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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

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6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: UGCG (ImmuneEditome ID:7357)

1. Gene summary of enriched editing regions for UGCG

check button Gene summary
Gene informationGene symbol

UGCG

Gene ID

7357

GeneSynonymsGCS|GLCT1
GeneCytomap

9q31.3

GeneTypeprotein-coding
GeneDescriptionceramide glucosyltransferase|UDP-glucose:N-acylsphingosine D-glucosyltransferase|glucosylceramide synthase|glycosylceramide synthase
GeneModificationdate20230329
UniprotIDQ16739;A0A024R157
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr9:111902874-111904791:+ENST00000489355.1ENSG00000148154.8UGCGncRNA_intronicAluSx1,AluSp,MER5B,AluSz6,AluJbchr9:111902874-111904791:+.alignment
chr9:111902874-111904791:+ENST00000490110.4ENSG00000148154.8UGCGncRNA_intronicAluSx1,AluSp,MER5B,AluSz6,AluJbchr9:111902874-111904791:+.alignment
chr9:111902874-111904791:+ENST00000495085.1ENSG00000148154.8UGCGncRNA_intronicAluSx1,AluSp,MER5B,AluSz6,AluJbchr9:111902874-111904791:+.alignment
chr9:111910836-111911821:+ENST00000489355.1ENSG00000148154.8UGCGncRNA_intronicAluSz,AluJb,L1ME4bchr9:111910836-111911821:+.alignment
chr9:111910836-111911821:+ENST00000490110.4ENSG00000148154.8UGCGncRNA_intronicAluSz,AluJb,L1ME4bchr9:111910836-111911821:+.alignment
chr9:111910836-111911821:+ENST00000495085.1ENSG00000148154.8UGCGncRNA_intronicAluSz,AluJb,L1ME4bchr9:111910836-111911821:+.alignment
chr9:111916447-111916992:+ENST00000490110.4ENSG00000148154.8UGCGncRNA_intronicAluJb,AluJrchr9:111916447-111916992:+.alignment
chr9:111916447-111916992:+ENST00000495085.1ENSG00000148154.8UGCGncRNA_intronicAluJb,AluJrchr9:111916447-111916992:+.alignment
chr9:111918056-111922090:+ENST00000490110.4ENSG00000148154.8UGCGncRNA_intronicAluYd8,MER5A,AluY,AluSq,MamSINE1,AluJr,AluJb,AluSx,AluSz,AluSgchr9:111918056-111922090:+.alignment
chr9:111918056-111922090:+ENST00000495085.1ENSG00000148154.8UGCGncRNA_intronicAluYd8,MER5A,AluY,AluSq,MamSINE1,AluJr,AluJb,AluSx,AluSz,AluSgchr9:111918056-111922090:+.alignment


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2. Tumor-specific enriched editing regions for UGCG


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr9:111918056-111922090:+STADPathEER5.3237e-033.1517e-030.2652image
ENSG00000148154.8,UGCGSTADPathEAG5.1535e-035.8969e-030.2308image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr9:111918056-111922090:+ESCAEER8.8760e-039.6556e-032.6680e+01image
ENSG00000148154.8,UGCGSTADEAG1.2561e-024.1406e-021.9692e+01image

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3. Enriched editing regions and immune related genes for UGCG


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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4. Enriched editing regions and immune related splicing for UGCG


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

More results



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5. Enriched editing regions and immune infiltration for UGCG


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr9:111916447-111916992:+BRCAEEREosinophils2.0633e-050.7036image
chr9:111918056-111922090:+BRCAEERMacrophages_M12.0067e-040.3636image
ENSG00000148154.8,UGCGBRCAEAGMacrophages_M17.4003e-040.3213image
chr9:111916447-111916992:+ESCAEERT_cells_CD84.3599e-020.3590image
chr9:111918056-111922090:+ESCAEERMacrophages_M11.9624e-020.2726image
ENSG00000148154.8,UGCGESCAEAGMacrophages_M12.1017e-020.2610image
ENSG00000148154.8,UGCGKIRCEAGT_cells_CD4_memory_activated1.6011e-030.5595image
ENSG00000148154.8,UGCGLUADEAGEosinophils4.0387e-02-0.4506image
chr9:111918056-111922090:+OVEERT_cells_CD85.0365e-050.7089image
ENSG00000148154.8,UGCGOVEAGMacrophages_M04.0080e-02-0.3769image
chr9:111910836-111911821:+STADEERMacrophages_M23.1052e-020.3256image
chr9:111916447-111916992:+STADEERT_cells_CD4_memory_activated4.8080e-030.3964image
chr9:111918056-111922090:+STADEERT_cells_CD4_memory_activated2.5702e-020.1987image
ENSG00000148154.8,UGCGSTADEAGMacrophages_M24.3461e-020.1679image


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6. Enriched editing regions and immune gene sets for UGCG


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr9:111916447-111916992:+BRCAGSVA_HALLMARK_P53_PATHWAYEER2.6993e-030.5365image
ENSG00000148154.8,UGCGBRCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.6255e-110.5934image
chr9:111918056-111922090:+BRCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.7614e-110.6091image
chr9:111918056-111922090:+ESCAGSVA_HALLMARK_HYPOXIAEER9.6027e-030.3012image
chr9:111916447-111916992:+ESCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.3826e-040.5712image
ENSG00000148154.8,UGCGESCAGSVA_HALLMARK_HYPOXIAEAG8.1778e-030.2974image
ENSG00000148154.8,UGCGKIRCGSVA_HALLMARK_G2M_CHECKPOINTEAG4.5254e-030.5120image
ENSG00000148154.8,UGCGKIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.8897e-020.3991image
chr9:111918056-111922090:+KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.0064e-020.3965image
ENSG00000148154.8,UGCGLUADGSVA_HALLMARK_APICAL_JUNCTIONEAG7.1817e-050.7567image
ENSG00000148154.8,UGCGSTADGSVA_HALLMARK_SPERMATOGENESISEAG8.5694e-040.2739image
chr9:111918056-111922090:+STADGSVA_HALLMARK_ANDROGEN_RESPONSEEER1.1387e-040.3370image


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7. Enriched editing regions and drugs for UGCG


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr9:111916447-111916992:+BRCAJNK.Inhibitor.VIIIEER8.9350e-030.4767image
ENSG00000148154.8,UGCGBRCAMethotrexateEAG8.9337e-080.4892image
chr9:111918056-111922090:+BRCAMG.132EER4.5425e-07-0.4793image
chr9:111918056-111922090:+ESCACMKEER1.1731e-02-0.2935image
chr9:111916447-111916992:+ESCAABT.888EER2.7583e-03-0.5117image
ENSG00000148154.8,UGCGESCACMKEAG4.6362e-03-0.3174image
chr9:111918056-111922090:+KIRCLFM.A13EER4.0626e-02-0.4207image
ENSG00000148154.8,UGCGKIRCFTI.277EAG1.9575e-04-0.6381image
ENSG00000148154.8,UGCGKIRPAG.014699EAG4.2494e-030.5070image
chr9:111918056-111922090:+KIRPAG.014699EER4.1967e-030.5075image
ENSG00000148154.8,UGCGLUADBexaroteneEAG7.9049e-04-0.6749image
chr9:111918056-111922090:+OVA.770041EER4.9964e-03-0.5336image
ENSG00000148154.8,UGCGSKCMErlotinibEAG7.5464e-03-0.5784image
chr9:111910836-111911821:+STADAZD.2281EER3.8865e-03-0.4265image
ENSG00000148154.8,UGCGSTADGW.441756EAG4.3458e-02-0.1680image
chr9:111916447-111916992:+STADCisplatinEER2.1597e-02-0.3275image
chr9:111918056-111922090:+STADErlotinibEER1.0891e-02-0.2270image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType