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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TLCD2 (ImmuneEditome ID:727910)

1. Gene summary of enriched editing regions for TLCD2

check button Gene summary
Gene informationGene symbol

TLCD2

Gene ID

727910

GeneSynonyms-
GeneCytomap

17p13.3

GeneTypeprotein-coding
GeneDescriptionTLC domain-containing protein 2
GeneModificationdate20230329
UniprotIDA6NGC4
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr17:1703396-1707207:-ENST00000330676.7ENSG00000185561.9TLCD2UTR3FLAM_C,AluSx,AluJb,(T)n,(TCTA)n,AluSz,AluSc8,A-rich,AluYc,AluSq,(CTAT)nchr17:1703396-1707207:-.alignment


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2. Tumor-specific enriched editing regions for TLCD2


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr17:1703396-1707207:-BRCAEER4.8541e-05image
ENSG00000185561.9,TLCD2BRCAEAG4.8541e-05image
chr17:1703396-1707207:-COADEER1.1947e-22image
ENSG00000185561.9,TLCD2COADEAG1.1947e-22image
chr17:1703396-1707207:-HNSCEER3.1993e-02image
ENSG00000185561.9,TLCD2HNSCEAG3.1993e-02image
chr17:1703396-1707207:-LUADEER1.1179e-02image
ENSG00000185561.9,TLCD2LUADEAG1.1179e-02image
chr17:1703396-1707207:-LUSCEER2.9316e-11image
ENSG00000185561.9,TLCD2LUSCEAG2.9316e-11image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr17:1703396-1707207:-READPathEER2.6538e-026.5731e-03-0.3092image
ENSG00000185561.9,TLCD2READPathEAG2.6538e-026.5731e-03-0.3092image
ENSG00000185561.9,TLCD2UCECCliEAG4.9227e-029.3716e-030.2586image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr17:1703396-1707207:-HNSCEER2.0984e-022.2457e-021.4817e+01image
ENSG00000185561.9,TLCD2HNSCEAG2.0984e-022.2457e-021.4817e+01image

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3. Enriched editing regions and immune related genes for TLCD2


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:1703396-1707207:-ESCAEERENSG00000185561,TLCD2-0.51604.3003e-071.5189e-08-0.4314imageNDDX54;EIF4A3;ELAVL1;FBL;FMR1;IGF2BP2;LIN28;MOV10;NOP56;NOP58;RANGAP1;RBFOX2;SLTM;SND1;SRSF1;U2AF2;UPF1;ZNF184;CSTF2T;DGCR8;DHX9;DKC1;FUS;HNRNPA1;HNRNPC;PRPF8;SRSF10;TAF15TLCD2T_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr17:1703396-1707207:-ESCAEERENSG00000163364,LINC011160.42699.4487e-052.3592e-140.5588imageNELAVL1;FBL;IGF2BP2;MOV10;NOP56;U2AF2;DHX9;DKC1;PTBP1;TAF15NAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr17:1703396-1707207:-ESCAEERENSG00000175550,DRAP10.42921.0468e-049.9902e-100.4620imageNBUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FXR1;IGF2BP2;LIN28;LIN28B;NOP58;NUMA1;RANGAP1;RBFOX2;SAFB2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;ACIN1;BCCIP;CPSF6;CSTF2T;DDX3X;DGCR8;FUS;FXR2;HNRNPA1;PRPF8;PTBP1;RBM10;SRSF10;TAF15;TARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr17:1703396-1707207:-ESCAEERENSG00000081870,HSPB110.34024.2149e-031.4781e-070.4034imageNBUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;IGF2BP2;LIN28;LIN28B;MOV10;NOP56;NOP58;NUMA1;RANGAP1;RBFOX2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;ACIN1;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;FUS;FXR2;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;TAF15;TARDBPHSPB11T_cells_CD4_memory_restingGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLY
chr17:1703396-1707207:-ESCAEERENSG00000159596,TMEM690.33135.8318e-039.8772e-100.4621imageNBUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FXR1;IGF2BP2;LIN28;LIN28B;MOV10;NOP56;NOP58;NUMA1;RANGAP1;RBFOX2;SAFB2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;ACIN1;BCCIP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;FUS;FXR2;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;SRSF10;TAF15;TARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_MYC_TARGETS_V1
chr17:1703396-1707207:-ESCAEERENSG00000221968,FADS30.31711.1338e-023.0182e-080.4232imageNALYREF;BUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FXR1;IGF2BP2;LIN28;LIN28B;NOP56;NOP58;NUMA1;RANGAP1;RBFOX2;SAFB2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;ACIN1;BCCIP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;FUS;FXR2;HNRNPA1;HNRNPC;PRPF8;PTBP1;SRSF10;TAF15;TARDBPNAT_cells_gamma_deltaGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr17:1703396-1707207:-ESCAEERENSG00000175334,BANF10.30071.7920e-023.0543e-100.4744imageNBUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FXR1;IGF2BP2;LIN28;LIN28B;MOV10;NOP58;NUMA1;RANGAP1;RBFOX2;SAFB2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;BCCIP;CPSF6;CSTF2T;DDX3X;DGCR8;FUS;FXR2;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;SRSF10;TAF15;TARDBPBANF1NK_cells_activatedGSVA_HALLMARK_DNA_REPAIR
chr17:1703396-1707207:-ESCAEERENSG00000225548,AC098973.20.25423.6791e-026.4131e-090.4414imageNDDX54;ELAVL1;FBL;FMR1;IGF2BP2;NOP56;NOP58;RBFOX2;U2AF2;UPF1;CSTF2T;DGCR8;DKC1;FUS;HNRNPC;PTBP1;TAF15;TARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_KRAS_SIGNALING_UP

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4. Enriched editing regions and immune related splicing for TLCD2


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr17:1703396-1707207:-
ESCAEERIRENSG00000084693.11chr227067493:27068744:27069047:27069094-0.38396.9201e-045.2217e-07-0.4174imageNBUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FXR1;IGF2BP2;LIN28;LIN28B;MOV10;NOP56;NOP58;NUMA1;RANGAP1;RBFOX2;SAFB2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;ACIN1;BCCIP;CPSF6;CSTF2T;DDX3X;DGCR8;DHX9;FUS;FXR2;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;SRSF10;TAF15;TARDBPNAT_cells_CD4_memory_restingGSVA_HALLMARK_SPERMATOGENESIS
ENSG00000185561.9,TLCD2
ESCAEAGESENSG00000074054.13chr2121407518:121407715:121409023:121409047:121410865:1214109690.35362.2091e-023.4435e-080.4216imageNADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;HNRNPA1;HNRNPC;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;LSM11;MOV10;MSI1;NOP56;NOP58;PRPF8;RANGAP1;RBFOX2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF7;TAF15;TARBP2;TIA1;U2AF2;UPF1;XRN2;ZNF184NAMacrophages_M1GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000185561.9,TLCD2
ESCAEAGIRENSG00000084693.11chr227067493:27068744:27069047:27069094-0.38427.5420e-045.2127e-07-0.4175imageNADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;HNRNPA1;HNRNPC;IGF2BP2;IGF2BP3;ILF3;LIN28;LSM11;MOV10;NOP56;NOP58;PRPF8;RANGAP1;RBFOX2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF7;TAF15;TARBP2;TIA1;U2AF2;UPF1;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_SPERMATOGENESIS
chr17:1703396-1707207:-
ESCAEERIRENSG00000166126.6chr14102928691:102928975:102929120:1029292580.33561.3924e-023.9160e-070.4159imageNBUD13;EIF4A3;FBL;LIN28B;MOV10;NOP58;RBFOX2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;BCCIP;CSTF2T;DGCR8;DKC1;FUS;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;TAF15NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr17:1703396-1707207:-
ESCAEERESENSG00000074054.13chr2121407518:121407715:121409023:121409047:121410865:1214109690.35581.7208e-023.3162e-080.4221imageNALYREF;BUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FXR1;IGF2BP2;LIN28;LIN28B;MOV10;NOP56;NOP58;NUMA1;RANGAP1;RBFOX2;SAFB2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;ACIN1;BCCIP;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;FUS;FXR2;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;SRSF10;TAF15;TARDBPNAMacrophages_M1GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr17:1703396-1707207:-
ESCAEERA3ENSG00000114270.11chr348595074:48595160:48594367:48594478:48594367:485945480.25464.6701e-022.3465e-060.4094imageNALYREF;BUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;IGF2BP2;LIN28;NOP56;NOP58;NUMA1;RANGAP1;RBFOX2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;ZNF184;ACIN1;BCCIP;CSTF2T;DGCR8;DKC1;FUS;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;SRSF10;TAF15;TARDBPCOL7A1T_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
ENSG00000185561.9,TLCD2
ESCAEAGA5ENSG00000074054.13chr2121407518:121407715:121410865:121410969:121409023:121410969-0.33963.5873e-021.3524e-07-0.4045imageNADAR;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;HNRNPA1;HNRNPC;IGF2BP2;IGF2BP3;KHDRBS2;LIN28;LSM11;MOV10;MSI1;NOP56;NOP58;PRPF8;RANGAP1;RBFOX2;SF3B4;SLTM;SND1;SRSF1;SRSF10;SRSF7;TAF15;TARBP2;TIA1;U2AF2;UPF1;XRN2;ZNF184NAMacrophages_M1GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000185561.9,TLCD2
ESCAEAGIRENSG00000166126.6chr14102928691:102928975:102929120:1029292580.33641.6148e-023.8693e-070.4161imageNADAR;CSTF2T;DGCR8;DICER1;DKC1;EIF4A3;FAM120A;FBL;FUS;HNRNPA1;HNRNPC;IGF2BP3;MOV10;NOP58;PRPF8;RBFOX2;SF3B4;SLTM;SND1;SRSF1;SRSF7;TAF15;TIA1;U2AF2;UPF1NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_BILE_ACID_METABOLISM
chr17:1703396-1707207:-
ESCAEERA5ENSG00000074054.13chr2121407518:121407715:121410865:121410969:121409023:121410969-0.34232.7509e-021.3011e-07-0.4050imageNALYREF;BUD13;DDX54;EIF4A3;ELAVL1;FBL;FMR1;FXR1;IGF2BP2;LIN28;LIN28B;MOV10;NOP56;NOP58;NUMA1;RANGAP1;RBFOX2;SAFB2;SLTM;SND1;SRSF1;SRSF9;U2AF2;UPF1;YWHAG;ZNF184;ACIN1;BCCIP;CSTF2T;DDX3X;DGCR8;DHX9;DKC1;FUS;FXR2;HNRNPA1;HNRNPC;PRPF8;PTBP1;RBM10;SRSF10;TAF15;TARDBPNAMacrophages_M1GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

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5. Enriched editing regions and immune infiltration for TLCD2


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr17:1703396-1707207:-BLCAEERT_cells_regulatory_(Tregs)2.9381e-02-0.1437image
ENSG00000185561.9,TLCD2BLCAEAGT_cells_regulatory_(Tregs)2.9381e-02-0.1437image
chr17:1703396-1707207:-BRCAEERT_cells_follicular_helper2.4703e-02-0.0858image
ENSG00000185561.9,TLCD2BRCAEAGT_cells_follicular_helper2.4703e-02-0.0858image
chr17:1703396-1707207:-CESCEERB_cells_memory3.8272e-020.1497image
ENSG00000185561.9,TLCD2CESCEAGB_cells_memory3.8272e-020.1497image
chr17:1703396-1707207:-CHOLEERT_cells_follicular_helper1.3295e-020.5308image
ENSG00000185561.9,TLCD2CHOLEAGT_cells_follicular_helper1.3295e-020.5308image
chr17:1703396-1707207:-COADEERT_cells_regulatory_(Tregs)2.1852e-02-0.1667image
ENSG00000185561.9,TLCD2COADEAGT_cells_regulatory_(Tregs)2.1852e-02-0.1667image
chr17:1703396-1707207:-ESCAEERT_cells_CD4_memory_resting3.5039e-04-0.2809image
ENSG00000185561.9,TLCD2ESCAEAGT_cells_CD4_memory_resting3.5513e-04-0.2806image
chr17:1703396-1707207:-GBMEERT_cells_CD4_memory_resting1.2774e-020.3903image
ENSG00000185561.9,TLCD2GBMEAGT_cells_CD4_memory_resting1.2774e-020.3903image
chr17:1703396-1707207:-HNSCEERT_cells_follicular_helper4.1498e-03-0.1608image
ENSG00000185561.9,TLCD2HNSCEAGT_cells_follicular_helper4.1498e-03-0.1608image
chr17:1703396-1707207:-KICHEERT_cells_follicular_helper2.0620e-02-0.4352image
ENSG00000185561.9,TLCD2KICHEAGT_cells_follicular_helper2.0620e-02-0.4352image
chr17:1703396-1707207:-KIRCEERT_cells_CD84.2286e-020.1383image
ENSG00000185561.9,TLCD2KIRCEAGT_cells_CD84.2286e-020.1383image
chr17:1703396-1707207:-KIRPEERMacrophages_M02.5393e-020.1725image
ENSG00000185561.9,TLCD2KIRPEAGMacrophages_M02.5393e-020.1725image
chr17:1703396-1707207:-LGGEERT_cells_gamma_delta2.7328e-030.4318image
ENSG00000185561.9,TLCD2LGGEAGT_cells_gamma_delta2.7328e-030.4318image
chr17:1703396-1707207:-LIHCEERT_cells_follicular_helper3.1153e-020.1816image
ENSG00000185561.9,TLCD2LIHCEAGT_cells_follicular_helper2.9729e-020.1831image
chr17:1703396-1707207:-LUADEERMast_cells_resting2.4144e-02-0.1219image
ENSG00000185561.9,TLCD2LUADEAGMast_cells_resting2.4144e-02-0.1219image
chr17:1703396-1707207:-LUSCEERMonocytes2.6915e-02-0.1282image
ENSG00000185561.9,TLCD2LUSCEAGMonocytes2.6915e-02-0.1282image
chr17:1703396-1707207:-MESOEERMonocytes8.6301e-04-0.3868image
ENSG00000185561.9,TLCD2MESOEAGMonocytes8.6301e-04-0.3868image
chr17:1703396-1707207:-OVEERT_cells_regulatory_(Tregs)1.9148e-020.1651image
ENSG00000185561.9,TLCD2OVEAGT_cells_regulatory_(Tregs)2.0052e-020.1639image
chr17:1703396-1707207:-PAADEERB_cells_naive4.4576e-020.1682image
ENSG00000185561.9,TLCD2PAADEAGB_cells_naive4.4576e-020.1682image
chr17:1703396-1707207:-PCPGEERNK_cells_resting4.4295e-030.4573image
ENSG00000185561.9,TLCD2PCPGEAGNK_cells_resting4.4295e-030.4573image
chr17:1703396-1707207:-READEERB_cells_naive2.5274e-02-0.2566image
ENSG00000185561.9,TLCD2READEAGB_cells_naive2.5274e-02-0.2566image
chr17:1703396-1707207:-SARCEERT_cells_follicular_helper2.4741e-020.1878image
ENSG00000185561.9,TLCD2SARCEAGT_cells_follicular_helper2.4741e-020.1878image
chr17:1703396-1707207:-SKCMEERT_cells_CD4_memory_activated4.7193e-02-0.1402image
ENSG00000185561.9,TLCD2SKCMEAGT_cells_CD4_memory_activated4.7193e-02-0.1402image
chr17:1703396-1707207:-STADEERT_cells_CD4_memory_resting3.2002e-02-0.1167image
ENSG00000185561.9,TLCD2STADEAGT_cells_CD4_memory_resting3.1397e-02-0.1171image
chr17:1703396-1707207:-TGCTEERT_cells_CD4_memory_resting3.5893e-02-0.4054image
ENSG00000185561.9,TLCD2TGCTEAGT_cells_CD4_memory_resting3.5893e-02-0.4054image
chr17:1703396-1707207:-THCAEERPlasma_cells8.5784e-030.1338image
ENSG00000185561.9,TLCD2THCAEAGPlasma_cells8.5784e-030.1338image
chr17:1703396-1707207:-THYMEERT_cells_CD4_naive5.2974e-050.7527image
ENSG00000185561.9,TLCD2THYMEAGT_cells_CD4_naive5.2974e-050.7527image
chr17:1703396-1707207:-UCECEERDendritic_cells_activated4.2267e-030.3613image
ENSG00000185561.9,TLCD2UCECEAGDendritic_cells_activated1.1428e-020.3193image
chr17:1703396-1707207:-UCSEERDendritic_cells_resting4.9981e-020.3961image
ENSG00000185561.9,TLCD2UCSEAGDendritic_cells_resting4.9981e-020.3961image
ENSG00000185561.9,TLCD2UVMEAGMast_cells_resting8.6381e-030.4565image


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6. Enriched editing regions and immune gene sets for TLCD2


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr17:1703396-1707207:-ESCAEER1.1489e-040.30203.6368e-020.16662.1926e-040.29003.6817e-020.1663image
ENSG00000185561.9,TLCD2ESCAEAG1.1459e-040.30213.6425e-020.16662.2171e-040.28983.7297e-020.1658image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000185561.9,TLCD2BLCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG1.5906e-020.1588image
chr17:1703396-1707207:-BLCAGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER1.5906e-020.1588image
ENSG00000185561.9,TLCD2BRCAGSVA_HALLMARK_PEROXISOMEEAG1.9502e-020.0892image
chr17:1703396-1707207:-BRCAGSVA_HALLMARK_PEROXISOMEEER1.9502e-020.0892image
chr17:1703396-1707207:-CESCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.1336e-03-0.2061image
ENSG00000185561.9,TLCD2CESCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG4.1336e-03-0.2061image
chr17:1703396-1707207:-CHOLGSVA_HALLMARK_P53_PATHWAYEER7.8885e-03-0.5629image
ENSG00000185561.9,TLCD2CHOLGSVA_HALLMARK_P53_PATHWAYEAG7.8885e-03-0.5629image
ENSG00000185561.9,TLCD2COADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.1786e-03-0.2342image
chr17:1703396-1707207:-COADGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.1786e-03-0.2342image
ENSG00000185561.9,TLCD2ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.3025e-07-0.3893image
chr17:1703396-1707207:-ESCAGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.4163e-07-0.3889image
chr17:1703396-1707207:-GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.6443e-030.4818image
ENSG00000185561.9,TLCD2GBMGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.6443e-030.4818image
chr17:1703396-1707207:-HNSCGSVA_HALLMARK_APICAL_JUNCTIONEER2.5953e-030.1689image
ENSG00000185561.9,TLCD2HNSCGSVA_HALLMARK_APICAL_JUNCTIONEAG2.5953e-030.1689image
ENSG00000185561.9,TLCD2LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.2850e-02-0.3350image
chr17:1703396-1707207:-LGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.2850e-02-0.3350image
chr17:1703396-1707207:-LUADGSVA_HALLMARK_MYC_TARGETS_V2EER1.9447e-040.2002image
ENSG00000185561.9,TLCD2LUADGSVA_HALLMARK_MYC_TARGETS_V2EAG1.9447e-040.2002image
chr17:1703396-1707207:-MESOGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER4.3613e-030.3345image
ENSG00000185561.9,TLCD2MESOGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG4.3613e-030.3345image
chr17:1703396-1707207:-OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER3.5970e-020.1480image
ENSG00000185561.9,TLCD2OVGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG3.6889e-020.1473image
chr17:1703396-1707207:-PCPGGSVA_HALLMARK_HEME_METABOLISMEER7.3749e-04-0.5302image
ENSG00000185561.9,TLCD2PCPGGSVA_HALLMARK_HEME_METABOLISMEAG7.3749e-04-0.5302image
ENSG00000185561.9,TLCD2PRADGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG7.6857e-03-0.1997image
chr17:1703396-1707207:-PRADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER7.6857e-03-0.1997image
ENSG00000185561.9,TLCD2READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG4.7468e-020.2281image
chr17:1703396-1707207:-READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER4.7468e-020.2281image
ENSG00000185561.9,TLCD2SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG1.2065e-03-0.2681image
chr17:1703396-1707207:-SARCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER1.2065e-03-0.2681image
ENSG00000185561.9,TLCD2SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG4.2079e-02-0.1435image
chr17:1703396-1707207:-SKCMGSVA_HALLMARK_BILE_ACID_METABOLISMEER4.2079e-02-0.1435image
ENSG00000185561.9,TLCD2STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG5.7464e-040.1863image
chr17:1703396-1707207:-STADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER5.4180e-040.1872image
chr17:1703396-1707207:-TGCTGSVA_HALLMARK_HYPOXIAEER1.8250e-020.4509image
ENSG00000185561.9,TLCD2TGCTGSVA_HALLMARK_HYPOXIAEAG1.8250e-020.4509image
ENSG00000185561.9,TLCD2THCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.4355e-02-0.1025image
chr17:1703396-1707207:-THCAGSVA_HALLMARK_MITOTIC_SPINDLEEER4.4355e-02-0.1025image
chr17:1703396-1707207:-THYMGSVA_HALLMARK_MITOTIC_SPINDLEEER5.2725e-030.5734image
ENSG00000185561.9,TLCD2THYMGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.2725e-030.5734image
chr17:1703396-1707207:-UCECGSVA_HALLMARK_PROTEIN_SECRETIONEER3.0449e-02-0.2774image
chr17:1703396-1707207:-UCSGSVA_HALLMARK_HEME_METABOLISMEER3.2386e-020.4290image
ENSG00000185561.9,TLCD2UCSGSVA_HALLMARK_HEME_METABOLISMEAG3.2386e-020.4290image
ENSG00000185561.9,TLCD2UVMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG6.4136e-03-0.4718image


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7. Enriched editing regions and drugs for TLCD2


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000185561.9,TLCD2ACCGDC0941EAG2.1414e-02-0.3154image
chr17:1703396-1707207:-ACCGDC0941EER2.1414e-02-0.3154image
chr17:1703396-1707207:-BLCAMG.132EER6.0987e-040.2243image
ENSG00000185561.9,TLCD2BLCAMG.132EAG6.0987e-040.2243image
ENSG00000185561.9,TLCD2CESCAZ628EAG4.0013e-05-0.2919image
chr17:1703396-1707207:-CESCAZ628EER4.0013e-05-0.2919image
ENSG00000185561.9,TLCD2CHOLCI.1040EAG4.2505e-020.4464image
chr17:1703396-1707207:-CHOLCI.1040EER4.2505e-020.4464image
ENSG00000185561.9,TLCD2COADMetforminEAG7.8140e-030.1930image
chr17:1703396-1707207:-COADMetforminEER7.8140e-030.1930image
ENSG00000185561.9,TLCD2ESCAA.770041EAG7.2213e-05-0.3104image
chr17:1703396-1707207:-ESCAA.770041EER7.1524e-05-0.3106image
chr17:1703396-1707207:-GBMJNJ.26854165EER3.0815e-020.3419image
ENSG00000185561.9,TLCD2GBMJNJ.26854165EAG3.0815e-020.3419image
chr17:1703396-1707207:-HNSCFTI.277EER3.8243e-04-0.1986image
ENSG00000185561.9,TLCD2HNSCFTI.277EAG3.8243e-04-0.1986image
chr17:1703396-1707207:-KIRCErlotinibEER4.2452e-020.1385image
ENSG00000185561.9,TLCD2KIRCErlotinibEAG4.2452e-020.1385image
ENSG00000185561.9,TLCD2KIRPAZD7762EAG1.6992e-03-0.2404image
chr17:1703396-1707207:-KIRPAZD7762EER1.6992e-03-0.2404image
ENSG00000185561.9,TLCD2LIHCBMS.708163EAG9.0052e-030.2192image
chr17:1703396-1707207:-LIHCBMS.708163EER1.3181e-020.2083image
chr17:1703396-1707207:-LUADGemcitabineEER1.4520e-03-0.1715image
ENSG00000185561.9,TLCD2LUADGemcitabineEAG1.4520e-03-0.1715image
chr17:1703396-1707207:-LUSCFTI.277EER1.7704e-04-0.2156image
ENSG00000185561.9,TLCD2LUSCFTI.277EAG1.7704e-04-0.2156image
chr17:1703396-1707207:-MESOGW.441756EER1.7253e-030.3654image
ENSG00000185561.9,TLCD2MESOGW.441756EAG1.7253e-030.3654image
chr17:1703396-1707207:-OVAZ628EER2.3124e-02-0.1602image
ENSG00000185561.9,TLCD2OVAZ628EAG2.3183e-02-0.1601image
chr17:1703396-1707207:-PAADBortezomibEER4.1795e-02-0.1711image
ENSG00000185561.9,TLCD2PAADBortezomibEAG4.1795e-02-0.1711image
ENSG00000185561.9,TLCD2PCPGAZD6482EAG4.7466e-020.3280image
chr17:1703396-1707207:-PCPGAZD6482EER4.7466e-020.3280image
chr17:1703396-1707207:-PRADGW.441756EER4.6183e-03-0.2120image
ENSG00000185561.9,TLCD2PRADGW.441756EAG4.6183e-03-0.2120image
ENSG00000185561.9,TLCD2READABT.263EAG3.3102e-02-0.2464image
chr17:1703396-1707207:-READABT.263EER3.3102e-02-0.2464image
chr17:1703396-1707207:-SARCAG.014699EER1.0340e-040.3190image
ENSG00000185561.9,TLCD2SARCAG.014699EAG1.0340e-040.3190image
chr17:1703396-1707207:-SKCMLapatinibEER7.2357e-030.1898image
ENSG00000185561.9,TLCD2SKCMLapatinibEAG7.2357e-030.1898image
ENSG00000185561.9,TLCD2STADAZ628EAG2.4920e-05-0.2271image
chr17:1703396-1707207:-STADAZ628EER2.1715e-05-0.2288image
ENSG00000185561.9,TLCD2TGCTABT.888EAG6.8796e-03-0.5076image
chr17:1703396-1707207:-TGCTABT.888EER6.8796e-03-0.5076image
chr17:1703396-1707207:-THCAGefitinibEER7.3826e-04-0.1713image
ENSG00000185561.9,TLCD2THCAGefitinibEAG7.3826e-04-0.1713image
ENSG00000185561.9,TLCD2THYMABT.263EAG1.0901e-02-0.5315image
chr17:1703396-1707207:-THYMABT.263EER1.0901e-02-0.5315image
chr17:1703396-1707207:-UCECErlotinibEER3.4956e-02-0.2705image
chr17:1703396-1707207:-UCSBI.2536EER1.0777e-020.5008image
ENSG00000185561.9,TLCD2UCSBI.2536EAG1.0777e-020.5008image
ENSG00000185561.9,TLCD2UVMKIN001.135EAG7.0874e-030.4667image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType