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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: NUTM2A-AS1 (ImmuneEditome ID:728190)

1. Gene summary of enriched editing regions for NUTM2A-AS1

check button Gene summary
Gene informationGene symbol

NUTM2A-AS1

Gene ID

728190

GeneSynonymsFAM22A-AS1
GeneCytomap

10q23.2

GeneTypencRNA
GeneDescriptionFAM22A antisense RNA 1
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:87208170-87209132:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJo,AluSx,L1MEg,AluJbchr10:87208170-87209132:-.alignment
chr10:87210431-87210730:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJbchr10:87210431-87210730:-.alignment
chr10:87212270-87212998:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluY,AluSq2chr10:87212270-87212998:-.alignment
chr10:87214940-87215783:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluY,AluSc,AluSzchr10:87214940-87215783:-.alignment
chr10:87241149-87241389:-ENST00000433530.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicMSTB1chr10:87241149-87241389:-.alignment
chr10:87241149-87241389:-ENST00000433920.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicMSTB1chr10:87241149-87241389:-.alignment
chr10:87241149-87241389:-ENST00000447424.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicMSTB1chr10:87241149-87241389:-.alignment
chr10:87241149-87241389:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronicMSTB1chr10:87241149-87241389:-.alignment
chr10:87241149-87241389:-ENST00000456104.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicMSTB1chr10:87241149-87241389:-.alignment
chr10:87247126-87247341:-ENST00000433530.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJb,MLT1Dchr10:87247126-87247341:-.alignment
chr10:87247126-87247341:-ENST00000433920.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJb,MLT1Dchr10:87247126-87247341:-.alignment
chr10:87247126-87247341:-ENST00000446751.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJb,MLT1Dchr10:87247126-87247341:-.alignment
chr10:87247126-87247341:-ENST00000447424.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJb,MLT1Dchr10:87247126-87247341:-.alignment
chr10:87247126-87247341:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJb,MLT1Dchr10:87247126-87247341:-.alignment
chr10:87247126-87247341:-ENST00000456104.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronicAluJb,MLT1Dchr10:87247126-87247341:-.alignment
chr10:87248564-87248772:-ENST00000433530.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(T)n,AluJbchr10:87248564-87248772:-.alignment
chr10:87248564-87248772:-ENST00000433920.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(T)n,AluJbchr10:87248564-87248772:-.alignment
chr10:87248564-87248772:-ENST00000446751.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(T)n,AluJbchr10:87248564-87248772:-.alignment
chr10:87248564-87248772:-ENST00000447424.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(T)n,AluJbchr10:87248564-87248772:-.alignment
chr10:87248564-87248772:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(T)n,AluJbchr10:87248564-87248772:-.alignment
chr10:87248564-87248772:-ENST00000456104.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(T)n,AluJbchr10:87248564-87248772:-.alignment
chr10:87261841-87262521:-ENST00000433530.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(TTCCTT)n,AluJr,AluJb,(TTCTTT)nchr10:87261841-87262521:-.alignment
chr10:87261841-87262521:-ENST00000433920.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(TTCCTT)n,AluJr,AluJb,(TTCTTT)nchr10:87261841-87262521:-.alignment
chr10:87261841-87262521:-ENST00000446751.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(TTCCTT)n,AluJr,AluJb,(TTCTTT)nchr10:87261841-87262521:-.alignment
chr10:87261841-87262521:-ENST00000447424.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(TTCCTT)n,AluJr,AluJb,(TTCTTT)nchr10:87261841-87262521:-.alignment
chr10:87261841-87262521:-ENST00000451940.5ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(TTCCTT)n,AluJr,AluJb,(TTCTTT)nchr10:87261841-87262521:-.alignment
chr10:87261841-87262521:-ENST00000456104.4ENSG00000223482.6NUTM2A-AS1ncRNA_intronic(TTCCTT)n,AluJr,AluJb,(TTCTTT)nchr10:87261841-87262521:-.alignment


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2. Tumor-specific enriched editing regions for NUTM2A-AS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr10:87241149-87241389:-BRCAEER3.6548e-02image
ENSG00000223482.6,NUTM2A-AS1BRCAEAG1.9678e-03image
ENSG00000223482.6,NUTM2A-AS1HNSCEAG4.7051e-03image
ENSG00000223482.6,NUTM2A-AS1KIRCEAG1.8383e-05image
chr10:87208170-87209132:-LUSCEER2.1538e-03image
chr10:87241149-87241389:-LUSCEER1.9504e-10image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr10:87241149-87241389:-BLCAPathEER5.6896e-032.1773e-020.1583image
ENSG00000223482.6,NUTM2A-AS1BLCAPathEAG3.7956e-029.9631e-030.1493image
chr10:87241149-87241389:-KIRPPathEER2.2720e-023.7254e-020.1703image
ENSG00000223482.6,NUTM2A-AS1KIRPPathEAG4.5823e-024.6082e-020.1281image
chr10:87210431-87210730:-MESOPathEER3.5090e-023.4514e-02-0.3159image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr10:87210431-87210730:-ACCEER2.4088e-039.6212e-033.3865e-05image
ENSG00000223482.6,NUTM2A-AS1UCSEAG5.5777e-031.7018e-029.7753e+03image

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3. Enriched editing regions and immune related genes for NUTM2A-AS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:87208170-87209132:-ESCAEERENSG00000113597,TRAPPC130.45742.9016e-042.3432e-060.4049imageNNNAMast_cells_activatedGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:87208170-87209132:-ESCAEERENSG00000003756,RBM50.42301.1170e-031.1478e-060.4160imageNNRBM5T_cells_regulatory_(Tregs)GSVA_HALLMARK_MTORC1_SIGNALING
chr10:87208170-87209132:-ESCAEERENSG00000163320,CGGBP10.42231.2584e-031.2201e-070.4487imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr10:87208170-87209132:-ESCAEERENSG00000170234,PWWP2A0.41102.0333e-031.3546e-060.4135imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:87208170-87209132:-ESCAEERENSG00000198160,MIER10.39373.7585e-031.1475e-060.4160imageNNNANeutrophilsGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:87208170-87209132:-ESCAEERENSG00000253797,UTP14C0.38544.2797e-033.9787e-070.4319imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr10:87208170-87209132:-ESCAEERENSG00000183323,CCDC1250.37284.8682e-031.0894e-060.4168imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr10:87208170-87209132:-ESCAEERENSG00000109618,SEPSECS0.36177.9078e-033.1393e-070.4353imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr10:87208170-87209132:-ESCAEERENSG00000143643,TTC130.36848.2881e-033.5128e-070.4337imageNNNAB_cells_naiveGSVA_HALLMARK_HYPOXIA
chr10:87208170-87209132:-ESCAEERENSG00000178177,LCORL0.35949.4515e-031.5708e-080.4758imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr10:87241149-87241389:-ESCAEERENSG00000105880,DLX50.27442.8492e-023.9991e-090.4602imageNNNAMast_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr10:87241149-87241389:-LAMLEERENSG00000223482,NUTM2A-AS1-0.44277.1857e-033.0561e-06-0.4082imageNNNAMonocytesGSVA_HALLMARK_COAGULATION
chr10:87241149-87241389:-LAMLEERENSG00000264773,MIR44200.40441.7561e-022.9387e-060.4088imageNNNAMonocytesGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr10:87241149-87241389:-ESCAEERENSG00000105880,DLX50.27442.8492e-023.9991e-090.4602imageNNNAMast_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr10:87241149-87241389:-LAMLEERENSG00000223482,NUTM2A-AS1-0.44277.1857e-033.0561e-06-0.4082imageNNNAMonocytesGSVA_HALLMARK_COAGULATION
chr10:87241149-87241389:-LAMLEERENSG00000264773,MIR44200.40441.7561e-022.9387e-060.4088imageNNNAMonocytesGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr10:87241149-87241389:-ESCAEERENSG00000105880,DLX50.27442.8492e-023.9991e-090.4602imageNNNAMast_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr10:87241149-87241389:-LAMLEERENSG00000223482,NUTM2A-AS1-0.44277.1857e-033.0561e-06-0.4082imageNNNAMonocytesGSVA_HALLMARK_COAGULATION
chr10:87241149-87241389:-LAMLEERENSG00000264773,MIR44200.40441.7561e-022.9387e-060.4088imageNNNAMonocytesGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr10:87241149-87241389:-ESCAEERENSG00000105880,DLX50.27442.8492e-023.9991e-090.4602imageNNNAMast_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr10:87241149-87241389:-LAMLEERENSG00000223482,NUTM2A-AS1-0.44277.1857e-033.0561e-06-0.4082imageNNNAMonocytesGSVA_HALLMARK_COAGULATION
chr10:87241149-87241389:-LAMLEERENSG00000264773,MIR44200.40441.7561e-022.9387e-060.4088imageNNNAMonocytesGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB
chr10:87241149-87241389:-ESCAEERENSG00000105880,DLX50.27442.8492e-023.9991e-090.4602imageNNNAMast_cells_activatedGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr10:87241149-87241389:-LAMLEERENSG00000223482,NUTM2A-AS1-0.44277.1857e-033.0561e-06-0.4082imageNNNAMonocytesGSVA_HALLMARK_COAGULATION
chr10:87241149-87241389:-LAMLEERENSG00000264773,MIR44200.40441.7561e-022.9387e-060.4088imageNNNAMonocytesGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKB

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4. Enriched editing regions and immune related splicing for NUTM2A-AS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:87208170-87209132:-
ESCAEERMEXENSG00000129657.10chr1777216166:77216179:77216270:77216283:77216348:77216387:77216413:772168020.23804.9722e-023.4022e-050.4077imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSE
chr10:87208170-87209132:-
ESCAEERIRENSG00000198925.6chr2219228423:219228485:219229009:2192291740.38171.9926e-022.1276e-060.4110imageNNATG9ANeutrophilsGSVA_HALLMARK_GLYCOLYSIS
chr10:87241149-87241389:-
ESCAEERA3ENSG00000196576.10chr2250284572:50284665:50284131:50284244:50284131:50284308-0.17981.0708e-028.2785e-06-0.4161imageNNNANeutrophilsGSVA_HALLMARK_PANCREAS_BETA_CELLS
chr10:87208170-87209132:-
ESCAEERIRENSG00000006576.12chr777940029:77940659:77942699:779427860.37441.3447e-021.9747e-060.4356imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr10:87208170-87209132:-
ESCAEERIRENSG00000164164.11chr4145143945:145144434:145146266:1451464290.39122.0523e-026.0133e-070.4258imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr10:87208170-87209132:-
ESCAEERIRENSG00000099904.11chr2220139719:20140217:20140616:201407080.38242.0935e-021.0216e-060.4193imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_SURFACE
chr10:87208170-87209132:-
ESCAEERIRENSG00000129480.8chr1431446991:31447569:31447704:31448454-0.31013.0849e-021.2802e-07-0.4742imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr10:87208170-87209132:-
ESCAEERIRENSG00000148339.8chr9128105728:128105881:128106149:1281062570.38152.5597e-021.8152e-060.4104imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_APICAL_SURFACE
chr10:87208170-87209132:-
ESCAEERIRENSG00000167615.12chr1954458313:54458521:54460765:544620370.40309.6082e-033.9810e-070.4319imageNNLENG8T_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr10:87208170-87209132:-
ESCAEERIRENSG00000108669.12chr1778674047:78676169:78680189:786802180.37183.1099e-028.3908e-070.4208imageNNCYTH1T_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING

More results



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5. Enriched editing regions and immune infiltration for NUTM2A-AS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr10:87210431-87210730:-ACCEERMast_cells_resting4.9903e-030.4114image
ENSG00000223482.6,NUTM2A-AS1ACCEAGMast_cells_resting3.7335e-030.3471image
chr10:87210431-87210730:-BLCAEERT_cells_regulatory_(Tregs)3.4529e-02-0.2478image
chr10:87241149-87241389:-BLCAEERT_cells_regulatory_(Tregs)1.1671e-02-0.1733image
ENSG00000223482.6,NUTM2A-AS1BLCAEAGMacrophages_M13.1028e-040.2079image
chr10:87241149-87241389:-BRCAEERT_cells_CD4_memory_activated7.7882e-030.1012image
ENSG00000223482.6,NUTM2A-AS1BRCAEAGMast_cells_resting1.3895e-030.1040image
chr10:87210431-87210730:-CESCEERMast_cells_activated3.6601e-020.2232image
ENSG00000223482.6,NUTM2A-AS1CESCEAGNK_cells_activated4.8365e-02-0.1295image
chr10:87210431-87210730:-COADEERDendritic_cells_activated5.4411e-040.6024image
ENSG00000223482.6,NUTM2A-AS1COADEAGDendritic_cells_activated3.2983e-040.2584image
chr10:87208170-87209132:-ESCAEERMast_cells_activated3.3875e-03-0.2581image
chr10:87210431-87210730:-ESCAEERMacrophages_M24.2643e-030.3143image
chr10:87212270-87212998:-ESCAEERT_cells_regulatory_(Tregs)5.9302e-030.4176image
chr10:87241149-87241389:-ESCAEERT_cells_CD4_memory_resting3.2926e-02-0.1755image
chr10:87248564-87248772:-ESCAEERMacrophages_M14.1204e-040.6126image
ENSG00000223482.6,NUTM2A-AS1ESCAEAGDendritic_cells_activated3.5736e-02-0.1677image
ENSG00000223482.6,NUTM2A-AS1GBMEAGT_cells_CD4_memory_resting6.9370e-030.2340image
chr10:87241149-87241389:-HNSCEERMacrophages_M11.1679e-020.1602image
ENSG00000223482.6,NUTM2A-AS1HNSCEAGNK_cells_resting8.1329e-040.1832image
chr10:87241149-87241389:-KIRCEEREosinophils5.7920e-030.1631image
ENSG00000223482.6,NUTM2A-AS1KIRCEAGMacrophages_M01.6795e-020.1281image
chr10:87241149-87241389:-KIRPEERPlasma_cells3.2595e-02-0.1665image
ENSG00000223482.6,NUTM2A-AS1KIRPEAGT_cells_CD4_memory_activated1.3557e-080.3400image
chr10:87241149-87241389:-LAMLEERMonocytes6.2049e-040.3056image
ENSG00000223482.6,NUTM2A-AS1LAMLEAGT_cells_CD4_memory_resting1.4585e-03-0.2647image
ENSG00000223482.6,NUTM2A-AS1LGGEAGT_cells_CD4_memory_activated6.8973e-030.1194image
chr10:87241149-87241389:-LIHCEERMacrophages_M11.2079e-020.2204image
chr10:87210431-87210730:-LUADEERT_cells_CD83.0611e-030.2320image
chr10:87241149-87241389:-LUADEERT_cells_CD4_memory_resting1.7933e-02-0.1514image
ENSG00000223482.6,NUTM2A-AS1LUADEAGMast_cells_activated3.9906e-03-0.1516image
chr10:87208170-87209132:-LUSCEERB_cells_memory2.2408e-030.1976image
chr10:87210431-87210730:-LUSCEERNK_cells_resting3.7895e-03-0.2366image
chr10:87241149-87241389:-LUSCEERMonocytes2.4596e-02-0.1694image
ENSG00000223482.6,NUTM2A-AS1LUSCEAGB_cells_naive9.0938e-03-0.1413image
chr10:87210431-87210730:-MESOEERT_cells_regulatory_(Tregs)9.5919e-03-0.3952image
chr10:87208170-87209132:-OVEERMacrophages_M01.7726e-02-0.1481image
chr10:87212270-87212998:-OVEERMacrophages_M02.3918e-02-0.2341image
chr10:87241149-87241389:-OVEERMacrophages_M17.2962e-030.1951image
ENSG00000223482.6,NUTM2A-AS1OVEAGMacrophages_M02.1570e-02-0.1383image
chr10:87241149-87241389:-PAADEERMacrophages_M21.8745e-020.2383image
chr10:87210431-87210730:-PCPGEERNK_cells_activated3.1680e-03-0.4173image
chr10:87241149-87241389:-PCPGEERMacrophages_M01.5099e-020.3124image
chr10:87208170-87209132:-PRADEERB_cells_naive1.1122e-020.1429image
chr10:87210431-87210730:-PRADEERT_cells_follicular_helper4.1891e-02-0.1774image
chr10:87241149-87241389:-PRADEERMacrophages_M12.4150e-030.1809image
ENSG00000223482.6,NUTM2A-AS1PRADEAGT_cells_CD4_memory_resting1.0617e-020.1278image
ENSG00000223482.6,NUTM2A-AS1READEAGMast_cells_resting4.0494e-020.2356image
chr10:87241149-87241389:-SARCEERDendritic_cells_activated5.1813e-030.2892image
ENSG00000223482.6,NUTM2A-AS1SARCEAGMast_cells_resting1.3965e-040.2648image
chr10:87210431-87210730:-SKCMEERT_cells_gamma_delta3.9946e-020.2182image
chr10:87241149-87241389:-SKCMEERMacrophages_M22.3428e-02-0.1524image
chr10:87208170-87209132:-STADEERB_cells_memory1.8252e-020.1495image
chr10:87212270-87212998:-STADEEREosinophils2.5329e-030.2904image
chr10:87241149-87241389:-STADEERT_cells_CD4_memory_activated1.9674e-050.2604image
chr10:87261841-87262521:-STADEERB_cells_naive1.7054e-02-0.4552image
ENSG00000223482.6,NUTM2A-AS1STADEAGT_cells_CD81.1497e-020.1388image
ENSG00000223482.6,NUTM2A-AS1TGCTEAGMacrophages_M25.6604e-05-0.4590image
chr10:87210431-87210730:-THCAEERT_cells_CD4_memory_activated1.6595e-020.1532image
chr10:87241149-87241389:-THCAEEREosinophils1.0059e-02-0.1342image
ENSG00000223482.6,NUTM2A-AS1THCAEAGT_cells_CD4_memory_activated8.3418e-050.1797image
chr10:87210431-87210730:-THYMEEREosinophils1.4056e-030.3694image
chr10:87241149-87241389:-THYMEERT_cells_CD4_memory_activated5.1180e-040.3753image
ENSG00000223482.6,NUTM2A-AS1THYMEAGDendritic_cells_activated1.4219e-030.2992image
chr10:87241149-87241389:-UCECEERB_cells_memory1.1766e-020.3287image
ENSG00000223482.6,NUTM2A-AS1UCECEAGMacrophages_M11.4540e-020.1966image
chr10:87208170-87209132:-UCSEERMacrophages_M18.3973e-030.3841image
chr10:87210431-87210730:-UCSEERMast_cells_activated6.3227e-030.5212image
ENSG00000223482.6,NUTM2A-AS1UCSEAGDendritic_cells_resting3.0616e-020.3031image
ENSG00000223482.6,NUTM2A-AS1UVMEAGT_cells_regulatory_(Tregs)4.8440e-020.2497image


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6. Enriched editing regions and immune gene sets for NUTM2A-AS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
ENSG00000223482.6,NUTM2A-AS1KIRPEAG4.1187e-02image3.7807e-030.1773image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000223482.6,NUTM2A-AS1ACCGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3828e-030.3802image
chr10:87210431-87210730:-ACCGSVA_HALLMARK_MYC_TARGETS_V2EER3.8766e-02-0.3092image
chr10:87210431-87210730:-BLCAGSVA_HALLMARK_GLYCOLYSISEER5.5491e-030.3215image
chr10:87241149-87241389:-BLCAGSVA_HALLMARK_UV_RESPONSE_UPEER1.4392e-030.2180image
ENSG00000223482.6,NUTM2A-AS1BLCAGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG3.0470e-060.2670image
ENSG00000223482.6,NUTM2A-AS1BRCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.2283e-070.1678image
chr10:87241149-87241389:-BRCAGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2769e-030.1224image
chr10:87208170-87209132:-CESCGSVA_HALLMARK_MYC_TARGETS_V1EER3.7557e-02-0.1616image
ENSG00000223482.6,NUTM2A-AS1CESCGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG4.7828e-040.2270image
chr10:87241149-87241389:-CESCGSVA_HALLMARK_MITOTIC_SPINDLEEER2.9624e-020.1765image
chr10:87210431-87210730:-CESCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER4.1480e-030.3027image
chr10:87208170-87209132:-CHOLGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.6048e-02-0.4128image
ENSG00000223482.6,NUTM2A-AS1CHOLGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.2950e-030.4724image
chr10:87210431-87210730:-COADGSVA_HALLMARK_SPERMATOGENESISEER1.4818e-02-0.4479image
ENSG00000223482.6,NUTM2A-AS1COADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.2744e-02-0.1809image
ENSG00000223482.6,NUTM2A-AS1ESCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG8.2628e-03-0.2101image
chr10:87208170-87209132:-ESCAGSVA_HALLMARK_APICAL_SURFACEEER1.0943e-03-0.2865image
chr10:87210431-87210730:-ESCAGSVA_HALLMARK_HYPOXIAEER1.7235e-030.3429image
chr10:87212270-87212998:-ESCAGSVA_HALLMARK_NOTCH_SIGNALINGEER4.8612e-020.3062image
ENSG00000223482.6,NUTM2A-AS1GBMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG4.5202e-030.2457image
ENSG00000223482.6,NUTM2A-AS1HNSCGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG6.2107e-060.2455image
chr10:87241149-87241389:-HNSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER6.2645e-030.1735image
ENSG00000223482.6,NUTM2A-AS1KICHGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG3.4953e-020.2824image
chr10:87208170-87209132:-KIRCGSVA_HALLMARK_COMPLEMENTEER1.5005e-020.1476image
ENSG00000223482.6,NUTM2A-AS1KIRCGSVA_HALLMARK_SPERMATOGENESISEAG5.3554e-050.2148image
ENSG00000223482.6,NUTM2A-AS1KIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG2.4315e-040.2236image
chr10:87241149-87241389:-LAMLGSVA_HALLMARK_KRAS_SIGNALING_DNEER3.4621e-040.3187image
ENSG00000223482.6,NUTM2A-AS1LAMLGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.7378e-030.2496image
ENSG00000223482.6,NUTM2A-AS1LGGGSVA_HALLMARK_MYC_TARGETS_V2EAG2.2223e-04-0.1626image
ENSG00000223482.6,NUTM2A-AS1LIHCGSVA_HALLMARK_ADIPOGENESISEAG4.6015e-070.3552image
chr10:87241149-87241389:-LIHCGSVA_HALLMARK_HEME_METABOLISMEER3.1520e-050.3577image
chr10:87210431-87210730:-LUADGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER6.1359e-050.3104image
chr10:87241149-87241389:-LUADGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.7968e-060.2880image
ENSG00000223482.6,NUTM2A-AS1LUADGSVA_HALLMARK_COMPLEMENTEAG3.6000e-030.1533image
chr10:87241149-87241389:-LUSCGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.8165e-020.1779image
chr10:87208170-87209132:-LUSCGSVA_HALLMARK_DNA_REPAIREER9.2683e-03-0.1687image
ENSG00000223482.6,NUTM2A-AS1LUSCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.0829e-050.2106image
chr10:87210431-87210730:-MESOGSVA_HALLMARK_SPERMATOGENESISEER3.8355e-02-0.3208image
ENSG00000223482.6,NUTM2A-AS1MESOGSVA_HALLMARK_DNA_REPAIREAG3.6095e-03-0.3278image
chr10:87208170-87209132:-OVGSVA_HALLMARK_MYC_TARGETS_V2EER1.4534e-02-0.1526image
ENSG00000223482.6,NUTM2A-AS1OVGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.7652e-03-0.1874image
chr10:87241149-87241389:-OVGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.2820e-030.2332image
chr10:87241149-87241389:-PAADGSVA_HALLMARK_GLYCOLYSISEER1.0547e-020.2586image
ENSG00000223482.6,NUTM2A-AS1PAADGSVA_HALLMARK_MYC_TARGETS_V1EAG2.0604e-02-0.1877image
ENSG00000223482.6,NUTM2A-AS1PCPGGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.1738e-02-0.1890image
chr10:87210431-87210730:-PCPGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER5.4343e-070.6510image
chr10:87210431-87210730:-PRADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.8698e-030.2498image
chr10:87208170-87209132:-PRADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.8833e-040.1987image
ENSG00000223482.6,NUTM2A-AS1PRADGSVA_HALLMARK_HEME_METABOLISMEAG3.4894e-060.2299image
chr10:87241149-87241389:-PRADGSVA_HALLMARK_UV_RESPONSE_UPEER1.1365e-020.1514image
ENSG00000223482.6,NUTM2A-AS1READGSVA_HALLMARK_UV_RESPONSE_DNEAG1.6417e-030.3552image
chr10:87241149-87241389:-SARCGSVA_HALLMARK_FATTY_ACID_METABOLISMEER2.8776e-020.2281image
ENSG00000223482.6,NUTM2A-AS1SARCGSVA_HALLMARK_MYC_TARGETS_V2EAG1.9542e-03-0.2167image
chr10:87210431-87210730:-SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.0431e-020.2454image
ENSG00000223482.6,NUTM2A-AS1SKCMGSVA_HALLMARK_KRAS_SIGNALING_UPEAG9.2752e-030.1391image
chr10:87241149-87241389:-SKCMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.2123e-020.1368image
chr10:87241149-87241389:-STADGSVA_HALLMARK_DNA_REPAIREER4.1272e-040.2166image
chr10:87212270-87212998:-STADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER3.2171e-030.2836image
chr10:87248564-87248772:-STADGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.0125e-030.3692image
ENSG00000223482.6,NUTM2A-AS1STADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.5151e-040.1953image
chr10:87261841-87262521:-STADGSVA_HALLMARK_FATTY_ACID_METABOLISMEER5.9023e-050.6942image
chr10:87208170-87209132:-STADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER1.3653e-030.2018image
ENSG00000223482.6,NUTM2A-AS1TGCTGSVA_HALLMARK_ANGIOGENESISEAG8.2154e-04-0.3882image
ENSG00000223482.6,NUTM2A-AS1THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.2600e-070.2398image
chr10:87241149-87241389:-THCAGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2283e-020.1193image
ENSG00000223482.6,NUTM2A-AS1THYMGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG9.4532e-040.3096image
chr10:87208170-87209132:-THYMGSVA_HALLMARK_UV_RESPONSE_DNEER1.6270e-030.3038image
chr10:87210431-87210730:-THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEER6.2662e-040.3935image
chr10:87241149-87241389:-THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER2.8243e-040.3909image
ENSG00000223482.6,NUTM2A-AS1UCECGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG7.0734e-050.3146image
chr10:87210431-87210730:-UCSGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.3687e-020.4178image
chr10:87208170-87209132:-UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER4.6552e-050.5629image
ENSG00000223482.6,NUTM2A-AS1UCSGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG4.4631e-040.4737image
ENSG00000223482.6,NUTM2A-AS1UVMGSVA_HALLMARK_APICAL_SURFACEEAG3.2961e-020.2691image


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7. Enriched editing regions and drugs for NUTM2A-AS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000223482.6,NUTM2A-AS1ACCABT.888EAG2.2982e-040.4326image
chr10:87210431-87210730:-ACCGSK.650394EER3.5615e-030.4256image
chr10:87241149-87241389:-BLCAKU.55933EER2.3500e-03-0.2084image
chr10:87210431-87210730:-BLCACMKEER1.3105e-03-0.3691image
ENSG00000223482.6,NUTM2A-AS1BLCAAICAREAG5.0993e-05-0.2328image
chr10:87241149-87241389:-BRCACGP.082996EER3.4570e-02-0.0805image
ENSG00000223482.6,NUTM2A-AS1BRCACEP.701EAG2.9972e-040.1176image
ENSG00000223482.6,NUTM2A-AS1CESCATRAEAG2.1237e-03-0.2003image
chr10:87208170-87209132:-CESCBleomycinEER9.7697e-030.2000image
chr10:87241149-87241389:-CESCMethotrexateEER3.3920e-02-0.1722image
chr10:87210431-87210730:-CESCCI.1040EER3.9526e-02-0.2199image
ENSG00000223482.6,NUTM2A-AS1CHOLAMG.706EAG1.4491e-030.5470image
chr10:87208170-87209132:-CHOLJW.7.52.1EER2.7576e-040.6266image
chr10:87210431-87210730:-COADLFM.A13EER7.1504e-03-0.4887image
ENSG00000223482.6,NUTM2A-AS1COADGefitinibEAG1.6765e-03-0.2271image
ENSG00000223482.6,NUTM2A-AS1DLBCCGP.60474EAG4.1088e-020.3751image
chr10:87241149-87241389:-ESCAAZD8055EER8.1575e-05-0.3181image
chr10:87212270-87212998:-ESCAElesclomolEER1.9514e-02-0.3591image
chr10:87248564-87248772:-ESCABleomycinEER2.2897e-03-0.5439image
chr10:87210431-87210730:-ESCABryostatin.1EER6.5458e-04-0.3708image
ENSG00000223482.6,NUTM2A-AS1ESCAAZD.2281EAG3.2117e-04-0.2844image
chr10:87208170-87209132:-ESCAErlotinibEER3.8019e-060.3971image
ENSG00000223482.6,NUTM2A-AS1GBMIPA.3EAG1.9945e-020.2024image
ENSG00000223482.6,NUTM2A-AS1HNSCDMOGEAG6.7576e-07-0.2690image
chr10:87210431-87210730:-KICHAUY922EER1.2779e-020.4492image
ENSG00000223482.6,NUTM2A-AS1KICHBryostatin.1EAG4.3451e-020.2709image
ENSG00000223482.6,NUTM2A-AS1KIRCEmbelinEAG9.0834e-04-0.1771image
chr10:87241149-87241389:-KIRCJNJ.26854165EER3.8083e-030.1709image
chr10:87208170-87209132:-KIRCBX.795EER7.6777e-03-0.1616image
ENSG00000223482.6,NUTM2A-AS1KIRPDMOGEAG1.7888e-07-0.3140image
chr10:87241149-87241389:-KIRPImatinibEER3.8762e-03-0.2237image
chr10:87241149-87241389:-LAMLAG.014699EER5.9815e-050.3551image
ENSG00000223482.6,NUTM2A-AS1LAMLGSK.650394EAG8.3883e-040.2772image
ENSG00000223482.6,NUTM2A-AS1LGGDocetaxelEAG1.7248e-040.1654image
ENSG00000223482.6,NUTM2A-AS1LIHCIPA.3EAG7.6526e-050.2829image
chr10:87241149-87241389:-LIHCEtoposideEER4.0434e-030.2515image
chr10:87241149-87241389:-LUADErlotinibEER6.9134e-04-0.2158image
chr10:87210431-87210730:-LUADGemcitabineEER2.8229e-03-0.2339image
ENSG00000223482.6,NUTM2A-AS1LUADKU.55933EAG1.8859e-02-0.1239image
chr10:87208170-87209132:-LUSCGDC0941EER7.0628e-05-0.2552image
chr10:87241149-87241389:-LUSCMG.132EER2.5872e-02-0.1684image
ENSG00000223482.6,NUTM2A-AS1LUSCGDC0941EAG5.9502e-04-0.1853image
ENSG00000223482.6,NUTM2A-AS1MESOGW843682XEAG3.1831e-030.3320image
chr10:87210431-87210730:-MESOBMS.708163EER1.7116e-03-0.4694image
ENSG00000223482.6,NUTM2A-AS1OVMG.132EAG1.3591e-04-0.2281image
chr10:87208170-87209132:-OVEmbelinEER1.7848e-02-0.1480image
chr10:87241149-87241389:-OVKU.55933EER2.9766e-02-0.1590image
chr10:87212270-87212998:-OVBMS.509744EER4.0133e-02-0.2133image
chr10:87241149-87241389:-PAADAZD.0530EER4.6043e-030.2929image
ENSG00000223482.6,NUTM2A-AS1PAADAP.24534EAG1.5451e-02-0.1961image
chr10:87210431-87210730:-PCPGCHIR.99021EER1.0603e-04-0.5302image
chr10:87241149-87241389:-PCPGBI.2536EER9.2286e-030.3334image
ENSG00000223482.6,NUTM2A-AS1PCPGMethotrexateEAG3.6288e-020.1575image
chr10:87241149-87241389:-PRADEmbelinEER3.9326e-040.2108image
chr10:87208170-87209132:-PRADEmbelinEER2.7215e-04-0.2038image
chr10:87210431-87210730:-PRADBMS.509744EER9.0633e-03-0.2263image
ENSG00000223482.6,NUTM2A-AS1PRADCEP.701EAG2.5461e-050.2091image
ENSG00000223482.6,NUTM2A-AS1READElesclomolEAG2.9435e-030.3367image
chr10:87241149-87241389:-SARCCamptothecinEER1.1604e-020.2621image
ENSG00000223482.6,NUTM2A-AS1SARCCCT007093EAG9.8449e-05-0.2706image
chr10:87210431-87210730:-SKCMDMOGEER1.1819e-02-0.2658image
ENSG00000223482.6,NUTM2A-AS1SKCMDMOGEAG1.2659e-02-0.1333image
chr10:87261841-87262521:-STADGDC0941EER4.2431e-030.5325image
chr10:87208170-87209132:-STADABT.263EER3.1756e-04-0.2268image
chr10:87241149-87241389:-STADCCT007093EER1.5676e-030.1944image
chr10:87247126-87247341:-STADAMG.706EER1.7527e-02-0.4454image
chr10:87214940-87215783:-STADAZ628EER3.3054e-02-0.3257image
chr10:87212270-87212998:-STADIPA.3EER2.5136e-020.2175image
ENSG00000223482.6,NUTM2A-AS1STADBMS.509744EAG2.9717e-04-0.1976image
chr10:87248564-87248772:-STADBortezomibEER5.3482e-040.4372image
ENSG00000223482.6,NUTM2A-AS1TGCTBryostatin.1EAG4.6818e-040.4045image
chr10:87241149-87241389:-THCAAxitinibEER1.8522e-020.1229image
ENSG00000223482.6,NUTM2A-AS1THCAAxitinibEAG1.8840e-070.2365image
chr10:87210431-87210730:-THCAAZD6482EER4.4502e-020.1288image
chr10:87241149-87241389:-THYMGW.441756EER1.5005e-05-0.4582image
ENSG00000223482.6,NUTM2A-AS1THYMIPA.3EAG4.2245e-030.2696image
chr10:87208170-87209132:-THYMAS601245EER2.1405e-02-0.2244image
chr10:87210431-87210730:-THYMLapatinibEER4.8981e-03-0.3281image
chr10:87241149-87241389:-UCECABT.888EER1.1997e-02-0.3278image
ENSG00000223482.6,NUTM2A-AS1UCECCGP.082996EAG1.5267e-03-0.2533image
chr10:87208170-87209132:-UCSBicalutamideEER1.4571e-03-0.4558image
ENSG00000223482.6,NUTM2A-AS1UCSBicalutamideEAG1.5407e-03-0.4322image
chr10:87210431-87210730:-UCSCHIR.99021EER1.9192e-03-0.5795image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType