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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TMPO (ImmuneEditome ID:7112)

1. Gene summary of enriched editing regions for TMPO

check button Gene summary
Gene informationGene symbol

TMPO

Gene ID

7112

GeneSynonymsCMD1T|LAP2|LEMD4|PRO0868|TP
GeneCytomap

12q23.1

GeneTypeprotein-coding
GeneDescriptionthymopoietin|LEM domain containing 4|lamina-associated polypeptide 2
GeneModificationdate20230409
UniprotIDP42166;P42167;A0A024RBE7;A0A024RBH7;G5E972;H0YJH7
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr12:98524684-98525705:+ENST00000546828.5ENSG00000120802.12TMPOncRNA_intronicAluSz,(TTTATT)nchr12:98524684-98525705:+.alignment
chr12:98524684-98525705:+ENST00000548911.1ENSG00000120802.12TMPOncRNA_intronicAluSz,(TTTATT)nchr12:98524684-98525705:+.alignment
chr12:98524684-98525705:+ENST00000549938.4ENSG00000120802.12TMPOncRNA_intronicAluSz,(TTTATT)nchr12:98524684-98525705:+.alignment
chr12:98526722-98527430:+ENST00000546828.5ENSG00000120802.12TMPOncRNA_intronicAluSc,AluJbchr12:98526722-98527430:+.alignment
chr12:98526722-98527430:+ENST00000548911.1ENSG00000120802.12TMPOncRNA_intronicAluSc,AluJbchr12:98526722-98527430:+.alignment
chr12:98526722-98527430:+ENST00000549938.4ENSG00000120802.12TMPOncRNA_intronicAluSc,AluJbchr12:98526722-98527430:+.alignment
chr12:98528728-98528991:+ENST00000546828.5ENSG00000120802.12TMPOncRNA_intronicAluJbchr12:98528728-98528991:+.alignment
chr12:98528728-98528991:+ENST00000547214.1ENSG00000120802.12TMPOncRNA_intronicAluJbchr12:98528728-98528991:+.alignment
chr12:98528728-98528991:+ENST00000549938.4ENSG00000120802.12TMPOncRNA_intronicAluJbchr12:98528728-98528991:+.alignment
chr12:98528728-98528991:+ENST00000552831.1ENSG00000120802.12TMPOncRNA_intronicAluJbchr12:98528728-98528991:+.alignment
chr12:98548816-98549473:+ENST00000343315.8ENSG00000120802.12TMPOUTR3AluSz,AluScchr12:98548816-98549473:+.alignment
chr12:98548816-98549473:+ENST00000393053.5ENSG00000120802.12TMPOUTR3AluSz,AluScchr12:98548816-98549473:+.alignment
chr12:98548816-98549473:+ENST00000556029.4ENSG00000120802.12TMPOUTR3AluSz,AluScchr12:98548816-98549473:+.alignment


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2. Tumor-specific enriched editing regions for TMPO


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr12:98548816-98549473:+KICHEER1.4147e-03image
ENSG00000120802.12,TMPOKICHEAG1.4147e-03image
chr12:98548816-98549473:+KIRPEER3.2275e-06image
ENSG00000120802.12,TMPOKIRPEAG3.2044e-06image
chr12:98548816-98549473:+LUADEER7.9777e-07image
ENSG00000120802.12,TMPOLUADEAG7.9225e-07image
chr12:98548816-98549473:+LUSCEER3.8457e-05image
ENSG00000120802.12,TMPOLUSCEAG3.8498e-05image
chr12:98548816-98549473:+PRADEER1.9858e-05image
ENSG00000120802.12,TMPOPRADEAG2.0032e-05image
chr12:98548816-98549473:+THCAEER1.1615e-04image
ENSG00000120802.12,TMPOTHCAEAG1.1651e-04image
chr12:98548816-98549473:+UCECEER1.9445e-06image
ENSG00000120802.12,TMPOUCECEAG1.3553e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for TMPO


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:98548816-98549473:+LUADEERENSG00000266910,CTC-448F2.60.19433.2741e-041.1993e-320.4913imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98548816-98549473:+LUADEERENSG00000269951,RP11-797A18.60.17132.4571e-038.3784e-230.4145imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000262979,CTD-2047H16.20.16842.7650e-033.2165e-250.4352imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98548816-98549473:+LUADEERENSG00000276571,AC002550.60.16613.4789e-031.6670e-310.4833imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000269899,RP11-589N15.20.16294.6928e-032.1699e-350.5096imageNNNAEosinophilsGSVA_HALLMARK_PEROXISOME
chr12:98548816-98549473:+LUADEERENSG00000206885,SNORA750.15824.8701e-031.4269e-230.4213imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000260565,CTD-2270P14.10.15646.2050e-033.4273e-220.4090imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000201151,SNORD560.15157.5437e-039.7375e-320.4850imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000277978,RP11-403P17.60.14968.7939e-038.1841e-220.4056imageNNNAEosinophilsGSVA_HALLMARK_ADIPOGENESIS
chr12:98548816-98549473:+LUADEERENSG00000236318,AC019117.10.14738.8259e-036.5312e-320.4862imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000266910,CTC-448F2.60.19433.2741e-041.1993e-320.4913imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98548816-98549473:+LUADEERENSG00000269951,RP11-797A18.60.17132.4571e-038.3784e-230.4145imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000262979,CTD-2047H16.20.16842.7650e-033.2165e-250.4352imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98548816-98549473:+LUADEERENSG00000276571,AC002550.60.16613.4789e-031.6670e-310.4833imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000269899,RP11-589N15.20.16294.6928e-032.1699e-350.5096imageNNNAEosinophilsGSVA_HALLMARK_PEROXISOME
chr12:98548816-98549473:+LUADEERENSG00000206885,SNORA750.15824.8701e-031.4269e-230.4213imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000260565,CTD-2270P14.10.15646.2050e-033.4273e-220.4090imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000201151,SNORD560.15157.5437e-039.7375e-320.4850imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000277978,RP11-403P17.60.14968.7939e-038.1841e-220.4056imageNNNAEosinophilsGSVA_HALLMARK_ADIPOGENESIS
chr12:98548816-98549473:+LUADEERENSG00000236318,AC019117.10.14738.8259e-036.5312e-320.4862imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000266910,CTC-448F2.60.19433.2741e-041.1993e-320.4913imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98548816-98549473:+LUADEERENSG00000269951,RP11-797A18.60.17132.4571e-038.3784e-230.4145imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000262979,CTD-2047H16.20.16842.7650e-033.2165e-250.4352imageNNNAEosinophilsGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr12:98548816-98549473:+LUADEERENSG00000276571,AC002550.60.16613.4789e-031.6670e-310.4833imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000269899,RP11-589N15.20.16294.6928e-032.1699e-350.5096imageNNNAEosinophilsGSVA_HALLMARK_PEROXISOME
chr12:98548816-98549473:+LUADEERENSG00000206885,SNORA750.15824.8701e-031.4269e-230.4213imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000260565,CTD-2270P14.10.15646.2050e-033.4273e-220.4090imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000201151,SNORD560.15157.5437e-039.7375e-320.4850imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+LUADEERENSG00000277978,RP11-403P17.60.14968.7939e-038.1841e-220.4056imageNNNAEosinophilsGSVA_HALLMARK_ADIPOGENESIS
chr12:98548816-98549473:+LUADEERENSG00000236318,AC019117.10.14738.8259e-036.5312e-320.4862imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP

More results



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4. Enriched editing regions and immune related splicing for TMPO


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr12:98548816-98549473:+
LUADEERIRENSG00000171720.5chr5141634810:141634953:141636547:1416366300.15381.4440e-022.3775e-220.4123imageNNHDAC3EosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000120802.12,TMPO
LUADEAGIRENSG00000171988.13chr1063197410:63197563:63198512:631987270.14661.7463e-023.3574e-270.4635imageNACIN1;ADAR;AIFM1;ALKBH5;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM47;RBM5;RC3H1;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZFP36;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+
LUADEERIRENSG00000111731.8chr1222456970:22457161:22458483:224585550.13581.4442e-024.4888e-200.4369imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000120802.12,TMPO
LUADEAGIRENSG00000101126.11chr2050902016:50902109:50903888:509040010.14101.7465e-022.0061e-180.4006imageNACIN1;ADAR;AIFM1;ALKBH5;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184ADNPEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+
LUADEERIRENSG00000171988.13chr1063197410:63197563:63198512:631987270.14681.4448e-026.4865e-270.4612imageNNNAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000120802.12,TMPO
LUADEAGIRENSG00000171720.5chr5141634810:141634953:141636547:1416366300.15351.7467e-021.6882e-220.4136imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CBX7;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184HDAC3EosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
chr12:98548816-98549473:+
LUADEERIRENSG00000114541.10chr369195230:69196396:69196899:691970380.13781.4608e-025.5790e-260.4829imageNNNAEosinophilsGSVA_HALLMARK_PEROXISOME
ENSG00000120802.12,TMPO
LUADEAGIRENSG00000114541.10chr369195230:69196396:69196899:691970380.13771.7511e-022.8791e-260.4854imageNACIN1;ADAR;BUD13;CELF2;CNBP;CSTF2T;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FBL;FMR1;FTO;FUS;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS2;KHDRBS3;LIN28;LIN28A;MBNL2;METTL3;MOV10;MSI1;NOP56;NOP58;PCBP2;PRPF8;PTBP1;PUM2;RBFOX2;RBM10;RBM47;RBM5;SRSF1;SRSF10;SRSF3;SRSF7;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184NAEosinophilsGSVA_HALLMARK_PEROXISOME
chr12:98548816-98549473:+
LUADEERIRENSG00000173744.13chr2227533548:227533758:227534844:2275348770.15221.5071e-022.3775e-310.4822imageNNAGFG1EosinophilsGSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000120802.12,TMPO
LUADEAGIRENSG00000111731.8chr1222456970:22457161:22458483:224585550.13561.7511e-023.4528e-200.4381imageNACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RC3H1;SAFB2;SF3A3;SF3B4;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZC3H7B;ZFP36;ZNF184NAEosinophilsGSVA_HALLMARK_UV_RESPONSE_UP

More results



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5. Enriched editing regions and immune infiltration for TMPO


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr12:98548816-98549473:+BLCAEERT_cells_CD4_naive8.2821e-070.2423image
ENSG00000120802.12,TMPOBLCAEAGT_cells_CD4_naive7.4317e-070.2433image
chr12:98548816-98549473:+CESCEERT_cells_regulatory_(Tregs)5.2151e-040.1985image
ENSG00000120802.12,TMPOCESCEAGT_cells_regulatory_(Tregs)3.5064e-030.1675image
chr12:98548816-98549473:+CHOLEERT_cells_CD81.1692e-020.4214image
ENSG00000120802.12,TMPOCHOLEAGT_cells_CD81.1692e-020.4214image
chr12:98548816-98549473:+COADEERMacrophages_M12.2466e-03-0.1839image
ENSG00000120802.12,TMPOCOADEAGMacrophages_M11.8720e-03-0.1871image
chr12:98548816-98549473:+DLBCEERB_cells_memory5.7333e-030.3929image
ENSG00000120802.12,TMPODLBCEAGB_cells_memory5.7448e-030.3928image
chr12:98548816-98549473:+ESCAEERNK_cells_activated1.8684e-020.1852image
ENSG00000120802.12,TMPOESCAEAGNK_cells_activated2.2111e-020.1803image
chr12:98548816-98549473:+GBMEERMacrophages_M07.8764e-06-0.3381image
ENSG00000120802.12,TMPOGBMEAGMacrophages_M07.8801e-06-0.3381image
chr12:98548816-98549473:+HNSCEERT_cells_CD4_memory_resting3.9552e-03-0.1290image
ENSG00000120802.12,TMPOHNSCEAGT_cells_CD4_memory_resting3.8425e-03-0.1294image
chr12:98548816-98549473:+KICHEERMacrophages_M03.7779e-020.2583image
ENSG00000120802.12,TMPOKICHEAGMacrophages_M03.7779e-020.2583image
chr12:98548816-98549473:+KIRCEERT_cells_regulatory_(Tregs)4.1006e-070.2553image
ENSG00000120802.12,TMPOKIRCEAGT_cells_regulatory_(Tregs)3.0538e-070.2580image
chr12:98548816-98549473:+KIRPEERMacrophages_M24.3667e-040.2084image
ENSG00000120802.12,TMPOKIRPEAGMacrophages_M24.3162e-040.2086image
chr12:98548816-98549473:+LAMLEERNK_cells_resting3.0883e-030.2400image
ENSG00000120802.12,TMPOLAMLEAGNK_cells_resting6.4854e-030.2214image
chr12:98548816-98549473:+LGGEERMacrophages_M01.6554e-02-0.1043image
ENSG00000120802.12,TMPOLGGEAGMacrophages_M01.6554e-02-0.1043image
chr12:98548816-98549473:+LIHCEERMacrophages_M12.6644e-02-0.1162image
ENSG00000120802.12,TMPOLIHCEAGMacrophages_M12.6640e-02-0.1162image
chr12:98548816-98549473:+LUADEEREosinophils1.2474e-200.3946image
ENSG00000120802.12,TMPOLUADEAGEosinophils1.1602e-200.3948image
chr12:98548816-98549473:+LUSCEERT_cells_follicular_helper1.0300e-030.1466image
ENSG00000120802.12,TMPOLUSCEAGT_cells_follicular_helper1.0342e-030.1466image
chr12:98548816-98549473:+MESOEERNK_cells_activated1.4973e-020.2695image
ENSG00000120802.12,TMPOMESOEAGNK_cells_activated1.4973e-020.2695image
chr12:98548816-98549473:+OVEERB_cells_memory6.7390e-030.1582image
ENSG00000120802.12,TMPOOVEAGB_cells_memory6.9648e-030.1576image
chr12:98548816-98549473:+PAADEERMacrophages_M02.4775e-020.1687image
ENSG00000120802.12,TMPOPAADEAGMacrophages_M02.4887e-020.1686image
chr12:98548816-98549473:+PRADEERDendritic_cells_resting7.3880e-04-0.1512image
ENSG00000120802.12,TMPOPRADEAGDendritic_cells_resting7.5294e-04-0.1510image
chr12:98548816-98549473:+READEERT_cells_CD82.8714e-020.2257image
ENSG00000120802.12,TMPOREADEAGT_cells_CD82.8714e-020.2257image
chr12:98548816-98549473:+SARCEERT_cells_CD4_naive4.1559e-02-0.1282image
ENSG00000120802.12,TMPOSARCEAGPlasma_cells2.3218e-020.1424image
chr12:98548816-98549473:+SKCMEERT_cells_CD83.2557e-020.0992image
ENSG00000120802.12,TMPOSKCMEAGT_cells_CD83.2557e-020.0992image
chr12:98526722-98527430:+STADEERPlasma_cells2.3795e-020.3525image
chr12:98548816-98549473:+STADEERMacrophages_M27.3543e-040.1740image
ENSG00000120802.12,TMPOSTADEAGMacrophages_M27.3933e-040.1740image
chr12:98548816-98549473:+TGCTEERDendritic_cells_resting6.6974e-060.3539image
ENSG00000120802.12,TMPOTGCTEAGDendritic_cells_resting6.7196e-060.3539image
chr12:98548816-98549473:+THCAEERT_cells_regulatory_(Tregs)1.2090e-040.1714image
ENSG00000120802.12,TMPOTHCAEAGT_cells_regulatory_(Tregs)1.2131e-040.1714image
chr12:98548816-98549473:+THYMEERT_cells_CD4_memory_resting4.3348e-02-0.1871image
chr12:98548816-98549473:+UCECEERDendritic_cells_activated1.2030e-040.2866image
ENSG00000120802.12,TMPOUCECEAGDendritic_cells_activated6.1655e-030.2051image
chr12:98548816-98549473:+UCSEERT_cells_CD83.3562e-020.2845image
ENSG00000120802.12,TMPOUCSEAGT_cells_CD83.3562e-020.2845image


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6. Enriched editing regions and immune gene sets for TMPO


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr12:98548816-98549473:+BLCAEER1.2151e-03image8.2807e-03-0.1312image
ENSG00000120802.12,TMPOBLCAEAG1.2566e-03image8.8454e-03-0.1301image
chr12:98548816-98549473:+HNSCEER1.3015e-02image2.6281e-02-0.0997image
ENSG00000120802.12,TMPOHNSCEAG1.2794e-02image2.6406e-02-0.0996image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000120802.12,TMPOCOADEAG8.5700e-04-0.20033.8798e-02-0.12497.2433e-04-0.20303.1811e-03-0.1776image
chr12:98548816-98549473:+KIRPEER5.3158e-04-0.20546.7684e-04-0.20167.0944e-03-0.16035.8149e-03-0.1642image
ENSG00000120802.12,TMPOKIRPEAG5.2278e-04-0.20566.7854e-04-0.20157.1157e-03-0.16025.7620e-03-0.1643image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr12:98548816-98549473:+ACCGSVA_HALLMARK_PROTEIN_SECRETIONEER5.4869e-03-0.3136image
ENSG00000120802.12,TMPOACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG5.4869e-03-0.3136image
ENSG00000120802.12,TMPOBLCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG7.4952e-06-0.2208image
chr12:98548816-98549473:+BLCAGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER7.0410e-06-0.2214image
ENSG00000120802.12,TMPOBRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG1.8062e-03-0.0948image
chr12:98548816-98549473:+BRCAGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER2.0799e-03-0.0935image
chr12:98548816-98549473:+CESCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.0988e-04-0.2207image
ENSG00000120802.12,TMPOCESCGSVA_HALLMARK_PROTEIN_SECRETIONEAG6.7988e-04-0.1945image
ENSG00000120802.12,TMPOCOADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG3.7823e-04-0.2133image
chr12:98548816-98549473:+COADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER2.9764e-04-0.2169image
chr12:98548816-98549473:+DLBCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER8.4725e-03-0.3758image
ENSG00000120802.12,TMPODLBCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG8.4976e-03-0.3757image
ENSG00000120802.12,TMPOESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG4.5159e-020.1581image
chr12:98548816-98549473:+ESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER4.9024e-020.1554image
chr12:98548816-98549473:+GBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER8.6255e-100.4521image
ENSG00000120802.12,TMPOGBMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG8.6239e-100.4521image
ENSG00000120802.12,TMPOHNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.6061e-09-0.2664image
chr12:98548816-98549473:+HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5848e-09-0.2665image
chr12:98548816-98549473:+KICHGSVA_HALLMARK_HYPOXIAEER5.1687e-05-0.4802image
ENSG00000120802.12,TMPOKICHGSVA_HALLMARK_HYPOXIAEAG5.1687e-05-0.4802image
ENSG00000120802.12,TMPOKIRCGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG6.2036e-05-0.2032image
chr12:98548816-98549473:+KIRCGSVA_HALLMARK_TGF_BETA_SIGNALINGEER5.2187e-05-0.2052image
ENSG00000120802.12,TMPOKIRPGSVA_HALLMARK_UV_RESPONSE_DNEAG9.3309e-08-0.3119image
chr12:98548816-98549473:+KIRPGSVA_HALLMARK_UV_RESPONSE_DNEER9.0783e-08-0.3122image
ENSG00000120802.12,TMPOLAMLGSVA_HALLMARK_ADIPOGENESISEAG2.3892e-03-0.2462image
chr12:98548816-98549473:+LAMLGSVA_HALLMARK_ADIPOGENESISEER3.1527e-03-0.2396image
ENSG00000120802.12,TMPOLGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.4995e-11-0.2803image
chr12:98548816-98549473:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER5.4995e-11-0.2803image
chr12:98548816-98549473:+LIHCGSVA_HALLMARK_HEME_METABOLISMEER5.5257e-10-0.3178image
ENSG00000120802.12,TMPOLIHCGSVA_HALLMARK_HEME_METABOLISMEAG5.5241e-10-0.3178image
ENSG00000120802.12,TMPOLUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG7.0570e-06-0.1965image
chr12:98548816-98549473:+LUADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER7.5001e-06-0.1959image
chr12:98548816-98549473:+LUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.6531e-030.1238image
ENSG00000120802.12,TMPOLUSCGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG5.6258e-030.1239image
chr12:98548816-98549473:+MESOGSVA_HALLMARK_TGF_BETA_SIGNALINGEER5.8536e-03-0.3037image
ENSG00000120802.12,TMPOMESOGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG5.8536e-03-0.3037image
ENSG00000120802.12,TMPOOVGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.3818e-03-0.1710image
chr12:98548816-98549473:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER3.4390e-03-0.1707image
ENSG00000120802.12,TMPOPAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEAG5.0214e-04-0.2589image
chr12:98548816-98549473:+PAADGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER5.0378e-04-0.2588image
ENSG00000120802.12,TMPOPCPGGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.9046e-02-0.1781image
chr12:98548816-98549473:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER1.9046e-02-0.1781image
chr12:98548816-98549473:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER1.1353e-10-0.2845image
ENSG00000120802.12,TMPOPRADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.0644e-10-0.2849image
ENSG00000120802.12,TMPOREADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG2.6572e-03-0.3065image
chr12:98548816-98549473:+READGSVA_HALLMARK_PANCREAS_BETA_CELLSEER2.6572e-03-0.3065image
ENSG00000120802.12,TMPOSARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG2.0889e-030.1922image
chr12:98548816-98549473:+SARCGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.1964e-030.1794image
ENSG00000120802.12,TMPOSKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.6472e-09-0.2695image
chr12:98548816-98549473:+SKCMGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.6472e-09-0.2695image
ENSG00000120802.12,TMPOSTADGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.9062e-02-0.1020image
ENSG00000120802.12,TMPOTGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.6689e-04-0.2988image
chr12:98548816-98549473:+TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER1.7145e-04-0.2983image
chr12:98548816-98549473:+THCAGSVA_HALLMARK_UV_RESPONSE_DNEER7.3279e-08-0.2383image
ENSG00000120802.12,TMPOTHCAGSVA_HALLMARK_UV_RESPONSE_DNEAG7.3331e-08-0.2383image
ENSG00000120802.12,TMPOTHYMGSVA_HALLMARK_HEME_METABOLISMEAG4.5368e-06-0.4095image
chr12:98548816-98549473:+THYMGSVA_HALLMARK_HEME_METABOLISMEER4.5073e-07-0.4465image
ENSG00000120802.12,TMPOUCECGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.3314e-03-0.2394image
chr12:98548816-98549473:+UCECGSVA_HALLMARK_MITOTIC_SPINDLEEER2.7233e-03-0.2253image
chr12:98548816-98549473:+UVMGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.5072e-04-0.4429image
ENSG00000120802.12,TMPOUVMGSVA_HALLMARK_ANDROGEN_RESPONSEEAG3.5072e-04-0.4429image


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7. Enriched editing regions and drugs for TMPO


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr12:98548816-98549473:+ACCLFM.A13EER2.3271e-02-0.2584image
ENSG00000120802.12,TMPOACCLFM.A13EAG2.3271e-02-0.2584image
ENSG00000120802.12,TMPOBLCACGP.082996EAG2.7703e-040.1800image
chr12:98548816-98549473:+BLCACGP.082996EER2.3874e-040.1818image
ENSG00000120802.12,TMPOBRCAGefitinibEAG8.0107e-03-0.0810image
chr12:98548816-98549473:+BRCAGefitinibEER8.6955e-03-0.0802image
ENSG00000120802.12,TMPOCESCCEP.701EAG4.9352e-03-0.1614image
chr12:98548816-98549473:+CESCCEP.701EER5.6647e-04-0.1972image
chr12:98548816-98549473:+CHOLAUY922EER4.5884e-02-0.3397image
ENSG00000120802.12,TMPOCHOLAUY922EAG4.5884e-02-0.3397image
ENSG00000120802.12,TMPOCOADBortezomibEAG3.6584e-040.2138image
chr12:98548816-98549473:+COADBortezomibEER4.7649e-040.2097image
chr12:98548816-98549473:+DLBCImatinibEER2.8443e-050.5652image
ENSG00000120802.12,TMPODLBCImatinibEAG2.8581e-050.5651image
chr12:98548816-98549473:+ESCABMS.536924EER1.9842e-03-0.2420image
ENSG00000120802.12,TMPOESCABMS.536924EAG2.1956e-03-0.2397image
chr12:98548816-98549473:+GBMBIBW2992EER1.5740e-04-0.2884image
ENSG00000120802.12,TMPOGBMBIBW2992EAG1.5752e-04-0.2884image
ENSG00000120802.12,TMPOHNSCBX.795EAG9.0295e-130.3132image
chr12:98548816-98549473:+HNSCBX.795EER8.8941e-130.3133image
ENSG00000120802.12,TMPOKICHLFM.A13EAG3.1106e-02-0.2677image
chr12:98548816-98549473:+KICHLFM.A13EER3.1106e-02-0.2677image
chr12:98548816-98549473:+KIRCEmbelinEER3.3384e-050.2103image
ENSG00000120802.12,TMPOKIRCEmbelinEAG2.3988e-050.2140image
ENSG00000120802.12,TMPOKIRPEmbelinEAG6.0634e-070.2924image
chr12:98548816-98549473:+KIRPEmbelinEER5.8664e-070.2928image
chr12:98548816-98549473:+LGGAMG.706EER2.4395e-08-0.2400image
ENSG00000120802.12,TMPOLGGAMG.706EAG2.4395e-08-0.2400image
ENSG00000120802.12,TMPOLIHCBryostatin.1EAG7.0073e-06-0.2331image
chr12:98548816-98549473:+LIHCBryostatin.1EER7.0211e-06-0.2330image
chr12:98548816-98549473:+LUADCEP.701EER1.8269e-060.2085image
ENSG00000120802.12,TMPOLUADCEP.701EAG1.6864e-060.2092image
chr12:98548816-98549473:+LUSCBMS.754807EER7.0764e-030.1206image
ENSG00000120802.12,TMPOLUSCBMS.754807EAG7.1114e-030.1205image
chr12:98548816-98549473:+MESOBIBW2992EER2.0246e-05-0.4545image
ENSG00000120802.12,TMPOMESOBIBW2992EAG2.0246e-05-0.4545image
ENSG00000120802.12,TMPOOVBMS.536924EAG6.2191e-05-0.2321image
chr12:98548816-98549473:+OVBMS.536924EER6.2661e-05-0.2320image
ENSG00000120802.12,TMPOPAADBMS.708163EAG1.7796e-030.2333image
chr12:98548816-98549473:+PAADBMS.708163EER1.7724e-030.2334image
chr12:98548816-98549473:+PCPGGW.441756EER3.7458e-03-0.2193image
ENSG00000120802.12,TMPOPCPGGW.441756EAG3.7458e-03-0.2193image
ENSG00000120802.12,TMPOPRADAZ628EAG1.1964e-06-0.2180image
chr12:98548816-98549473:+PRADAZ628EER1.2968e-06-0.2173image
chr12:98548816-98549473:+READGSK.650394EER1.5717e-02-0.2485image
ENSG00000120802.12,TMPOREADGSK.650394EAG1.5717e-02-0.2485image
chr12:98548816-98549473:+SARCAZD6482EER8.1150e-030.1661image
ENSG00000120802.12,TMPOSARCBAY.61.3606EAG1.0053e-030.2052image
ENSG00000120802.12,TMPOSKCMGNF.2EAG3.6626e-06-0.2130image
chr12:98548816-98549473:+SKCMGNF.2EER3.6626e-06-0.2130image
chr12:98548816-98549473:+STADAxitinibEER3.0445e-030.1532image
ENSG00000120802.12,TMPOSTADAxitinibEAG2.9497e-030.1537image
ENSG00000120802.12,TMPOTGCTBMS.536924EAG6.6495e-06-0.3540image
chr12:98548816-98549473:+TGCTBMS.536924EER7.0038e-06-0.3532image
ENSG00000120802.12,TMPOTHCABAY.61.3606EAG6.2251e-180.3735image
chr12:98548816-98549473:+THCABAY.61.3606EER6.3147e-180.3734image
chr12:98548816-98549473:+THYMDasatinibEER1.4982e-12-0.5971image
ENSG00000120802.12,TMPOTHYMDasatinibEAG1.2520e-12-0.5988image
ENSG00000120802.12,TMPOUCECA.770041EAG6.2876e-14-0.5250image
chr12:98548816-98549473:+UCECBAY.61.3606EER5.7658e-060.3352image
ENSG00000120802.12,TMPOUCSDMOGEAG3.0856e-020.2888image
chr12:98548816-98549473:+UCSDMOGEER3.0856e-020.2888image
chr12:98548816-98549473:+UVMGW843682XEER4.9391e-04-0.4328image
ENSG00000120802.12,TMPOUVMGW843682XEAG4.9391e-04-0.4328image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType