAG5.5518e-03-0.14694.3923e-03-0.15091.8235e-02-0.12521.2049e-040.2027image
chr19:9561594-9564391:-SKCMEER6.2405e-03-0.14494.6681e-03-0.14981.8681e-02-0.12481.3514e-040.2012image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000197961.10,ZNF121ACCGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.0887e-030.4569image
chr19:9561594-9564391:-ACCGSVA_HALLMARK_MITOTIC_SPINDLEEER5.0887e-030.4569image
chr19:9561594-9564391:-BLCAGSVA_HALLMARK_MYOGENESISEER6.8415e-040.1918image
ENSG00000197961.10,ZNF121BLCAGSVA_HALLMARK_MYOGENESISEAG8.2000e-040.1891image
ENSG00000197961.10,ZNF121BRCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.3926e-110.2120image
chr19:9561594-9564391:-BRCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.3427e-110.2123image
chr19:9561594-9564391:-CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.4896e-030.2102image
ENSG00000197961.10,ZNF121CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.1036e-030.2051image
chr19:9561594-9564391:-COADGSVA_HALLMARK_MYC_TARGETS_V2EER2.3802e-06-0.3028image
ENSG00000197961.10,ZNF121COADGSVA_HALLMARK_MYC_TARGETS_V2EAG2.0456e-06-0.3047image
ENSG00000197961.10,ZNF121ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG8.8119e-03-0.2104image
chr19:9561594-9564391:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.1894e-02-0.2022image
ENSG00000197961.10,ZNF121GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG3.3989e-030.2622image
chr19:9561594-9564391:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.1688e-030.2640image
ENSG00000197961.10,ZNF121HNSCGSVA_HALLMARK_G2M_CHECKPOINTEAG4.9118e-05-0.2180image
chr19:9561594-9564391:-HNSCGSVA_HALLMARK_G2M_CHECKPOINTEER4.7056e-05-0.2185image
ENSG00000197961.10,ZNF121KIRCGSVA_HALLMARK_GLYCOLYSISEAG3.7946e-050.2317image
chr19:9561594-9564391:-KIRCGSVA_HALLMARK_GLYCOLYSISEER3.5133e-050.2327image
chr19:9561594-9564391:-KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER7.1363e-040.2549image
ENSG00000197961.10,ZNF121KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG7.1803e-040.2548image
chr19:9561594-9564391:-LAMLGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.4869e-020.1970image
ENSG00000197961.10,ZNF121LGGGSVA_HALLMARK_G2M_CHECKPOINTEAG1.1521e-10-0.3185image
chr19:9561594-9564391:-LGGGSVA_HALLMARK_G2M_CHECKPOINTEER1.1188e-10-0.3187image
chr19:9561594-9564391:-LUADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.0960e-050.2110image
ENSG00000197961.10,ZNF121LUADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.1372e-050.2106image
chr19:9561594-9564391:-LUSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.6739e-040.1672image
ENSG00000197961.10,ZNF121LUSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.4277e-040.1681image
chr19:9561594-9564391:-MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.6750e-02-0.2773image
ENSG00000197961.10,ZNF121MESOGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.6750e-02-0.2773image
ENSG00000197961.10,ZNF121OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.4923e-07-0.2963image
chr19:9561594-9564391:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER9.4289e-07-0.2856image
ENSG00000197961.10,ZNF121PAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.9750e-020.1752image
chr19:9561594-9564391:-PAADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.9750e-020.1752image
ENSG00000197961.10,ZNF121PCPGGSVA_HALLMARK_MYC_TARGETS_V2EAG1.7031e-02-0.2114image
chr19:9561594-9564391:-PCPGGSVA_HALLMARK_MYC_TARGETS_V2EER1.7504e-02-0.2105image
chr19:9561594-9564391:-PRADGSVA_HALLMARK_MYOGENESISEER1.8230e-030.1526image
ENSG00000197961.10,ZNF121PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.9246e-03-0.1516image
ENSG00000197961.10,ZNF121READGSVA_HALLMARK_HYPOXIAEAG4.5999e-020.2376image
chr19:9561594-9564391:-READGSVA_HALLMARK_HYPOXIAEER2.4509e-020.2668image
ENSG00000197961.10,ZNF121SARCGSVA_HALLMARK_P53_PATHWAYEAG2.4398e-020.1825image
chr19:9561594-9564391:-SARCGSVA_HALLMARK_P53_PATHWAYEER2.4780e-020.1821image
ENSG00000197961.10,ZNF121SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.1945e-080.2968image
chr19:9561594-9564391:-SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEER2.1467e-080.2917image
ENSG00000197961.10,ZNF121STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.4445e-040.1748image
chr19:9561594-9564391:-STADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.8224e-050.2173image
chr19:9561594-9564391:-TGCTGSVA_HALLMARK_HEME_METABOLISMEER1.2408e-020.2315image
ENSG00000197961.10,ZNF121TGCTGSVA_HALLMARK_HEME_METABOLISMEAG1.2524e-020.2312image
chr19:9561594-9564391:-THCAGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER9.9087e-040.1683image
ENSG00000197961.10,ZNF121THCAGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG1.0067e-030.1681image
ENSG00000197961.10,ZNF121THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.4268e-05-0.5124image
chr19:9561594-9564391:-THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.7860e-040.4655image
chr19:9561594-9564391:-UCECGSVA_HALLMARK_MYOGENESISEER4.0093e-030.2546image
ENSG00000197961.10,ZNF121UCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.0610e-03-0.2598image
ENSG00000197961.10,ZNF121UCSGSVA_HALLMARK_KRAS_SIGNALING_UPEAG3.6901e-02-0.3892image
chr19:9561594-9564391:-UCSGSVA_HALLMARK_KRAS_SIGNALING_UPEER3.6901e-02-0.3892image


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7. Enriched editing regions and drugs for ZNF121


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000197961.10,ZNF121ACCGefitinibEAG7.5735e-030.4378image
chr19:9561594-9564391:-ACCGefitinibEER7.5735e-030.4378image
chr19:9561594-9564391:-BLCACGP.60474EER8.1335e-06-0.2504image
ENSG00000197961.10,ZNF121BLCACGP.60474EAG9.4972e-06-0.2486image
ENSG00000197961.10,ZNF121BRCABryostatin.1EAG1.0081e-07-0.1698image
chr19:9561594-9564391:-BRCABryostatin.1EER1.2268e-07-0.1688image
chr19:9561594-9564391:-CESCGDC.0449EER2.9868e-06-0.3196image
ENSG00000197961.10,ZNF121CESCGDC.0449EAG3.2528e-06-0.3178image
chr19:9561594-9564391:-COADCCT007093EER1.1002e-06-0.3122image
ENSG00000197961.10,ZNF121COADCCT007093EAG7.7536e-07-0.3164image
chr19:9561594-9564391:-ESCAJNJ.26854165EER2.5608e-03-0.2422image
ENSG00000197961.10,ZNF121ESCAJNJ.26854165EAG3.7350e-03-0.2331image
ENSG00000197961.10,ZNF121GBMJNK.9LEAG1.6166e-050.3781image
chr19:9561594-9564391:-GBMJNK.9LEER1.6187e-050.3781image
ENSG00000197961.10,ZNF121HNSCBAY.61.3606EAG8.4520e-110.3422image
chr19:9561594-9564391:-HNSCBAY.61.3606EER9.8401e-110.3410image
ENSG00000197961.10,ZNF121KICHBMS.536924EAG3.7998e-02-0.3175image
chr19:9561594-9564391:-KIRCDasatinibEER2.3471e-05-0.2388image
ENSG00000197961.10,ZNF121KIRCDasatinibEAG2.6019e-05-0.2376image
ENSG00000197961.10,ZNF121KIRPBosutinibEAG1.2847e-050.3250image
chr19:9561594-9564391:-KIRPBosutinibEER1.2951e-050.3249image
chr19:9561594-9564391:-LAMLCGP.082996EER4.2386e-02-0.1896image
ENSG00000197961.10,ZNF121LGGDoxorubicinEAG8.7843e-100.3036image
chr19:9561594-9564391:-LGGDoxorubicinEER8.7008e-100.3037image
chr19:9561594-9564391:-LIHCBMS.754807EER6.3997e-030.2224image
ENSG00000197961.10,ZNF121LIHCBMS.754807EAG6.3997e-030.2224image
chr19:9561594-9564391:-LUADEpothilone.BEER6.8504e-030.1307image
ENSG00000197961.10,ZNF121LUADEpothilone.BEAG6.2814e-030.1320image
ENSG00000197961.10,ZNF121LUSCCI.1040EAG1.3197e-03-0.1510image
chr19:9561594-9564391:-LUSCEmbelinEER1.2278e-030.1519image
ENSG00000197961.10,ZNF121MESOMG.132EAG1.5021e-02-0.3207image
chr19:9561594-9564391:-MESOMG.132EER1.5021e-02-0.3207image
chr19:9561594-9564391:-OVEmbelinEER5.0489e-090.3375image
ENSG00000197961.10,ZNF121OVEmbelinEAG8.0416e-090.3333image
ENSG00000197961.10,ZNF121PAADBMS.509744EAG1.3963e-02-0.2185image
chr19:9561594-9564391:-PAADBMS.509744EER1.3963e-02-0.2185image
chr19:9561594-9564391:-PCPGBMS.536924EER1.9930e-020.2072image
ENSG00000197961.10,ZNF121PCPGBMS.536924EAG2.1251e-020.2051image
chr19:9561594-9564391:-PRADGNF.2EER6.3884e-06-0.2198image
ENSG00000197961.10,ZNF121PRADGNF.2EAG6.2309e-06-0.2198image
ENSG00000197961.10,ZNF121READBleomycinEAG3.1318e-02-0.2558image
chr19:9561594-9564391:-READEHT.1864EER3.7280e-02-0.2477image
chr19:9561594-9564391:-SARCBosutinibEER5.9251e-03-0.2222image
ENSG00000197961.10,ZNF121SARCBosutinibEAG5.8025e-03-0.2228image
ENSG00000197961.10,ZNF121SKCMGNF.2EAG5.5504e-07-0.2620image
chr19:9561594-9564391:-SKCMGNF.2EER5.9728e-07-0.2613image
chr19:9561594-9564391:-STADCI.1040EER1.3832e-03-0.1696image
ENSG00000197961.10,ZNF121STADCisplatinEAG1.8795e-02-0.1247image
chr19:9565497-9565663:-STADDocetaxelEER1.1241e-02-0.4719image
ENSG00000197961.10,ZNF121TGCTGDC0941EAG1.4674e-03-0.2921image
chr19:9561594-9564391:-TGCTGDC0941EER1.4461e-03-0.2924image
chr19:9561594-9564391:-THCAABT.263EER6.0099e-040.1752image
ENSG00000197961.10,ZNF121THCAABT.263EAG5.8558e-040.1756image
ENSG00000197961.10,ZNF121THYMJNK.9LEAG1.0169e-100.7144image
chr19:9561594-9564391:-THYMAMG.706EER8.1762e-04-0.4207image
chr19:9561594-9564391:-UCECA.770041EER2.8960e-16-0.6466image
ENSG00000197961.10,ZNF121UCECJNK.9LEAG5.0220e-100.5149image
ENSG00000197961.10,ZNF121UCSCyclopamineEAG5.7483e-03-0.5000image
chr19:9561594-9564391:-UCSCyclopamineEER5.7483e-03-0.5000image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType