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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TIAL1 (ImmuneEditome ID:7073)

1. Gene summary of enriched editing regions for TIAL1

check button Gene summary
Gene informationGene symbol

TIAL1

Gene ID

7073

GeneSynonymsTCBP|TIAR
GeneCytomap

10q26.11

GeneTypeprotein-coding
GeneDescriptionnucleolysin TIAR|T-cluster binding protein|TIA-1-related nucleolysin|TIA1 related|aging-associated gene 7 protein
GeneModificationdate20230329
UniprotIDQ01085;A6NKZ9;A0A087WX93;E7ETJ9;E7ETC0
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:119572184-119573374:-ENST00000369093.5ENSG00000151923.16TIAL1UTR3AluSx1,AluSc,AluSx3,AluSc5chr10:119572184-119573374:-.alignment
chr10:119588402-119588666:-ENST00000462373.1ENSG00000151923.16TIAL1ncRNA_intronicAluSq2chr10:119588402-119588666:-.alignment
chr10:119588402-119588666:-ENST00000470781.4ENSG00000151923.16TIAL1ncRNA_intronicAluSq2chr10:119588402-119588666:-.alignment
chr10:119588402-119588666:-ENST00000489822.4ENSG00000151923.16TIAL1ncRNA_intronicAluSq2chr10:119588402-119588666:-.alignment


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2. Tumor-specific enriched editing regions for TIAL1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr10:119572184-119573374:-BRCAEER4.0347e-15image
ENSG00000151923.16,TIAL1BRCAEAG3.7381e-15image
chr10:119572184-119573374:-COADEER7.6377e-10image
ENSG00000151923.16,TIAL1COADEAG8.3782e-10image
chr10:119572184-119573374:-HNSCEER5.9245e-07image
ENSG00000151923.16,TIAL1HNSCEAG5.9245e-07image
chr10:119572184-119573374:-KIRCEER1.5231e-02image
ENSG00000151923.16,TIAL1KIRCEAG1.5231e-02image
chr10:119572184-119573374:-LIHCEER2.7545e-02image
ENSG00000151923.16,TIAL1LIHCEAG2.7487e-02image
chr10:119572184-119573374:-LUSCEER2.0701e-08image
ENSG00000151923.16,TIAL1LUSCEAG2.0701e-08image
chr10:119572184-119573374:-THCAEER3.0157e-06image
ENSG00000151923.16,TIAL1THCAEAG3.0157e-06image
chr10:119572184-119573374:-UCECEER2.3920e-06image
ENSG00000151923.16,TIAL1UCECEAG3.7826e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000151923.16,TIAL1BLCAPathEAG9.8877e-061.1666e-030.1714image
chr10:119572184-119573374:-BLCAPathEER1.1132e-051.4902e-030.1678image
chr10:119572184-119573374:-LUSCPathEER5.1824e-031.4352e-030.1640image
ENSG00000151923.16,TIAL1LUSCPathEAG5.1824e-031.4352e-030.1640image
chr10:119572184-119573374:-THCAPathEER4.3850e-032.3227e-030.1358image
ENSG00000151923.16,TIAL1THCAPathEAG4.3850e-032.3227e-030.1358image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr10:119572184-119573374:-LIHCEER3.0876e-022.0434e-026.0714e-02image
ENSG00000151923.16,TIAL1LIHCEAG3.0876e-022.0434e-026.0714e-02image

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3. Enriched editing regions and immune related genes for TIAL1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:119572184-119573374:-BLCAEERENSG00000269044,CTC-429P9.3-0.44654.7565e-153.0049e-16-0.4150imageNNNAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
chr10:119572184-119573374:-BLCAEERENSG00000007392,LUC7L-0.43878.4427e-155.0946e-16-0.4120imageTIAL1NNAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
chr10:119572184-119573374:-BLCAEERENSG00000006282,SPATA20-0.38581.0778e-112.8177e-15-0.4022imageNNNAMacrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
chr10:119572184-119573374:-BRCAEERENSG00000269044,CTC-429P9.3-0.45291.6181e-482.1735e-45-0.4185imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MTORC1_SIGNALING
chr10:119572184-119573374:-GBMEERENSG00000003756,RBM5-0.47401.9438e-061.0531e-09-0.4550imageTIAL1NRBM5T_cells_follicular_helperGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr10:119572184-119573374:-GBMEERENSG00000182841,RRP7B-0.45794.4358e-061.2454e-08-0.4276imageNNNAT_cells_follicular_helperGSVA_HALLMARK_BILE_ACID_METABOLISM
chr10:119572184-119573374:-GBMEERENSG00000166261,ZNF202-0.45854.5617e-061.2930e-08-0.4272imageTIAL1NNAMonocytesGSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr10:119572184-119573374:-GBMEERENSG00000120458,MSANTD2-0.45615.8839e-069.7811e-08-0.4028imageTIAL1NNAMonocytesGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr10:119572184-119573374:-GBMEERENSG00000124193,SRSF6-0.45406.6099e-068.0994e-08-0.4052imageTIAL1NNAMonocytesGSVA_HALLMARK_ESTROGEN_RESPONSE_LATE
chr10:119572184-119573374:-GBMEERENSG00000281468,CTC-459F4.9-0.45466.9914e-061.9644e-08-0.4223imageNNNAT_cells_follicular_helperGSVA_HALLMARK_HEME_METABOLISM

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4. Enriched editing regions and immune related splicing for TIAL1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr10:119572184-119573374:-
BLCAEERMEXENSG00000112715.16chr643777539:43777665:43778459:43778536:43782010:43782087:43784540:437845620.40125.3153e-112.1770e-150.4037imageTIAL1NVEGFAT_cells_CD4_naiveGSVA_HALLMARK_APOPTOSIS
chr10:119572184-119573374:-
BLCAEERIRENSG00000118518.11chr6127285207:127286177:127286615:127286643-0.36365.7540e-116.3420e-14-0.4157imageTIAL1NNAT_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP
chr10:119572184-119573374:-
BLCAEERIRENSG00000104957.9chr1913758867:13759010:13759099:13759272-0.39601.2442e-101.4845e-15-0.4064imageNNNAT_cells_CD4_memory_activatedGSVA_HALLMARK_MTORC1_SIGNALING
chr10:119572184-119573374:-
BLCAEERIRENSG00000113240.8chr5178616877:178616948:178617343:178617434-0.33933.7738e-105.3558e-14-0.4188imageTIAL1NNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr10:119572184-119573374:-
BLCAEERIRENSG00000013441.11chr2200859679:200860215:200861237:200861466-0.37254.9610e-103.1869e-15-0.4036imageTIAL1NNAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
chr10:119572184-119573374:-
BLCAEERIRENSG00000134444.9chr1862277595:62280442:62280645:62280709-0.35406.7442e-102.0223e-13-0.4001imageTIAL1NNAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000151923.16,TIAL1
BLCAEAGIRENSG00000130985.12chrX47193828:47198355:47198802:47198919-0.26771.7717e-064.6557e-12-0.4019imageTIAL1ACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL14;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM5;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000151923.16,TIAL1
BLCAEAGIRENSG00000138073.9chr227133116:27133337:27133531:27133568-0.42422.6090e-122.6144e-15-0.4027imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CBX7;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000151923.16,TIAL1
BLCAEAGIRENSG00000125901.5chr203046613:3046900:3047734:3048254-0.40275.5726e-122.4958e-15-0.4132imageNAIFM1;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP4B;LIN28;LIN28A;LIN28B;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAMacrophages_M1GSVA_HALLMARK_UV_RESPONSE_UP
ENSG00000151923.16,TIAL1
BLCAEAGIRENSG00000112715.16chr643773171:43777665:43778459:43778536-0.41021.1601e-112.5935e-16-0.4158imageTIAL1ACIN1;ADAR;AIFM1;ALYREF;AUH;BCCIP;BUD13;CAPRIN1;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;PUM2;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RBM5;RC3H1;RNF219;RTCB;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZFP36;ZNF184VEGFAT_cells_CD4_naiveGSVA_HALLMARK_UV_RESPONSE_UP

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5. Enriched editing regions and immune infiltration for TIAL1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr10:119572184-119573374:-ACCEERB_cells_naive1.6314e-02-0.2803image
ENSG00000151923.16,TIAL1ACCEAGB_cells_naive1.6314e-02-0.2803image
chr10:119572184-119573374:-BLCAEERMacrophages_M13.1698e-080.2880image
ENSG00000151923.16,TIAL1BLCAEAGMacrophages_M13.7815e-080.2864image
chr10:119572184-119573374:-BRCAEERT_cells_CD4_memory_activated1.5870e-050.1333image
ENSG00000151923.16,TIAL1BRCAEAGT_cells_CD4_memory_activated1.4372e-050.1339image
chr10:119572184-119573374:-CESCEERPlasma_cells6.7058e-04-0.2000image
ENSG00000151923.16,TIAL1CESCEAGPlasma_cells6.7485e-04-0.1999image
chr10:119572184-119573374:-CHOLEERB_cells_memory3.9719e-02-0.3598image
ENSG00000151923.16,TIAL1CHOLEAGB_cells_memory3.9719e-02-0.3598image
chr10:119572184-119573374:-COADEERNeutrophils8.4952e-040.2089image
ENSG00000151923.16,TIAL1COADEAGDendritic_cells_activated5.2321e-040.2170image
chr10:119572184-119573374:-DLBCEERMacrophages_M15.7204e-030.4099image
ENSG00000151923.16,TIAL1DLBCEAGMacrophages_M15.7204e-030.4099image
chr10:119572184-119573374:-ESCAEERNK_cells_resting9.4484e-030.2085image
ENSG00000151923.16,TIAL1ESCAEAGNK_cells_resting1.0432e-020.2058image
chr10:119572184-119573374:-GBMEERMonocytes5.7389e-040.2669image
ENSG00000151923.16,TIAL1GBMEAGMonocytes5.7385e-040.2669image
chr10:119572184-119573374:-HNSCEERT_cells_regulatory_(Tregs)2.0721e-05-0.2165image
ENSG00000151923.16,TIAL1HNSCEAGT_cells_regulatory_(Tregs)2.0721e-05-0.2165image
chr10:119572184-119573374:-KICHEEREosinophils1.4197e-030.3877image
ENSG00000151923.16,TIAL1KICHEAGEosinophils1.4197e-030.3877image
chr10:119572184-119573374:-KIRCEERT_cells_CD4_memory_activated1.0881e-030.1683image
ENSG00000151923.16,TIAL1KIRCEAGT_cells_CD4_memory_activated1.0881e-030.1683image
chr10:119572184-119573374:-KIRPEERNK_cells_activated2.6140e-05-0.2476image
ENSG00000151923.16,TIAL1KIRPEAGNK_cells_activated2.6140e-05-0.2476image
chr10:119572184-119573374:-LAMLEERMast_cells_activated2.8473e-020.3131image
ENSG00000151923.16,TIAL1LAMLEAGMast_cells_activated3.5828e-020.2890image
chr10:119572184-119573374:-LGGEERT_cells_CD4_naive3.7284e-07-0.2188image
ENSG00000151923.16,TIAL1LGGEAGT_cells_CD4_naive3.7284e-07-0.2188image
chr10:119572184-119573374:-LIHCEERT_cells_follicular_helper4.8140e-04-0.1917image
ENSG00000151923.16,TIAL1LIHCEAGT_cells_follicular_helper4.8147e-04-0.1917image
chr10:119572184-119573374:-LUADEERT_cells_CD4_memory_activated5.2985e-050.1900image
ENSG00000151923.16,TIAL1LUADEAGT_cells_CD4_memory_activated5.2985e-050.1900image
chr10:119572184-119573374:-LUSCEERB_cells_naive1.1434e-02-0.1307image
ENSG00000151923.16,TIAL1LUSCEAGB_cells_naive1.1434e-02-0.1307image
chr10:119572184-119573374:-MESOEERT_cells_follicular_helper1.6528e-020.2690image
ENSG00000151923.16,TIAL1MESOEAGT_cells_follicular_helper1.6528e-020.2690image
chr10:119572184-119573374:-OVEERMacrophages_M17.3324e-050.2351image
ENSG00000151923.16,TIAL1OVEAGMacrophages_M18.6179e-050.2329image
chr10:119572184-119573374:-PAADEERMacrophages_M03.4541e-020.1627image
ENSG00000151923.16,TIAL1PAADEAGMacrophages_M03.4541e-020.1627image
chr10:119572184-119573374:-PCPGEERT_cells_regulatory_(Tregs)1.8931e-020.1748image
ENSG00000151923.16,TIAL1PCPGEAGT_cells_regulatory_(Tregs)1.8931e-020.1748image
chr10:119572184-119573374:-PRADEERMacrophages_M13.0223e-050.1863image
ENSG00000151923.16,TIAL1PRADEAGMacrophages_M13.0892e-050.1861image
chr10:119572184-119573374:-READEERPlasma_cells1.8261e-02-0.2484image
ENSG00000151923.16,TIAL1READEAGPlasma_cells1.8261e-02-0.2484image
chr10:119572184-119573374:-SARCEERMacrophages_M16.8647e-030.1741image
ENSG00000151923.16,TIAL1SARCEAGMacrophages_M16.8647e-030.1741image
chr10:119572184-119573374:-SKCMEERB_cells_memory1.2596e-03-0.1563image
ENSG00000151923.16,TIAL1SKCMEAGB_cells_memory1.2596e-03-0.1563image
chr10:119572184-119573374:-STADEERMacrophages_M22.8843e-030.1682image
ENSG00000151923.16,TIAL1STADEAGMacrophages_M22.3722e-030.1709image
chr10:119572184-119573374:-TGCTEERT_cells_regulatory_(Tregs)9.1308e-05-0.3130image
ENSG00000151923.16,TIAL1TGCTEAGT_cells_regulatory_(Tregs)9.1308e-05-0.3130image
chr10:119572184-119573374:-THCAEERDendritic_cells_activated5.5665e-040.1535image
ENSG00000151923.16,TIAL1THCAEAGDendritic_cells_activated5.5665e-040.1535image
chr10:119572184-119573374:-THYMEERMast_cells_resting2.2718e-060.4245image
ENSG00000151923.16,TIAL1THYMEAGMast_cells_resting2.2718e-060.4245image
chr10:119572184-119573374:-UCECEERDendritic_cells_resting1.7458e-02-0.1837image
ENSG00000151923.16,TIAL1UCECEAGDendritic_cells_resting2.9757e-02-0.1677image
chr10:119572184-119573374:-UCSEERB_cells_naive1.8429e-02-0.3168image
ENSG00000151923.16,TIAL1UCSEAGB_cells_naive1.8429e-02-0.3168image
chr10:119572184-119573374:-UVMEERNK_cells_resting3.1255e-02-0.2506image
ENSG00000151923.16,TIAL1UVMEAGNK_cells_resting3.1255e-02-0.2506image


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6. Enriched editing regions and immune gene sets for TIAL1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot
chr10:119572184-119573374:-KIRPEER4.1052e-03image9.2736e-050.2306image
ENSG00000151923.16,TIAL1KIRPEAG4.1052e-03image9.2736e-050.2306image


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr10:119572184-119573374:-BLCAEER7.0012e-070.25948.9725e-060.23296.9713e-060.23573.0439e-080.2883image
ENSG00000151923.16,TIAL1BLCAEAG5.5436e-070.26167.6425e-060.23474.9038e-060.23952.8542e-080.2889image
chr10:119572184-119573374:-BRCAEER1.4356e-130.22642.7395e-100.19401.0274e-060.15082.5612e-110.2048image
ENSG00000151923.16,TIAL1BRCAEAG1.5163e-130.22612.3019e-100.19481.0525e-060.15053.7647e-110.2030image
chr10:119572184-119573374:-LIHCEER2.3627e-04-0.20174.4177e-07-0.27451.7422e-06-0.26041.1260e-020.1398image
ENSG00000151923.16,TIAL1LIHCEAG2.3603e-04-0.20174.3574e-07-0.27461.7326e-06-0.26051.1204e-020.1399image
chr10:119572184-119573374:-LUADEER4.5883e-050.19152.9910e-030.14011.4233e-040.17902.7639e-040.1712image
ENSG00000151923.16,TIAL1LUADEAG4.5883e-050.19152.9910e-030.14011.4233e-040.17902.7639e-040.1712image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr10:119572184-119573374:-ACCGSVA_HALLMARK_PROTEIN_SECRETIONEER1.2471e-020.2911image
ENSG00000151923.16,TIAL1ACCGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2471e-020.2911image
ENSG00000151923.16,TIAL1BLCAGSVA_HALLMARK_MTORC1_SIGNALINGEAG8.0674e-120.3520image
chr10:119572184-119573374:-BLCAGSVA_HALLMARK_UV_RESPONSE_UPEER8.9727e-120.3512image
ENSG00000151923.16,TIAL1BRCAGSVA_HALLMARK_GLYCOLYSISEAG1.2104e-310.3514image
chr10:119572184-119573374:-BRCAGSVA_HALLMARK_GLYCOLYSISEER3.6718e-320.3544image
ENSG00000151923.16,TIAL1CESCGSVA_HALLMARK_HYPOXIAEAG1.1144e-080.3297image
chr10:119572184-119573374:-CESCGSVA_HALLMARK_HYPOXIAEER1.1113e-080.3298image
chr10:119572184-119573374:-CHOLGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.8958e-020.4063image
ENSG00000151923.16,TIAL1CHOLGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG1.8958e-020.4063image
ENSG00000151923.16,TIAL1COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG1.3044e-030.2014image
chr10:119572184-119573374:-COADGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER7.8619e-040.2102image
chr10:119572184-119573374:-DLBCGSVA_HALLMARK_HYPOXIAEER1.6732e-050.6000image
ENSG00000151923.16,TIAL1DLBCGSVA_HALLMARK_HYPOXIAEAG1.6732e-050.6000image
ENSG00000151923.16,TIAL1ESCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.8608e-020.1895image
chr10:119572184-119573374:-ESCAGSVA_HALLMARK_COMPLEMENTEER1.3607e-020.1985image
ENSG00000151923.16,TIAL1GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.3470e-080.4267image
chr10:119572184-119573374:-GBMGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.3482e-080.4267image
ENSG00000151923.16,TIAL1HNSCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG5.8740e-060.2301image
chr10:119572184-119573374:-HNSCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER5.8740e-060.2301image
ENSG00000151923.16,TIAL1KICHGSVA_HALLMARK_HEME_METABOLISMEAG1.0235e-020.3164image
chr10:119572184-119573374:-KICHGSVA_HALLMARK_HEME_METABOLISMEER1.0235e-020.3164image
ENSG00000151923.16,TIAL1KIRCGSVA_HALLMARK_MTORC1_SIGNALINGEAG1.0530e-170.4234image
chr10:119572184-119573374:-KIRCGSVA_HALLMARK_MTORC1_SIGNALINGEER1.0530e-170.4234image
ENSG00000151923.16,TIAL1KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG3.0244e-200.5120image
chr10:119572184-119573374:-KIRPGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.0244e-200.5120image
ENSG00000151923.16,TIAL1LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.6641e-02-0.2878image
chr10:119572184-119573374:-LAMLGSVA_HALLMARK_PROTEIN_SECRETIONEER2.4311e-02-0.3214image
chr10:119572184-119573374:-LGGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER9.6671e-280.4500image
ENSG00000151923.16,TIAL1LGGGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG9.6671e-280.4500image
ENSG00000151923.16,TIAL1LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.4280e-120.3778image
chr10:119572184-119573374:-LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.4031e-120.3780image
chr10:119572184-119573374:-LUADGSVA_HALLMARK_GLYCOLYSISEER3.0183e-070.2394image
ENSG00000151923.16,TIAL1LUADGSVA_HALLMARK_GLYCOLYSISEAG3.0183e-070.2394image
ENSG00000151923.16,TIAL1LUSCGSVA_HALLMARK_UV_RESPONSE_UPEAG5.9171e-080.2758image
chr10:119572184-119573374:-LUSCGSVA_HALLMARK_UV_RESPONSE_UPEER5.9171e-080.2758image
ENSG00000151923.16,TIAL1MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG5.8851e-050.4361image
chr10:119572184-119573374:-MESOGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER5.8851e-050.4361image
chr10:119572184-119573374:-OVGSVA_HALLMARK_APOPTOSISEER2.6999e-060.2767image
ENSG00000151923.16,TIAL1OVGSVA_HALLMARK_APOPTOSISEAG2.4614e-060.2777image
ENSG00000151923.16,TIAL1PAADGSVA_HALLMARK_HYPOXIAEAG6.8068e-070.3711image
chr10:119572184-119573374:-PAADGSVA_HALLMARK_HYPOXIAEER6.8068e-070.3711image
chr10:119572184-119573374:-PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER3.7987e-060.3367image
ENSG00000151923.16,TIAL1PCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.7987e-060.3367image
chr10:119572184-119573374:-PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER2.0961e-060.2114image
ENSG00000151923.16,TIAL1PRADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.8865e-060.2123image
ENSG00000151923.16,TIAL1READGSVA_HALLMARK_UV_RESPONSE_DNEAG9.3174e-030.2727image
chr10:119572184-119573374:-READGSVA_HALLMARK_UV_RESPONSE_DNEER9.3174e-030.2727image
chr10:119572184-119573374:-SARCGSVA_HALLMARK_HYPOXIAEER8.3278e-040.2143image
ENSG00000151923.16,TIAL1SARCGSVA_HALLMARK_HYPOXIAEAG8.3278e-040.2143image
chr10:119572184-119573374:-SKCMGSVA_HALLMARK_UV_RESPONSE_UPEER1.2109e-110.3218image
ENSG00000151923.16,TIAL1SKCMGSVA_HALLMARK_UV_RESPONSE_UPEAG1.2109e-110.3218image
ENSG00000151923.16,TIAL1STADGSVA_HALLMARK_UV_RESPONSE_UPEAG1.9539e-090.3304image
chr10:119572184-119573374:-STADGSVA_HALLMARK_UV_RESPONSE_UPEER9.5523e-090.3177image
ENSG00000151923.16,TIAL1TGCTGSVA_HALLMARK_DNA_REPAIREAG8.8546e-060.3528image
chr10:119572184-119573374:-TGCTGSVA_HALLMARK_DNA_REPAIREER8.8546e-060.3528image
chr10:119572184-119573374:-THCAGSVA_HALLMARK_GLYCOLYSISEER2.1296e-160.3555image
ENSG00000151923.16,TIAL1THCAGSVA_HALLMARK_GLYCOLYSISEAG2.1296e-160.3555image
chr10:119572184-119573374:-THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEER5.9447e-080.4794image
ENSG00000151923.16,TIAL1THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG5.9447e-080.4794image
chr10:119572184-119573374:-UCECGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER5.2622e-030.2150image
ENSG00000151923.16,TIAL1UCECGSVA_HALLMARK_MTORC1_SIGNALINGEAG8.7876e-060.3355image
ENSG00000151923.16,TIAL1UCSGSVA_HALLMARK_GLYCOLYSISEAG2.4690e-050.5360image
chr10:119572184-119573374:-UCSGSVA_HALLMARK_GLYCOLYSISEER2.4690e-050.5360image
chr10:119572184-119573374:-UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.7529e-050.4768image
ENSG00000151923.16,TIAL1UVMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.7529e-050.4768image


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7. Enriched editing regions and drugs for TIAL1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr10:119572184-119573374:-ACCGefitinibEER8.6122e-030.3054image
ENSG00000151923.16,TIAL1ACCGefitinibEAG8.6122e-030.3054image
ENSG00000151923.16,TIAL1BLCACMKEAG3.3167e-11-0.3420image
chr10:119572184-119573374:-BLCAAICAREER4.5740e-11-0.3397image
ENSG00000151923.16,TIAL1BRCACCT007093EAG1.7451e-060.1475image
chr10:119572184-119573374:-BRCACCT007093EER1.2892e-060.1494image
ENSG00000151923.16,TIAL1CESCAKT.inhibitor.VIIIEAG2.7099e-040.2138image
chr10:119572184-119573374:-CESCAKT.inhibitor.VIIIEER2.7065e-040.2138image
chr10:119572184-119573374:-CHOLMidostaurinEER1.0209e-02-0.4410image
ENSG00000151923.16,TIAL1CHOLMidostaurinEAG1.0209e-02-0.4410image
ENSG00000151923.16,TIAL1COADBMS.708163EAG8.7874e-05-0.2445image
chr10:119572184-119573374:-COADBMS.708163EER1.4119e-04-0.2375image
chr10:119572184-119573374:-DLBCBexaroteneEER1.1107e-02-0.3793image
ENSG00000151923.16,TIAL1DLBCBexaroteneEAG1.1107e-02-0.3793image
ENSG00000151923.16,TIAL1ESCABexaroteneEAG4.2027e-02-0.1641image
chr10:119588402-119588666:-ESCAAZD6244EER5.8143e-03-0.4448image
chr10:119572184-119573374:-ESCABexaroteneEER4.9244e-02-0.1587image
chr10:119572184-119573374:-GBMAxitinibEER4.0224e-060.3522image
ENSG00000151923.16,TIAL1GBMAxitinibEAG4.0220e-060.3522image
ENSG00000151923.16,TIAL1HNSCBMS.708163EAG4.7866e-06-0.2322image
chr10:119572184-119573374:-HNSCBMS.708163EER4.7866e-06-0.2322image
chr10:119572184-119573374:-KICHEHT.1864EER7.0048e-040.4097image
ENSG00000151923.16,TIAL1KICHEHT.1864EAG7.0048e-040.4097image
chr10:119572184-119573374:-KIRCBIRB.0796EER9.4413e-080.2720image
ENSG00000151923.16,TIAL1KIRCBIRB.0796EAG9.4413e-080.2720image
ENSG00000151923.16,TIAL1KIRPCCT018159EAG2.9200e-170.4748image
chr10:119572184-119573374:-KIRPCCT018159EER2.9200e-170.4748image
chr10:119572184-119573374:-LAMLAZD7762EER3.5881e-02-0.3005image
ENSG00000151923.16,TIAL1LAMLAZD7762EAG4.3930e-02-0.2779image
chr10:119572184-119573374:-LGGBexaroteneEER4.2573e-17-0.3544image
ENSG00000151923.16,TIAL1LGGBexaroteneEAG4.2573e-17-0.3544image
ENSG00000151923.16,TIAL1LIHCBleomycinEAG1.0497e-090.3321image
chr10:119572184-119573374:-LIHCBleomycinEER1.0470e-090.3322image
ENSG00000151923.16,TIAL1LUADCGP.60474EAG1.4446e-04-0.1788image
chr10:119572184-119573374:-LUADCGP.60474EER1.4446e-04-0.1788image
ENSG00000151923.16,TIAL1LUSCCCT007093EAG8.7759e-030.1353image
chr10:119572184-119573374:-LUSCCCT007093EER8.7759e-030.1353image
chr10:119572184-119573374:-MESOEHT.1864EER5.4031e-030.3102image
ENSG00000151923.16,TIAL1MESOEHT.1864EAG5.4031e-030.3102image
chr10:119572184-119573374:-OVGW.441756EER1.2249e-020.1498image
ENSG00000151923.16,TIAL1OVGW.441756EAG1.2044e-020.1501image
ENSG00000151923.16,TIAL1PAADBexaroteneEAG1.3718e-03-0.2443image
chr10:119572184-119573374:-PAADBexaroteneEER1.3718e-03-0.2443image
chr10:119572184-119573374:-PCPGBosutinibEER4.4229e-090.4199image
ENSG00000151923.16,TIAL1PCPGBosutinibEAG4.4229e-090.4199image
chr10:119572184-119573374:-PRADEHT.1864EER1.7344e-030.1404image
ENSG00000151923.16,TIAL1PRADEHT.1864EAG1.8272e-030.1398image
ENSG00000151923.16,TIAL1READBIBW2992EAG1.7542e-020.2499image
chr10:119572184-119573374:-READBIBW2992EER1.7542e-020.2499image
chr10:119572184-119573374:-SARCDoxorubicinEER3.5444e-040.2287image
ENSG00000151923.16,TIAL1SARCDoxorubicinEAG3.5444e-040.2287image
chr10:119572184-119573374:-SKCMGNF.2EER2.7695e-08-0.2660image
ENSG00000151923.16,TIAL1SKCMGNF.2EAG2.7695e-08-0.2660image
ENSG00000151923.16,TIAL1STADAZ628EAG3.9451e-07-0.2815image
chr10:119572184-119573374:-STADAZ628EER4.3600e-07-0.2814image
ENSG00000151923.16,TIAL1TGCTCCT007093EAG1.2267e-050.3476image
chr10:119572184-119573374:-TGCTCCT007093EER1.2267e-050.3476image
chr10:119572184-119573374:-THCAIPA.3EER2.7704e-120.3052image
ENSG00000151923.16,TIAL1THCAIPA.3EAG2.7704e-120.3052image
chr10:119572184-119573374:-THYMGW.441756EER2.0896e-10-0.5491image
ENSG00000151923.16,TIAL1THYMGW.441756EAG2.0896e-10-0.5491image
chr10:119572184-119573374:-UCECCGP.60474EER2.7555e-03-0.2303image
ENSG00000151923.16,TIAL1UCECCGP.082996EAG6.9092e-04-0.2592image
ENSG00000151923.16,TIAL1UCSBortezomibEAG1.2521e-05-0.5520image
chr10:119572184-119573374:-UCSBortezomibEER1.2521e-05-0.5520image
chr10:119572184-119573374:-UVMMG.132EER1.5807e-07-0.5649image
ENSG00000151923.16,TIAL1UVMMG.132EAG1.5807e-07-0.5649image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType