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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF8 (ImmuneEditome ID:7554)

1. Gene summary of enriched editing regions for ZNF8

check button Gene summary
Gene informationGene symbol

ZNF8

Gene ID

7554

GeneSynonymsHF.18|Zfp128
GeneCytomap

19q13.43

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 8|zinc finger protein 272|zinc finger protein 8 (clone HF.18)|zinc finger protein HF.18
GeneModificationdate20230518
UniprotIDP17098
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:58284787-58285272:+ENST00000621650.1ENSG00000278129.1ZNF8intronicAluSc8,MER102c,AluSz6chr19:58284787-58285272:+.alignment
chr19:58296423-58299800:+ENST00000621650.1ENSG00000278129.1ZNF8UTR3AluYf1,AluY,Charlie1a,AluJr,AluJb,AluSz6,AluSz,AluSg,L1MC5,MER20chr19:58296423-58299800:+.alignment


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2. Tumor-specific enriched editing regions for ZNF8


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr19:58296423-58299800:+BLCAPathEER3.3288e-021.0670e-020.3274image
chr19:58296423-58299800:+COADPathEER4.4926e-029.1350e-030.5670image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000278129.1,ZNF8BLCAEAG3.3333e-031.2549e-042.7768e+05image

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3. Enriched editing regions and immune related genes for ZNF8


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:58296423-58299800:+STADEERENSG00000278129,ZNF8-0.41563.3278e-117.0766e-15-0.4144imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NANeutrophilsGSVA_HALLMARK_FATTY_ACID_METABOLISM
chr19:58296423-58299800:+ESCAEERENSG00000278129,ZNF8-0.64117.3831e-126.5971e-14-0.5506imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr19:58296423-58299800:+ESCAEERENSG00000083814,ZNF671-0.58142.5080e-091.2296e-09-0.4597imageNEIF4A3;FBL;FUS;IGF2BP2;NOP58;RBFOX2;SRSF1;TAF15;TARDBP;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
chr19:58296423-58299800:+ESCAEERENSG00000204519,ZNF551-0.57729.1820e-093.8537e-08-0.4203imageNCNBP;DDX54;DHX9;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;RBFOX2;RBM10;SLTM;SRSF1;SRSF9;TAF15;TARBP2;TARDBP;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr19:58296423-58299800:+ESCAEERENSG00000204514,ZNF814-0.54606.0353e-081.4085e-09-0.4583imageNADAR;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;MOV10;NOP56;NOP58;RBFOX2;SLTM;SRSF1;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr19:58296423-58299800:+ESCAEERENSG00000263002,ZNF234-0.55056.1232e-081.7562e-09-0.4559imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARBP2;TARDBP;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr19:58296423-58299800:+ESCAEERENSG00000167637,ZNF283-0.54716.3536e-088.0122e-09-0.4389imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr19:58296423-58299800:+ESCAEERENSG00000188785,ZNF548-0.54259.6844e-088.3795e-09-0.4384imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;MOV10;NOP56;NOP58;NPM1;PTBP1;RBFOX2;RBM10;SLTM;SRSF1;SRSF9;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:58296423-58299800:+ESCAEERENSG00000142396,ERVK3-1-0.53331.1913e-073.7257e-08-0.4207imageNADAR;CNBP;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SLTM;SRSF1;SRSF9;TAF15;TARDBP;U2AF2;UPF1NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr19:58296423-58299800:+ESCAEERENSG00000268201,CTD-3138B18.6-0.53641.2769e-075.5216e-09-0.4431imageNDHX9;EIF4A3;ELAVL1;FBL;HNRNPC;KHDRBS1;MOV10;NOP56;NOP58;SLTM;TAF15;TARDBP;U2AF2NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING

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4. Enriched editing regions and immune related splicing for ZNF8


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:58296423-58299800:+
ESCAEERIRENSG00000187954.8chr8144453221:144453460:144462282:144462415-0.47198.4457e-054.0649e-08-0.4196imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;MOV10;NOP56;NOP58;NPM1;PTBP1;RBFOX2;RBM10;SLTM;SRSF1;SRSF9;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr19:58296423-58299800:+
ESCAEERIRENSG00000146707.10chr776618182:76618300:76618496:76618615-0.35041.4761e-032.5714e-06-0.4241imageNADAR;EIF4A3;FBL;FUS;HNRNPC;IGF2BP2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SLTM;SRSF1;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr19:58296423-58299800:+
ESCAEERIRENSG00000138468.11chr3101332769:101332862:101337508:101337631-0.45611.2707e-051.2757e-08-0.4625imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS2;MOV10;NOP56;NOP58;NPM1;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARBP2;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
chr19:58296423-58299800:+
ESCAEERIRENSG00000111011.13chr12122518838:122519051:122521384:122521428-0.28761.9616e-022.9751e-06-0.4010imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;NPM1;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARBP2;TARDBP;U2AF2;UPF1;YTHDC1NAMonocytesGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr19:58296423-58299800:+
ESCAEERIRENSG00000189180.11chr1038012297:38012350:38016870:38017011-0.49641.3878e-055.9819e-08-0.4173imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;NPM1;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARBP2;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr19:58296423-58299800:+
ESCAEERIRENSG00000168003.12chr1162883988:62884112:62884456:62884512-0.49131.3878e-056.2469e-09-0.4469imageNADAR;CNBP;DDX54;DHX9;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;NPM1;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARBP2;TARDBP;U2AF2;UPF1;YTHDC1SLC3A2T_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr19:58296423-58299800:+
ESCAEERIRENSG00000164576.7chr5154451090:154452499:154453401:154453485-0.31141.0495e-021.0718e-05-0.4027imageNADAR;CNBP;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FUS;HNRNPC;HNRNPK;HNRNPM;IGF2BP2;KHDRBS1;KHDRBS2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SLTM;SRSF1;SRSF9;TAF15;TARDBP;U2AF2;UPF1;YTHDC1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
ENSG00000278129.1,ZNF8
ESCAEAGIRENSG00000198353.6chr1254053159:54054361:54054849:54055327-0.36354.2770e-041.4276e-06-0.4373imageNADAR;AIFM1;ALYREF;AUH;CAPRIN1;CNBP;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;METTL3;MOV10;NONO;NOP56;NOP58;NUMA1;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RC3H1;SAFB2;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YTHDF2;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
ENSG00000278129.1,ZNF8
ESCAEAGIRENSG00000102317.13chrX48575560:48576083:48576313:48576419-0.54087.5466e-071.2700e-09-0.4594imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LIN28;LIN28A;LIN28B;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
ENSG00000278129.1,ZNF8
ESCAEAGIRENSG00000204859.7chr16580540:6581299:6582057:6582223-0.54098.7302e-074.6540e-09-0.4503imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHSRP;LIN28;LIN28B;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS

More results



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5. Enriched editing regions and immune infiltration for ZNF8


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:58296423-58299800:+BRCAEERT_cells_CD4_memory_resting2.7014e-03-0.1515image
ENSG00000278129.1,ZNF8BRCAEAGB_cells_naive3.2230e-020.0993image
chr19:58296423-58299800:+ESCAEERT_cells_CD4_memory_resting1.7652e-03-0.2469image
ENSG00000278129.1,ZNF8ESCAEAGT_cells_CD4_memory_resting2.0697e-03-0.2433image
chr19:58296423-58299800:+GBMEERT_cells_CD81.7753e-020.3103image
ENSG00000278129.1,ZNF8GBMEAGT_cells_CD81.7753e-020.3103image
ENSG00000278129.1,ZNF8HNSCEAGT_cells_CD4_naive1.9761e-030.3768image
ENSG00000278129.1,ZNF8KICHEAGMast_cells_activated3.4664e-020.4421image
ENSG00000278129.1,ZNF8KIRPEAGDendritic_cells_resting4.3912e-02-0.2834image
chr19:58296423-58299800:+LAMLEERMonocytes2.0576e-020.2157image
ENSG00000278129.1,ZNF8LAMLEAGMonocytes2.0603e-020.2148image
chr19:58296423-58299800:+LGGEERT_cells_CD4_naive1.6335e-020.1640image
ENSG00000278129.1,ZNF8LGGEAGT_cells_CD4_naive6.9214e-030.1820image
chr19:58296423-58299800:+LUADEERT_cells_CD4_memory_resting4.8411e-020.2148image
chr19:58296423-58299800:+LUSCEERT_cells_gamma_delta2.8286e-040.3739image
ENSG00000278129.1,ZNF8LUSCEAGB_cells_naive1.1009e-020.2449image
chr19:58296423-58299800:+OVEERNK_cells_activated2.3220e-030.2106image
ENSG00000278129.1,ZNF8OVEAGNK_cells_resting3.7981e-03-0.1962image
ENSG00000278129.1,ZNF8PCPGEAGPlasma_cells1.0337e-020.3595image
ENSG00000278129.1,ZNF8PRADEAGT_cells_gamma_delta6.4259e-030.3141image
ENSG00000278129.1,ZNF8SARCEAGMast_cells_resting3.7735e-030.4232image
ENSG00000278129.1,ZNF8SKCMEAGT_cells_CD4_memory_resting2.1205e-020.2362image
chr19:58296423-58299800:+STADEERNK_cells_resting3.8529e-020.1150image
ENSG00000278129.1,ZNF8STADEAGNK_cells_resting3.1596e-020.1194image
chr19:58296423-58299800:+THCAEERNK_cells_activated6.9770e-030.2582image
ENSG00000278129.1,ZNF8THCAEAGNK_cells_activated5.1735e-040.3038image
ENSG00000278129.1,ZNF8UCECEAGT_cells_regulatory_(Tregs)3.1498e-040.5810image
ENSG00000278129.1,ZNF8UCSEAGT_cells_regulatory_(Tregs)4.1417e-020.4284image


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6. Enriched editing regions and immune gene sets for ZNF8


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000278129.1,ZNF8STADEAG1.9799e-050.23464.2121e-020.11302.2909e-030.16893.1780e-060.2555image
chr19:58296423-58299800:+STADEER2.3199e-050.23284.3689e-020.11212.1496e-030.16992.0006e-060.2605image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000278129.1,ZNF8BLCAGSVA_HALLMARK_HEME_METABOLISMEAG3.8746e-02-0.2260image
ENSG00000278129.1,ZNF8BRCAGSVA_HALLMARK_MYC_TARGETS_V2EAG4.3746e-02-0.0936image
chr19:58296423-58299800:+BRCAGSVA_HALLMARK_GLYCOLYSISEER6.4799e-030.1376image
chr19:58296423-58299800:+ESCAGSVA_HALLMARK_P53_PATHWAYEER1.1318e-050.3414image
ENSG00000278129.1,ZNF8ESCAGSVA_HALLMARK_P53_PATHWAYEAG2.7038e-050.3273image
chr19:58296423-58299800:+GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER9.7061e-040.4219image
ENSG00000278129.1,ZNF8GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG9.7061e-040.4219image
ENSG00000278129.1,ZNF8KICHGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.5105e-02-0.4658image
chr19:58296423-58299800:+KIRPGSVA_HALLMARK_APICAL_SURFACEEER2.0883e-04-0.5479image
ENSG00000278129.1,ZNF8KIRPGSVA_HALLMARK_APICAL_SURFACEEAG2.9380e-03-0.4083image
chr19:58296423-58299800:+LAMLGSVA_HALLMARK_NOTCH_SIGNALINGEER5.6624e-030.2565image
ENSG00000278129.1,ZNF8LAMLGSVA_HALLMARK_NOTCH_SIGNALINGEAG5.0035e-030.2590image
chr19:58296423-58299800:+LGGGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.2058e-020.1713image
ENSG00000278129.1,ZNF8LGGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.2787e-02-0.1538image
ENSG00000278129.1,ZNF8LUADGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2891e-04-0.3445image
chr19:58296423-58299800:+LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER2.0168e-02-0.2516image
ENSG00000278129.1,ZNF8LUSCGSVA_HALLMARK_ADIPOGENESISEAG2.5015e-02-0.2166image
chr19:58296423-58299800:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER2.5055e-04-0.2519image
ENSG00000278129.1,ZNF8OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.2700e-06-0.3019image
ENSG00000278129.1,ZNF8PRADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG2.9939e-02-0.2526image
ENSG00000278129.1,ZNF8SARCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.1202e-03-0.4701image
ENSG00000278129.1,ZNF8SKCMGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG2.1598e-02-0.2355image
chr19:58296423-58299800:+SKCMGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.1760e-02-0.2254image
ENSG00000278129.1,ZNF8STADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG9.8606e-100.3312image
chr19:58296423-58299800:+STADGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER6.9192e-100.3341image
chr19:58296423-58299800:+TGCTGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER7.1462e-050.4825image
ENSG00000278129.1,ZNF8TGCTGSVA_HALLMARK_ADIPOGENESISEAG1.2710e-030.3941image
chr19:58296423-58299800:+THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.0131e-04-0.3653image
ENSG00000278129.1,ZNF8THCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG9.8158e-05-0.3387image


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7. Enriched editing regions and drugs for ZNF8


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000278129.1,ZNF8BRCAEtoposideEAG7.3772e-030.1241image
chr19:58296423-58299800:+BRCAMG.132EER1.4894e-02-0.1232image
chr19:58296423-58299800:+ESCADocetaxelEER3.4439e-05-0.3232image
ENSG00000278129.1,ZNF8ESCADocetaxelEAG2.0999e-04-0.2908image
chr19:58296423-58299800:+GBMBosutinibEER2.4686e-030.3901image
ENSG00000278129.1,ZNF8GBMBosutinibEAG2.4686e-030.3901image
ENSG00000278129.1,ZNF8HNSCBMS.754807EAG4.5444e-02-0.2490image
ENSG00000278129.1,ZNF8KICHAZD8055EAG3.4322e-03-0.5840image
ENSG00000278129.1,ZNF8KIRCFTI.277EAG2.9227e-020.2589image
ENSG00000278129.1,ZNF8KIRPFTI.277EAG2.4883e-020.3139image
chr19:58296423-58299800:+LAMLAG.014699EER3.1373e-040.3302image
ENSG00000278129.1,ZNF8LAMLAG.014699EAG3.8032e-040.3245image
chr19:58296423-58299800:+LGGATRAEER8.5666e-040.2263image
ENSG00000278129.1,ZNF8LGGATRAEAG3.0951e-030.1990image
ENSG00000278129.1,ZNF8LUSCBAY.61.3606EAG1.4600e-02-0.2355image
chr19:58296423-58299800:+LUSCGefitinibEER2.8287e-02-0.2313image
chr19:58296423-58299800:+OVBMS.509744EER2.8369e-06-0.3188image
ENSG00000278129.1,ZNF8OVAZD6482EAG1.5872e-070.3483image
ENSG00000278129.1,ZNF8PRADAZD6244EAG1.5108e-02-0.2815image
ENSG00000278129.1,ZNF8SARCCisplatinEAG1.4907e-020.3608image
chr19:58296423-58299800:+SKCMBI.D1870EER1.7553e-020.2617image
ENSG00000278129.1,ZNF8STADCCT007093EAG7.2309e-040.1869image
chr19:58296423-58299800:+STADCCT007093EER7.5913e-040.1862image
chr19:58296423-58299800:+TGCTMetforminEER5.6049e-04-0.4258image
ENSG00000278129.1,ZNF8TGCTDocetaxelEAG1.9539e-02-0.2913image
chr19:58296423-58299800:+THCAJNK.Inhibitor.VIIIEER2.2912e-040.3475image
ENSG00000278129.1,ZNF8THCAJNK.Inhibitor.VIIIEAG1.9772e-040.3245image
ENSG00000278129.1,ZNF8THYMBX.795EAG2.5355e-02-0.4376image
ENSG00000278129.1,ZNF8UCECAZD6244EAG3.3904e-03-0.4883image
ENSG00000278129.1,ZNF8UCSJNK.Inhibitor.VIIIEAG3.5707e-020.4398image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType