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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZKSCAN1 (ImmuneEditome ID:7586)

1. Gene summary of enriched editing regions for ZKSCAN1

check button Gene summary
Gene informationGene symbol

ZKSCAN1

Gene ID

7586

GeneSynonymsKOX18|PHZ-37|ZNF139|ZNF36|ZSCAN33
GeneCytomap

7q22.1

GeneTypeprotein-coding
GeneDescriptionzinc finger protein with KRAB and SCAN domains 1|zinc finger protein 139|zinc finger protein 36 (KOX 18)
GeneModificationdate20230517
UniprotIDB3KRF7;P17029;E9PC66;C9JRM9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:100019756-100020585:+ENST00000482979.4ENSG00000106261.15ZKSCAN1ncRNA_intronicAluSx,MIRchr7:100019756-100020585:+.alignment
chr7:100031293-100033167:+ENST00000324306.9ENSG00000106261.15ZKSCAN1intronicAluSx,AluJb,AluJr,AluYchr7:100031293-100033167:+.alignment
chr7:100031293-100033167:+ENST00000426572.4ENSG00000106261.15ZKSCAN1intronicAluSx,AluJb,AluJr,AluYchr7:100031293-100033167:+.alignment
chr7:100031293-100033167:+ENST00000535170.4ENSG00000106261.15ZKSCAN1intronicAluSx,AluJb,AluJr,AluYchr7:100031293-100033167:+.alignment
chr7:100031293-100033167:+ENST00000620510.1ENSG00000106261.15ZKSCAN1intronicAluSx,AluJb,AluJr,AluYchr7:100031293-100033167:+.alignment
chr7:100036522-100036780:+ENST00000324306.9ENSG00000106261.15ZKSCAN1UTR3AluSx1chr7:100036522-100036780:+.alignment
chr7:100036522-100036780:+ENST00000535170.4ENSG00000106261.15ZKSCAN1UTR3AluSx1chr7:100036522-100036780:+.alignment
chr7:100036522-100036780:+ENST00000620510.1ENSG00000106261.15ZKSCAN1UTR3AluSx1chr7:100036522-100036780:+.alignment


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2. Tumor-specific enriched editing regions for ZKSCAN1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000106261.15,ZKSCAN1BRCAEAG4.4236e-021.0482e-021.6036e-02image

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3. Enriched editing regions and immune related genes for ZKSCAN1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ZKSCAN1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for ZKSCAN1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr7:100031293-100033167:+BRCAEERT_cells_follicular_helper1.0909e-020.1762image
ENSG00000106261.15,ZKSCAN1COADEAGT_cells_CD4_memory_activated2.0981e-02-0.3471image
chr7:100031293-100033167:+ESCAEERMast_cells_resting2.0919e-02-0.2579image
ENSG00000106261.15,ZKSCAN1ESCAEAGNK_cells_resting3.7760e-02-0.2060image
ENSG00000106261.15,ZKSCAN1HNSCEAGB_cells_memory6.7350e-030.4378image
ENSG00000106261.15,ZKSCAN1KIRPEAGT_cells_CD82.8331e-02-0.4475image
ENSG00000106261.15,ZKSCAN1LGGEAGNK_cells_resting4.5016e-020.3410image
ENSG00000106261.15,ZKSCAN1LIHCEAGMast_cells_resting1.5098e-020.4258image
ENSG00000106261.15,ZKSCAN1LUADEAGDendritic_cells_activated4.0838e-020.3132image
ENSG00000106261.15,ZKSCAN1LUSCEAGB_cells_memory1.3752e-020.4127image
ENSG00000106261.15,ZKSCAN1OVEAGT_cells_CD84.1722e-02-0.2477image
ENSG00000106261.15,ZKSCAN1PAADEAGB_cells_memory8.8873e-040.6226image
ENSG00000106261.15,ZKSCAN1PRADEAGB_cells_memory1.6172e-020.2769image
ENSG00000106261.15,ZKSCAN1SKCMEAGB_cells_naive2.7633e-020.2754image
chr7:100031293-100033167:+STADEERT_cells_CD4_memory_activated1.2935e-020.2236image
ENSG00000106261.15,ZKSCAN1THCAEAGNK_cells_activated5.8677e-03-0.4563image


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6. Enriched editing regions and immune gene sets for ZKSCAN1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000106261.15,ZKSCAN1BLCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG1.3731e-03-0.5843image
ENSG00000106261.15,ZKSCAN1BRCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.9925e-03-0.1954image
chr7:100031293-100033167:+BRCAGSVA_HALLMARK_DNA_REPAIREER2.9014e-040.2488image
ENSG00000106261.15,ZKSCAN1ESCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.2347e-02-0.2469image
chr7:100031293-100033167:+ESCAGSVA_HALLMARK_MYC_TARGETS_V2EER5.5219e-030.3075image
ENSG00000106261.15,ZKSCAN1KIRCGSVA_HALLMARK_UV_RESPONSE_UPEAG4.8858e-05-0.4815image
ENSG00000106261.15,ZKSCAN1KIRPGSVA_HALLMARK_MTORC1_SIGNALINGEAG3.8214e-03-0.5675image
ENSG00000106261.15,ZKSCAN1LGGGSVA_HALLMARK_SPERMATOGENESISEAG3.4728e-03-0.4806image
ENSG00000106261.15,ZKSCAN1LIHCGSVA_HALLMARK_P53_PATHWAYEAG2.4345e-02-0.3973image
ENSG00000106261.15,ZKSCAN1LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.3831e-02-0.3244image
ENSG00000106261.15,ZKSCAN1LUSCGSVA_HALLMARK_ADIPOGENESISEAG4.4163e-02-0.3423image
ENSG00000106261.15,ZKSCAN1OVGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG4.5300e-03-0.3402image
ENSG00000106261.15,ZKSCAN1PAADGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG5.9800e-03-0.5339image
ENSG00000106261.15,ZKSCAN1PRADGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.9257e-02-0.2698image
ENSG00000106261.15,ZKSCAN1SKCMGSVA_HALLMARK_PEROXISOMEEAG8.1227e-05-0.4724image
ENSG00000106261.15,ZKSCAN1STADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.4869e-020.1888image
chr7:100031293-100033167:+STADGSVA_HALLMARK_KRAS_SIGNALING_DNEER9.6686e-030.2325image
ENSG00000106261.15,ZKSCAN1THCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG7.4123e-05-0.6188image


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7. Enriched editing regions and drugs for ZKSCAN1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000106261.15,ZKSCAN1BRCACCT007093EAG1.0397e-02-0.1624image
chr7:100031293-100033167:+BRCAAZD6482EER3.7741e-020.1449image
ENSG00000106261.15,ZKSCAN1ESCAGDC.0449EAG4.2797e-04-0.3424image
chr7:100031293-100033167:+ESCAAZD6244EER4.7026e-03-0.3130image
ENSG00000106261.15,ZKSCAN1HNSCGSK.650394EAG1.5430e-020.3954image
ENSG00000106261.15,ZKSCAN1KIRCMG.132EAG2.9408e-030.3632image
ENSG00000106261.15,ZKSCAN1KIRPCI.1040EAG1.0043e-040.7104image
ENSG00000106261.15,ZKSCAN1LGGJNK.9LEAG2.0912e-03-0.5026image
ENSG00000106261.15,ZKSCAN1LIHCCamptothecinEAG1.9919e-020.4096image
ENSG00000106261.15,ZKSCAN1LUADCamptothecinEAG1.4759e-020.3694image
ENSG00000106261.15,ZKSCAN1OVKU.55933EAG6.1536e-030.3290image
ENSG00000106261.15,ZKSCAN1PAADABT.888EAG7.3056e-03-0.5230image
ENSG00000106261.15,ZKSCAN1PRADBosutinibEAG1.6258e-03-0.3578image
ENSG00000106261.15,ZKSCAN1SKCMJW.7.52.1EAG6.9530e-040.4130image
ENSG00000106261.15,ZKSCAN1STADErlotinibEAG2.5642e-040.2810image
chr7:100031293-100033167:+STADAMG.706EER1.0192e-03-0.2927image
ENSG00000106261.15,ZKSCAN1THCABosutinibEAG4.5898e-03-0.4744image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType