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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: UBA1 (ImmuneEditome ID:7317)

1. Gene summary of enriched editing regions for UBA1

check button Gene summary
Gene informationGene symbol

UBA1

Gene ID

7317

GeneSynonymsA1S9|A1S9T|A1ST|AMCX1|CFAP124|GXP1|POC20|SMAX2|UBA1A|UBE1|UBE1X|VEXAS
GeneCytomap

Xp11.3

GeneTypeprotein-coding
GeneDescriptionubiquitin-like modifier-activating enzyme 1|A1S9T and BN75 temperature sensitivity complementing|POC20 centriolar protein homolog|UBA1, ubiquitin-activating enzyme E1 homolog A|testicular secretory protein Li 63
GeneModificationdate20230517
UniprotIDP22314;Q5JRS1;Q5JRR6;Q5JRS2;Q5JRS0;Q5JRR9;Q5JRS3
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chrX:47203878-47204058:+ENST00000490869.1ENSG00000130985.15UBA1ncRNA_intronicAluSpchrX:47203878-47204058:+.alignment
chrX:47208139-47209400:+ENST00000377269.3ENSG00000130985.15UBA1exonicAluJo,AluJb,AluSq,AluSx1chrX:47208139-47209400:+.alignment


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2. Tumor-specific enriched editing regions for UBA1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chrX:47208139-47209400:+ACCPathEER2.9140e-028.1905e-03-0.4339image
ENSG00000130985.15,UBA1ACCPathEAG9.2996e-035.1792e-03-0.4337image
ENSG00000130985.15,UBA1BRCAPathEAG2.8924e-022.7517e-030.1152image
ENSG00000130985.15,UBA1KIRPCliEAG2.4667e-034.9397e-020.2663image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for UBA1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chrX:47208139-47209400:+ESCAEERENSG00000280063,RP11-295D4.3-0.42436.7164e-041.9265e-06-0.4036imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chrX:47208139-47209400:+ESCAEERENSG00000266124,MIR5587-0.42506.9235e-041.5359e-06-0.4071imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chrX:47208139-47209400:+ESCAEERENSG00000250682,LINC004910.38051.3836e-031.3398e-060.4092imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chrX:47208139-47209400:+ESCAEERENSG00000197976,AKAP17A-0.40211.8118e-032.0254e-06-0.4028imageNNAKAP17ADendritic_cells_restingGSVA_HALLMARK_APICAL_SURFACE
chrX:47208139-47209400:+ESCAEERENSG00000175741,RWDD4P20.38602.0255e-031.7448e-060.4051imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_MYC_TARGETS_V1
chrX:47208139-47209400:+ESCAEERENSG00000253706,RP11-758M4.40.28263.8378e-029.5284e-070.4144imageNNNAB_cells_naiveGSVA_HALLMARK_BILE_ACID_METABOLISM

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4. Enriched editing regions and immune related splicing for UBA1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000130985.15,UBA1
ESCAEAGIRENSG00000067225.13chr1572202689:72203188:72206727:72206748-0.42961.0172e-031.8511e-08-0.4491imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_MYOGENESIS
ENSG00000130985.15,UBA1
ESCAEAGIRENSG00000149657.15chr2062126303:62127701:62129784:62129952-0.42894.1376e-041.3901e-08-0.4526imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184LSM14BT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000130985.15,UBA1
ESCAEAGIRENSG00000075413.13chr14103498501:103498528:103500155:103500200-0.30823.7878e-028.2431e-06-0.4025imageNACIN1;ADAR;AIFM1;ALKBH5;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184MARK3B_cells_naiveGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000130985.15,UBA1
ESCAEAGIRENSG00000067836.8chr164796967:4800578:4801266:4801301-0.42371.5401e-031.8448e-07-0.4194imageNAIFM1;AUH;BCCIP;BUD13;CELF2;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;LIN28;LIN28B;LSM11;METTL3;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
ENSG00000130985.15,UBA1
ESCAEAGIRENSG00000055950.12chr10100981375:100981543:100983754:100983817-0.42211.5493e-033.5821e-07-0.4103imageNACIN1;ADAR;AIFM1;AUH;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;LARP4B;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000130985.15,UBA1
ESCAEAGIRENSG00000138468.11chr3101332769:101332862:101337508:101337631-0.33571.7057e-023.1033e-06-0.4064imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28B;LSM11;MOV10;MSI1;MSI2;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000130985.15,UBA1
ESCAEAGIRENSG00000168003.12chr1162882666:62882807:62882907:62882930-0.33916.0824e-039.6447e-08-0.4881imageNACIN1;ADAR;AIFM1;ALKBH5;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL1;METTL14;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184SLC3A2T_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chrX:47208139-47209400:+
ESCAEERIRENSG00000067225.13chr1572202689:72203188:72206727:72206748-0.42452.9653e-031.3838e-06-0.4087imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYOGENESIS
chrX:47208139-47209400:+
ESCAEERIRENSG00000099814.11chr14104868423:104868555:104876255:104876345-0.45081.4990e-031.5627e-06-0.4068imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chrX:47208139-47209400:+
ESCAEERIRENSG00000161547.10chr1776734118:76735158:76735771:76735803-0.41945.1849e-031.8979e-06-0.4038imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY

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5. Enriched editing regions and immune infiltration for UBA1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chrX:47208139-47209400:+ACCEERT_cells_regulatory_(Tregs)3.3423e-02-0.3505image
ENSG00000130985.15,UBA1ACCEAGT_cells_gamma_delta4.6920e-020.3122image
chrX:47208139-47209400:+BLCAEERT_cells_CD4_memory_activated3.3448e-020.1755image
ENSG00000130985.15,UBA1BLCAEAGMacrophages_M12.2929e-020.1754image
chrX:47208139-47209400:+BRCAEERNeutrophils8.4614e-03-0.1039image
ENSG00000130985.15,UBA1BRCAEAGMast_cells_resting1.1817e-02-0.0968image
chrX:47208139-47209400:+CESCEERNK_cells_activated2.4763e-03-0.2663image
ENSG00000130985.15,UBA1CESCEAGMacrophages_M13.7523e-020.1729image
ENSG00000130985.15,UBA1COADEAGMast_cells_activated1.1559e-020.2468image
chrX:47208139-47209400:+ESCAEERNK_cells_activated8.7157e-030.2292image
ENSG00000130985.15,UBA1ESCAEAGT_cells_CD4_memory_resting3.1494e-03-0.2453image
chrX:47208139-47209400:+GBMEEREosinophils2.9106e-020.2120image
chrX:47208139-47209400:+KIRPEERNeutrophils8.3150e-030.2968image
ENSG00000130985.15,UBA1KIRPEAGMast_cells_resting2.4320e-030.3124image
chrX:47208139-47209400:+LGGEERT_cells_regulatory_(Tregs)2.1162e-030.1833image
ENSG00000130985.15,UBA1LGGEAGT_cells_regulatory_(Tregs)2.1579e-030.1779image
chrX:47208139-47209400:+LUADEEREosinophils2.5682e-030.2198image
ENSG00000130985.15,UBA1LUADEAGEosinophils2.5186e-040.2518image
chrX:47208139-47209400:+LUSCEERB_cells_memory6.9316e-040.2472image
ENSG00000130985.15,UBA1LUSCEAGB_cells_memory1.7961e-030.2163image
chrX:47203878-47204058:+OVEERT_cells_CD4_memory_activated2.3266e-020.3143image
chrX:47208139-47209400:+OVEERT_cells_CD81.2807e-030.2168image
ENSG00000130985.15,UBA1OVEAGT_cells_CD87.3243e-030.1764image
ENSG00000130985.15,UBA1PCPGEAGB_cells_naive3.6633e-020.2503image
chrX:47208139-47209400:+READEERMonocytes2.5721e-020.3822image
ENSG00000130985.15,UBA1READEAGMonocytes1.7658e-020.3932image
ENSG00000130985.15,UBA1SARCEAGT_cells_gamma_delta2.2930e-020.2660image
chrX:47208139-47209400:+SKCMEERMast_cells_resting8.7107e-030.2637image
ENSG00000130985.15,UBA1SKCMEAGMast_cells_resting8.0966e-030.2480image
chrX:47208139-47209400:+STADEEREosinophils1.9605e-020.1805image
ENSG00000130985.15,UBA1STADEAGT_cells_CD4_memory_resting4.5084e-03-0.2021image
chrX:47208139-47209400:+THYMEERMacrophages_M13.9699e-02-0.3149image
chrX:47208139-47209400:+UCECEERPlasma_cells1.4455e-020.2556image
chrX:47208139-47209400:+UCSEERDendritic_cells_resting1.2577e-020.5116image
ENSG00000130985.15,UBA1UCSEAGMacrophages_M01.7258e-020.4544image
ENSG00000130985.15,UBA1UVMEAGT_cells_CD4_memory_activated2.9020e-040.7260image


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6. Enriched editing regions and immune gene sets for UBA1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000130985.15,UBA1ESCAEAG6.2352e-050.32841.5245e-020.20261.7459e-060.38753.7221e-020.1744image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000130985.15,UBA1ACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.7136e-030.4328image
chrX:47208139-47209400:+ACCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.8504e-030.4768image
chrX:47208139-47209400:+BLCAGSVA_HALLMARK_HYPOXIAEER6.0722e-040.2795image
ENSG00000130985.15,UBA1BLCAGSVA_HALLMARK_APOPTOSISEAG3.6240e-030.2233image
ENSG00000130985.15,UBA1BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.5858e-070.1942image
chrX:47208139-47209400:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER5.6414e-070.1961image
ENSG00000130985.15,UBA1CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG5.2117e-030.2309image
chrX:47208139-47209400:+COADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.9040e-020.2415image
ENSG00000130985.15,UBA1ESCAGSVA_HALLMARK_MYC_TARGETS_V1EAG4.8296e-030.2344image
chrX:47208139-47209400:+ESCAGSVA_HALLMARK_APICAL_SURFACEEER1.3701e-030.2779image
chrX:47208139-47209400:+GBMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER3.3036e-040.3422image
ENSG00000130985.15,UBA1GBMGSVA_HALLMARK_ADIPOGENESISEAG1.9142e-050.3954image
chrX:47208139-47209400:+KIRCGSVA_HALLMARK_DNA_REPAIREER6.3529e-050.3434image
ENSG00000130985.15,UBA1KIRCGSVA_HALLMARK_DNA_REPAIREAG2.6762e-050.3493image
chrX:47208139-47209400:+KIRPGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6697e-03-0.3502image
ENSG00000130985.15,UBA1KIRPGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.1489e-03-0.3047image
ENSG00000130985.15,UBA1LGGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.6697e-030.1607image
chrX:47208139-47209400:+LGGGSVA_HALLMARK_NOTCH_SIGNALINGEER6.2218e-030.1634image
ENSG00000130985.15,UBA1LUADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG2.5676e-020.1551image
chrX:47208139-47209400:+LUADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER3.9046e-030.2106image
chrX:47208139-47209400:+LUSCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER8.4943e-030.1930image
ENSG00000130985.15,UBA1LUSCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.5513e-020.1684image
ENSG00000130985.15,UBA1OVGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG4.7679e-060.2965image
chrX:47208139-47209400:+OVGSVA_HALLMARK_MYC_TARGETS_V1EER5.4066e-040.2324image
chrX:47203878-47204058:+OVGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.1828e-030.4375image
ENSG00000130985.15,UBA1PAADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG3.7209e-030.3227image
ENSG00000130985.15,UBA1PCPGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.9303e-020.2791image
ENSG00000130985.15,UBA1PRADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG8.7302e-030.1748image
chrX:47208139-47209400:+PRADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER1.9090e-020.1616image
ENSG00000130985.15,UBA1READGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG4.7868e-030.4598image
chrX:47208139-47209400:+READGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER6.8143e-030.4553image
ENSG00000130985.15,UBA1SARCGSVA_HALLMARK_APICAL_SURFACEEAG1.2377e-020.2914image
ENSG00000130985.15,UBA1SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.1466e-02-0.2371image
ENSG00000130985.15,UBA1STADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG1.8661e-020.1679image
ENSG00000130985.15,UBA1TGCTGSVA_HALLMARK_DNA_REPAIREAG3.8567e-020.2248image
chrX:47208139-47209400:+TGCTGSVA_HALLMARK_DNA_REPAIREER3.9492e-020.2383image
chrX:47208139-47209400:+THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.0225e-020.1390image
ENSG00000130985.15,UBA1THCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.1461e-030.1694image
chrX:47208139-47209400:+UCECGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.3609e-02-0.2578image
ENSG00000130985.15,UBA1UCSGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.7315e-020.4542image
ENSG00000130985.15,UBA1UVMGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG4.8522e-020.4464image


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7. Enriched editing regions and drugs for UBA1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000130985.15,UBA1ACCAxitinibEAG3.8864e-030.4412image
chrX:47208139-47209400:+ACCAZD6482EER7.3796e-04-0.5302image
chrX:47208139-47209400:+BLCAAZD7762EER8.7012e-04-0.2717image
ENSG00000130985.15,UBA1BLCAAZD7762EAG1.3419e-04-0.2904image
chrX:47208139-47209400:+BRCACCT007093EER1.9420e-050.1678image
ENSG00000130985.15,UBA1BRCACCT007093EAG2.3090e-050.1620image
ENSG00000130985.15,UBA1CESCKU.55933EAG2.2344e-03-0.2520image
chrX:47208139-47209400:+CESCKU.55933EER2.7781e-04-0.3173image
ENSG00000130985.15,UBA1CHOLFH535EAG2.0418e-02-0.5140image
chrX:47208139-47209400:+COADCI.1040EER3.9480e-02-0.2128image
ENSG00000130985.15,UBA1ESCADocetaxelEAG2.8638e-05-0.3423image
chrX:47208139-47209400:+ESCAAZD7762EER3.2738e-04-0.3103image
ENSG00000130985.15,UBA1GBMLenalidomideEAG2.1253e-030.2899image
chrX:47208139-47209400:+GBMMG.132EER2.6539e-03-0.2891image
ENSG00000130985.15,UBA1HNSCCytarabineEAG3.4204e-020.3755image
chrX:47208139-47209400:+KIRCErlotinibEER3.3047e-04-0.3101image
ENSG00000130985.15,UBA1KIRCGNF.2EAG2.9183e-04-0.3038image
ENSG00000130985.15,UBA1KIRPBMS.536924EAG2.8322e-020.2287image
chrX:47208139-47209400:+KIRPAP.24534EER1.4311e-020.2764image
ENSG00000130985.15,UBA1LGGBIRB.0796EAG1.0573e-030.1897image
chrX:47208139-47209400:+LGGBIRB.0796EER5.7786e-040.2048image
ENSG00000130985.15,UBA1LUADBIBW2992EAG1.5954e-02-0.1673image
chrX:47208139-47209400:+LUADLFM.A13EER3.6648e-03-0.2120image
chrX:47208139-47209400:+LUSCBMS.708163EER8.0338e-05-0.2858image
ENSG00000130985.15,UBA1LUSCBMS.708163EAG1.1330e-05-0.3006image
ENSG00000130985.15,UBA1OVElesclomolEAG1.2758e-05-0.2834image
chrX:47208139-47209400:+OVElesclomolEER1.7304e-05-0.2866image
chrX:47203878-47204058:+OVBosutinibEER1.5490e-020.3341image
ENSG00000130985.15,UBA1PAADAKT.inhibitor.VIIIEAG9.1485e-03-0.2952image
ENSG00000130985.15,UBA1PCPGJNK.9LEAG3.6620e-020.2503image
ENSG00000130985.15,UBA1PRADABT.263EAG6.6876e-040.2266image
chrX:47208139-47209400:+PRADBicalutamideEER3.2056e-04-0.2459image
ENSG00000130985.15,UBA1READBIRB.0796EAG2.5737e-050.6406image
chrX:47208139-47209400:+READBIRB.0796EER1.2421e-040.6109image
ENSG00000130985.15,UBA1SARCAZD.0530EAG1.7253e-02-0.2780image
ENSG00000130985.15,UBA1SKCMAUY922EAG2.2595e-03-0.2845image
chrX:47208139-47209400:+SKCMLapatinibEER1.6107e-03-0.3161image
ENSG00000130985.15,UBA1STADATRAEAG1.7268e-020.1699image
chrX:47208139-47209400:+STADABT.263EER4.9601e-020.1522image
ENSG00000130985.15,UBA1TGCTCHIR.99021EAG3.4857e-020.2292image
chrX:47208139-47209400:+THCABMS.708163EER3.3942e-04-0.2130image
ENSG00000130985.15,UBA1THCABMS.708163EAG2.8323e-05-0.2384image
ENSG00000130985.15,UBA1THYMAKT.inhibitor.VIIIEAG4.8124e-020.2930image
chrX:47208139-47209400:+UCECEpothilone.BEER8.5571e-040.3436image
ENSG00000130985.15,UBA1UCECBAY.61.3606EAG2.4266e-030.3015image
ENSG00000130985.15,UBA1UCSFTI.277EAG1.6928e-02-0.4556image
chrX:47208139-47209400:+UCSBX.795EER3.0706e-02-0.4512image
ENSG00000130985.15,UBA1UVMBMS.708163EAG1.4124e-04-0.7497image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType