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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: OIP5-AS1 (ImmuneEditome ID:729082)

1. Gene summary of enriched editing regions for OIP5-AS1

check button Gene summary
Gene informationGene symbol

OIP5-AS1

Gene ID

729082

GeneSynonymscyrano|linc-OIP5
GeneCytomap

15q15.1

GeneTypencRNA
GeneDescriptionOIP5 antisense RNA 1 (non-protein coding)
GeneModificationdate20230410
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:41286362-41289633:+ENST00000557993.4ENSG00000247556.5OIP5-AS1ncRNA_exonicMLT1C,L1MA9,L1M1,L1ME4b,AluSx,AluSq2,L1MB3,(TA)n,AluSz,FAMchr15:41286362-41289633:+.alignment
chr15:41286362-41289633:+ENST00000558457.4ENSG00000247556.5OIP5-AS1ncRNA_exonicMLT1C,L1MA9,L1M1,L1ME4b,AluSx,AluSq2,L1MB3,(TA)n,AluSz,FAMchr15:41286362-41289633:+.alignment
chr15:41286362-41289633:+ENST00000559368.4ENSG00000247556.5OIP5-AS1ncRNA_exonicMLT1C,L1MA9,L1M1,L1ME4b,AluSx,AluSq2,L1MB3,(TA)n,AluSz,FAMchr15:41286362-41289633:+.alignment
chr15:41286362-41289633:+ENST00000561226.4ENSG00000247556.5OIP5-AS1ncRNA_exonicMLT1C,L1MA9,L1M1,L1ME4b,AluSx,AluSq2,L1MB3,(TA)n,AluSz,FAMchr15:41286362-41289633:+.alignment
chr15:41291024-41292170:+ENST00000500949.5ENSG00000247556.5OIP5-AS1ncRNA_intronicMLT1F,L1M4,AluSz,MER21C,AluYchr15:41291024-41292170:+.alignment
chr15:41291024-41292170:+ENST00000501665.2ENSG00000247556.5OIP5-AS1ncRNA_intronicMLT1F,L1M4,AluSz,MER21C,AluYchr15:41291024-41292170:+.alignment
chr15:41291024-41292170:+ENST00000558945.4ENSG00000247556.5OIP5-AS1ncRNA_intronicMLT1F,L1M4,AluSz,MER21C,AluYchr15:41291024-41292170:+.alignment
chr15:41291024-41292170:+ENST00000560706.4ENSG00000247556.5OIP5-AS1ncRNA_intronicMLT1F,L1M4,AluSz,MER21C,AluYchr15:41291024-41292170:+.alignment
chr15:41291024-41292170:+ENST00000561275.4ENSG00000247556.5OIP5-AS1ncRNA_intronicMLT1F,L1M4,AluSz,MER21C,AluYchr15:41291024-41292170:+.alignment
chr15:41293595-41299295:+ENST00000500949.5ENSG00000247556.5OIP5-AS1ncRNA_exonicAluSx1,AluSq,L2a,L1MB4,AluSg,AluSz,AluJo,AluSx,AluScchr15:41293595-41299295:+.alignment
chr15:41293595-41299295:+ENST00000558945.4ENSG00000247556.5OIP5-AS1ncRNA_exonicAluSx1,AluSq,L2a,L1MB4,AluSg,AluSz,AluJo,AluSx,AluScchr15:41293595-41299295:+.alignment
chr15:41293595-41299295:+ENST00000560706.4ENSG00000247556.5OIP5-AS1ncRNA_exonicAluSx1,AluSq,L2a,L1MB4,AluSg,AluSz,AluJo,AluSx,AluScchr15:41293595-41299295:+.alignment
chr15:41293595-41299295:+ENST00000561275.4ENSG00000247556.5OIP5-AS1ncRNA_exonicAluSx1,AluSq,L2a,L1MB4,AluSg,AluSz,AluJo,AluSx,AluScchr15:41293595-41299295:+.alignment
chr15:41301022-41301185:+ENST00000500949.5ENSG00000247556.5OIP5-AS1ncRNA_exonicAluSz6chr15:41301022-41301185:+.alignment
chr15:41302192-41302462:+ENST00000500949.5ENSG00000247556.5OIP5-AS1ncRNA_exonicAluScchr15:41302192-41302462:+.alignment
chr15:41305237-41305508:+ENST00000500949.5ENSG00000247556.5OIP5-AS1ncRNA_exonicAluSz6chr15:41305237-41305508:+.alignment


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2. Tumor-specific enriched editing regions for OIP5-AS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr15:41293595-41299295:+BRCAEER8.9483e-05image
ENSG00000247556.5,OIP5-AS1BRCAEAG8.8718e-05image
chr15:41293595-41299295:+HNSCEER1.7916e-02image
ENSG00000247556.5,OIP5-AS1HNSCEAG2.2103e-02image
chr15:41293595-41299295:+KICHEER5.8665e-14image
ENSG00000247556.5,OIP5-AS1KICHEAG8.1976e-13image
chr15:41305237-41305508:+KIRCEER4.4895e-03image
chr15:41293595-41299295:+KIRPEER6.5090e-04image
ENSG00000247556.5,OIP5-AS1KIRPEAG4.7734e-03image
ENSG00000247556.5,OIP5-AS1LIHCEAG8.8548e-04image
chr15:41293595-41299295:+LUSCEER1.3437e-04image
chr15:41305237-41305508:+LUSCEER1.3257e-04image
ENSG00000247556.5,OIP5-AS1LUSCEAG7.7398e-06image
ENSG00000247556.5,OIP5-AS1PRADEAG2.1802e-02image
ENSG00000247556.5,OIP5-AS1THCAEAG8.6429e-03image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000247556.5,OIP5-AS1MESOPathEAG4.9126e-026.7738e-030.2899image
chr15:41293595-41299295:+MESOPathEER1.5575e-021.5556e-030.3380image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr15:41293595-41299295:+STADEER4.9169e-024.3395e-026.4833e-02image
ENSG00000247556.5,OIP5-AS1STADEAG1.5965e-021.2435e-028.3422e-03image

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3. Enriched editing regions and immune related genes for OIP5-AS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:41293595-41299295:+KICHEERENSG00000065600,TMEM206-0.56362.1578e-021.5769e-04-0.4519imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMonocytesGSVA_HALLMARK_P53_PATHWAY
chr15:41293595-41299295:+KICHEERENSG00000143553,SNAPIN-0.52384.2387e-024.7534e-08-0.6159imageNCELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SRSF1;TAF15;TIAL1;U2AF1;U2AF2;UPF1SNAPINMonocytesGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr15:41293595-41299295:+KICHEERENSG00000228487,RP13-225O21.20.50404.8732e-027.1092e-050.4723imageNDGCR8;EIF4A3;TAF15;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr15:41293595-41299295:+KIRCEERENSG00000125037,EMC30.20831.3360e-031.5482e-250.4981imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000151366,NDUFC20.19782.7032e-038.1724e-260.5006imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:41293595-41299295:+KIRCEERENSG00000172115,CYCS0.18604.7101e-031.4671e-170.4162imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1CYCSDendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000144455,SUMF10.17459.7772e-034.2100e-210.4553imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000124243,BCAS40.16811.2804e-027.3062e-210.4528imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;TAF15;TIAL1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ANGIOGENESIS
chr15:41293595-41299295:+KIRCEERENSG00000164825,DEFB10.16441.5861e-021.5924e-170.4158imageNEWSR1;UPF1DEFB1Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr15:41293595-41299295:+KIRCEERENSG00000107262,BAG10.14962.6214e-021.2161e-230.4806imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;HNRNPC;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1BAG1Dendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KICHEERENSG00000065600,TMEM206-0.56362.1578e-021.5769e-04-0.4519imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMonocytesGSVA_HALLMARK_P53_PATHWAY
chr15:41293595-41299295:+KICHEERENSG00000143553,SNAPIN-0.52384.2387e-024.7534e-08-0.6159imageNCELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SRSF1;TAF15;TIAL1;U2AF1;U2AF2;UPF1SNAPINMonocytesGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr15:41293595-41299295:+KICHEERENSG00000228487,RP13-225O21.20.50404.8732e-027.1092e-050.4723imageNDGCR8;EIF4A3;TAF15;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr15:41293595-41299295:+KIRCEERENSG00000125037,EMC30.20831.3360e-031.5482e-250.4981imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000151366,NDUFC20.19782.7032e-038.1724e-260.5006imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:41293595-41299295:+KIRCEERENSG00000172115,CYCS0.18604.7101e-031.4671e-170.4162imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1CYCSDendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000144455,SUMF10.17459.7772e-034.2100e-210.4553imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000124243,BCAS40.16811.2804e-027.3062e-210.4528imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;TAF15;TIAL1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ANGIOGENESIS
chr15:41293595-41299295:+KIRCEERENSG00000164825,DEFB10.16441.5861e-021.5924e-170.4158imageNEWSR1;UPF1DEFB1Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr15:41293595-41299295:+KIRCEERENSG00000107262,BAG10.14962.6214e-021.2161e-230.4806imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;HNRNPC;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1BAG1Dendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KICHEERENSG00000065600,TMEM206-0.56362.1578e-021.5769e-04-0.4519imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMonocytesGSVA_HALLMARK_P53_PATHWAY
chr15:41293595-41299295:+KICHEERENSG00000143553,SNAPIN-0.52384.2387e-024.7534e-08-0.6159imageNCELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SRSF1;TAF15;TIAL1;U2AF1;U2AF2;UPF1SNAPINMonocytesGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr15:41293595-41299295:+KICHEERENSG00000228487,RP13-225O21.20.50404.8732e-027.1092e-050.4723imageNDGCR8;EIF4A3;TAF15;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr15:41293595-41299295:+KIRCEERENSG00000125037,EMC30.20831.3360e-031.5482e-250.4981imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000151366,NDUFC20.19782.7032e-038.1724e-260.5006imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:41293595-41299295:+KIRCEERENSG00000172115,CYCS0.18604.7101e-031.4671e-170.4162imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1CYCSDendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000144455,SUMF10.17459.7772e-034.2100e-210.4553imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000124243,BCAS40.16811.2804e-027.3062e-210.4528imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;TAF15;TIAL1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ANGIOGENESIS
chr15:41293595-41299295:+KIRCEERENSG00000164825,DEFB10.16441.5861e-021.5924e-170.4158imageNEWSR1;UPF1DEFB1Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr15:41293595-41299295:+KIRCEERENSG00000107262,BAG10.14962.6214e-021.2161e-230.4806imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;HNRNPC;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1BAG1Dendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KICHEERENSG00000065600,TMEM206-0.56362.1578e-021.5769e-04-0.4519imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMonocytesGSVA_HALLMARK_P53_PATHWAY
chr15:41293595-41299295:+KICHEERENSG00000143553,SNAPIN-0.52384.2387e-024.7534e-08-0.6159imageNCELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SRSF1;TAF15;TIAL1;U2AF1;U2AF2;UPF1SNAPINMonocytesGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
chr15:41293595-41299295:+KICHEERENSG00000228487,RP13-225O21.20.50404.8732e-027.1092e-050.4723imageNDGCR8;EIF4A3;TAF15;UPF1NAT_cells_follicular_helperGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr15:41293595-41299295:+KIRCEERENSG00000125037,EMC30.20831.3360e-031.5482e-250.4981imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000151366,NDUFC20.19782.7032e-038.1724e-260.5006imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:41293595-41299295:+KIRCEERENSG00000172115,CYCS0.18604.7101e-031.4671e-170.4162imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1CYCSDendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000144455,SUMF10.17459.7772e-034.2100e-210.4553imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMacrophages_M1GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+KIRCEERENSG00000124243,BCAS40.16811.2804e-027.3062e-210.4528imageNADAR;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;MOV10;NOP56;NOP58;PTBP1;RBFOX2;TAF15;TIAL1;U2AF2;UPF1NADendritic_cells_activatedGSVA_HALLMARK_ANGIOGENESIS
chr15:41293595-41299295:+KIRCEERENSG00000164825,DEFB10.16441.5861e-021.5924e-170.4158imageNEWSR1;UPF1DEFB1Dendritic_cells_activatedGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr15:41293595-41299295:+KIRCEERENSG00000107262,BAG10.14962.6214e-021.2161e-230.4806imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;HNRNPC;HNRNPK;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1BAG1Dendritic_cells_activatedGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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4. Enriched editing regions and immune related splicing for OIP5-AS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:41293595-41299295:+
DLBCEERA3ENSG00000198399.10chr224208236:24208316:24205213:24205297:24205213:242062750.59653.9494e-022.9221e-040.5153imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1ITSN2NeutrophilsGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
ENSG00000247556.5,OIP5-AS1
KICHEAGIRENSG00000197111.11chr1253467220:53467293:53468779:53468832-0.59954.4473e-022.6529e-06-0.5452imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184PCBP2T_cells_CD4_memory_activatedGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASIS
ENSG00000247556.5,OIP5-AS1
KICHEAGA5ENSG00000197111.11chr1253468779:53468832:53467220:53467293:53467220:534678430.59694.8320e-022.8070e-070.5867imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184PCBP2MonocytesGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
ENSG00000247556.5,OIP5-AS1
KICHEAGESENSG00000197111.11chr1253467220:53467293:53467804:53467843:53468779:53468832-0.59694.8320e-022.8070e-07-0.5867imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184PCBP2MonocytesGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALING
ENSG00000247556.5,OIP5-AS1
KICHEAGA5ENSG00000197111.11chr1253468776:53468832:53467220:53467293:53467220:534678430.60793.7901e-025.6854e-070.5743imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184PCBP2MonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000247556.5,OIP5-AS1
KICHEAGESENSG00000197111.11chr1253467220:53467293:53467804:53467843:53468776:53468832-0.60793.7901e-025.6854e-07-0.5743imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184PCBP2MonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
ENSG00000247556.5,OIP5-AS1
KIRCEAGESENSG00000127603.19chr139479797:39480009:39480919:39481030:39484600:394847090.29381.8302e-062.8658e-170.4132imageNADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NAMast_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:41293595-41299295:+
KIRCEERA5ENSG00000070371.11chr2219180732:19180806:19183389:19183611:19181149:19183611-0.06341.9551e-033.6408e-16-0.4453imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;U2AF1;U2AF2;UPF1CLTCL1Macrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr15:41293595-41299295:+
KIRCEERIRENSG00000104892.12chr1945350340:45350551:45350640:45350747-0.18582.7466e-031.8105e-13-0.4081imageNADAR;CSTF2T;DGCR8;EIF4A3;ELAVL1;FBL;FMR1;HNRNPC;HNRNPK;HNRNPL;IGF2BP2;ILF3;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM47;SRSF1;TAF15;U2AF2NAMacrophages_M1GSVA_HALLMARK_INTERFERON_GAMMA_RESPONSE
chr15:41293595-41299295:+
KIRCEERA3ENSG00000127603.19chr139479797:39480009:39484600:39484709:39480919:39484709-0.20466.9250e-031.8008e-16-0.4035imageNADAR;CELF2;CSTF2T;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;IGF2BP2;ILF3;LIN28B;MOV10;NOP56;NOP58;PTBP1;RBFOX2;RBM10;RBM47;SF3A3;SRSF1;SRSF3;SRSF9;TAF15;TIAL1;U2AF1;U2AF2;UPF1NAMast_cells_restingGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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5. Enriched editing regions and immune infiltration for OIP5-AS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:41293595-41299295:+BLCAEERT_cells_gamma_delta1.6306e-020.1208image
ENSG00000247556.5,OIP5-AS1BLCAEAGEosinophils5.8772e-030.1378image
chr15:41293595-41299295:+BRCAEEREosinophils9.6297e-030.0787image
chr15:41305237-41305508:+BRCAEERT_cells_regulatory_(Tregs)3.1771e-020.0908image
ENSG00000247556.5,OIP5-AS1BRCAEAGMacrophages_M16.2053e-03-0.0831image
chr15:41286362-41289633:+CESCEERPlasma_cells2.7437e-020.3782image
chr15:41293595-41299295:+CESCEERMacrophages_M05.1944e-040.1982image
ENSG00000247556.5,OIP5-AS1CESCEAGMacrophages_M02.3004e-040.2101image
chr15:41293595-41299295:+CHOLEERMacrophages_M29.5008e-040.5341image
ENSG00000247556.5,OIP5-AS1CHOLEAGMacrophages_M26.0280e-040.5510image
chr15:41293595-41299295:+COADEERMacrophages_M16.7596e-06-0.2701image
ENSG00000247556.5,OIP5-AS1COADEAGMacrophages_M13.2122e-05-0.2502image
chr15:41286362-41289633:+ESCAEERT_cells_follicular_helper2.2832e-02-0.2275image
chr15:41293595-41299295:+ESCAEERT_cells_gamma_delta3.5785e-020.1656image
ENSG00000247556.5,OIP5-AS1ESCAEAGMacrophages_M21.0923e-02-0.2001image
chr15:41286362-41289633:+GBMEERT_cells_follicular_helper3.7003e-02-0.3396image
chr15:41293595-41299295:+GBMEERT_cells_follicular_helper3.7846e-020.1633image
ENSG00000247556.5,OIP5-AS1GBMEAGT_cells_CD4_memory_resting3.7998e-02-0.1622image
chr15:41293595-41299295:+HNSCEERMast_cells_activated1.2981e-040.1705image
ENSG00000247556.5,OIP5-AS1HNSCEAGMast_cells_activated6.5130e-040.1521image
chr15:41293595-41299295:+KICHEERMonocytes8.1243e-03-0.3256image
chr15:41286362-41289633:+KIRCEERT_cells_regulatory_(Tregs)1.7838e-02-0.4444image
chr15:41293595-41299295:+KIRCEEREosinophils1.4466e-070.2641image
chr15:41305237-41305508:+KIRCEERT_cells_CD81.0320e-020.1562image
ENSG00000247556.5,OIP5-AS1KIRCEAGEosinophils3.5335e-100.3127image
ENSG00000247556.5,OIP5-AS1KIRPEAGNK_cells_activated9.0773e-030.1546image
chr15:41293595-41299295:+LAMLEERT_cells_regulatory_(Tregs)2.7617e-02-0.1817image
ENSG00000247556.5,OIP5-AS1LAMLEAGT_cells_regulatory_(Tregs)2.7532e-02-0.1800image
chr15:41293595-41299295:+LGGEERNK_cells_activated3.9089e-020.0902image
ENSG00000247556.5,OIP5-AS1LGGEAGMonocytes9.3463e-03-0.1132image
chr15:41293595-41299295:+LIHCEERMacrophages_M21.2576e-02-0.1293image
ENSG00000247556.5,OIP5-AS1LIHCEAGMast_cells_resting7.4496e-03-0.1384image
chr15:41286362-41289633:+LUADEEREosinophils2.2734e-02-0.3428image
chr15:41293595-41299295:+LUADEEREosinophils5.5768e-030.1226image
ENSG00000247556.5,OIP5-AS1LUADEAGEosinophils1.5765e-030.1390image
chr15:41293595-41299295:+LUSCEERMacrophages_M11.2167e-02-0.1124image
chr15:41302192-41302462:+LUSCEERT_cells_follicular_helper8.0063e-030.2064image
chr15:41305237-41305508:+LUSCEERMast_cells_activated3.7337e-030.1909image
ENSG00000247556.5,OIP5-AS1LUSCEAGT_cells_CD81.7085e-03-0.1404image
chr15:41293595-41299295:+MESOEERNK_cells_activated2.0523e-020.2571image
ENSG00000247556.5,OIP5-AS1MESOEAGNK_cells_activated4.6697e-020.2203image
ENSG00000247556.5,OIP5-AS1OVEAGMast_cells_resting3.0177e-030.1733image
chr15:41293595-41299295:+PAADEERMacrophages_M01.8936e-020.1804image
ENSG00000247556.5,OIP5-AS1PAADEAGMacrophages_M03.4109e-020.1621image
chr15:41293595-41299295:+PRADEERT_cells_regulatory_(Tregs)1.0356e-03-0.1475image
ENSG00000247556.5,OIP5-AS1PRADEAGT_cells_regulatory_(Tregs)1.7393e-03-0.1403image
chr15:41293595-41299295:+READEERMast_cells_resting3.0425e-020.2246image
ENSG00000247556.5,OIP5-AS1READEAGT_cells_follicular_helper2.6436e-020.2290image
chr15:41293595-41299295:+SARCEERNK_cells_resting6.4021e-040.2145image
ENSG00000247556.5,OIP5-AS1SARCEAGNK_cells_resting3.1641e-040.2246image
chr15:41286362-41289633:+SKCMEERB_cells_naive2.5474e-02-0.4073image
chr15:41293595-41299295:+SKCMEERT_cells_CD83.9055e-04-0.1647image
ENSG00000247556.5,OIP5-AS1SKCMEAGT_cells_CD82.2724e-04-0.1707image
ENSG00000247556.5,OIP5-AS1STADEAGMonocytes2.5411e-02-0.1157image
chr15:41293595-41299295:+TGCTEERT_cells_regulatory_(Tregs)3.3245e-020.1706image
ENSG00000247556.5,OIP5-AS1TGCTEAGDendritic_cells_resting1.4960e-020.1945image
chr15:41293595-41299295:+THCAEERMacrophages_M22.8703e-030.1331image
ENSG00000247556.5,OIP5-AS1THCAEAGMacrophages_M21.3775e-030.1421image
chr15:41293595-41299295:+THYMEERMacrophages_M11.9203e-04-0.3396image
ENSG00000247556.5,OIP5-AS1THYMEAGMacrophages_M14.1564e-04-0.3224image
chr15:41293595-41299295:+UCECEERT_cells_CD4_naive2.3473e-020.1722image
ENSG00000247556.5,OIP5-AS1UCECEAGT_cells_CD4_naive1.4278e-020.1849image
chr15:41293595-41299295:+UCSEERPlasma_cells3.8398e-020.2775image
ENSG00000247556.5,OIP5-AS1UCSEAGPlasma_cells4.0659e-020.2745image


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6. Enriched editing regions and immune gene sets for OIP5-AS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr15:41293595-41299295:+BLCAEER1.9813e-02image4.4541e-02-0.1011image
ENSG00000247556.5,OIP5-AS1BLCAEAG7.2647e-03image2.1450e-02-0.1153image
chr15:41293595-41299295:+THCAEER3.3361e-05image7.1558e-03-0.1201image
ENSG00000247556.5,OIP5-AS1THCAEAG4.1640e-05image3.4626e-05-0.1833image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000247556.5,OIP5-AS1KIRCEAG2.8684e-03-0.15161.6709e-03-0.15974.0368e-02-0.10458.1459e-05-0.1994image
chr15:41293595-41299295:+KIRCEER2.3026e-03-0.15491.4263e-04-0.19261.3910e-02-0.12538.1915e-04-0.1698image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr15:41293595-41299295:+ACCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.8522e-03-0.3411image
ENSG00000247556.5,OIP5-AS1ACCGSVA_HALLMARK_P53_PATHWAYEAG2.8413e-02-0.2602image
chr15:41293595-41299295:+BLCAGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.3812e-03-0.1524image
ENSG00000247556.5,OIP5-AS1BLCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG1.0779e-03-0.1633image
ENSG00000247556.5,OIP5-AS1BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.3826e-04-0.1050image
chr15:41293595-41299295:+BRCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER7.4304e-04-0.1024image
chr15:41305237-41305508:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.6591e-040.1502image
chr15:41293595-41299295:+CESCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.5414e-08-0.3178image
ENSG00000247556.5,OIP5-AS1CESCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.0167e-10-0.3493image
chr15:41293595-41299295:+CHOLGSVA_HALLMARK_HEME_METABOLISMEER6.8820e-030.4485image
ENSG00000247556.5,OIP5-AS1CHOLGSVA_HALLMARK_MYC_TARGETS_V2EAG1.3397e-02-0.4141image
ENSG00000247556.5,OIP5-AS1COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.5146e-06-0.2780image
chr15:41293595-41299295:+COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.6718e-07-0.2929image
chr15:41286362-41289633:+ESCAGSVA_HALLMARK_MYC_TARGETS_V1EER2.2388e-02-0.2282image
chr15:41293595-41299295:+ESCAGSVA_HALLMARK_SPERMATOGENESISEER4.9861e-020.1548image
chr15:41293595-41299295:+GBMGSVA_HALLMARK_E2F_TARGETSEER1.3246e-020.1943image
chr15:41286362-41289633:+GBMGSVA_HALLMARK_ADIPOGENESISEER4.2491e-030.4534image
ENSG00000247556.5,OIP5-AS1GBMGSVA_HALLMARK_MYC_TARGETS_V2EAG9.5719e-030.2018image
chr15:41293595-41299295:+HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.7028e-07-0.2216image
ENSG00000247556.5,OIP5-AS1HNSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.4147e-06-0.2139image
chr15:41293595-41299295:+KICHGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER6.7158e-03-0.3330image
ENSG00000247556.5,OIP5-AS1KICHGSVA_HALLMARK_APICAL_SURFACEEAG3.7089e-020.2592image
chr15:41286362-41289633:+KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER4.8170e-020.3767image
chr15:41293595-41299295:+KIRCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER2.3135e-05-0.2139image
ENSG00000247556.5,OIP5-AS1KIRCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.6027e-06-0.2274image
chr15:41293595-41299295:+LAMLGSVA_HALLMARK_E2F_TARGETSEER9.2979e-030.2139image
ENSG00000247556.5,OIP5-AS1LAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEAG3.8705e-02-0.1690image
ENSG00000247556.5,OIP5-AS1LGGGSVA_HALLMARK_MYC_TARGETS_V2EAG7.1782e-110.2792image
chr15:41293595-41299295:+LGGGSVA_HALLMARK_MYC_TARGETS_V2EER6.9355e-070.2148image
chr15:41293595-41299295:+LIHCGSVA_HALLMARK_HEME_METABOLISMEER4.2518e-02-0.1052image
ENSG00000247556.5,OIP5-AS1LIHCGSVA_HALLMARK_UV_RESPONSE_DNEAG5.5387e-06-0.2328image
chr15:41286362-41289633:+LUADGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.8835e-040.5341image
ENSG00000247556.5,OIP5-AS1LUADGSVA_HALLMARK_COMPLEMENTEAG7.1770e-04-0.1487image
chr15:41293595-41299295:+LUADGSVA_HALLMARK_COMPLEMENTEER2.3974e-03-0.1342image
chr15:41305237-41305508:+LUSCGSVA_HALLMARK_GLYCOLYSISEER5.8087e-030.1818image
chr15:41293595-41299295:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.5273e-04-0.1691image
chr15:41302192-41302462:+LUSCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER8.6882e-03-0.2043image
ENSG00000247556.5,OIP5-AS1LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.7637e-05-0.1814image
chr15:41293595-41299295:+MESOGSVA_HALLMARK_BILE_ACID_METABOLISMEER6.0990e-040.3728image
ENSG00000247556.5,OIP5-AS1MESOGSVA_HALLMARK_DNA_REPAIREAG1.3768e-02-0.2711image
chr15:41286362-41289633:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER8.5962e-030.2341image
ENSG00000247556.5,OIP5-AS1OVGSVA_HALLMARK_MYC_TARGETS_V2EAG6.1639e-040.1996image
chr15:41293595-41299295:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER3.1869e-030.1726image
ENSG00000247556.5,OIP5-AS1PAADGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.9756e-04-0.2678image
chr15:41293595-41299295:+PAADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER4.3960e-04-0.2674image
ENSG00000247556.5,OIP5-AS1PCPGGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4726e-02-0.1890image
chr15:41293595-41299295:+PCPGGSVA_HALLMARK_UV_RESPONSE_DNEER1.4680e-03-0.2627image
ENSG00000247556.5,OIP5-AS1PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.5450e-05-0.1846image
chr15:41293595-41299295:+PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.6740e-04-0.1689image
chr15:41293595-41299295:+READGSVA_HALLMARK_MYC_TARGETS_V2EER1.1634e-020.2606image
ENSG00000247556.5,OIP5-AS1READGSVA_HALLMARK_MYC_TARGETS_V1EAG1.2872e-030.3272image
chr15:41293595-41299295:+SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.1064e-03-0.1766image
ENSG00000247556.5,OIP5-AS1SARCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.4281e-04-0.2234image
chr15:41286362-41289633:+SKCMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER5.2967e-040.5946image
chr15:41293595-41299295:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.6872e-04-0.1581image
ENSG00000247556.5,OIP5-AS1SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.1360e-06-0.2059image
chr15:41305237-41305508:+STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.0837e-050.2461image
chr15:41286362-41289633:+STADGSVA_HALLMARK_P53_PATHWAYEER2.2358e-030.2371image
chr15:41293595-41299295:+STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER2.0597e-030.1595image
ENSG00000247556.5,OIP5-AS1TGCTGSVA_HALLMARK_G2M_CHECKPOINTEAG3.3396e-02-0.1704image
chr15:41293595-41299295:+TGCTGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.6089e-030.2208image
chr15:41293595-41299295:+THCAGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER9.5164e-07-0.2171image
ENSG00000247556.5,OIP5-AS1THCAGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.6586e-08-0.2481image
ENSG00000247556.5,OIP5-AS1THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG9.5985e-07-0.4366image
chr15:41293595-41299295:+THYMGSVA_HALLMARK_PROTEIN_SECRETIONEER2.3083e-06-0.4225image
chr15:41293595-41299295:+UCECGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.3396e-02-0.1877image
ENSG00000247556.5,OIP5-AS1UVMGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.1685e-02-0.2689image


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7. Enriched editing regions and drugs for OIP5-AS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr15:41293595-41299295:+BLCACGP.60474EER1.8340e-030.1563image
ENSG00000247556.5,OIP5-AS1BLCACGP.60474EAG3.8424e-040.1771image
ENSG00000247556.5,OIP5-AS1BRCAGemcitabineEAG8.8975e-03-0.0795image
chr15:41293595-41299295:+BRCAABT.263EER2.6197e-03-0.0916image
chr15:41305237-41305508:+BRCAMG.132EER3.6533e-06-0.1951image
ENSG00000247556.5,OIP5-AS1CESCCI.1040EAG1.0744e-050.2499image
chr15:41286362-41289633:+CESCDasatinibEER2.7029e-020.3848image
chr15:41293595-41299295:+CESCCI.1040EER3.1840e-060.2640image
ENSG00000247556.5,OIP5-AS1CHOLCamptothecinEAG7.2551e-030.4459image
chr15:41293595-41299295:+CHOLCamptothecinEER1.7049e-030.5111image
chr15:41293595-41299295:+COADBexaroteneEER1.1522e-060.2909image
ENSG00000247556.5,OIP5-AS1COADBexaroteneEAG1.2029e-050.2629image
ENSG00000247556.5,OIP5-AS1ESCAABT.263EAG3.2642e-03-0.2312image
chr15:41286362-41289633:+ESCACHIR.99021EER2.2075e-02-0.2287image
ENSG00000247556.5,OIP5-AS1GBMDMOGEAG4.6150e-030.2202image
chr15:41293595-41299295:+GBMDMOGEER5.7311e-030.2162image
chr15:41286362-41289633:+GBMBIRB.0796EER6.7246e-030.4323image
ENSG00000247556.5,OIP5-AS1HNSCLenalidomideEAG7.1591e-050.1768image
chr15:41293595-41299295:+HNSCJNK.Inhibitor.VIIIEER1.9034e-030.1387image
chr15:41293595-41299295:+KICHCisplatinEER4.7523e-040.4212image
ENSG00000247556.5,OIP5-AS1KICHCisplatinEAG7.3563e-040.4082image
chr15:41305237-41305508:+KIRCBMS.536924EER4.4131e-03-0.1737image
ENSG00000247556.5,OIP5-AS1KIRCBAY.61.3606EAG1.2607e-070.2653image
chr15:41293595-41299295:+KIRCBAY.61.3606EER3.5441e-110.3291image
chr15:41293595-41299295:+KIRPATRAEER1.2697e-020.1485image
chr15:41293595-41299295:+LAMLLFM.A13EER1.8776e-020.1936image
chr15:41293595-41299295:+LGGGSK.650394EER1.3733e-06-0.2091image
ENSG00000247556.5,OIP5-AS1LGGGSK.650394EAG1.5797e-11-0.2883image
chr15:41293595-41299295:+LIHCKIN001.135EER4.6076e-030.1466image
ENSG00000247556.5,OIP5-AS1LIHCBMS.708163EAG1.4528e-050.2224image
ENSG00000247556.5,OIP5-AS1LUADBMS.509744EAG5.2230e-030.1230image
chr15:41293595-41299295:+LUADBMS.509744EER6.3131e-040.1509image
chr15:41286362-41289633:+LUADAG.014699EER3.7109e-040.5129image
chr15:41302192-41302462:+LUSCEmbelinEER1.0000e-050.3373image
chr15:41293595-41299295:+LUSCCGP.60474EER1.2491e-020.1120image
chr15:41305237-41305508:+LUSCGSK269962AEER1.5247e-03-0.2083image
ENSG00000247556.5,OIP5-AS1LUSCGDC0941EAG6.1269e-030.1228image
ENSG00000247556.5,OIP5-AS1MESOBIRB.0796EAG2.8704e-020.2417image
chr15:41293595-41299295:+MESOBIRB.0796EER1.0295e-030.3581image
chr15:41293595-41299295:+OVCHIR.99021EER1.3984e-02-0.1442image
ENSG00000247556.5,OIP5-AS1OVAKT.inhibitor.VIIIEAG3.6918e-040.2074image
chr15:41286362-41289633:+OVLFM.A13EER4.9916e-020.1758image
chr15:41293595-41299295:+PAADBIRB.0796EER1.4653e-03-0.2429image
ENSG00000247556.5,OIP5-AS1PCPGBMS.708163EAG1.5361e-03-0.2440image
chr15:41293595-41299295:+PCPGBleomycinEER2.6438e-03-0.2488image
ENSG00000247556.5,OIP5-AS1PRADGW.441756EAG8.1756e-05-0.1759image
chr15:41293595-41299295:+PRADGW.441756EER9.6815e-04-0.1483image
ENSG00000247556.5,OIP5-AS1READGDC0941EAG4.9099e-030.2878image
chr15:41293595-41299295:+READGDC0941EER2.8208e-020.2276image
chr15:41293595-41299295:+SARCEpothilone.BEER1.4800e-04-0.2377image
ENSG00000247556.5,OIP5-AS1SARCEpothilone.BEAG6.0558e-05-0.2494image
ENSG00000247556.5,OIP5-AS1SKCMGSK269962AEAG7.3924e-06-0.2079image
chr15:41293595-41299295:+SKCMGSK269962AEER5.5724e-06-0.2111image
chr15:41286362-41289633:+SKCMErlotinibEER4.5302e-040.6003image
chr15:41293595-41299295:+STADLFM.A13EER1.3683e-020.1279image
chr15:41286362-41289633:+STADAUY922EER8.4999e-04-0.2580image
ENSG00000247556.5,OIP5-AS1STADLapatinibEAG1.3978e-060.2484image
chr15:41305237-41305508:+STADAZ628EER5.3342e-07-0.2984image
ENSG00000247556.5,OIP5-AS1TGCTCGP.082996EAG3.7111e-050.3239image
chr15:41293595-41299295:+TGCTJNK.9LEER1.6598e-040.2971image
chr15:41293595-41299295:+THCAAICAREER5.1648e-070.2222image
ENSG00000247556.5,OIP5-AS1THCAAICAREAG2.0510e-070.2289image
ENSG00000247556.5,OIP5-AS1THYMCEP.701EAG2.3792e-08-0.4899image
chr15:41293595-41299295:+THYMCEP.701EER1.5241e-07-0.4643image
ENSG00000247556.5,OIP5-AS1UCECDMOGEAG8.1239e-030.1995image
chr15:41293595-41299295:+UCECGefitinibEER2.0278e-020.1764image
chr15:41293595-41299295:+UCSAICAREER4.1744e-02-0.2730image
ENSG00000247556.5,OIP5-AS1UCSAICAREAG1.5784e-02-0.3212image
ENSG00000247556.5,OIP5-AS1UVMAMG.706EAG2.2324e-020.2853image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType