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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF69 (ImmuneEditome ID:7620)

1. Gene summary of enriched editing regions for ZNF69

check button Gene summary
Gene informationGene symbol

ZNF69

Gene ID

7620

GeneSynonymsCos5|hZNF3
GeneCytomap

19p13.2

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 69|ZNF3
GeneModificationdate20230518
UniprotIDQ9UC07;C9JR48
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:11888664-11891326:+ENST00000340180.5ENSG00000198429.8ZNF69intronicAluSz,MER41D,AluJb,LTR24C,AluSx1,LTR5B,MER57E3,MER4D,MER49chr19:11888664-11891326:+.alignment
chr19:11888664-11891326:+ENST00000429654.5ENSG00000198429.8ZNF69intronicAluSz,MER41D,AluJb,LTR24C,AluSx1,LTR5B,MER57E3,MER4D,MER49chr19:11888664-11891326:+.alignment
chr19:11888664-11891326:+ENST00000445911.4ENSG00000198429.8ZNF69intronicAluSz,MER41D,AluJb,LTR24C,AluSx1,LTR5B,MER57E3,MER4D,MER49chr19:11888664-11891326:+.alignment
chr19:11895932-11898699:+ENST00000340180.5ENSG00000198429.8ZNF69intronicMLT1A,AluSq2,AluSx4,L1M5,AluJo,L1MC2,AluY,AluSp,L1ME3Bchr19:11895932-11898699:+.alignment
chr19:11895932-11898699:+ENST00000429654.5ENSG00000198429.8ZNF69intronicMLT1A,AluSq2,AluSx4,L1M5,AluJo,L1MC2,AluY,AluSp,L1ME3Bchr19:11895932-11898699:+.alignment
chr19:11895932-11898699:+ENST00000445911.4ENSG00000198429.8ZNF69intronicMLT1A,AluSq2,AluSx4,L1M5,AluJo,L1MC2,AluY,AluSp,L1ME3Bchr19:11895932-11898699:+.alignment
chr19:11901537-11903352:+ENST00000340180.5ENSG00000198429.8ZNF69intronicAluSz,LTR60,MER68B,AluSc8,AluSp,L1MB2chr19:11901537-11903352:+.alignment
chr19:11901537-11903352:+ENST00000429654.5ENSG00000198429.8ZNF69intronicAluSz,LTR60,MER68B,AluSc8,AluSp,L1MB2chr19:11901537-11903352:+.alignment
chr19:11901537-11903352:+ENST00000445911.4ENSG00000198429.8ZNF69intronicAluSz,LTR60,MER68B,AluSc8,AluSp,L1MB2chr19:11901537-11903352:+.alignment
chr19:11912919-11914315:+ENST00000340180.5ENSG00000198429.8ZNF69exonicMER90a,AluY,AluSx3,AluSq2chr19:11912919-11914315:+.alignment


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2. Tumor-specific enriched editing regions for ZNF69


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:11912919-11914315:+COADEER2.4758e-04image
ENSG00000198429.8,ZNF69COADEAG1.2659e-04image
chr19:11912919-11914315:+KICHEER2.0050e-02image
ENSG00000198429.8,ZNF69KICHEAG2.0050e-02image
chr19:11912919-11914315:+KIRCEER3.4095e-02image
ENSG00000198429.8,ZNF69KIRCEAG3.8700e-02image
chr19:11912919-11914315:+LIHCEER9.0368e-03image
ENSG00000198429.8,ZNF69LIHCEAG8.8546e-03image
chr19:11912919-11914315:+STADEER6.0145e-03image
ENSG00000198429.8,ZNF69STADEAG7.8221e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000198429.8,ZNF69BLCAPathEAG7.3944e-033.4293e-020.1133image
chr19:11912919-11914315:+BLCAPathEER8.6658e-034.5865e-020.1073image
ENSG00000198429.8,ZNF69KIRPPathEAG4.6452e-022.4319e-020.1466image
chr19:11912919-11914315:+KIRPPathEER3.9548e-022.3076e-020.1479image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ZNF69


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:11912919-11914315:+BLCAEERENSG00000198429,ZNF69-0.49546.4885e-191.1699e-27-0.5407imageNCSTF2T;ELAVL1;HNRNPA2B1;HNRNPC;IGF2BP2;KHDRBS1;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
chr19:11912919-11914315:+BLCAEERENSG00000156587,UBE2L60.49828.7627e-195.6555e-170.4296imageNCSTF2T;ELAVL1;HNRNPA2B1;HNRNPC;IGF2BP2;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:11912919-11914315:+BLCAEERENSG00000142089,IFITM30.49301.0450e-182.2197e-170.4347imageNCSTF2T;HNRNPC;IGF2BP2;KHDRBS1;U2AF2IFITM3T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr19:11912919-11914315:+BLCAEERENSG00000101347,SAMHD10.49401.1595e-181.1212e-170.4383imageNCSTF2T;ELAVL1;HNRNPA2B1;HNRNPC;IGF2BP2;KHDRBS1;U2AF2SAMHD1T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr19:11912919-11914315:+BLCAEERENSG00000025708,TYMP0.48249.2441e-187.0362e-170.4284imageNCSTF2T;IGF2BP2;U2AF2TYMPT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr19:11912919-11914315:+BLCAEERENSG00000204267,TAP20.48122.1095e-171.3169e-150.4120imageNCSTF2T;ELAVL1;HNRNPA2B1;HNRNPC;IGF2BP2;KHDRBS1;U2AF2TAP2T_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr19:11912919-11914315:+BLCAEERENSG00000269837,IPO5P1-0.46342.5626e-173.0659e-18-0.4451imageNNNAMacrophages_M1GSVA_HALLMARK_APOPTOSIS
chr19:11912919-11914315:+BLCAEERENSG00000165030,NFIL30.47153.0891e-178.7335e-200.4630imageNCSTF2T;ELAVL1;HNRNPA2B1;HNRNPC;IGF2BP2;KHDRBS1;U2AF2NFIL3T_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr19:11912919-11914315:+BLCAEERENSG00000132481,TRIM470.47023.6609e-176.5323e-160.4160imageNCSTF2T;HNRNPC;IGF2BP2;U2AF2TRIM47T_cells_regulatory_(Tregs)GSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr19:11912919-11914315:+BLCAEERENSG00000134470,IL15RA0.47683.8380e-179.8867e-160.4136imageNCSTF2T;ELAVL1;HNRNPC;IGF2BP2;KHDRBS1;U2AF2IL15RAT_cells_CD4_memory_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE

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4. Enriched editing regions and immune related splicing for ZNF69


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:11912919-11914315:+
BLCAEERIRENSG00000076928.13chr1941897314:41897326:41897945:41897982-0.35055.4140e-116.2270e-15-0.4525imageNCSTF2T;ELAVL1;HNRNPA2B1;HNRNPC;IGF2BP2;KHDRBS1;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000198429.8,ZNF69
BLCAEAGIRENSG00000153048.6chr168857463:8859335:8860104:8860131-0.32433.2481e-094.1129e-13-0.4232imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28A;LIN28B;MSI1;NONO;NOP56;PCBP2;PRPF8;RBFOX2;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198429.8,ZNF69
BLCAEAGIRENSG00000112715.16chr643773171:43777665:43778459:43778536-0.44504.3150e-141.7017e-17-0.4361imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28A;LIN28B;MBNL1;MSI1;NONO;NOP56;PCBP2;PRPF8;RBFOX2;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1VEGFAT_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP
chr19:11912919-11914315:+
BLCAEERIRENSG00000139211.5chr1247075706:47079065:47079461:47079642-0.35981.8128e-101.3855e-13-0.4137imageNCSTF2T;ELAVL1;IGF2BP2;U2AF2AMIGO2T_cells_CD4_naiveGSVA_HALLMARK_COMPLEMENT
ENSG00000198429.8,ZNF69
BLCAEAGIRENSG00000124181.10chr2041162641:41162992:41163202:41163275-0.32532.1850e-085.1959e-13-0.4079imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28B;MBNL1;MSI1;NONO;NOP56;PCBP2;PRPF8;RBFOX2;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1PLCG1T_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000198429.8,ZNF69
BLCAEAGIRENSG00000124181.10chr2041162641:41162725:41162957:41162992-0.32382.8258e-088.2071e-13-0.4046imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28B;MBNL1;MSI1;NONO;NOP56;PCBP2;PRPF8;RBFOX2;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1PLCG1T_cells_CD4_naiveGSVA_HALLMARK_COMPLEMENT
chr19:11912919-11914315:+
BLCAEERIRENSG00000184922.9chr1745238563:45238638:45238954:45239054-0.34864.1302e-108.6327e-14-0.4312imageNCSTF2T;ELAVL1;IGF2BP2;KHDRBS1;U2AF2NAT_cells_CD4_memory_activatedGSVA_HALLMARK_IL2_STAT5_SIGNALING
ENSG00000198429.8,ZNF69
BLCAEAGIRENSG00000139278.5chr1275495576:75498720:75498823:75503853-0.43503.0502e-131.5987e-19-0.4600imageNADAR;DKC1;EIF4A3;ELAVL1;FMR1;FUS;HNRNPC;HNRNPL;IGF2BP1;IGF2BP2;LIN28B;MSI1;NOP56;RBFOX2;SAFB2;SND1;SRSF1;SRSF7;SRSF9;TAF15;TIA1;U2AF1;UPF1NADendritic_cells_activatedGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000198429.8,ZNF69
BLCAEAGIRENSG00000076928.13chr1941897314:41898113:41898441:41898587-0.41823.4403e-131.9782e-16-0.4418imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28A;LIN28B;MBNL1;MSI1;NONO;NOP56;PCBP2;PRPF8;RBFOX2;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
ENSG00000198429.8,ZNF69
BLCAEAGIRENSG00000177479.15chr348924717:48924971:48927461:48927725-0.28343.1547e-071.7181e-11-0.4001imageNADAR;AUH;BCCIP;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28A;LIN28B;MSI1;NONO;NOP56;PCBP2;PRPF8;RBFOX2;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDF1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_UV_RESPONSE_UP

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5. Enriched editing regions and immune infiltration for ZNF69


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:11912919-11914315:+BLCAEERT_cells_regulatory_(Tregs)5.2997e-08-0.2874image
ENSG00000198429.8,ZNF69BLCAEAGT_cells_regulatory_(Tregs)4.3955e-08-0.2882image
chr19:11912919-11914315:+BRCAEERT_cells_CD4_memory_activated2.9916e-050.1332image
ENSG00000198429.8,ZNF69BRCAEAGT_cells_CD4_memory_activated2.7465e-050.1337image
chr19:11912919-11914315:+CESCEERT_cells_CD81.6344e-020.2408image
ENSG00000198429.8,ZNF69CESCEAGT_cells_CD81.6267e-020.2410image
chr19:11912919-11914315:+CHOLEERT_cells_CD4_naive1.1271e-020.4422image
ENSG00000198429.8,ZNF69CHOLEAGT_cells_CD4_naive1.1076e-020.4432image
chr19:11912919-11914315:+COADEERMacrophages_M11.7334e-050.2620image
ENSG00000198429.8,ZNF69COADEAGDendritic_cells_activated2.0646e-040.2252image
ENSG00000198429.8,ZNF69DLBCEAGT_cells_CD4_memory_activated3.8820e-030.5194image
chr19:11912919-11914315:+ESCAEERT_cells_follicular_helper4.2301e-02-0.2110image
ENSG00000198429.8,ZNF69ESCAEAGT_cells_follicular_helper3.8288e-02-0.2152image
chr19:11912919-11914315:+GBMEERMonocytes1.4157e-050.3431image
ENSG00000198429.8,ZNF69GBMEAGMonocytes1.4137e-050.3431image
chr19:11912919-11914315:+KICHEERT_cells_regulatory_(Tregs)6.3769e-03-0.4462image
ENSG00000198429.8,ZNF69KICHEAGT_cells_regulatory_(Tregs)6.3769e-03-0.4462image
chr19:11912919-11914315:+KIRCEERT_cells_gamma_delta5.2297e-040.1822image
ENSG00000198429.8,ZNF69KIRCEAGT_cells_gamma_delta2.1393e-040.1939image
chr19:11912919-11914315:+KIRPEERMacrophages_M11.4581e-050.2643image
ENSG00000198429.8,ZNF69KIRPEAGMacrophages_M11.3246e-050.2655image
chr19:11888664-11891326:+LAMLEERMast_cells_activated3.3693e-02-0.2181image
chr19:11895932-11898699:+LAMLEERNeutrophils9.1485e-030.3259image
chr19:11912919-11914315:+LAMLEERMacrophages_M01.1780e-020.2292image
ENSG00000198429.8,ZNF69LAMLEAGMacrophages_M04.4179e-040.3038image
chr19:11912919-11914315:+LGGEEREosinophils2.9164e-020.1032image
ENSG00000198429.8,ZNF69LGGEAGEosinophils2.9164e-020.1032image
chr19:11912919-11914315:+LIHCEERNK_cells_resting3.4394e-020.1232image
ENSG00000198429.8,ZNF69LIHCEAGNK_cells_resting3.3224e-020.1240image
chr19:11912919-11914315:+LUADEERMast_cells_resting8.6353e-03-0.1318image
ENSG00000198429.8,ZNF69LUADEAGMast_cells_resting6.6596e-03-0.1360image
chr19:11912919-11914315:+MESOEERMacrophages_M23.9912e-02-0.3710image
ENSG00000198429.8,ZNF69MESOEAGMacrophages_M23.9912e-02-0.3710image
chr19:11895932-11898699:+OVEERMonocytes1.8215e-02-0.4510image
chr19:11912919-11914315:+OVEERT_cells_CD89.3477e-040.2236image
ENSG00000198429.8,ZNF69OVEAGT_cells_CD81.0046e-030.2223image
chr19:11912919-11914315:+PAADEERT_cells_CD4_memory_activated6.1529e-030.2099image
ENSG00000198429.8,ZNF69PAADEAGT_cells_CD4_memory_activated6.1529e-030.2099image
chr19:11912919-11914315:+PRADEERPlasma_cells7.1460e-05-0.1792image
ENSG00000198429.8,ZNF69PRADEAGPlasma_cells4.1818e-05-0.1847image
chr19:11912919-11914315:+READEERNK_cells_resting7.6108e-030.2751image
ENSG00000198429.8,ZNF69READEAGNK_cells_resting3.0052e-020.2251image
chr19:11912919-11914315:+SARCEERB_cells_naive1.8449e-02-0.1750image
ENSG00000198429.8,ZNF69SARCEAGB_cells_naive1.8433e-02-0.1750image
chr19:11912919-11914315:+SKCMEERT_cells_CD81.2094e-040.2088image
ENSG00000198429.8,ZNF69SKCMEAGT_cells_CD81.2145e-040.2088image
chr19:11888664-11891326:+STADEERT_cells_gamma_delta2.0516e-040.3201image
chr19:11895932-11898699:+STADEERB_cells_memory3.8212e-050.3995image
chr19:11912919-11914315:+STADEERMonocytes2.0738e-030.1713image
ENSG00000198429.8,ZNF69STADEAGMonocytes1.4682e-030.1766image
chr19:11912919-11914315:+TGCTEERMacrophages_M22.1311e-06-0.3896image
ENSG00000198429.8,ZNF69TGCTEAGMacrophages_M22.1311e-06-0.3896image
chr19:11912919-11914315:+THCAEERNeutrophils6.5216e-040.1540image
ENSG00000198429.8,ZNF69THCAEAGNeutrophils7.3044e-040.1526image
chr19:11912919-11914315:+THYMEERT_cells_regulatory_(Tregs)1.1778e-05-0.4189image
ENSG00000198429.8,ZNF69THYMEAGT_cells_regulatory_(Tregs)9.7789e-07-0.4627image
chr19:11912919-11914315:+UCSEERT_cells_regulatory_(Tregs)1.4713e-020.3431image
ENSG00000198429.8,ZNF69UCSEAGT_cells_regulatory_(Tregs)1.4713e-020.3431image


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6. Enriched editing regions and immune gene sets for ZNF69


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr19:11912919-11914315:+BLCAEER3.6086e-05image1.5451e-150.4110image
ENSG00000198429.8,ZNF69BLCAEAG4.0218e-05image2.6337e-150.4068image
chr19:11912919-11914315:+KIRPEER7.3001e-03image8.8798e-050.2397image
ENSG00000198429.8,ZNF69KIRPEAG7.5280e-03image1.1399e-040.2361image
chr19:11912919-11914315:+STADEER2.9166e-03image1.1903e-050.2417image
ENSG00000198429.8,ZNF69STADEAG2.3802e-03image4.5306e-060.2524image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000198429.8,ZNF69BLCAEAG2.7957e-090.31177.8520e-030.14237.6071e-100.32228.1963e-240.5040image
chr19:11912919-11914315:+BLCAEER2.4156e-090.31388.1876e-030.14208.4838e-100.32221.5338e-240.5122image
ENSG00000198429.8,ZNF69LIHCEAG1.0368e-02-0.14905.3618e-06-0.26144.1699e-05-0.23622.9179e-020.1270image
chr19:11912919-11914315:+LIHCEER9.8489e-03-0.15015.3867e-06-0.26134.2680e-05-0.23593.3305e-020.1240image
ENSG00000198429.8,ZNF69LUADEAG1.7312e-060.23735.0410e-040.17382.6180e-040.18222.3726e-100.3110image
chr19:11912919-11914315:+LUADEER2.3784e-060.23455.2760e-040.17343.0585e-040.18054.3134e-100.3070image
ENSG00000198429.8,ZNF69THYMEAG2.6988e-04-0.35331.9081e-06-0.45151.9849e-030.30278.8693e-040.3242image
chr19:11912919-11914315:+THYMEER2.9632e-04-0.35111.4437e-06-0.45621.3328e-020.24433.3544e-030.2878image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr19:11912919-11914315:+BLCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER5.6459e-280.5434image
ENSG00000198429.8,ZNF69BLCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.6634e-270.5380image
ENSG00000198429.8,ZNF69BRCAGSVA_HALLMARK_HEME_METABOLISMEAG1.1757e-110.2146image
chr19:11912919-11914315:+BRCAGSVA_HALLMARK_HEME_METABOLISMEER3.8607e-110.2095image
chr19:11912919-11914315:+CESCGSVA_HALLMARK_P53_PATHWAYEER4.6981e-060.4418image
ENSG00000198429.8,ZNF69CESCGSVA_HALLMARK_P53_PATHWAYEAG4.8283e-060.4413image
ENSG00000198429.8,ZNF69CHOLGSVA_HALLMARK_ANGIOGENESISEAG3.6201e-02-0.3717image
chr19:11912919-11914315:+CHOLGSVA_HALLMARK_ANGIOGENESISEER3.4870e-02-0.3742image
chr19:11912919-11914315:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.8871e-090.3470image
ENSG00000198429.8,ZNF69COADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG4.8947e-060.2755image
ENSG00000198429.8,ZNF69DLBCGSVA_HALLMARK_G2M_CHECKPOINTEAG1.3954e-02-0.4515image
chr19:11888664-11891326:+ESCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER1.6360e-020.3224image
chr19:11895932-11898699:+ESCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.7861e-020.3772image
chr19:11901537-11903352:+ESCAGSVA_HALLMARK_MYC_TARGETS_V1EER4.6415e-020.3664image
ENSG00000198429.8,ZNF69GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG6.1718e-060.3563image
chr19:11912919-11914315:+GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER6.1939e-060.3562image
ENSG00000198429.8,ZNF69HNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.4923e-02-0.3786image
chr19:11912919-11914315:+HNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.4923e-02-0.3786image
ENSG00000198429.8,ZNF69KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.4163e-02-0.3374image
chr19:11912919-11914315:+KICHGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.4163e-02-0.3374image
chr19:11912919-11914315:+KIRCGSVA_HALLMARK_MTORC1_SIGNALINGEER1.0580e-130.3789image
ENSG00000198429.8,ZNF69KIRCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.5367e-150.4036image
ENSG00000198429.8,ZNF69KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEAG9.3086e-100.3666image
chr19:11912919-11914315:+KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEER5.6413e-100.3711image
ENSG00000198429.8,ZNF69LAMLGSVA_HALLMARK_ANDROGEN_RESPONSEEAG5.2725e-030.2434image
chr19:11888664-11891326:+LAMLGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER1.7336e-030.3172image
chr19:11912919-11914315:+LAMLGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.6205e-020.1824image
ENSG00000198429.8,ZNF69LGGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.7708e-060.2238image
chr19:11912919-11914315:+LGGGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.7708e-060.2238image
ENSG00000198429.8,ZNF69LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.0119e-070.3039image
chr19:11912919-11914315:+LIHCGSVA_HALLMARK_BILE_ACID_METABOLISMEER8.5120e-080.3056image
chr19:11912919-11914315:+LUADGSVA_HALLMARK_UV_RESPONSE_UPEER2.8619e-130.3559image
ENSG00000198429.8,ZNF69LUADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.2877e-130.3603image
ENSG00000198429.8,ZNF69LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.5873e-020.2189image
chr19:11912919-11914315:+LUSCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.5873e-020.2189image
ENSG00000198429.8,ZNF69MESOGSVA_HALLMARK_APOPTOSISEAG2.7804e-020.3951image
chr19:11912919-11914315:+MESOGSVA_HALLMARK_APOPTOSISEER2.7804e-020.3951image
chr19:11912919-11914315:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER5.5204e-050.2708image
ENSG00000198429.8,ZNF69OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG6.8320e-050.2675image
ENSG00000198429.8,ZNF69PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.9365e-040.2752image
chr19:11912919-11914315:+PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.9365e-040.2752image
ENSG00000198429.8,ZNF69PCPGGSVA_HALLMARK_P53_PATHWAYEAG1.5821e-040.3859image
chr19:11912919-11914315:+PCPGGSVA_HALLMARK_P53_PATHWAYEER1.5821e-040.3859image
chr19:11912919-11914315:+PRADGSVA_HALLMARK_HEME_METABOLISMEER2.4094e-050.1903image
ENSG00000198429.8,ZNF69PRADGSVA_HALLMARK_HEME_METABOLISMEAG1.0266e-040.1753image
chr19:11912919-11914315:+READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.0627e-050.4074image
ENSG00000198429.8,ZNF69READGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.9272e-060.4579image
chr19:11912919-11914315:+SARCGSVA_HALLMARK_UV_RESPONSE_UPEER4.8012e-030.2088image
ENSG00000198429.8,ZNF69SARCGSVA_HALLMARK_UV_RESPONSE_UPEAG4.8082e-030.2087image
chr19:11912919-11914315:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.4138e-070.2701image
ENSG00000198429.8,ZNF69SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.4530e-070.2700image
chr19:11912919-11914315:+STADGSVA_HALLMARK_MYOGENESISEER2.7990e-080.3038image
chr19:11895932-11898699:+STADGSVA_HALLMARK_UV_RESPONSE_DNEER1.1440e-030.3206image
ENSG00000198429.8,ZNF69STADGSVA_HALLMARK_MYOGENESISEAG2.0743e-090.3260image
chr19:11888664-11891326:+STADGSVA_HALLMARK_APICAL_JUNCTIONEER1.3516e-030.2782image
chr19:11901537-11903352:+STADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.6934e-020.2215image
chr19:11912919-11914315:+TGCTGSVA_HALLMARK_SPERMATOGENESISEER1.7032e-030.2638image
ENSG00000198429.8,ZNF69TGCTGSVA_HALLMARK_SPERMATOGENESISEAG1.7032e-030.2638image
chr19:11912919-11914315:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.3194e-130.3204image
ENSG00000198429.8,ZNF69THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.7486e-120.3097image
chr19:11912919-11914315:+THYMGSVA_HALLMARK_E2F_TARGETSEER2.2758e-09-0.5492image
ENSG00000198429.8,ZNF69THYMGSVA_HALLMARK_E2F_TARGETSEAG4.5435e-10-0.5686image
ENSG00000198429.8,ZNF69UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.6382e-040.2562image
chr19:11912919-11914315:+UCSGSVA_HALLMARK_P53_PATHWAYEER3.1476e-020.3046image
ENSG00000198429.8,ZNF69UCSGSVA_HALLMARK_P53_PATHWAYEAG3.1476e-020.3046image
ENSG00000198429.8,ZNF69UVMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.5222e-030.4737image
chr19:11912919-11914315:+UVMGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER3.5222e-030.4737image


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7. Enriched editing regions and drugs for ZNF69


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr19:11912919-11914315:+ACCBI.2536EER2.1509e-030.4886image
ENSG00000198429.8,ZNF69ACCBI.2536EAG2.1509e-030.4886image
chr19:11912919-11914315:+BLCACGP.60474EER1.1515e-20-0.4727image
ENSG00000198429.8,ZNF69BLCACGP.60474EAG6.6801e-20-0.4631image
ENSG00000198429.8,ZNF69BRCAGSK.650394EAG9.0765e-060.1414image
chr19:11912919-11914315:+BRCAGSK.650394EER7.9821e-060.1425image
chr19:11912919-11914315:+CESCLapatinibEER4.4803e-05-0.4000image
ENSG00000198429.8,ZNF69CESCLapatinibEAG4.5040e-05-0.3999image
ENSG00000198429.8,ZNF69CHOLBicalutamideEAG1.6349e-030.5342image
chr19:11912919-11914315:+CHOLBicalutamideEER1.8069e-030.5300image
ENSG00000198429.8,ZNF69COADJNJ.26854165EAG6.1279e-06-0.2728image
chr19:11912919-11914315:+COADJNJ.26854165EER9.1027e-05-0.2394image
ENSG00000198429.8,ZNF69DLBCAZD.2281EAG1.3450e-02-0.4536image
chr19:11888664-11891326:+ESCACCT018159EER4.8944e-02-0.2693image
ENSG00000198429.8,ZNF69GBMDoxorubicinEAG2.0713e-040.2956image
chr19:11912919-11914315:+GBMDoxorubicinEER2.0671e-040.2957image
ENSG00000198429.8,ZNF69KICHGefitinibEAG8.0495e-03-0.4348image
chr19:11912919-11914315:+KICHGefitinibEER8.0495e-03-0.4348image
chr19:11912919-11914315:+KIRCCI.1040EER3.1680e-08-0.2868image
ENSG00000198429.8,ZNF69KIRCCI.1040EAG1.8323e-07-0.2707image
ENSG00000198429.8,ZNF69KIRPBI.2536EAG1.8979e-100.3804image
chr19:11912919-11914315:+KIRPBI.2536EER1.6872e-100.3814image
chr19:11888664-11891326:+LAMLEHT.1864EER1.7267e-020.2438image
chr19:11895932-11898699:+LAMLGSK269962AEER1.2104e-020.3144image
ENSG00000198429.8,ZNF69LAMLBX.795EAG7.6886e-03-0.2328image
chr19:11912919-11914315:+LAMLAP.24534EER6.0069e-030.2494image
ENSG00000198429.8,ZNF69LGGGemcitabineEAG8.9431e-080.2496image
chr19:11912919-11914315:+LGGGemcitabineEER8.9431e-080.2496image
ENSG00000198429.8,ZNF69LIHCIPA.3EAG8.1595e-080.3066image
chr19:11912919-11914315:+LIHCIPA.3EER8.5793e-080.3061image
chr19:11912919-11914315:+LUADCGP.60474EER1.7364e-04-0.1876image
ENSG00000198429.8,ZNF69LUADBMS.509744EAG9.6383e-05-0.1945image
chr19:11912919-11914315:+LUSCBMS.708163EER3.2421e-02-0.1946image
ENSG00000198429.8,ZNF69LUSCBMS.708163EAG3.2421e-02-0.1946image
ENSG00000198429.8,ZNF69MESOFH535EAG3.9522e-020.3717image
chr19:11912919-11914315:+MESOFH535EER3.9522e-020.3717image
chr19:11912919-11914315:+OVAZ628EER1.2994e-05-0.2919image
ENSG00000198429.8,ZNF69OVAZ628EAG1.7615e-05-0.2876image
chr19:11895932-11898699:+OVBMS.754807EER3.6832e-030.5395image
ENSG00000198429.8,ZNF69PAADBMS.754807EAG1.8145e-030.2440image
chr19:11912919-11914315:+PAADBMS.754807EER1.8145e-030.2440image
ENSG00000198429.8,ZNF69PCPGDocetaxelEAG1.8361e-02-0.2468image
chr19:11912919-11914315:+PCPGDocetaxelEER1.8361e-02-0.2468image
chr19:11912919-11914315:+PRADCEP.701EER2.3653e-050.1905image
ENSG00000198429.8,ZNF69PRADCEP.701EAG2.2813e-060.2125image
chr19:11912919-11914315:+READA.770041EER5.5156e-05-0.4076image
ENSG00000198429.8,ZNF69READBortezomibEAG1.2827e-03-0.3290image
chr19:11912919-11914315:+SARCMG.132EER5.3506e-03-0.2062image
ENSG00000198429.8,ZNF69SARCMG.132EAG5.3578e-03-0.2062image
chr19:11912919-11914315:+SKCMDasatinibEER1.9899e-05-0.2321image
ENSG00000198429.8,ZNF69SKCMDasatinibEAG2.0025e-05-0.2321image
chr19:11895932-11898699:+STADEmbelinEER1.7748e-03-0.3088image
chr19:11901537-11903352:+STADAMG.706EER1.0784e-02-0.2819image
ENSG00000198429.8,ZNF69STADAZ628EAG6.3784e-10-0.3357image
chr19:11912919-11914315:+STADAZ628EER4.1408e-10-0.3397image
chr19:11888664-11891326:+STADCisplatinEER7.7599e-030.2325image
chr19:11912919-11914315:+TGCTBMS.754807EER1.3762e-040.3178image
ENSG00000198429.8,ZNF69TGCTBMS.754807EAG1.3762e-040.3178image
chr19:11912919-11914315:+THCAAMG.706EER1.8548e-100.2836image
ENSG00000198429.8,ZNF69THCAAMG.706EAG3.3398e-100.2797image
ENSG00000198429.8,ZNF69THYMABT.263EAG6.0268e-110.5913image
chr19:11912919-11914315:+THYMABT.263EER1.1857e-090.5572image
chr19:11912919-11914315:+UCECGW.441756EER1.2424e-020.1942image
ENSG00000198429.8,ZNF69UCECCGP.082996EAG1.8218e-03-0.2402image
chr19:11912919-11914315:+UCSCyclopamineEER2.5560e-03-0.4175image
ENSG00000198429.8,ZNF69UCSCyclopamineEAG2.5560e-03-0.4175image
chr19:11912919-11914315:+UVMErlotinibEER1.8870e-02-0.3895image
ENSG00000198429.8,ZNF69UVMErlotinibEAG1.8870e-02-0.3895image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType