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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: UBE2B (ImmuneEditome ID:7320)

1. Gene summary of enriched editing regions for UBE2B

check button Gene summary
Gene informationGene symbol

UBE2B

Gene ID

7320

GeneSynonymsE2-17kDa|HHR6B|HR6B|RAD6B|UBC2
GeneCytomap

5q31.1

GeneTypeprotein-coding
GeneDescriptionubiquitin-conjugating enzyme E2 B|E2 protein|E2 ubiquitin-conjugating enzyme B|RAD6 homolog B|ubiquitin carrier protein B|ubiquitin conjugating enzyme E2B|ubiquitin-conjugating enzyme E2-17 kDa|ubiquitin-conjugating enzyme E2B (RAD6 homolog)|ubiquitin-protein ligase B
GeneModificationdate20230404
UniprotIDP63146;D6RDW8;H0YA80
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr5:134378005-134380212:+ENST00000511807.1ENSG00000119048.6UBE2BncRNA_intronicAluJb,AluSx,AluSq2,Charlie1a,AluSx1chr5:134378005-134380212:+.alignment
chr5:134381232-134383693:+ENST00000511807.1ENSG00000119048.6UBE2BncRNA_intronicFLAM_A,AluSx,AluJr,AluSc,AluJb,AluJr4,AluY,AluSx1,L1ME4a,AluSc8chr5:134381232-134383693:+.alignment
chr5:134385701-134389062:+ENST00000265339.5ENSG00000119048.6UBE2BexonicL1ME4a,MSTD,AluSc8,AluSq2,AluSz,MIRc,AluSx4,AluSx,AluSx3chr5:134385701-134389062:+.alignment
chr5:134385701-134389062:+ENST00000506787.4ENSG00000119048.6UBE2BexonicL1ME4a,MSTD,AluSc8,AluSq2,AluSz,MIRc,AluSx4,AluSx,AluSx3chr5:134385701-134389062:+.alignment
chr5:134385701-134389062:+ENST00000507277.1ENSG00000119048.6UBE2BexonicL1ME4a,MSTD,AluSc8,AluSq2,AluSz,MIRc,AluSx4,AluSx,AluSx3chr5:134385701-134389062:+.alignment
chr5:134385701-134389062:+ENST00000510021.4ENSG00000119048.6UBE2BexonicL1ME4a,MSTD,AluSc8,AluSq2,AluSz,MIRc,AluSx4,AluSx,AluSx3chr5:134385701-134389062:+.alignment


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2. Tumor-specific enriched editing regions for UBE2B


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000119048.6,UBE2BLUSCEAG1.2016e-031.5883e-027.2170e+02image
ENSG00000119048.6,UBE2BPAADEAG2.0485e-023.0542e-021.6758e+06image

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3. Enriched editing regions and immune related genes for UBE2B


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for UBE2B


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000119048.6,UBE2B
ESCAEAGIRENSG00000204394.8chr631781357:31781602:31781690:31781761-0.12854.5206e-025.8414e-07-0.4818imageNACIN1;ADAR;ALYREF;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS3;KHSRP;LARP7;LIN28;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM22;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NA

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5. Enriched editing regions and immune infiltration for UBE2B


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000119048.6,UBE2BACCEAGNK_cells_resting3.8300e-020.4345image
ENSG00000119048.6,UBE2BBLCAEAGMacrophages_M14.9783e-020.3443image
chr5:134381232-134383693:+BRCAEERMonocytes4.0935e-02-0.3524image
ENSG00000119048.6,UBE2BBRCAEAGMacrophages_M11.4050e-02-0.1555image
ENSG00000119048.6,UBE2BCOADEAGDendritic_cells_activated1.1253e-020.4982image
chr5:134381232-134383693:+ESCAEERB_cells_memory1.5812e-03-0.3682image
chr5:134385701-134389062:+ESCAEERNK_cells_activated3.6908e-020.2020image
ENSG00000119048.6,UBE2BESCAEAGT_cells_gamma_delta7.4270e-030.2347image
ENSG00000119048.6,UBE2BKIRCEAGT_cells_regulatory_(Tregs)1.6364e-020.2012image
ENSG00000119048.6,UBE2BKIRPEAGNK_cells_resting3.0856e-020.4717image
chr5:134378005-134380212:+LAMLEERNK_cells_activated2.7075e-040.5177image
ENSG00000119048.6,UBE2BLGGEAGDendritic_cells_resting2.5414e-02-0.2171image
ENSG00000119048.6,UBE2BLUADEAGT_cells_CD83.2013e-020.2415image
ENSG00000119048.6,UBE2BLUSCEAGNK_cells_activated7.6548e-03-0.3883image
chr5:134378005-134380212:+OVEERT_cells_CD4_memory_resting7.5546e-04-0.5499image
ENSG00000119048.6,UBE2BPAADEAGNeutrophils1.3796e-030.5939image
ENSG00000119048.6,UBE2BPCPGEAGPlasma_cells4.7843e-020.2842image
ENSG00000119048.6,UBE2BPRADEAGT_cells_regulatory_(Tregs)1.0149e-030.3955image
ENSG00000119048.6,UBE2BSARCEAGNeutrophils1.1579e-030.5730image
ENSG00000119048.6,UBE2BSKCMEAGT_cells_CD4_naive9.2700e-070.7466image
chr5:134385701-134389062:+STADEERMacrophages_M12.4706e-030.2129image
chr5:134385701-134389062:+THCAEERMacrophages_M01.9897e-02-0.3077image


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6. Enriched editing regions and immune gene sets for UBE2B


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000119048.6,UBE2BESCAEAG2.2695e-040.31925.9630e-030.24092.2313e-040.31962.6592e-020.1952image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000119048.6,UBE2BBLCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.7985e-020.4094image
ENSG00000119048.6,UBE2BBRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.9182e-06-0.2914image
chr5:134385701-134389062:+ESCAGSVA_HALLMARK_E2F_TARGETSEER7.7707e-040.3201image
ENSG00000119048.6,UBE2BESCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG4.6341e-040.3039image
chr5:134381232-134383693:+ESCAGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER5.9933e-03-0.3231image
chr5:134378005-134380212:+ESCAGSVA_HALLMARK_APICAL_SURFACEEER2.4047e-030.3002image
ENSG00000119048.6,UBE2BGBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.5251e-02-0.3558image
ENSG00000119048.6,UBE2BKIRCGSVA_HALLMARK_UV_RESPONSE_DNEAG1.0690e-07-0.4281image
ENSG00000119048.6,UBE2BKIRPGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.8404e-03-0.6385image
chr5:134381232-134383693:+LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEER3.9852e-02-0.2618image
ENSG00000119048.6,UBE2BLGGGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG2.3070e-020.2206image
ENSG00000119048.6,UBE2BLUSCGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG9.1014e-03-0.3804image
chr5:134385701-134389062:+OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.6747e-020.2489image
ENSG00000119048.6,UBE2BOVGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.7060e-02-0.1752image
ENSG00000119048.6,UBE2BPCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.5209e-04-0.4702image
ENSG00000119048.6,UBE2BPRADGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.3238e-02-0.3035image
ENSG00000119048.6,UBE2BSARCGSVA_HALLMARK_HYPOXIAEAG2.6758e-020.4110image
ENSG00000119048.6,UBE2BSKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.1580e-04-0.6289image
chr5:134381232-134383693:+STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.0322e-030.2971image
chr5:134378005-134380212:+STADGSVA_HALLMARK_MITOTIC_SPINDLEEER1.2024e-040.2851image
chr5:134385701-134389062:+STADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.0882e-030.2164image
chr5:134385701-134389062:+THCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.7595e-090.6832image
ENSG00000119048.6,UBE2BTHCAGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.9188e-050.4040image


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7. Enriched editing regions and drugs for UBE2B


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000119048.6,UBE2BACCBMS.708163EAG2.0385e-020.4802image
ENSG00000119048.6,UBE2BBLCAGDC.0449EAG2.1786e-02-0.3980image
chr5:134381232-134383693:+BRCAKIN001.135EER3.0374e-02-0.3718image
ENSG00000119048.6,UBE2BBRCAMetforminEAG1.1068e-04-0.2425image
ENSG00000119048.6,UBE2BCOADGefitinibEAG6.3878e-03-0.5304image
chr5:134385701-134389062:+ESCAGW.441756EER6.7063e-03-0.2606image
ENSG00000119048.6,UBE2BESCADocetaxelEAG1.7682e-02-0.2086image
chr5:134381232-134383693:+ESCAABT.888EER3.1151e-02-0.2560image
chr5:134378005-134380212:+ESCAEHT.1864EER7.7876e-030.2647image
ENSG00000119048.6,UBE2BGBMAZD8055EAG9.2944e-030.3795image
ENSG00000119048.6,UBE2BKIRCLapatinibEAG1.8438e-050.3510image
ENSG00000119048.6,UBE2BKIRPEpothilone.BEAG2.0812e-020.5006image
chr5:134381232-134383693:+LAMLBMS.708163EER3.0279e-020.2754image
chr5:134378005-134380212:+LAMLCCT007093EER1.0828e-020.3764image
ENSG00000119048.6,UBE2BLGGKU.55933EAG1.5424e-02-0.2348image
ENSG00000119048.6,UBE2BLUSCAUY922EAG1.0869e-02-0.3722image
chr5:134378005-134380212:+OVAMG.706EER1.3884e-020.4180image
ENSG00000119048.6,UBE2BOVAUY922EAG4.2077e-030.2388image
ENSG00000119048.6,UBE2BPAADAZD6244EAG4.9087e-03-0.5345image
ENSG00000119048.6,UBE2BPCPGATRAEAG1.3414e-03-0.4454image
ENSG00000119048.6,UBE2BPRADGefitinibEAG5.4774e-03-0.3382image
ENSG00000119048.6,UBE2BSARCABT.263EAG1.2423e-06-0.7666image
ENSG00000119048.6,UBE2BSKCMEmbelinEAG3.8503e-050.6608image
chr5:134381232-134383693:+STADGW843682XEER2.6181e-02-0.2038image
chr5:134378005-134380212:+STADAG.014699EER1.0544e-030.2442image
ENSG00000119048.6,UBE2BSTADBI.D1870EAG6.0299e-030.1772image
chr5:134385701-134389062:+STADBosutinibEER1.2861e-02-0.1756image
chr5:134385701-134389062:+THCACCT007093EER3.1963e-060.5730image
ENSG00000119048.6,UBE2BTHCACCT007093EAG2.8655e-080.5094image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType