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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF3 (ImmuneEditome ID:7551)

1. Gene summary of enriched editing regions for ZNF3

check button Gene summary
Gene informationGene symbol

ZNF3

Gene ID

7551

GeneSynonymsA8-51|HF.12|KOX25|PP838|Zfp113
GeneCytomap

7q22.1

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 3|C2-H2 type zinc finger protein|zinc finger protein HF.12|zinc finger protein HZF3.1|zinc finger protein KOX25
GeneModificationdate20230518
UniprotIDQ86U76;P17036;C9J5S8;C9JE35;C9JK31
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr7:100065144-100069835:-ENST00000413658.5ENSG00000166526.15ZNF3intronicAluSp,AluSx1,AluY,HERV16-int,AluSq4,AluSx,AluJo,AluJr,AluSg,AluSzchr7:100065144-100069835:-.alignment
chr7:100076341-100078701:-ENST00000299667.7ENSG00000166526.15ZNF3exonicFLAM_C,AluSx,AluSx3,AluSq2,AluSc8,L2c,AluSx1,(AAACA)nchr7:100076341-100078701:-.alignment
chr7:100076341-100078701:-ENST00000303915.9ENSG00000166526.15ZNF3exonicFLAM_C,AluSx,AluSx3,AluSq2,AluSc8,L2c,AluSx1,(AAACA)nchr7:100076341-100078701:-.alignment
chr7:100076341-100078701:-ENST00000413658.5ENSG00000166526.15ZNF3exonicFLAM_C,AluSx,AluSx3,AluSq2,AluSc8,L2c,AluSx1,(AAACA)nchr7:100076341-100078701:-.alignment
chr7:100076341-100078701:-ENST00000415068.1ENSG00000166526.15ZNF3exonicFLAM_C,AluSx,AluSx3,AluSq2,AluSc8,L2c,AluSx1,(AAACA)nchr7:100076341-100078701:-.alignment
chr7:100076341-100078701:-ENST00000424697.4ENSG00000166526.15ZNF3exonicFLAM_C,AluSx,AluSx3,AluSq2,AluSc8,L2c,AluSx1,(AAACA)nchr7:100076341-100078701:-.alignment
chr7:100076341-100078701:-ENST00000428683.4ENSG00000166526.15ZNF3exonicFLAM_C,AluSx,AluSx3,AluSq2,AluSc8,L2c,AluSx1,(AAACA)nchr7:100076341-100078701:-.alignment
chr7:100076341-100078701:-ENST00000449785.4ENSG00000166526.15ZNF3exonicFLAM_C,AluSx,AluSx3,AluSq2,AluSc8,L2c,AluSx1,(AAACA)nchr7:100076341-100078701:-.alignment
chr7:100079787-100080740:-ENST00000460331.4ENSG00000166526.15ZNF3ncRNA_intronicAluSx1,AluJr,AluJochr7:100079787-100080740:-.alignment
chr7:100079787-100080740:-ENST00000466121.1ENSG00000166526.15ZNF3ncRNA_intronicAluSx1,AluJr,AluJochr7:100079787-100080740:-.alignment
chr7:100079787-100080740:-ENST00000479192.1ENSG00000166526.15ZNF3ncRNA_intronicAluSx1,AluJr,AluJochr7:100079787-100080740:-.alignment
chr7:100079787-100080740:-ENST00000485892.4ENSG00000166526.15ZNF3ncRNA_intronicAluSx1,AluJr,AluJochr7:100079787-100080740:-.alignment
chr7:100079787-100080740:-ENST00000487620.1ENSG00000166526.15ZNF3ncRNA_intronicAluSx1,AluJr,AluJochr7:100079787-100080740:-.alignment


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2. Tumor-specific enriched editing regions for ZNF3


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr7:100076341-100078701:-OVCliEER3.4180e-026.3117e-030.3212image
ENSG00000166526.15,ZNF3UCECCliEAG2.4149e-021.1348e-020.5076image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for ZNF3


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for ZNF3


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for ZNF3


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000166526.15,ZNF3ESCAEAGB_cells_naive2.6714e-02-0.2814image
chr7:100065144-100069835:-GBMEERT_cells_CD4_memory_activated6.5498e-030.3834image
ENSG00000166526.15,ZNF3GBMEAGT_cells_CD4_memory_activated1.0425e-020.3523image
ENSG00000166526.15,ZNF3LGGEAGNK_cells_resting3.5614e-020.2742image
chr7:100065144-100069835:-OVEERMonocytes2.6319e-020.2755image
chr7:100076341-100078701:-OVEERB_cells_naive2.0516e-020.3062image
ENSG00000166526.15,ZNF3OVEAGMast_cells_resting6.6732e-03-0.2415image
ENSG00000166526.15,ZNF3PRADEAGDendritic_cells_activated2.5819e-030.5659image
chr7:100065144-100069835:-STADEERT_cells_follicular_helper9.6936e-040.3998image
chr7:100079787-100080740:-STADEERDendritic_cells_resting4.9376e-020.4143image
ENSG00000166526.15,ZNF3STADEAGNeutrophils2.1616e-02-0.2209image
ENSG00000166526.15,ZNF3THCAEAGT_cells_CD4_memory_activated3.4807e-040.7196image


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6. Enriched editing regions and immune gene sets for ZNF3


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr7:100076341-100078701:-OVEER1.8558e-030.40354.7791e-030.36866.6667e-030.35544.0117e-030.3754image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr7:100065144-100069835:-BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER3.2190e-020.1831image
ENSG00000166526.15,ZNF3COADGSVA_HALLMARK_APICAL_SURFACEEAG1.6934e-020.4641image
ENSG00000166526.15,ZNF3ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.0031e-020.2948image
chr7:100076341-100078701:-ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.4972e-020.4228image
ENSG00000166526.15,ZNF3GBMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG3.0000e-030.4037image
chr7:100065144-100069835:-GBMGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.1263e-030.4137image
ENSG00000166526.15,ZNF3KIRPGSVA_HALLMARK_APOPTOSISEAG1.3051e-020.4801image
ENSG00000166526.15,ZNF3LGGGSVA_HALLMARK_HEME_METABOLISMEAG4.0517e-020.2675image
ENSG00000166526.15,ZNF3LUSCGSVA_HALLMARK_MYOGENESISEAG2.5637e-020.4546image
chr7:100065144-100069835:-OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.4515e-020.2501image
chr7:100076341-100078701:-OVGSVA_HALLMARK_GLYCOLYSISEER9.8995e-050.4927image
ENSG00000166526.15,ZNF3OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7271e-030.2775image
ENSG00000166526.15,ZNF3PRADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.8559e-020.4582image
chr7:100065144-100069835:-STADGSVA_HALLMARK_P53_PATHWAYEER2.4857e-020.2782image
chr7:100076341-100078701:-STADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.8033e-020.2943image
chr7:100079787-100080740:-STADGSVA_HALLMARK_APICAL_SURFACEEER7.4924e-030.5424image
ENSG00000166526.15,ZNF3STADGSVA_HALLMARK_P53_PATHWAYEAG1.4312e-020.2351image
ENSG00000166526.15,ZNF3THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG9.2195e-040.6822image


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7. Enriched editing regions and drugs for ZNF3


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr7:100065144-100069835:-BRCABI.2536EER1.3315e-02-0.2110image
ENSG00000166526.15,ZNF3BRCABI.2536EAG1.1395e-02-0.1857image
ENSG00000166526.15,ZNF3COADCGP.60474EAG1.3335e-03-0.5954image
ENSG00000166526.15,ZNF3ESCAGNF.2EAG1.8355e-03-0.3880image
chr7:100065144-100069835:-ESCAA.770041EER1.9996e-02-0.4158image
chr7:100076341-100078701:-ESCAAZD.2281EER4.0336e-04-0.6226image
ENSG00000166526.15,ZNF3GBMJNK.9LEAG1.2815e-030.4347image
chr7:100065144-100069835:-GBMJNK.9LEER2.2426e-030.4265image
ENSG00000166526.15,ZNF3KIRPCCT018159EAG1.5570e-020.4693image
ENSG00000166526.15,ZNF3LUSCAG.014699EAG3.3369e-020.4356image
chr7:100065144-100069835:-OVLFM.A13EER1.4897e-020.3008image
chr7:100076341-100078701:-OVCMKEER1.6941e-02-0.3152image
ENSG00000166526.15,ZNF3OVAMG.706EAG6.3998e-030.2426image
ENSG00000166526.15,ZNF3PRADKIN001.135EAG8.4578e-03-0.5053image
chr7:100065144-100069835:-STADJNJ.26854165EER4.2329e-020.2526image
chr7:100076341-100078701:-STADBosutinibEER8.1075e-03-0.3704image
chr7:100079787-100080740:-STADGemcitabineEER4.4996e-020.4218image
ENSG00000166526.15,ZNF3STADBosutinibEAG3.8613e-02-0.1993image
ENSG00000166526.15,ZNF3THCABMS.708163EAG8.1077e-04-0.6874image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType