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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: UBE2D2 (ImmuneEditome ID:7322)

1. Gene summary of enriched editing regions for UBE2D2

check button Gene summary
Gene informationGene symbol

UBE2D2

Gene ID

7322

GeneSynonymsE2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH4|UBCH5B
GeneCytomap

5q31.2

GeneTypeprotein-coding
GeneDescriptionubiquitin-conjugating enzyme E2 D2|(E3-independent) E2 ubiquitin-conjugating enzyme D2|E2 ubiquitin-conjugating enzyme D2|p53-regulated ubiquitin-conjugating enzyme 1|ubiquitin carrier protein D2|ubiquitin conjugating enzyme E2D 2|ubiquitin-conjugating enzyme E2-17 kDa 2|ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D2
GeneModificationdate20230528
UniprotIDP62837;D6RFM0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:139531681-139543206:+ENST00000511725.4ENSG00000131508.14UBE2D2intronicL1MD2,FLAM_A,L1M5,AluSg4,L1MB8,AluSg,L1MB3,L1MC5,AluSq2,AluSz,AluSg7,L1ME4b,AluSx3,AluSz6,AluSx,Alu,AluJb,AluSp,AluSx1,AluY,(AAAAG)nchr5:139531681-139543206:+.alignment
chr5:139544339-139549063:+ENST00000511725.4ENSG00000131508.14UBE2D2intronicAluSg7,AluSx3,FLAM_C,AluJr4,L1ME3G,AluSc,AluSq2,AluSz,(CA)n,L1ME3,AluSc8,(TTCC)n,(AAAT)n,AluSx1,AluY,(ATC)n,MIRchr5:139544339-139549063:+.alignment
chr5:139551081-139551350:+ENST00000511725.4ENSG00000131508.14UBE2D2intronicAluSq2chr5:139551081-139551350:+.alignment
chr5:139552695-139553954:+ENST00000511725.4ENSG00000131508.14UBE2D2intronicAluSp,AluSx1chr5:139552695-139553954:+.alignment
chr5:139555096-139559406:+ENST00000511725.4ENSG00000131508.14UBE2D2intronicAluJr,AluSc,AluJb,AluSz6,AluSx,AluSg,AluSq2,MADE1,L1M5,L1ME4a,AluY,AluSpchr5:139555096-139559406:+.alignment
chr5:139566047-139567386:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluSx4,AluJb,AluSx1,MER102bchr5:139566047-139567386:+.alignment
chr5:139570097-139571382:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluSc8,MER41A,AluJb,AluSg4chr5:139570097-139571382:+.alignment
chr5:139572448-139573831:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluY,AluYm1,AluSz,AluJo,Charlie14achr5:139572448-139573831:+.alignment
chr5:139575822-139575998:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluJochr5:139575822-139575998:+.alignment
chr5:139577512-139579470:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluSz,AluSq2,AluJr,MER104,AluSp,(TG)nchr5:139577512-139579470:+.alignment
chr5:139579851-139580671:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluJr,AluJb,AluSx3,AluSc8chr5:139579851-139580671:+.alignment
chr5:139583065-139583276:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicL1MA8,AluSxchr5:139583065-139583276:+.alignment
chr5:139584993-139585906:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluSp,AluJo,AluScchr5:139584993-139585906:+.alignment
chr5:139587454-139592197:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluY,(TTTTG)n,AluSx1,AluSp,LTR17,AluSz,L1ME3C,AluSx,AluJo,AluJrchr5:139587454-139592197:+.alignment
chr5:139599064-139606336:+ENST00000253815.3ENSG00000131508.14UBE2D2exonicAluSx1,AluY,MIRc,L1M4,AluSg,AluSq2,AluSz,(TCTC)n,AluSg7,AluSz6,AluSx,AluJb,AluJr,(TTTCC)n,(TAATACA)nchr5:139599064-139606336:+.alignment
chr5:139599064-139606336:+ENST00000398733.6ENSG00000131508.14UBE2D2exonicAluSx1,AluY,MIRc,L1M4,AluSg,AluSq2,AluSz,(TCTC)n,AluSg7,AluSz6,AluSx,AluJb,AluJr,(TTTCC)n,(TAATACA)nchr5:139599064-139606336:+.alignment
chr5:139599064-139606336:+ENST00000398734.7ENSG00000131508.14UBE2D2exonicAluSx1,AluY,MIRc,L1M4,AluSg,AluSq2,AluSz,(TCTC)n,AluSg7,AluSz6,AluSx,AluJb,AluJr,(TTTCC)n,(TAATACA)nchr5:139599064-139606336:+.alignment
chr5:139599064-139606336:+ENST00000505007.4ENSG00000131508.14UBE2D2exonicAluSx1,AluY,MIRc,L1M4,AluSg,AluSq2,AluSz,(TCTC)n,AluSg7,AluSz6,AluSx,AluJb,AluJr,(TTTCC)n,(TAATACA)nchr5:139599064-139606336:+.alignment
chr5:139599064-139606336:+ENST00000505548.4ENSG00000131508.14UBE2D2exonicAluSx1,AluY,MIRc,L1M4,AluSg,AluSq2,AluSz,(TCTC)n,AluSg7,AluSz6,AluSx,AluJb,AluJr,(TTTCC)n,(TAATACA)nchr5:139599064-139606336:+.alignment
chr5:139599064-139606336:+ENST00000511725.4ENSG00000131508.14UBE2D2exonicAluSx1,AluY,MIRc,L1M4,AluSg,AluSq2,AluSz,(TCTC)n,AluSg7,AluSz6,AluSx,AluJb,AluJr,(TTTCC)n,(TAATACA)nchr5:139599064-139606336:+.alignment
chr5:139607732-139608920:+ENST00000510470.1ENSG00000131508.14UBE2D2ncRNA_intronicAluJr,AluSx,FLAM_Cchr5:139607732-139608920:+.alignment
chr5:139607732-139608920:+ENST00000511691.1ENSG00000131508.14UBE2D2ncRNA_intronicAluJr,AluSx,FLAM_Cchr5:139607732-139608920:+.alignment
chr5:139623717-139624715:+ENST00000253815.3ENSG00000131508.14UBE2D2intronicSVA_E,AluSg,AluSx,AluSz6chr5:139623717-139624715:+.alignment
chr5:139623717-139624715:+ENST00000398733.6ENSG00000131508.14UBE2D2intronicSVA_E,AluSg,AluSx,AluSz6chr5:139623717-139624715:+.alignment
chr5:139623717-139624715:+ENST00000398734.7ENSG00000131508.14UBE2D2intronicSVA_E,AluSg,AluSx,AluSz6chr5:139623717-139624715:+.alignment
chr5:139623717-139624715:+ENST00000505548.4ENSG00000131508.14UBE2D2intronicSVA_E,AluSg,AluSx,AluSz6chr5:139623717-139624715:+.alignment
chr5:139623717-139624715:+ENST00000511725.4ENSG00000131508.14UBE2D2intronicSVA_E,AluSg,AluSx,AluSz6chr5:139623717-139624715:+.alignment
chr5:139626059-139626284:+ENST00000253815.3ENSG00000131508.14UBE2D2intronicAluJbchr5:139626059-139626284:+.alignment
chr5:139626059-139626284:+ENST00000398733.6ENSG00000131508.14UBE2D2intronicAluJbchr5:139626059-139626284:+.alignment
chr5:139626059-139626284:+ENST00000398734.7ENSG00000131508.14UBE2D2intronicAluJbchr5:139626059-139626284:+.alignment
chr5:139626059-139626284:+ENST00000505548.4ENSG00000131508.14UBE2D2intronicAluJbchr5:139626059-139626284:+.alignment
chr5:139626059-139626284:+ENST00000511725.4ENSG00000131508.14UBE2D2intronicAluJbchr5:139626059-139626284:+.alignment


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2. Tumor-specific enriched editing regions for UBE2D2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
ENSG00000131508.14,UBE2D2UCECEAG4.6676e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr5:139555096-139559406:+KIRCPathEER2.6732e-024.7107e-02-0.1745image
chr5:139599064-139606336:+OVCliEER4.2070e-024.0097e-020.1392image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr5:139599064-139606336:+KIRCEER1.3978e-024.8442e-033.1059e+02image
chr5:139570097-139571382:+LAMLEER3.7409e-023.4214e-021.3844e+01image
chr5:139572448-139573831:+STADEER1.4854e-039.8717e-038.8110e-05image
ENSG00000131508.14,UBE2D2UCSEAG3.6604e-034.6475e-026.0596e+03image

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3. Enriched editing regions and immune related genes for UBE2D2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:139570097-139571382:+LAMLEERENSG00000142168,SOD10.33974.0506e-021.4041e-080.4482imageNDDX54;DHX9;EIF4A3;ELAVL1;FUS;NOP58;TAF15;U2AF2SOD1Plasma_cellsGSVA_HALLMARK_FATTY_ACID_METABOLISM

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4. Enriched editing regions and immune related splicing for UBE2D2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr5:139531681-139543206:+
KIRCEERIRENSG00000007541.10chr16580182:581341:582247:582309-0.37424.1859e-128.0129e-13-0.4279imageNADAR;CSTF2T;DKC1;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;IGF2BP2;LIN28B;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;SRSF1;TAF15;U2AF2NADendritic_cells_activatedGSVA_HALLMARK_ADIPOGENESIS
chr5:139531681-139543206:+
KIRCEERIRENSG00000167615.12chr1954458313:54458521:54460765:54462037-0.47411.2668e-152.3957e-14-0.4040imageNADAR;CSTF2T;DKC1;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;IGF2BP2;LIN28B;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;SRSF1;TAF15;U2AF2LENG8T_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
ENSG00000131508.14,UBE2D2
KIRCEAGIRENSG00000169592.10chr1630001211:30001530:30004567:30004657-0.41878.9208e-145.4131e-17-0.4304imageNAIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF3B;EIF3D;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr5:139531681-139543206:+
KIRCEERIRENSG00000140398.9chr1575351945:75352701:75353738:75353866-0.38901.2717e-141.6010e-12-0.4305imageNADAR;CSTF2T;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;SRSF1;TAF15;U2AF2NAT_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:139531681-139543206:+
KIRCEERIRENSG00000185499.12chr1155185826:155186209:155186729:155186804-0.37141.1846e-119.3028e-13-0.4145imageNCSTF2T;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;IGF2BP2;LIN28B;PRPF8;PTBP1;RBFOX2;SLTM;SRSF1;TAF15;U2AF2MUC1T_cells_follicular_helperGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:139531681-139543206:+
KIRCEERIRENSG00000169592.10chr1630001211:30004657:30005220:30005323-0.40331.6738e-111.7780e-14-0.4140imageNCSTF2T;DKC1;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;IGF2BP2;LIN28B;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;SRSF1;TAF15;U2AF2NADendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr5:139531681-139543206:+
KIRCEERIRENSG00000106538.5chr7150340435:150340629:150341397:150341643-0.15861.7184e-028.4514e-12-0.4115imageNADAR;CSTF2T;DKC1;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;LIN28B;PCBP2;PRPF8;RBFOX2;SLTM;SRSF1;TAF15;U2AF2RARRES2NK_cells_activatedGSVA_HALLMARK_COAGULATION
chr5:139531681-139543206:+
KIRCEERIRENSG00000198203.5chr2108294228:108294354:108300837:108300935-0.44291.8538e-153.8915e-14-0.4189imageNADAR;CSTF2T;DKC1;FUS;HNRNPA1;HNRNPC;PCBP2;PRPF8;RBFOX2;SRSF1;TAF15;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_UV_RESPONSE_UP
chr5:139531681-139543206:+
KIRCEERIRENSG00000079805.12chr1910811752:10811764:10812263:10812377-0.45032.1407e-148.8558e-15-0.4130imageNADAR;CSTF2T;DKC1;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;IGF2BP2;LIN28B;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;SRSF1;TAF15;TARBP2;U2AF2DNM2Dendritic_cells_activatedGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr5:139531681-139543206:+
KIRCEERIRENSG00000118046.10chr191222950:1223172:1226458:1226663-0.32431.2298e-094.1100e-12-0.4264imageNADAR;CSTF2T;DKC1;EIF4A3;FAM120A;FUS;GTF2F1;HNRNPA1;HNRNPC;IGF2BP2;LIN28B;PCBP2;PRPF8;PTBP1;RBFOX2;SLTM;SRSF1;TAF15;U2AF2NAMacrophages_M2GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for UBE2D2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000131508.14,UBE2D2BRCAEAGT_cells_follicular_helper1.7876e-020.1842image
chr5:139544339-139549063:+CESCEERT_cells_CD86.3564e-030.4869image
ENSG00000131508.14,UBE2D2CESCEAGT_cells_follicular_helper3.9889e-020.2916image
chr5:139572448-139573831:+ESCAEERPlasma_cells1.3174e-020.3294image
chr5:139584993-139585906:+ESCAEERNK_cells_resting1.0917e-020.3606image
chr5:139599064-139606336:+ESCAEERNK_cells_activated2.5159e-020.2321image
chr5:139626059-139626284:+ESCAEERB_cells_naive1.3097e-02-0.5443image
chr5:139531681-139543206:+KIRCEERMacrophages_M29.2091e-03-0.1425image
chr5:139544339-139549063:+KIRCEERPlasma_cells6.7795e-040.1845image
chr5:139555096-139559406:+KIRCEERT_cells_gamma_delta3.2930e-02-0.2289image
chr5:139599064-139606336:+KIRCEERB_cells_naive4.5909e-020.2866image
chr5:139623717-139624715:+KIRCEERMast_cells_activated2.1717e-020.2580image
ENSG00000131508.14,UBE2D2KIRCEAGPlasma_cells2.9095e-030.1569image
chr5:139544339-139549063:+KIRPEERMast_cells_activated1.0246e-030.3952image
ENSG00000131508.14,UBE2D2KIRPEAGMacrophages_M23.7167e-02-0.2027image
chr5:139570097-139571382:+LAMLEERT_cells_CD4_memory_resting3.0519e-030.2436image
chr5:139587454-139592197:+LAMLEERNK_cells_activated2.0304e-02-0.2366image
ENSG00000131508.14,UBE2D2LAMLEAGT_cells_CD4_memory_resting1.2860e-020.2041image
ENSG00000131508.14,UBE2D2LUADEAGNeutrophils2.3568e-02-0.3078image
ENSG00000131508.14,UBE2D2LUSCEAGNK_cells_activated3.0280e-030.4934image
chr5:139531681-139543206:+OVEERB_cells_naive2.9891e-02-0.1385image
chr5:139544339-139549063:+OVEERT_cells_CD87.1651e-030.1714image
chr5:139551081-139551350:+OVEERMacrophages_M24.8414e-030.1985image
chr5:139599064-139606336:+OVEERT_cells_CD83.0206e-030.2255image
chr5:139607732-139608920:+OVEERNK_cells_activated2.9763e-02-0.4350image
ENSG00000131508.14,UBE2D2OVEAGT_cells_CD83.0303e-030.1788image
chr5:139572448-139573831:+STADEERB_cells_naive4.9388e-02-0.2066image
chr5:139575822-139575998:+STADEERT_cells_CD4_memory_activated1.4332e-050.7985image
chr5:139577512-139579470:+STADEERPlasma_cells1.8646e-020.3849image
chr5:139584993-139585906:+STADEERT_cells_CD4_memory_resting1.7926e-04-0.3644image
chr5:139587454-139592197:+STADEERT_cells_CD85.2413e-040.2904image
chr5:139599064-139606336:+STADEERB_cells_memory6.9094e-03-0.2141image
ENSG00000131508.14,UBE2D2STADEAGNK_cells_resting3.0877e-020.1476image
chr5:139544339-139549063:+UCECEERT_cells_CD4_naive1.1305e-040.3696image
chr5:139555096-139559406:+UCECEERT_cells_regulatory_(Tregs)2.6929e-02-0.3039image
ENSG00000131508.14,UBE2D2UCECEAGT_cells_CD4_naive1.3307e-080.4619image


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6. Enriched editing regions and immune gene sets for UBE2D2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr5:139555096-139559406:+UCECEER5.9237e-030.37321.3380e-030.42933.7555e-030.39144.1097e-020.2816image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000131508.14,UBE2D2BRCAGSVA_HALLMARK_COMPLEMENTEAG4.4213e-030.2205image
ENSG00000131508.14,UBE2D2CESCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG4.5408e-040.4775image
chr5:139570097-139571382:+ESCAGSVA_HALLMARK_UV_RESPONSE_DNEER6.8715e-030.3181image
ENSG00000131508.14,UBE2D2ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.7838e-020.1992image
chr5:139599064-139606336:+ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEER1.1317e-020.2616image
chr5:139626059-139626284:+ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.8049e-03-0.6528image
chr5:139544339-139549063:+KIRCGSVA_HALLMARK_COAGULATIONEER3.6630e-070.2732image
ENSG00000131508.14,UBE2D2KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG2.3863e-120.3593image
chr5:139623717-139624715:+KIRCGSVA_HALLMARK_HYPOXIAEER2.1100e-030.3409image
chr5:139531681-139543206:+KIRCGSVA_HALLMARK_UV_RESPONSE_UPEER1.1193e-130.3920image
chr5:139555096-139559406:+KIRCGSVA_HALLMARK_HEME_METABOLISMEER5.2024e-040.3644image
chr5:139599064-139606336:+KIRCGSVA_HALLMARK_DNA_REPAIREER1.2671e-020.3537image
chr5:139531681-139543206:+KIRPGSVA_HALLMARK_PANCREAS_BETA_CELLSEER8.2968e-03-0.3847image
chr5:139570097-139571382:+LAMLGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.7500e-020.1964image
ENSG00000131508.14,UBE2D2LIHCGSVA_HALLMARK_PEROXISOMEEAG3.5806e-02-0.4303image
chr5:139544339-139549063:+OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.3965e-060.2886image
chr5:139587454-139592197:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.1328e-030.3324image
chr5:139623717-139624715:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.5787e-030.3902image
chr5:139531681-139543206:+OVGSVA_HALLMARK_DNA_REPAIREER4.4469e-060.2878image
chr5:139570097-139571382:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.9543e-030.2477image
chr5:139551081-139551350:+OVGSVA_HALLMARK_ADIPOGENESISEER7.2418e-030.1894image
ENSG00000131508.14,UBE2D2OVGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.6506e-070.3104image
chr5:139555096-139559406:+OVGSVA_HALLMARK_KRAS_SIGNALING_UPEER1.0287e-060.4224image
chr5:139599064-139606336:+OVGSVA_HALLMARK_DNA_REPAIREER3.2898e-050.3119image
chr5:139572448-139573831:+OVGSVA_HALLMARK_P53_PATHWAYEER4.9159e-030.2501image
chr5:139577512-139579470:+STADGSVA_HALLMARK_MYC_TARGETS_V2EER1.6166e-020.3928image
chr5:139599064-139606336:+STADGSVA_HALLMARK_HYPOXIAEER5.5857e-060.3524image
chr5:139584993-139585906:+STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.9213e-02-0.2055image
chr5:139572448-139573831:+STADGSVA_HALLMARK_HYPOXIAEER2.2826e-020.2385image
chr5:139566047-139567386:+STADGSVA_HALLMARK_APOPTOSISEER2.1906e-020.5090image
chr5:139587454-139592197:+STADGSVA_HALLMARK_PROTEIN_SECRETIONEER2.8574e-030.2512image
ENSG00000131508.14,UBE2D2STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG3.5349e-040.2420image
chr5:139575822-139575998:+STADGSVA_HALLMARK_P53_PATHWAYEER6.2927e-050.7605image
chr5:139570097-139571382:+STADGSVA_HALLMARK_SPERMATOGENESISEER2.9853e-020.1944image
ENSG00000131508.14,UBE2D2THCAGSVA_HALLMARK_MYC_TARGETS_V2EAG3.2549e-02-0.3730image
ENSG00000131508.14,UBE2D2UCECGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.7163e-030.2463image
chr5:139599064-139606336:+UCECGSVA_HALLMARK_ADIPOGENESISEER3.5609e-020.3728image
chr5:139531681-139543206:+UCECGSVA_HALLMARK_ADIPOGENESISEER6.6890e-030.2595image
chr5:139544339-139549063:+UCECGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.9151e-030.2806image
chr5:139555096-139559406:+UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER1.5389e-060.6058image
chr5:139551081-139551350:+UCECGSVA_HALLMARK_HYPOXIAEER1.3926e-02-0.3724image


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7. Enriched editing regions and drugs for UBE2D2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr5:139626059-139626284:+BRCAEtoposideEER2.1482e-03-0.2731image
ENSG00000131508.14,UBE2D2BRCAAMG.706EAG9.2066e-030.2022image
ENSG00000131508.14,UBE2D2CESCGDC0941EAG7.5247e-040.4611image
ENSG00000131508.14,UBE2D2ESCAImatinibEAG8.4169e-03-0.2376image
chr5:139572448-139573831:+ESCAGW.441756EER4.1643e-02-0.2732image
chr5:139599064-139606336:+ESCABI.D1870EER7.6172e-03-0.2751image
chr5:139570097-139571382:+ESCAImatinibEER8.3257e-03-0.3109image
chr5:139584993-139585906:+ESCAGW843682XEER5.1791e-030.3933image
chr5:139626059-139626284:+ESCABMS.708163EER6.0438e-04-0.6991image
chr5:139623717-139624715:+KIRCAZD6482EER1.0388e-030.3644image
ENSG00000131508.14,UBE2D2KIRCMG.132EAG3.6685e-08-0.2871image
chr5:139544339-139549063:+KIRCBortezomibEER3.0258e-06-0.2516image
chr5:139531681-139543206:+KIRCMG.132EER3.0964e-09-0.3184image
chr5:139555096-139559406:+KIRCJNK.9LEER3.0873e-03-0.3137image
chr5:139599064-139606336:+KIRCLenalidomideEER4.0254e-020.2941image
chr5:139531681-139543206:+KIRPCCT018159EER1.0706e-03-0.4669image
chr5:139626059-139626284:+KIRPBMS.708163EER4.3226e-020.3388image
ENSG00000131508.14,UBE2D2KIRPEtoposideEAG1.1826e-02-0.2437image
chr5:139544339-139549063:+KIRPBI.2536EER2.0937e-030.3721image
chr5:139572448-139573831:+LAMLGefitinibEER8.4097e-03-0.4015image
chr5:139570097-139571382:+LAMLKU.55933EER1.8193e-03-0.2560image
chr5:139587454-139592197:+LAMLCisplatinEER3.0708e-020.2207image
ENSG00000131508.14,UBE2D2LAMLImatinibEAG7.2738e-03-0.2198image
ENSG00000131508.14,UBE2D2LIHCBortezomibEAG8.0266e-05-0.7171image
ENSG00000131508.14,UBE2D2LUADCCT018159EAG4.0377e-02-0.2799image
ENSG00000131508.14,UBE2D2LUSCCytarabineEAG3.5244e-020.3623image
chr5:139555096-139559406:+OVAUY922EER8.8217e-04-0.2950image
chr5:139599064-139606336:+OVEmbelinEER5.7371e-060.3390image
chr5:139584993-139585906:+OVCyclopamineEER3.4393e-02-0.2515image
chr5:139551081-139551350:+OVAG.014699EER3.7424e-030.2041image
chr5:139587454-139592197:+OVBAY.61.3606EER1.3019e-03-0.3286image
chr5:139623717-139624715:+OVCisplatinEER7.0006e-04-0.4678image
chr5:139531681-139543206:+OVA.770041EER3.9509e-05-0.2589image
chr5:139572448-139573831:+OVABT.263EER3.6975e-030.2578image
chr5:139570097-139571382:+OVBAY.61.3606EER8.4934e-030.2373image
chr5:139544339-139549063:+OVBexaroteneEER1.3306e-060.3032image
chr5:139607732-139608920:+OVDocetaxelEER2.0361e-02-0.4610image
ENSG00000131508.14,UBE2D2OVEmbelinEAG3.2265e-080.3269image
chr5:139587454-139592197:+STADA.443654EER4.0912e-04-0.2957image
chr5:139584993-139585906:+STADBMS.708163EER2.1911e-030.3014image
chr5:139599064-139606336:+STADMethotrexateEER2.0813e-020.1844image
chr5:139572448-139573831:+STADAKT.inhibitor.VIIIEER4.8795e-030.2926image
chr5:139566047-139567386:+STADBMS.509744EER6.4935e-04-0.6963image
ENSG00000131508.14,UBE2D2STADCI.1040EAG7.6942e-030.1817image
chr5:139575822-139575998:+STADGW843682XEER1.1052e-02-0.5425image
chr5:139570097-139571382:+STADBIRB.0796EER2.4167e-02-0.2016image
ENSG00000131508.14,UBE2D2THCAMetforminEAG3.1112e-020.3759image
chr5:139551081-139551350:+UCECCCT018159EER1.7709e-020.3601image
ENSG00000131508.14,UBE2D2UCECA.770041EAG1.6087e-03-0.2670image
chr5:139555096-139559406:+UCECJNK.9LEER6.6825e-05-0.5196image
chr5:139599064-139606336:+UCECCamptothecinEER1.7929e-030.5304image
chr5:139587454-139592197:+UCECLapatinibEER1.2593e-020.4915image
chr5:139544339-139549063:+UCECAZD6482EER2.5374e-070.4799image
chr5:139531681-139543206:+UCECGDC0941EER1.7784e-030.2973image
chr5:139584993-139585906:+UCECA.770041EER3.0019e-07-0.8807image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType